Tag: M.W=150-200

Singh, Gurjaspreet published the artcileSelective mercury ion recognition using a methyl red (MR) based silatrane sensor, Safety of Triisopropanolamine, the publication is New Journal of Chemistry (2018), 42(8), 6315-6321, database is CAplus.

A new Methyl red (MR) based silatrane was synthesized in high yield by the transesterification reaction of Methyl red-amidopropyltrimethoxysilane 1 (MR-APTMS) and trisisopropanolamine. Single crystal x-ray diffraction anal. was used to deduce the structure of silatrane 2 which was also supported by NMR (¹H, ¹³C) spectroscopy, mass spectrometry, FTIR, UV-visible and DFT studies. Silatrane 2 when surveyed for cation recognition ability with a library of metal ions in CH₃CN/H₂O (9 : 1, volume/volume) was found to act as an excellent UV-visible probe for the selective recognition of Hg²⁺in vitro. Also, quantum mech. calculations of the interaction complex [MR-APS-Hg]²⁺3 using DFT at the B3LYP level in conjunction with the LanL2DZ basis set determined the geometric and the stability parameters of the surveyed interaction.

New Journal of Chemistry published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C8H6ClN, Safety of Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Delgado, Pete published the artcileUse of Green Solvents in Metallaphotoredox Cross-Electrophile Coupling Reactions Utilizing Lipophilic Modified Dual Ir/Ni Catalyst System, Recommanded Product: (1-Bromocyclopropyl)methanol, the publication is Journal of Organic Chemistry (2021), 86(23), 17428-17436, database is CAplus and MEDLINE.

Facilitating photoredox coupling reactions in process friendly green solvents was achieved by the successful application of the dual Ir/Ni catalyst system with enhanced solubility properties. These photochem. reactions (specifically Br-Br sp²-sp³ cross electrophile coupling) are reported in a head to head comparison to the reactions using standard di-t-Bu bipyridine ligand Ir/Ni catalyst system. This presentation highlights the benefits of altering the solubility properties of the ligands used in the Ir/Ni dual catalyst.

Journal of Organic Chemistry published new progress about 50915-29-2. 50915-29-2 belongs to alcohols-buliding-blocks, auxiliary class Cyclopropanes, name is (1-Bromocyclopropyl)methanol, and the molecular formula is C4H7BrO, Recommanded Product: (1-Bromocyclopropyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Salaun, J. published the artcileSmall rings. XXX. Ring expansion of cyclopropanols. 1-(Halomethyl)-, 1-(hydroxymethyl)-, 1-vinyl-, 1-acylcyclopropanols, and oxaspiropentanes to cyclobutanones, Safety of (1-Bromocyclopropyl)methanol, the publication is Tetrahedron (1974), 30(11), 1413-21, database is CAplus.

1-(Hydroxymethyl)-, 1-(tolysulfonyloxymethyl)-, 1-(bromomethyl)cyclopropanol, and oxaspiropentane (I), prepared from methylenecyclopropane, underwent ring expansion to form cyclobutanones. 1-Vinyl-, 1-(1-cyclopentenyl)- and 1-(1-cyclohexenyl)cyclopropanol, prepared from (ClCH2)2CO underwent similar ring expansion. 1-Cyclopropylcyclopropanol under similar conditions gave cyclopropyl Et ketone. II with NaOMe followed by treatment with ClSiMe3, gave cyclobutanone III.

Tetrahedron published new progress about 50915-29-2. 50915-29-2 belongs to alcohols-buliding-blocks, auxiliary class Cyclopropanes, name is (1-Bromocyclopropyl)methanol, and the molecular formula is C4H7BrO, Safety of (1-Bromocyclopropyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rubert, Josep published the artcileA Screening of Native (Poly)phenols and Gut-Related Metabolites on 3D HCT116 Spheroids Reveals Gut Health Benefits of a Flavan-3-ol Metabolite, Product Details of C8H8O3, the publication is Molecular Nutrition & Food Research, database is CAplus and MEDLINE.

Epidemiol. evidence suggests that a reduced risk of colorectal cancer (CRC) is correlated with high consumption of fruits and vegetables, which are major sources of fiber and phytochems., such as flavan-3-ols. However, it remains unknown how these phytochems. and their specific gut-related metabolites may alter cancer cell behavior. A focused screening using native (poly)phenols and gut microbial metabolites (GMMs) on 3D HCT116 spheroids is carried out using a high-throughput imaging approach. Dose-responses, IC50, and long-term exposure are calculated for the most promising native (poly)phenols and GMMs. As a result, this research shows that (poly)phenol catabolites may play a key role in preventing cancer propagation. Indeed, μM concentration levels of (4R)-5-(3′,4-dihydroxyphenyl)-γ-valerolactone significantly decrease spheroid size at early stages of spheroid aggregation and gene expression of matrix metalloproteinases. A chronic exposure to (4R)-5-(3,-d4ihydroxyphenyl)-γ-valerolactone may lead to a reduced CRC risk. Daily intake of monomeric, oligomeric, and polymeric flavan-3-ols may increase the colonic concentrations of this metabolite, and, in turn, this compound may act locally interacting with intestinal epithelial cells, precancerous and cancer cells.

Molecular Nutrition & Food Research published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Product Details of C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bogdanov, A. V. published the artcileSynthesis of New (2-Acetamido)phenylglyoxylamides Containing an Acetal Fragment, Application of 4,4-Diethoxybutan-1-amine, the publication is Russian Journal of Organic Chemistry (2019), 55(1), 121-123, database is CAplus.

