Tag: M.W=150-200

Armbruster, Michael R. published the artcileIsobaric 4-Plex Tagging for Absolute Quantitation of Biological Acids in Diabetic Urine Using Capillary LC-MS/MS, Safety of 2-Hydroxy-2-phenylacetic acid, the publication is ACS Measurement Science Au (2022), 2(3), 287-295, database is CAplus and MEDLINE.

Isobaric labeling in mass spectrometry enables multiplexed absolute quantitation and high throughput, while minimizing full scan spectral complexity. Here, we use 4-plex isobaric labeling with a fixed pos. charge tag to improve quantitation and throughput for polar carboxylic acid metabolites. The isobaric tag uses an isotope-encoded neutral loss to create mass-dependent reporters spaced 2 Da apart and was validated for both single- and double-tagged analytes. Tags were synthesized inhouse using deuterated formaldehyde and Me iodide in a total of four steps, producing cost-effective multiplexing. No chromatog. deuterium shifts were observed for single- or double-tagged analytes, producing consistent reporter ratios across each peak. Perfluoropentanoic acid was added to the sample to drastically increase retention of double-tagged analytes on a C18 column. Excess tag was scavenged and extracted using hexadecyl chloroformate after reaction completion. This allowed for removal of excess tag that typically causes ion suppression and column overloading. A total of 54 organic acids were investigated, producing an average linearity of 0.993, retention time relative standard deviation (RSD) of 0.58%, and intensity RSD of 12.1%. This method was used for absolute quantitation of acid metabolites comparing control and type 1 diabetic urine. Absolute quantitation of organic acids was achieved by using one isobaric lane for standards, thereby allowing for anal. of six urine samples in two injections. Quantified acids showed good agreement with previous work, and six significant changes were found. Overall, this method demonstrated 4-plex absolute quantitation of acids in a complex biol. sample.

ACS Measurement Science Au published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Safety of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Diaw, A. K. D. published the artcileAn experimental study of the electronic absorption and fluorescence spectral properties of new p-substituted-N-phenylpyrroles and their electrosynthesized polymers, Application of 4-(1H-Pyrrol-1-yl)phenol, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2015), 1107-1114, database is CAplus and MEDLINE.

Electronic absorption and fluorescence spectral properties of new p-substituted-N-phenylpyrroles (N-PhPys), including HOPhPy, MeOPhPy, ThPhPy, PhDPy, DPhDPy, PyPhThThPhPy, and their available, electrosynthesized polymers were investigated. Electronic absorption spectra, fluorescence excitation and emission spectra, fluorescence quantum yields (Φ_F) and lifetimes (τ_F), and other photophys. parameters of these N-PhPy derivatives and their polymers were measured in DMF, DMSO diluted solutions and/or solid state at room temperature The electronic absorption spectra of N-PhPy derivatives and their polymers included one to several bands, located in the 270-395 nm region, according to the p-Ph substituent electron-donating effect and conjugated heteroaromatic system length. The fluorescence excitation spectra were characterized by one broad main peak, with, in most cases, one (or more) poorly resolved shoulder (s), appearing in the 270-405 nm region, and their emission spectra were generally constituted of several bands located in the 330-480 nm region. No significant shift of the absorption, fluorescence excitation and emission spectra wavelengths was found upon going from the monomers to the corresponding polymers. Φ_F Values were high, varying between 0.11 and 0.63, according to the nature of substituents(s) and to the conjugated system extension. Fluorescence decays were mono-exponential for the monomers and poly-exponential for PyPhThThPhPy and for polymers. τ_F Values were relatively short (0.35-5.17 ns), and markedly decreased with the electron-donor character of the Ph group p-substituent and the conjugated system extension.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Diaw, A. K. D. published the artcileNew poly(p-substituted-N-phenylpyrrole)s. Electrosynthesis, electrochemical properties and characterization, Safety of 4-(1H-Pyrrol-1-yl)phenol, the publication is Synthetic Metals (2013), 74-85, database is CAplus.

Poly(N-p-hydroxyphenylpyrrole) [poly(HOPhPy)], poly(N-p-methoxyphenylpyrrole) [poly(MeOPhPy)], poly(N-p-thiophene-phenylpyrrole) [poly(ThPhPy)], poly(1,1′-phenylene dipyrridyl) [poly(PhDPy)] and poly(1,1′-diphenylene dipyrridyl) [poly(DPhDPy)] were electrosynthesized from the corresponding monomers on Pt electrode in 0.1 M tetrabutylammonium hexafluorophosphate (TBAPF₆) acetonitrile solutions, using cyclic voltammetry (CV), galvanostatic and potentiostatic modes. The electrodeposited films were characterized by CV, FT-IR spectrometry, X-ray photoelectron spectra (XPS), and SEM. Electron-donating substituent effects on the polymer electrochem. properties were investigated by CV. The CV of the films indicated a good redox behavior and a peak position depending on the nature of substituent. FT-IR spectral studies allowed one to predict a linear and regular structure of the polymer chains, the coupling taking place in the 2 and 5 positions of the pyrrole rings. XPS anal. showed a variation of the film doping levels (26-42% for oxidized films and 6-12% for reduced films) with the electron-donor character of the Ph p-substituents. The conjugated π-electronic system was extended by strong electron-donating substituents which led to a higher doping level of the polypyrrolic chains and a polymer structure with high-energy and polar bonds like CN⁺ and CN⁺. SEM anal. revealed changes in the polymer film morphol. and thickness with the nature of substituents.

