Tag: M.W=200-300

Electric Literature of 25574-11-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 25574-11-2 as follows.

3-(4-Bromophenyl) propan-1-ol (4 g, 18.5 mmol, 1.0 equiv) was dissolved into dichloromethane (60 mL) and cooled to 0C. PCC (5.21 g, 24.1 mmol, 1.5 equiv) was added in portions and the reaction mixture was stirred at room temperature for 4 hours. The reaction mixture was filtered through celite bed and the filtrate was concentrated to afford a crude residue. The crude residue was purified by silica gel column chromatography (10-20 % diethyl ether/n-pentane) to afford the desired product 5.21a (3.05 g, 76.9 % yield). 1H NMR (400 MHz, CDCI3) 69.83 (s, 1H), 7.43 (d, J = 8.3 Hz, 2H), 7.10 (d, J 8.2 Hz, 2H), 2.94 (t, J 7.3 Hz, 2H), 2.79 (t, J 7.4 Hz, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,25574-11-2, its application will become more common.

Reference:
Patent; NOVARTIS AG; FU, Jiping; LEE, Patrick; MADERA, Ann Marie; SWEENEY, Zachary Kevin; WO2015/66413; (2015); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.107859-98-3, name is Ethyl 3-(4-(hydroxymethyl)phenyl)propanoate, molecular formula is C12H16O3, molecular weight is 208.25, as common compound, the synthetic route is as follows.SDS of cas: 107859-98-3

Example 40 Ethyl 3-{4-[(methoxymethoxy)methyl]phenyl}propanoate A tetrahydrofuran solution (16 mL) of the compound (1.64 g) as produced in Example 2 was admixed with triethylamine (1.6 mL) and chloromethylmethylether (0.71 mL), followed by stirring at room temperature for one day. The reaction mixture was diluted with ethyl acetate, and the organic layer was washed with water and an aqueous saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated. The resultant residue was purified on a silica gel column chromatography (n-hexane:ethyl acetate = 4:1) to give the subject title compound (1.47 g) showing the below-described physico-chemical values. TLC: Rf 0.43 (n-hexane:ethyl acetate = 3:1); 1H-NMR (CDCl3): d 1.24, 2.57-2.65, 2.95, 3.41, 4.13, 4.56, 4.70, 7.19, 7.28.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,107859-98-3, Ethyl 3-(4-(hydroxymethyl)phenyl)propanoate, and friends who are interested can also refer to it.

Reference:
Patent; ONO PHARMACEUTICAL CO., LTD.; EP1785421; (2007); A1;,
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Application of 55489-58-2 ,Some common heterocyclic compound, 55489-58-2, molecular formula is C13H20O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

tert-But l l-phenyl-2,5,8,ll-tetraoxatridecan-13-oate Potassium tert-butoxide (commercially available from for example Aldrich) (7.71 g, 69 mmol) was added to a stirred solution of 2-(2-(2-(benzyloxy)ethoxy)ethoxy)ethanol (commercially available from for example Fluorochem) (15 g, 62 mmol) in tert-butanol (200 mL) and the reaction mixture was stirred at room temperature for 2 h. The reaction mixture was cooled to 0C, tert-butyl 2- bromoacetate (commercially available from for example Aldrich) (17 mL, 112 mmol) was added, and the mixture was stirred at room temperature overnight. DCM (300 mL) was added ant the organic phase was washed with water (300 mL) and then brine (2 x 200 mL). The organic extract was dried using a hydrophobic frit and concentrated under reduced pressure to give the crude product as a yellow oil. The product was purified by chromatography on silica using a gradient elution from 0% to 100% methyl tert-butyl ether in cyclohexane to afford the title compound (13.3 g, 38 mmol, 60% yield). LCMS RT= 1.10 min, ES+ve m/z 372.4 [M+NH4]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,55489-58-2, its application will become more common.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CAMPOS, Sebastien, Andre; HARLING, John, David; MIAH, Afjal, Hussain; SMITH, Ian, Edward, David; WO2015/867; (2015); A1;,
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Electric Literature of 575-03-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin, molecular formula is C10H5F3O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[Syntheses of 6a and 6b] ; The compounds 6 and 6b were synthesized in the same manner. Firstly, triethylamine (1.1 eq) was added to a suspension of 7-hydroxy-4-(trifluoromethyl)coumarin (1.0 g) and 2,4-dinitrobenzenesulfon 1 chloride or, 2-nitro-4-(trifluoromethyl)benzenesulfonyl chloride (1.1 eq) in dichloromethane (20 mL) at 0°C. Next, the obtained mixed solution was stirred at room temperature for 1 hour. The reaction solution was diluted with dichloromethane (200 mL), was washed with 1M hydrochloric acid (200 mL) and saturated saline (200 mL), and was dried over magnesium sulfate. The residue obtained by evaporating the solvent under a reduced pressure was refined by silica gel column-chromatography (dichloromethane), thereby obtaining each objective compound. Yields and instrumental analytical values of these compounds will be described below. 6a: 1.9 g (95percent) as a white crystal. m.p. 123-124.5° C (from benzene). 1H-NMR(270 MHz, [D]6-DMSO, TMS): delta= 9.13 (d, 4JH,H=2.3 Hz, 1H; aromatic), 8.64 (dd, 3JH,H= 8.7 Hz, 4JH,H=2.3 Hz, 1H; aromatic), 8.35 (d, 3JH,H= 8.7 Hz, 1H; aromatic), 7.79 (dd, 3JH,H=8.9 Hz, 8JH,H=1.5 Hz, 1H; aromatic), 7.54 (d, 4JH,H=2.5 Hz, 1H, aromatic), 7.32 (dd, 3JH,H=8.9, 4JH,H= 2.5 Hz, 1H; aromatic), 7.15 (s, 1H; aromatic). FTIR (KBr): nu = 1751 (CO, s), 1558(NO2, s), 1542 (NO2, s)cm-1. Elemental analysis (percent) calcd for C16H7 F3N2O9S: C 41.75, H 1.53, N6.09; found: C 41.74, H 1.63, N 5,92. FAB HRMS calcd for C16H8F3N2O9S (MH+): 460.9903; found: 460.9888. 6b: 2.0 g (95percent) as a white crystal. m.p. 134.5-136°C (from AcOEt-hexane). 1H-NMR (270 MHz, [D]6-DMSO, TMS): delta = 5.82 (s, 1H; aromatic), 8.33 (d, 4JH,H = 1.5 Hz, 2H; aromatic), 7.83 (dd, 3JH,H= 8.9 Hz, 4JH,H= 1.8 Hz, 1H; aromatic), 7.57 (t, 4JH,H= 2.2 Hz, 1H; aromatic), 7.34 (dt, 3JH,H= 8.9 Hz, 4JH,H= 2.2 Hz, 1H, aromatic), 7.15 (s, 1H; aromatic). FTIR (KBr): nu = 1752 (CO, s), 1557 (NO2, s) cm-1. Elemental analysis (percent) calcd for C17H7F6NO7S: C 42.25, H 1.46, N 2.90; found: C 42.24, H 1.55, N 2.72. FAB HRMS calcd for C17H8F6NO7S (MH+): 483.9926; found: 483.9925.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin.

Reference:
Patent; Osaka Industrial Promotion Organization; EP1650200; (2006); A1;,
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Reference of 7541-49-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7541-49-3, name is 3,7,11,15-Tetramethylhexadec-2-en-1-ol. A new synthetic method of this compound is introduced below.

In a 100 mL round bottom flask, phytol (trans: cis (2:1) isomeric mixture of 34.9 mL, 100 mmol) and triethylamine (1.4 mL, 10 mmol) were added to toluene (100 mL), the reaction mixture was cooled down to -78 0C. Phosphorus tribromide (4.7 mL, 50 mmol) was added dropwise. After addition complete, the reaction mixture was warmed up to room temperature and stirred for 4 hours. Water (100 mL) was added dropwise to quench the reaction. Ethyl acetate (200 mL) was added and then washed with water (50 mL x 2) and brine (50 mL x 2) sequentially. The ethyl acetate solution was dried by Na2SO4 and concentrated in vacuo. The resulting residue was directly used for the next reaction. L-cysteine hydrochloride monohydrate (1.90 g, 10.73 mmol) and potassium carbonate (2.96 mg, 21.45 mmol) were added to ethanol (40 mL) and water (40 mL), the reaction was stirred at room temperature for 30 min, phytyl bromide (2.56 g, 7.15 mmol) was added. The reaction mixture was stirred at room temperature under argon for 4 hours. The precipitate obtained was washed by water, ethanol and dry in vacuum for 72 hours. White solid obtained was product which was directly used for the next reaction. Mono-methyl succinate (132 mg, 1 mmol), 2~S7-Aza-1 H-be?zotriazole- l -y[)-lj ,.}53-tetramelhy[urotiium hexalluoropho^phate ( 1.1 mg, 1.1 mmol) and N5N- diisopropyl-ethyl-amine (0.52 mL, 3 mmol) were mixed in THF (5 mL). The reaction solution was stirred at room temperature for ten minutes. 2-Amino-3-(3,7,l 1,15-tetramethyl- hexadec-2-enylsulfanyl)-propionic acid (399 mg, 1 mmol) was added to reaction mixture. The reaction solution was stirred at room temperature overnight. Ethyl acetate (50 mL) was added and then washed with saturated ammonium chloride aqueous solution (20 mL x 2), DI water (20 mL x 2) and brine (20 mL x 2) sequentially. The ethyl acetate solution was dried by Na2SO4 and concentrated in vacuo to afford a crude mixture of 1 : 1 trans isomers and 1 : 1 cis isomers of compound N-53, wherein the ratio of trans isomers to cis isomers is 7:3 (200 mg, 40%). 1H-NMR (500 MHz, MeOH-d4): delta 0.76-0.79 (m, 12H), 1.00-1.46 (m, 19H), 1.58 and 1.63 (s, 3H), 1.91-1.99 (m, 2H), 2.48-2.52 (m, 4H), 2.60-2.64 (m, IH), 2.87 (dd, J = 4.5, 14.0 Hz, IH), 3.04-3.07(m, IH), 3.14-3.18 (m, IH), 3.57 (s, 3H), 4.46-4.49 (m, IH), 5.12 (t, J = 7.5 Hz, IH). 13C-NMR (125 MHz, MeOH-d4): delta 20.12, 20.17, 20.23, 23.05, 23.14, 23.59, 25.52, 25.94, 25.96, 26.30, 26.31, 26.64, 29.19, 30.20, 30.40, 31.26, 32.87, 33.54, 33.79, 33.82, 33.88, 33.94, 33.97, 37.62, 37.71, 38.41, 38.50, 40.56, 40.95, 52.27, 53.40, 53.53, 121.43, 121.89, 140.87, 141.01; ES-MS: mass calcd for Chemical Formula: C28H5INO5S 513.3. Found (M+Na) m/z 536.3.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7541-49-3, its application will become more common.

Reference:
Patent; SIGNUM BIOSCIENCES, INC.; STOCK, Jeffry, B.; STOCK, Maxwell; RAPOLE, Keshava; LEE, Seung-yub; VORONKOV, Michael; PEREZ, Eduardo; CHEN, Shuyi; CHEN, Jinglong; GORDON, Joel; WO2010/56778; (2010); A1;,
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Electric Literature of 92093-23-7 ,Some common heterocyclic compound, 92093-23-7, molecular formula is C8H9BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A diol 6c or 6d or 6e (2 equiv) and PPTS (0.1 equiv) was added to a toluene (25.0 mL/1 mmol of substrate) solution of a substituted-4,4-dimethoxycyclohexa-2,5-dienone 5a or 5b (1 equiv) at room temperature. After stirring at 40 C for 18 h, the reaction mixture was quenched by the addition of saturated aqueous NaHCO3 and the product was extracted with ethyl acetate three times. The combined organic extracts were washed with brine, dried over anhydrous magnesium sulphate, filtered, and concentrated under reduced pressure. The residue was purified by preparative TLC to give the title compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,92093-23-7, its application will become more common.