Mild opening of the five-membered ring in 1-acetylisatins by the action of an equimolar amount of 4,4-diethoxybutan-1-amine afforded 2-(2-acetamidophenyl)-N-(4,4-diethoxybutyl)-2-oxoacetamides in almost quant. yield.

Russian Journal of Organic Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Application of 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smolobochkin, A. V. published the artcileTandem intramolecular cyclisation/1,3-aryl shift in N-(4,4-diethoxybutyl)-1-arylmethanimines (Kazan reaction): synthesis of 3-benzylidene-1-pyrrolines, Application of 4,4-Diethoxybutan-1-amine, the publication is RSC Advances (2017), 7(80), 50955-50960, database is CAplus.

In this article, a novel tandem reaction, which transformed N-(4,4-diethoxybutyl)imines into 3-arylidene-1-pyrrolines, was described. The substrate scope of the starting acetals included arenes with electron-donating and withdrawing groups. The X-ray study of products confirmed the E-stereochem. of the double bonds formed. The best yields (99%) were found in boiling xylene in the presence of TsOH (or 2-nitroresocinol) during 40 (50) hours. The study of substituents effect on the course of the reaction revealed that cascade process took place, combining acid-catalyzed intramol. cyclization of N-(4,4-diethoxybutyl)imines and unusual 1,3-sigmatropic shift of the aryl fragment. Cyclic imines that were formed in high/excellent yields were of interest both from the viewpoint of their biol. activity and synthetic usefulness.

RSC Advances published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C6H12N2O, Application of 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smolobochkin, A. V. published the artcileCyclization of 1-(4,4-diethoxybutyl)-3-aryl(thio)ureas to 2-arylpyrrolidines and 2,3′-bipyrrole derivatives, Quality Control of 6346-09-4, the publication is Russian Chemical Bulletin (2016), 65(3), 731-734, database is CAplus.

A reaction of 1-(4,4-diethoxybutyl)-3-phenylthiourea with resorcinol, 2-methylresorcinol, pyrogallol and hydroquinone in chloroform in the presence of trifluoroacetic acid leading to 2-aryl-1-(N-phenylcarbamothioyl)pyrrolidines I [R = H, Me, OH] and II has been described. The compounds such as 1-(4,4-diethoxybutyl)-3-aryl(thio)ureas R¹NHC(X)NH(CH₂)₃CH(OC₂H₅)₂ [R¹ = C₆H₅, 4-H₃COC₆H₄, 4-BrC₆H₄; X = O, S] in the presence of an acid catalyst undergo intramol. cyclization and dimerization with the formation of 1,1′-bis(N-arylcarbamo(thio)yl)-2,3′-bipyrrole derivatives III.

Russian Chemical Bulletin published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C18H26ClN3O, Quality Control of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smolobochkin, A. V. published the artcileSynthesis of functionalized diarylbutane derivatives by the reaction of 2-methylresorcinol with γ-ureidoacetals, Recommanded Product: 4,4-Diethoxybutan-1-amine, the publication is Russian Journal of General Chemistry (2015), 85(7), 1779-1782, database is CAplus.

The synthesis of the target compounds was achieved by a reaction of N-(4,4-diethoxybutyl)urea derivatives (urea acetals) with 2-methyl-1,3-benzenediol (methylresorcinol, phenol derivative). The title compounds thus formed included N-[4-bis(2,4-dihydroxy-3-methylphenyl)butyl]urea derivatives A reaction of N-(4,4-diethoxybutyl)-N’,N’-dimethylurea with 2-naphthalenol (phenol analog) gave N,N-dimethyl-N’-[3-(14H-dibenzo[a,j]xanthen-14-yl)propyl]urea.

Russian Journal of General Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C17H14F3N3O2S, Recommanded Product: 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smolobochkin, A. V. published the artcileInteraction of 1,1′-(hexane-1,6-diyl)bis[3-(4,4-diethoxybutyl)urea] with resorcinol derivatives. Synthesis of bisarylpyrrolidines, Quality Control of 6346-09-4, the publication is Russian Journal of General Chemistry (2015), 85(2), 517-519, database is CAplus.

In this letter to the editor, the synthesis of 2-aryl-pyrrolidines from 1,1′-(hexane-1,6-diyl)bis[3-(4,4-diethoxybutyl)urea] with resorcinol derivatives is presented. Of note, when chloroform, benzene or acetone solvents were used with trifluoroacetic acid catalyst, complex mixtures of polymers were formed. However, using water in diluted sulfuric acid presented the desired products.

Russian Journal of General Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C4H3Cl2N3, Quality Control of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smolobochkin, A. V. published the artcileSynthesis of (E)-4-(4-chlorobenzylidene)-3,4-dihydro-2H-pyrrole-based pyrrolinium salts, Synthetic Route of 6346-09-4, the publication is Russian Chemical Bulletin (2020), 69(2), 382-385, database is CAplus.

Pyrrolinium salts containing 3-arylidene fragment were obtained. Their synthesis is based on the reaction of (E)-4-(4-chlorobenzylidene)-3,4-dihydro-2H-pyrrole with various bromo-alkanes. Structures of the obtained compounds were confirmed by a set of physico-chem. anal. methods.

Russian Chemical Bulletin published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C9H9ClO4, Synthetic Route of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts