Tag: M.W=200-300

Related Products of 722-92-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, molecular formula is C9H7F6NO, molecular weight is 259.15, as common compound, the synthetic route is as follows.

Dichloroglyoxime (0.160 g, 1 mmol) was dissolved in 15 mL of absolute ethanol and was added dropwise to a solution of 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol (1.04 g, 4 mmol) in 10 mL of absolute ethanol.The mixture was stirred overnight. Water was added dropwise until a white precipitate formed. It was filtered off, washed with water, and then dried. Compound 2 is soluble in acetone, DMSO, DMF, and THF. Yield:56%; mp 67 C; found: C 39.80, H 2.30, N 9.25; calc. for C20 H14 F12 N4 O4 : C 39.88, H 2.34, N 9.30, IR, numax(cm-1) : 3400 (NH), 3200 (OH), 1610 (C=N), 1519, 1372, 1267 (C-F), 1186 (C-F), 1108, 963 (N-O), 931, 825, 705. 1 H NMR (DMSO-d6) , (ppm): 11.00 (s, 2H, NOH, disappeared upon D2 O), 9.00 (b, 2H, ArCH-OH),8.77-8.51 (d, 4H, Ar-H), 7.66-7.29 (d, 4H, Ar-H), 6.71 (s, 2H, NH); MS (ES), (m/z): 602.3 [M]+.

Statistics shows that 722-92-9 is playing an increasingly important role. we look forward to future research findings about 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol.

Reference:
Article; Harbeck, Mika; ?en, Zafer; Erbahar, Dilek; Guemue?, Guelay; Musluo?lu, Emel; Turkish Journal of Chemistry; vol. 43; 3; (2019); p. 890 – 901;,
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Reference of 101597-25-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 101597-25-5 as follows.

Step 6; To the product in toluene from Step 5, 1 )1 -bis{4~methoxypr¾enyl)prop-2-yn-1 -ol {0.8 g), a few crystals of p-toiuene sulfonic acid were added. After stirring for one hour at room temperature, all the solvent was. evaporated. The recovered product was purified by ComfaiFlash followed by re-crystailization. from diethyl ether. White crystals {0.95 g) were obtained as the product. NMR indicated that the product had a structure consistent with 3,3- bis(4-rrtethoxyphenyl)~l 0, 12-dibromo-6,7-dimethoxy-11 ,13, 13-trimethyl-3H,l 3H- indeno^’.^^jnaphthop ,2-b]pyran as represented by the following graphic formula.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,101597-25-5, its application will become more common.

Reference:
Patent; TRANSITIONS OPTICAL, INC.; WO2012/82506; (2012); A1;,
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Electric Literature of 480449-99-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 480449-99-8, name is Benzyl 3-hydroxycyclobutanecarboxylate. A new synthetic method of this compound is introduced below.

REFERENTIAL EXAMPLE 152 3-Hydroxycyclobutanecarboxylic acid: 10% Palladium on carbon (108 mg) was added to a solution of the compound (706 mg) obtained in Referential Example 151 in ethanol (10 ml), and the mixture was stirred at room temperature for 2 hours in a hydrogen atmosphere. After the catalyst was removed by filtration through Celite, the filtrate was concentrated under reduced pressure to obtain the title compound (399 mg). 1H-NMR (CD3OD) delta: 2.00-2.21(2H,m), 2.41-2.61(3H,m), 4.01-4.13(1H,m).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,480449-99-8, its application will become more common.

Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; US2005/20645; (2005); A1;,
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Synthetic Route of 2077-19-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2077-19-2, name is 2-(4-Bromophenyl)propan-2-ol, molecular formula is C9H11BrO, molecular weight is 215.09, as common compound, the synthetic route is as follows.

Example 2: Synthesis of 1-bromo-4-(1-methoxy-1-methyl-ethyl)-benzene:A mixture of 6.87 g of ethyl 4-bromobenzoate (10) was allowed to react with 64 mL(1.4 M in toluene) of methyl magnesium bromide in THF at -4O0C for 1 hour, and the reaction mixture was gradually warmed to O0C. The reaction was quenched with saturated aqueous ammonium chloride solution and the resultant mixture was extracted with ethyl acetate. The organic layer was washed with brine, was dried over magnesium sulfate, was filtered, and the solvent was removed in vacuo. Purification by silica gel chromatography (50:1 to 10:1 EPO hexanes-ethyl acetate) afforded 6.44 g (99% yield) of 2-(4-bromophenyl)propan-2-o1 ; MS (AP/CI) observed: 199.1 (M+H – H2O)+, 100%; 213.1 , 215.1 (M-H)”, 60%, 80%. 2-(4- Bromophenyl)propan-2-o1 (1.77 g) and iodomethane (1.16 g) in THF (100 mL) were treated with sodium hydride, 60% in mineral oil (328 mg). After stirring for 24 h at room temperature, the reaction mixture was quenched with dilute aqueous hydrochloric acid, was extracted with ethyl acetate, and the organic layer was washed with brine, was dried over magnesium sulfate, was filtered, and the solvent was removed in vacuo. The resultant oil was purified by silica gel chromatography (200:1 hexanes-ethylacetate) to afford 0.5 g of 1-bromo-4-(1- methoxy-1-methyl-ethyl)-benzene; 13C NMR (400 MHz, CDCI3) delta 145.35, 131.53, 127.91 , 121.00, 50.90, 28.60.

Statistics shows that 2077-19-2 is playing an increasingly important role. we look forward to future research findings about 2-(4-Bromophenyl)propan-2-ol.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2006/75226; (2006); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 25574-11-2, name is 3-(4-Bromophenyl)propan-1-ol, molecular formula is C9H11BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C9H11BrO

A round-bottom-flask was charged with 3-(4-bromophenyl)propan-1-ol (88) (406 mg, 1.89 mmol, 1 eq), pyridin-3-ylboronic acid (348 mg, 2.83 mmol, 1.5 eq) and Pd(PPh3)4 (20 mg, 0.02 mmol, 0.01 eq) dissolved in DCM (1.9 mL) and DMF (4.2 mL). The flask was put under an argon atmosphere and aqueous K2CO3 (2 M, 2.36 mL, 4.73 mmol, 2.5 eq) was added. The reaction mixture was stirred at 85C for 2.5 h, filtered over Celite and concentrated under reduced pressure. The residue was purified via flash-column-chromatography (SiO2, 50% to 90% EtOAc in pentane) to yield the product (296 mg, 74%). 1H NMR (400 MHz, chloroform-d) delta 8.83 (d, J = 1.9 Hz, 1H), 8.57 (dd, J = 4.8, 1.3 Hz, 1H), 7.88 (dt, J = 7.9, 1.9 Hz, 1H), 7.51 (d, J = 8.1 Hz, 2H), 7.37 (dd, J = 7.8, 4.9 Hz, 1H), 7.32 (d, J = 8.1 Hz, 2H), 3.72 (t, J = 6.4 Hz, 2H), 2.83 – 2.74 (m, 2H), 2.59 (s, 1H), 1.94 (dt, J = 13.9, 6.4 Hz, 2H). 13C NMR (101 MHz, chloroform-d) delta 148.12, 148.09, 142.25, 136.70, 135.37, 134.49, 129.34, 127.23, 123.75, 62.13, 34.28, 31.85.

With the rapid development of chemical substances, we look forward to future research findings about 25574-11-2.

Reference:
Article; Grimm, Sebastian H.; Gagestein, Berend; Keijzer, Jordi F.; Liu, Nora; Wijdeven, Ruud H.; Lenselink, Eelke B.; Tuin, Adriaan W.; van den Nieuwendijk, Adrianus M.C.H.; van Westen, Gerard J.P.; van Boeckel, Constant A.A.; Overkleeft, Herman S.; Neefjes, Jacques; van der Stelt, Mario; Bioorganic and Medicinal Chemistry; vol. 27; 5; (2019); p. 692 – 699;,
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Related Products of 83647-43-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 83647-43-2, name is (3-Bromo-2-methylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

To a flask charged with (3-bromo-2-methylphenyl)methanol (6.0 g, 30 mmol) was added a 1M TFA solution of Thallium Trifluoroacetate (16.2 g, 29.8 mmol). The mixture was stirred at RT overnight. Analysis by TLC showed no starting material remaining. The solvent was removed under vacuum, and the residue was pumped under high vacuum for 30 min to ensure complete removal of TFA. To the residue was then added Palladium(II) Chloride (529 mg, 2.98 mmol), Lithium Chloride (2.53 g, 59.7 mmol), Magnesium Oxide (2.41 g, 59.7 mmol), and MeOH (150 mL). The reaction was flushed with CO twice, and kept under CO at room temperature. Analysis by LC showed a big product spot within 2 hours. To this solution was added ethyl acetate to precipitate the salts. The black solution was filtered through a celite pad, washed with EtOAc, adsorbed onto silica and purified by silica gel chromatography to afford 5-bromo-4-methyl-2-benzofuran-1(3H)-one. 1H-NMR (500 MHz, CDCl3) delta ppm 7.71 (d, J = 8.0 Hz, 1H), 7.58 (d, J = 8.0 Hz, 1H), 5.25 (s, 2H), 2.37 (s, 3H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 83647-43-2, (3-Bromo-2-methylphenyl)methanol.

Reference:
Patent; Merck Sharp & Dohme Corp.; TANG, Haifeng; PASTERNAK, Alexander; YANG, Lihu; WALSH, Shawn, P.; PIO, Barbara; SHAHRIPOUR, Aurash; TEUMELSAN, Nardos; (111 pag.)EP2632465; (2015); B1;,
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Synthetic Route of 5333-42-6, Adding some certain compound to certain chemical reactions, such as: 5333-42-6, name is 2-octyldodecan-1-ol,molecular formula is C20H42O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5333-42-6.

Into a 250 ml glass reactor fitted with an Argon purge was placed the hexanoic acid (23.2 grams, 0.2 moles), 2-octyl-1-dodecanol (29.9 grams, 0.1 moles) (Aldrich 97%) (the “C20-alcohol”, which is a Guerbet alcohol) and p-toluene sulfonic acid monohydrate (19 grams, 0.1 mole). The mixture above was purged with Argon at room temperature for one hour. The mixture was then heated to 100 C. under Argon purge for 18 hours. The mixture was then cooled to room temperature. The residue was then dissolved into 100 ml with ethyl acetate and placed into a separatory funnel. The ethyl acetate solution was extracted once with 100 ml of distilled water. The ethyl acetate layer was washed with 250 ml 10 wt % NaHCO3 aqueous solution followed by 250 ml saturated NaCl aqueous solution. The ethyl acetate solution was dried over MgSO4 and then filtered. The ethyl acetate was removed on the rotary evaporator from the solution. The residue from the rotary evaporator was placed on a Kugelrohr vacuum distillation apparatus where the ester was distilled. 1H NMR (CDCl13): delta3.96 (d, 2H, O-CH2-), 2.31 (d, 2H, O=C-CH2-), 1.61-1.26 (m, 39H, -CH2-), 0.80 (t, 9H, CH3). IR (cm-1): 2955, 2925, 2854, 1733, 1466, 1378, 1234, 1168, 1102, 722.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5333-42-6, 2-octyldodecan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ExxonMobil Chemical Patents Inc.; Patil, Abhimanyu O.; Lewis, Kyle G.; Bodige, Satish; Zushma, Stephen; US2019/62663; (2019); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64372-62-9, name is 2-Chloro-5-(trifluoromethyl)benzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 64372-62-9

A 3 M K2CO3 solution is prepared by adding solid K2CO3 (31 g, 0.22 mol) to water (100 mL). Cooling is applied to keep the solution at 20-25 C. (2-chloro-5-(trifluoromethyl)phenyl) methanol (compound of formula 13) (17.5 g, 84 mmol), and boronic acid 5 (Scheme 3) (18.1 g, 85 mmol) are added to the K2CO3 followed by THF (100 mL) rinse. The solution is degassed by sparging with argon gas for 20 min. The catalyst, 1,1 bis(di-tert-butyiphosphino)ferrocene palladium dichloride (300 mg, 0.55 mol%) is added. The organic layer turns dark brown immediately. The biphasic mixture is aged at 35-45 C with vigorous stirring for 32 hours. The mixture is cooled to room temperature and water (150 mL) is added, followed by petroleum ether (150 mL) and the aqueous layer is removed. The organic layer was washed with water (2×200 mL) and filtered through silica gel and the solvent is removed under reduced pressure to yield brownish oil which is crystallized from heptane to give a pale white solid (28.5 g, 80%). mp 93.5-95.5 C; 1H NMR (CDCl3) delta 1.24 (d, J = 6.9 Hz, 6H), 1.95 (t, J =6.1 Hz, 1H), 3.21 (sept, J = 6.9 Hz, 1H), 3.73 (s, 3H), 4.49 (m, 2H), 6.68 (d, J =12.0 Hz, 1H), 6.99 (d, J = 8.6 Hz, 1H), 7.30 (d, J = 7.9 Hz, 1H), 7.59 (dd, J1 = 8.0 Hz, J2 =1.3 Hz, 1H), 7.86 (d, J = 0.7 Hz, 1H). The impurity (5′-ethyl-4′-fluoro-2′-methoxy-4-(trifluoromethyl)biphenyl-2-yl)methanol (~ 3 %), which is formed from 5-ethyl-4-fluoro-2-methoxyphenylboronic acid present in the starting material under the conditions described in Step 5, was detected in the product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 64372-62-9, 2-Chloro-5-(trifluoromethyl)benzyl alcohol.

Reference:
Patent; LEK Pharmaceuticals d.d.; EP2468736; (2012); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 83647-43-2, name is (3-Bromo-2-methylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 83647-43-2

Compound I-2-5 (3.5 g, 19.45 mmol),Compound I-2-6 (2.61 g, 12.97 mmol),Pd(dppf)Cl2·CH2Cl2 (120 mg, 1.30 mmol) was added to a 250 mL three-neck bottle.Add toluene (19 mL) and ethanol (6.35 mL).Replace N2 three times, add NaHCO3 (19mL, 2M, 38.92mmol) for 3h at room temperature,The reaction was completely detected by TLC, the reaction system was spun dry, dissolved with ethyl acetate, washed with water, and the organic phase was dried.Column chromatography gave Compound I-2-7 in an amount of 3.1 g, yield 93.2%.

With the rapid development of chemical substances, we look forward to future research findings about 83647-43-2.

Reference:
Patent; Guangzhou Dankang Pharmaceutical Biological Co., Ltd.; Xu Yong; Lin Dang; Huang Lu; Hu Hai; (36 pag.)CN110092779; (2019); A;,
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Application of 68120-35-4, Adding some certain compound to certain chemical reactions, such as: 68120-35-4, name is (3-Bromo-4-methylphenyl)methanol,molecular formula is C8H9BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 68120-35-4.

A mixture of (3-Bromo-4-methyl-phenyl)-methanol (8.5 g, 42.2 mmol) and bis(pinacolato)diboron (11.8 g, 46.50 mmol) in 1 ,4-dioxane (50 ml_) was degassed under N2 atmosphere for 10 min. Potassium acetate (8.2 g, 84.55 mmol) was added to the above followed by [1 ,1 – Bis(diphenylphosphino)ferrocene]dichloropalladium(ll).CH2Cl2 (1.54 g, 2.11 mmol) and the reaction mixture was heated at 100 C for 15 h. The solvents were removed under reduced pressure, the residue obtained was diluted with water and extracted with EtOAc (2×150 mL). Combined organic phases were washed with water, brine, dried over anhydrous Na2S04, filtered and concentrated. Purification of this crude by flash chromatography on silica (EtOAc:n-hexane; 70:30) afforded the title compound as a brown liquid (5.0 g, 84%). 1H NMR (400 MHz, DMSO-d6): delta 7.59 (d, J = 1.72 Hz, 1 H), 7.25 (dd, J = 7.76, 1.88 Hz, 1 H), 7.11 (d, J = 7.76 Hz, 1 H), 5.10 (t, J = 5.72 Hz, 1 H), 4.43 (d, J = 5.72 Hz, 2H), 2.42 (s, 3H), 1.29 (s, 12H).

According to the analysis of related databases, 68120-35-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK PATENT GMBH; JORAND-LEBRUN, Catherine; KULKARNI, Santosh; CHRISTMANN-FRANCK, Serge; WO2014/121942; (2014); A1;,
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