Reference:
Article; Fuse, Shinichiro; Inaba, Kennichi; Takagi, Motoki; Tanaka, Masahiro; Hirokawa, Takatsugu; Johmoto, Kohei; Uekusa, Hidehiro; Shin-ya, Kazuo; Takahashi, Takashi; Doi, Takayuki; European Journal of Medicinal Chemistry; vol. 66; (2013); p. 180 – 184;,
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Related Products of 24034-73-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 24034-73-9, name is (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Geranylgeraniol (600 mg, 2.07 mmol) and 15 mE of anhydrous tetrahydroffiran were added to a rubber septum coyered, oven-dried 50 mE round-bottom flask with a magneticstirring bar and a nitrogen inlet. The solution was stirred andcooled to -45 C. Upon cooling of this solution, methanesulfonyl chloride (207.5 pL, 2.67 mmol) was added slowlyvia syringe to the reaction flask. Over a 5-minute period,574.74 jiL of triethylamine was then added via syringe. Theresulting suspension was stirred for 45 minutes at -45 C. Asolution of lithium bromide (717.5mg, 8.26 mmol) inS mE oftetrahydroffiran was added dropwise via syringe. The suspen10 sion was warmed to 0 C. and stirred for 1 hout The reactionmixture was poured into 8 mE of iced water and the aqueouslayer was extracted with ice-cold diethyl ether (3×4 mE). Thecombined organic extracts were washed with ice-cold saturated NaHCO3 (10 mE) and brine (10 mE), and dried overanhydrous Mg504. The organic layer was filtered and concentrated in vacuo to obtain the crude geranylgeranyl bromide, which was then used immediately for the following stepwithout thrther purifications.

According to the analysis of related databases, 24034-73-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Wellesley College; Carrico-Moniz, Dora; (19 pag.)US9388155; (2016); B1;,
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Related Products of 7073-69-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol, molecular formula is C9H11BrO, molecular weight is 215.087, as common compound, the synthetic route is as follows.

