Tag: M.W=200-300

Related Products of 2425-41-4 ,Some common heterocyclic compound, 2425-41-4, molecular formula is C12H16O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The monobenzalpentaerythritol, 12 (4.16 g, 18.5 mmol), (3.4) 12G1-C02H (4a) (20.00 g, 40.75 mmol), and DPTS (5.45 g, 18.5 mmol) were dissolved in anhydrous CH2C12 (100 mL). DCC (9.94 g, 48.2 mmol) dissolved in anhydrous CH2C12 (10 mL) was added and the reaction was stirred for 12 h at room temperature under nitrogen atmosphere. After the reaction was complete, the mixture was diluted, filtered, and rinsed with Et20. The solvent was removed and the crude product was purified by column chromatography (Si02, 10% Et20:hexane) and followed by precipitation in MeOH to give a white solid as a product: 21.18 g (98%). NMR (500 MHz, CDC13) delta 7.60 (m, 2H, 2ArH-6), 7.54 – 7.48 (m, 4Eta, 2ArH-2, PhH- 3, 5), 7.38 (m, 3Eta, 3PhH-2, 4, 6), 6.83 (overlapped d, 2Eta, 2ArH-5), 5.51 (s, 1Eta, CH-acetal), 4.81 (s, 2Eta, ArC02CH2), 4.32 (d, J= 1 1.7 Hz, 2H, 20CHaHb-ring), 4.25 (s, 2H, ArC02CH2), 4.07 – 3.98 (m, 10Eta, 4ArOCH2, 20CHaHb-ring), 1.87 – 1.78 (m, 8Eta, 4ArOCH2CH2), 1.51 – 1.43 (m, 8Eta, 4ArOCH2CH2CH2), 1.26 (m, 64Eta, 4(CH2)8CH3), 0.88 (t, J= 6.8 Hz, 12H, 4G). 13C NMR (126 MHz, CDC13) delta 166.0 (C=0), 165.9 (C=0′), 153.5 (ArC-4), 153.3 (ArC-4′), 148.6 (ArC-3), 148.51 (ArC-3′), 137.6 (PhC-1), 129.1 (PhC-3, 5), 128.3 (PhC-4), 126.1 (PhC-2, 6), 123.5 (ArC- 1), 123.4 (ArC-1 ‘), 122.0 (ArC-6), 121.5 (ArC-6′), H4.3 (ArC-2), 1 14.2 (ArC-2′), 11 1.84 (ArC- 5), 1 11.80 (ArC-5′), 102.2 (CH-acetal), 69.7 (OC-ring), 69.2 (ArOCH2), 69.0 (ArOCH2), 68.9 (ArOCH2′), 63.7 (ArC02CH2), 62.9 (ArC02CH2’), 37.73 (C(CH20)4), 31.8 (CH2CH2CH3), 29.62, 29.60, 29.57, 29.55, 29.52, 29.35, 29.30, 29.28, 29.1, 28.98, 28.96, 25.94 (ArOCH2CH2CH2), 25.88 (ArOCH2CH2CH2), 22.6 (CH2CH3), 14.0 (CH3). The spectroscopic data of 16a are in agreement with those previously reported.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2425-41-4, (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PERCEC, Virgil; WO2014/190024; (2014); A1;,
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Adding a certain compound to certain chemical reactions, such as: 7541-49-3, 3,7,11,15-Tetramethylhexadec-2-en-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 7541-49-3, blongs to alcohols-buliding-blocks compound. COA of Formula: C20H40O

Product obtained by hydrogenating phytol. [1234] To a solution of phytol (30.00 g, 101.20 mmol) in THF (450 mL) in argon is added platinum dioxide (PtO2, 1.15 g, 6.61 mmol). The medium is placed under 1 bar of dihydrogen then stirred for 4 h at ambient temperature. After filtering on celite by rinsing with THF, a black oil of molecule 47 is obtained after concentration at reduced pressure. [1235] Yield: 29.00 g (96%) [1236] 1H NMR (CDCl3, ppm): 0.84 (6H); 0.86 (6H); 0.89 (3H); 1.00-1.46 (22H); 1.46-1.68 (3H); 3.61-3.73 (2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7541-49-3, its application will become more common.

Reference:
Patent; ADOCIA; CHAN, You-Ping; GEISSLER, Alexandre; NOEL, Romain; ROGER, Walter; CHARVET, Richard; LAURENT, Nicolas; (75 pag.)US2019/275156; (2019); A1;,
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Electric Literature of 7073-69-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol, molecular formula is C9H11BrO, molecular weight is 215.087, as common compound, the synthetic route is as follows.