To a mixture of methyl 2-bromobenzoate (20 g, 93.00 mmol, 13.07 mL, 1 eq) in THF (200 mL) was added dropwise MeMgBr (3 M, 65.10 mL, 2.1 eq) at 5C under N2. The mixture was stirred at 25C for 2 h and then quenched with aqueous NH4CI (200 mL). The aqueous phase was extracted with ethyl acetate (100 mL x 3). The combined organic phase was washed with brine (150 mL), dried with anhydrous Na2S04, filtered and concentrated in vacuum. The residue was purified by flash silica gel chromatography (ISCO; 120 g SepaFlash Silica Flash Column, Eluent of 0- 30% Ethyl acetate/Petroleum ethergradient, 80 mL/min) to afford 2-(2- bromophenyl)propan-2-ol (13 g, 60.44 mmol, 64.99% yield) as light-yellow oil. 1H NMR (CDCIs, 400 MHz): d 7.67 (d, J = 7.6 Hz, 1 H), 7.59 (d, J = 7.6 Hz, 1 H), 7.31 (t, J = 7.6 Hz, 1 H), 7.12 (t, = 7.6 Hz, 1 H), 1.77 (s, 6H) ppm. To a mixture of 2-(2- bromophenyl)propan-2-ol (12 g, 55.79 mmol, 1 eq) in THF (120 ml_) was added n- BuLi (2.5 M, 55.79 ml_, 2.5 eq) in one portion at -70C. The mixture was stirred at – 70C for 2 h. Then triisopropyl borate (20.99 g, 111.58 mmol, 25.65 ml_, 2 eq) was added to the mixture. The mixture was warmed to 20C and stirred for 15 h. The residue was poured into ice-water (w/w = 1/1) (10 ml_) and adjust to pH 5. The aqueous phase was extracted with ethyl acetate (10 mL x 3). The combined organic phase was washed with brine (15 mL), dried with anhydrous Na2S04, filtered and concentrated in vacuum. The residue was purified by flash silica gel chromatography (ISCO; 80 g SepaFlash Silica Flash Column, Eluent of 0-100% Ethyl (0480) acetate/Petroleum ethergradient, 100 mL/min) to afford 3,3-dimethylbenzo (0481) [c][1 ,2]oxaborol-1 (3H)-ol (9 g, 55.56 mmol, 99.6% yield) as crude yellow oil. 1H NMR (CDCIs, 400 MHz): d 9.00 (s, 1 H), 7.67 (d, J = 7.2 Hz, 1 H), 7.47-7.41 (m, 2H), 7.33- 7.31 (m, 1 H), 1.45 (s, 6H) ppm. To a mixture of 3,3-dimethylbenzo[c][1 ,2]oxaborol- 1 (3H)-ol (9 g, 55.56 mmol, 1 eq) in H2S04 (100 mL) was added HNOs (10.50 g, 166.67 mmol, 7.50 mL, 3 eq) at -20C. The mixture was stirred at -15C for 10 min. Ice-water (100 mL) was added to the mixture at -10C and stirred for 10 min. It was filtered and then the solid was washed by petroleum ether (50 mL) to afford crude 3,3-dimethyl-6-nitrobenzo[c][1 ,2]oxaborol-1 (3H)-ol (8 g, 38.65 mmol, 69.6% yield) as yellow solid. 150 mg of crude product was purified by pre-HPLC (column: Xtimate C18 150*25mm*5um; mobile phase: [water (10mM NH4HC03)-ACN]; B%: 10%-40%, 10.5 min) to afford the purified material of 3,3-dimethyl-6-nitrobenzo[c][1 ,2]oxaborol- 1 (3H)-ol (91 mg) as yellow solid. 1H NMR (DMSO-cfe, 400 MHz): d 9.47 (s, 1 H), 8.52 (d, J = 2.4 Hz, 1 H), 8.32 (dd, J = 8.4, 2.4 Hz, 1 H), 7.73 (d, J = 8.4 Hz, 1 H), 1.49 (s, 6H) ppm. MS (ESI): mass calcd. For C9HI0BNO4 207.07, m/z found 206.1 [M-H] HPLC purity: 100% (220 nm) and 100% (254 nm). To a solution of 3,3-dimethyl-6- nitrobenzo[c][1 ,2]oxaborol-1 (3H)-ol (2 g, 9.66 mmol, 1 eq) in EtOAc (70 mL) was added Pd/C (0.5 g, 10% purity) under N2. The suspension was degassed under vacuum and purged with H2 several times. The mixture was stirred under H2 (15 psi) at 20C for 15 h. The reaction mixture was filtered, and the filtrate was concentrated to affrord 6-amino-3,3-dimethylbenzo[c][1 ,2] oxaborol-1 (3H)-ol (1.5 g, 8.47 mmol, 87.70% yield) as red solid. 100 mg of the crude product was purified by pre-HPLC (column: Xtimate C18 150*25mm*5um; mobile phase: [water (10mM NH4HC03)- ACN]; B%: 10%-40%, 10.5 min) to afford 6-amino-3,3-dimethylbenzo[c][1 ,2]oxaborol- 1 (3H)-ol (51 mg) as yellow solid. 1H NMR (DMSO-cfe, 400 MHz): d 8.73 (s, 1 H), 7.02 (d, J = 8.0 Hz, 1 H), 6.79 (d, J = 2.0 Hz, 1 H), 6.67 (dd, J = 8.0, 2.4 Hz, 1 H), 4.95 (s, 2H), 1.37 (s, 6H) ppm. MS (ESI): mass calcd. For C9Hi2BN02 177.10, m/z found 176.1 [M-H]-. HPLC: 99.4% (220 nm), 98.6% (254 nm). To a mixture of 6-amino-3,3- dimethylbenzo[c][1 ,2]oxaborol-1 (3H)-ol (1 g, 5.65 mmol, 1 eq) in t-BuOH (20 mL) was added (Boc)20 (3.70 g, 16.95 mmol, 3.89 mL, 3 eq) in one portion at 20C under N2. The mixture was stirred at 50C for 12 h and concentrated under reduced pressure. The residue was purified by flash silica gel chromatography (ISCO; 12 g SepaFlash Silica Flash Column, Eluent of 0-80% Ethyl acetate/Petroleum ethergradient: 30 mL/min) to afford tert-butyl (1-hydroxy-3,3-dimethyl-1 ,3-dihydrobenzo[c][1 ,2]oxaborol- 6- yl)carbamate (0.6 g, 2.17 mmol, 38.32% yield) as yellow oil. 1H NMR (CDCh, 400 MHz): d 7.60 (s, 1 H), 7.54 (d, J = 8.0 Hz, 1 H), 7.21 (d, J = 8.0 Hz, 1 H), 6.53 (s, 1 H), 1.55 (s, 9H), 1.54 (s, 6H). To a mixture of tert-butyl (1 -hydroxy-3, 3-dimethyl-1 , 3- dihydrobenzo[c][1 ,2]oxaborol-6-yl)carbamate (0.5 g, 1.80 mmol, 1 eq) in DMF (10 mL) was added NCS (240.93 mg, 1.80 mmol, 1 eq) in one portions at 0C. The mixture was stirred at 50C for 15 h and then poured into water (10 mL). The aqueous phase was extracted with ethyl acetate (10 mL x 3). The combined organic phase was washed with brine (10 mL),…