General procedure: Using diaryl acetylenesA 5-mL two-necked flask equipped with a stir bar was charged with [RhCl(cod)]2 (0.0125 mmol,6.16 mg), BINAP (0.0125 mmol, 7.78 mg), 1a-c (0.25 mmol), KI (0.25 mmol, 41.5 mg), and Na2CO3(1.0 mmol, 106.0 mg). The central neck of the flask was equipped with a reflux condenser havinga N2 gas-bag (2 L), which was connected by a three-way stopcock at its top, and a rubber septumwas inserted i n to the side neck. The flask was evacuated and backfilled with N2 (three times).Xylene (1.0 mL), 2a (0.75 mmol, 161.3 mg), and furfural (1.75 mmol, 168.2 mg), were then added.After degassing the reaction mixture three times by the freeze-pump-thaw method, the flask wasfilled with N2. The mixture was placed in an oil bath that had been preheated to 140 C for 20 h.After cooling to room temperature, the resulting solution was filtered through a pad of celite, andthe filtrate was concentrated in vacuo. The resulting crude product was purified by flash columnchromatography on silica-gel to afford 3aa-3ac.

Statistics shows that 7073-69-0 is playing an increasingly important role. we look forward to future research findings about 2-(2-Bromophenyl)propan-2-ol.

Reference:
Article; Furusawa, Takuma; Tanimoto, Hiroki; Nishiyama, Yasuhiro; Morimoto, Tsumoru; Kakiuchi, Kiyomi; Chemistry Letters; vol. 46; 7; (2017); p. 926 – 929;,
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Electric Literature of 1346674-69-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1346674-69-8, name is (2,6-Dibromo-4-fluorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Example 104m 2,6-Dibromo-4-fluorobenzyl Acetate 104m To a solution of (2,6-dibromo-4-fluorophenyl)methanol (1041) (20 g, 71 mmol) in CH2Cl2 (500 mL) at 0 C. was added pyridine (8.4 g, 107 mmol) and acetyl chloride (8.3 g, 107 mmol). The mixture was stirred at room temperature for 5 h. TLC showed the start material disappeared. The reaction was evaporated in vacuum and the residue was purified by silica-gel column chromatography eluting with petroleum ether/ethyl acetate (from 50:1 to 20:1) to give 104m as a white solid (20 g, 87%). MS: [M-Oac]+ 267. 1H NMR (500 MHz, CDCl3) delta 7.36 (d, J=7.5, 2H), 5.38 (s, 2H), 2.10 (s, 3H)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1346674-69-8, (2,6-Dibromo-4-fluorophenyl)methanol.

Reference:
Patent; GENENTECH, INC.; Crawford, James John; Young, Wendy B.; US2013/116245; (2013); A1;,
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Related Products of 355-80-6 ,Some common heterocyclic compound, 355-80-6, molecular formula is C5H4F8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Glucose (9 g, 0.05 mol), 1-octafluoropentanol (116 g, 0.5 mol) and a catalyst (3.6 g) were placed in a glass reactor. The mixture was stirred for 5 h at 100 C under 200 Torr pressure. The unreacted glucose and the catalyst were separated by filtration, and the reaction products were obtained as a solution in fluoroalcohol. The alcohol was distilled off under reduced pressure on a rotary evaporator.Then 100 mL of water was added to the concentrated products and the remaining fluoroalcohol was removed as an azeotrope. In this way, the water solution of glucoside (containing 20% of non-volatile residue) was prepared. Next, the products were dried to give a pale-green viscous oil and analyzed by the GC/MS method. Analysis was performed using a HP 6890 series GC system (Hewlett-Packard, Palo Alto, CA, USA) equipped with a MSD detector (HP 5973 Network). A 30 m capillary column with 0.2 mm diameter, modified with HP-5M methylphenylsilicone, was used for separation of the reaction products.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 355-80-6, 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Nowicki, Janusz; Mokrzycki, ?ukasz; Sulikowski, Bogdan; Molecules; vol. 20; 4; (2015); p. 6140 – 6152;,
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Application of 722-92-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

To the stirred solution of 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (2.0 g, 7.72 mmol) in water (5 mL) was added HC1 (3.86 mL, 23.15 mmol) at 0 C. To this, sodium nitrite (0.639 g, 9.26 mmol) in water was added drop wise at 0 C and stirred for 1 hour. Potassium iodide (1.922 g, 11.58 mmol) was added and the reaction mixture was stirred at ambient temperature. After completion of the reaction, the aqueous layer was extracted with DCM. The DCM layer was dried over sodium sulphate and evaporated. The crude material obtained was purified by flash column chromatography (silica gel, hexane and ethyl acetate). 1H NMR (DMSO-d6, 300 MHz): oe ppm 8.87(s, 1H), 7.92 (d, J=8.7Hz, 2H), 7.46 (d, J=8.lHz,2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 722-92-9, 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol.

Reference:
Patent; PIRAMAL ENTERPRISES LIMITED; SHARMA, Rajiv; SAHU, Bichismita; MALI, Sunil, Vasantrao; SINGH, Deepak; KUMAR, Pramod, Bhaskar; DAWANGE, Mahesh; MISTRY, Hitesh; (108 pag.)WO2015/145371; (2015); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 329218-12-4, name is 3-Bromo-4-chlorobenzyl Alcohol. This compound has unique chemical properties. The synthetic route is as follows. name: 3-Bromo-4-chlorobenzyl Alcohol

260 g (about 1.05 mol) of crude (3-bromo-4-chlorophenyl)methanol were dissolved in 2.86 litres of dichloromethane, the solution was cooled to -5 C. and 127.1 g (44.6 ml, 460 mmol) of phosphorus tribromide were added slowly. After the end of the addition, the mixture was stirred at -5 C. for another 1 h and then diluted with diluted with dichloromethane and water. The organic phase was removed, dried over magnesium sulphate and concentrated under reduced pressure. This gave, as a crude product, 280.5 g (about 84% of theory) of 2-bromo-4-(bromomethyl)-1-chlorobenzene. [0432] GC-MS (Method 1): Rt=5.36 min; m/z=281/283/285 (M+H)+. [0433] 1H-NMR (400 MHz, DMSO-d6): delta [ppm]=4.71 (s, 2H), 7.49 (dd, 1H), 7.63 (d, 1H), 7.89 (d, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 329218-12-4, 3-Bromo-4-chlorobenzyl Alcohol.

Reference:
Patent; Lampe, Thomas; Hahn, Michael; Stasch, Johannes-Peter; Schlemmer, Karl-Heinz; Wunder, Frank; El Sheikh, Sherif; Li, Volkhart Min-Jian; Becker-Pelster, Eva Maria; Stoll, Friederike; Knorr, Andreas; US2015/152050; (2015); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5333-42-6, name is 2-octyldodecan-1-ol, the common compound, a new synthetic route is introduced below. Computed Properties of C20H42O

Example 7 Preparation of 2-octyldodecyl heptanoate To a 3-neck 1000 ml round-bottomed flask was added 2-octyl-1-dodecanol (250.0 g, 837.37 mmol, 1.0 equiv.), n-heptanoic acid (141.72 g, 1088.6 mmol, 1.30 equiv.), toluene (250 ml) and p-toluenesulfonic acid monohydrate (1.5929 g, 8.374 mmol, 0.010 equiv.) at room temperature. The resulting mixture was heated at reflux with stirring in an oil bath at 134 C. under a nitrogen atmosphere for 18 hours. The water produced in the reaction was collected in a Dean-Stark trap. The cooled mixture was diluted with hexanes, washed with dilute aqueous 10% Na2CO3 solution, water, brine, dried (MgSO4), filtered, and concentrated in vacuo to afford a crude product. Excess solvent was further removed by heating the crude product with stirring in an oil bath under high vacuum for 3 hours to afford a light yellow liquid (326.7 g, 95%).

The synthetic route of 5333-42-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ExxonMobil Research and Engineering Company; Ng, Man Kit; Oumar-Mahamat, Halou; Cheng, Hong; Blain, David A.; Cooper, Kathleen K.; Carey, James T.; Douglass, Michael R.; Kanga, Percy R.; Patil, Abhimanyu O.; Bodige, Satish; Lewis, Kyle G.; Hagemeister, Mark P.; (40 pag.)US2017/183595; (2017); A1;,
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Electric Literature of 1113-21-9, Adding some certain compound to certain chemical reactions, such as: 1113-21-9, name is 3,7,11,15-Tetramethylhexadeca-1,6,10,14-tetraen-3-ol,molecular formula is C20H34O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1113-21-9.

Menadiol monoacetate (4) (30.5 g) was dissolved in toluene (150 mL) and methanesulfonic acid (2 mL) was added. While this solution was being stirred, all-trans-geranyllinalool (5) (27.7 g) was added dropwise over 45 minutes at 49 to 51 C., the reaction was then continued for 2 hours and 55 minutes at the same temperature. The reaction solution was washed with aqueous sodium chloride solution (40 mL, 5%) twice. The organic layer was washed three times with a solution prepared by the addition of sodium hydrosulfite (2 g) to aqueous potassium hydroxide solution (40 mL, 10%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1113-21-9, 3,7,11,15-Tetramethylhexadeca-1,6,10,14-tetraen-3-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Eisai Co., Ltd.; US2007/60761; (2007); A1;,
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Electric Literature of 149965-40-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 149965-40-2, name is (5-Bromo-2-chlorophenyl)methanol. A new synthetic method of this compound is introduced below.

Step 2: ((5 -bromo-2-chlorobenzyl)oxy)(tert-butyl)dimethylsilane A solution of (5 -bromo-2- chlorophenyl)methanol (3.80 g, 17.2 mmol), tert-butylchlorodimethylsilane (2.84 g, 18.9 mmol), and 1H-imidazole (2.34 g, 34.3 mmol) in DMF (30 mL) was maintained with stirring at 10 C for 16 hours. Then the reaction mixture was poured into diethyl ether (10 mL) and washed three times with 5% LiC1 (15 mL). The organic layer was separated, dried over sodium sulfate, filtered, taken toa residue under reduced pressure. The residue was purified by column chromatography (Si02, petroleum ether= 100%) to give the title compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,149965-40-2, (5-Bromo-2-chlorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; CHEN, Helen; COLLETTI, Steven, L.; DEMONG, Duane; GUO, Yan; MILLER, Michael; NAIR, Anilkumar; PLUMMER, Christopher, W.; XIAO, Dong; YANG, De-Yi; (289 pag.)WO2016/22742; (2016); A1;,
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