The chemical industry reduces the impact on the environment during synthesis 7073-69-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BORAGEN, INC.; LIU, Chunliang; ZHANG, Yong-Kang; LIU, Chun, Yu; ZHOU, Yasheen; (372 pag.)WO2020/51575; (2020); A1;,
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Electric Literature of 2043-47-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2043-47-2, name is 1H,1H,2H,2H-Nonafluoro-1-hexanol, molecular formula is C6H5F9O, molecular weight is 264.0889, as common compound, the synthetic route is as follows.

Example 3In a 200-ml, three-necked glass reactor were placed 80 ml of methylene chloride, 10 g (38 mmol) of 3,3,4,4,5,5,6,6,6-nonafluorohexanol, 5 g (58 mmol) of methacrylic acid, 10 g (57 mmol) of benzenesulfonic acid chloride and 0.1 g of a polymerization inhibitor, Sumilizer GM. While the reaction temperature was kept at 40 C. or lower, 12 g (119 mmol) of triethylamine was added dropwise. After the completion of the dropwise addition, stirring was conducted at room temperature for 1 hour. At this point, the conversion was 99% and the selectivity was 99%.

Statistics shows that 2043-47-2 is playing an increasingly important role. we look forward to future research findings about 1H,1H,2H,2H-Nonafluoro-1-hexanol.

Reference:
Patent; TOKUYAMA CORPORATION; DAIKIN INDUSTRIES, LTD.; US2009/23948; (2009); A1;,
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Adding a certain compound to certain chemical reactions, such as: 229027-89-8, 2-Bromo-4-fluorobenzyl Alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 229027-89-8, blongs to alcohols-buliding-blocks compound. Recommanded Product: 229027-89-8

General procedure: To a solution of compound 7 in DCM was added compound 8 (0.12mmol) and K2CO3 (0.24mmol) The resulting mixture was refluxed at 80C for 3h before it was quenched with 5mL of brine The organic layer was collected and purified by flash column chromatography on a silica column using cyclohexane/acetone (0-50%) to get compound 9.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,229027-89-8, 2-Bromo-4-fluorobenzyl Alcohol, and friends who are interested can also refer to it.

Reference:
Article; Pan, Ting; Ding, Yanchao; Wu, Liyang; Liang, Liting; He, Xin; Li, Qianwen; Bai, Chuan; Zhang, Hui; European Journal of Medicinal Chemistry; vol. 166; (2019); p. 480 – 501;,
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