Synthetic Metals published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Safety of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Blandamer, Michael J. published the artcileMechanism and solvent reorganization accompanying hydrolyses of anchimerically assisted alkyl halides in water, SDS of cas: 2588-77-4, the publication is Journal of the American Chemical Society (1969), 91(10), 2678-83, database is CAplus.

This paper deals with the problem of solvent reorganization, anchimeric assistance, and mechanism for hydrolysis of 9 alkyl halides where the neighboring group is -OH, -OMe, or -SMe. By using the temperature coefficient of the enthalpy as a gauge of relative solvent reorganization, we show that the transition state in the hydrolysis of those alkyl halides giving evidence of anchimeric assistance resembles that for an SN1 mechanism. This conclusion was supported in one case by 13C labeling experiments in spite of product analysis seemingly favoring SN2 nucleophilic displacement by the solvent.

Journal of the American Chemical Society published new progress about 2588-77-4. 2588-77-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 2-Methyl-3-bromo-2-butanol, and the molecular formula is C5H11BrO, SDS of cas: 2588-77-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Garcia-Abuin, Alicia published the artcileCarbon dioxide capture with tertiary amines. Absorption rate and reaction mechanism, Category: alcohols-buliding-blocks, the publication is Journal of the Taiwan Institute of Chemical Engineers (2017), 356-362, database is CAplus.

Present work analyzes the overall carbon dioxide chem. absorption process using tertiary amines in aqueous solution, taking into account absorption rate exptl. data and ¹³C and ¹H NMR. These studies try to detect the causes because different behaviors are obtained for absorption curves at different carbon dioxide loadings. The combined use of these techniques allows to evaluate the weight of different variables (chem. kinetics, mechanism, hydrodynamics, etc) upon the absorption overall process.

Journal of the Taiwan Institute of Chemical Engineers published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Carbo, Jorge J. published the artcileConstruction of titanasiloxanes by incorporation of silanols to the metal oxide model [{Ti(η⁵-C₅Me₅)(μ-O)}₃(μ₃-CR)]: DFT elucidation of the reaction mechanism, Product Details of C9H22OSi, the publication is Chemistry – A European Journal (2008), 14(26), 7930-7938, database is CAplus and MEDLINE.

A family of novel titanasiloxanes containing the structural unit {[Ti(η⁵-C₅Me₅)O]₃} were synthesized by hydron-transfer processes involving reactions with equimol. amounts of μ₃-alkylidyne derivatives [{Ti(η⁵-C₅Me₅)(μ-O)}₃(μ₃-CR)] (R = H (1), Me (2)) and monosilanols, R₃‘Si(OH), silanediols, R₂‘Si(OH)₂, and the silanetriol tBuSi(OH)₃. Treatment of 1 and 2 with triorganosilanols (R’ = Ph, iPr) in hexane affords the new metallasiloxane derivatives [{Ti(η⁵-C₅Me₅)(μ-O)}₃(μ-CHR)(OSiR₃‘)] (R = H, R’ = Ph (3), iPr (4); R = Me, R’ = Ph (5), iPr (6)). Analogous reactions with silanediols, (R’ = Ph, iPr), give the cyclic titanasiloxanes [{Ti(η⁵-C₅Me₅)(μ-O)}₃(μ-O₂SiR’₂)(R)] (R = Me, R’ = Ph (7), iPr (8): R = Et, R’ = Ph (9), iPr (10)). Use of tBuSi(OH)₃ with 1 or 2 at room temperature produces the intermediate complexes [{Ti(η⁵-C₅Me₅)(μ-O)}₃(μ-O₂Si(OH)tBu)(R)] (R = Me (11), Et (12)). Further heating of solutions of 11 or 12 affords the same compound with an adamantanoid structure, [{Ti(η⁵-C₅Me₅)(μ-O)}₃(η-O₃SitBu)] (13) and methane or ethane elimination, resp. The x-ray crystal structures of 3, 4, 6, 8, 10, 12, and 13 were determined To gain an insight into the mechanism of these reactions, DFT calculations were performed on the incorporation of monosilanol to the model complex [{Ti(η⁵-C₅H₅)(μ-O)}₃(μ₃-CMe)] (2H). The propose mechanism consists of three steps: (1) hydron transfer from the silanol to one of the O atoms of the Ti₃O₃ ring, forming a titanasiloxane; (2) intramol. hydron migration to the alkylidyne moiety; and (3) a μ-alkylidene ligand rotation to give the final product.

Chemistry – A European Journal published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Product Details of C9H22OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Qingzhuo published the artcileBacterial mandelic acid degradation pathway and its application in biotechnology, Quality Control of 90-64-2, the publication is Journal of Applied Microbiology (2022), 133(2), 273-286, database is CAplus and MEDLINE.

A review. Mandelic acid and its derivatives are an important class of chem. synthetic blocks, which is widely used in drug synthesis and stereochem. research. In nature, mandelic acid degradation pathway has been widely identified and analyzed as a representative pathway of aromatic compounds degradation The most studied mandelic acid degradation pathway from Pseudomonas putida consists of mandelate racemase, S-mandelate dehydrogenase, benzoylformate decarboxylase, benzaldehyde dehydrogenase and downstream benzoic acid degradation pathways. Because of the ability to catalyze various reactions of aromatic substrates, pathway enzymes have been widely used in biocatalysis, kinetic resolution, chiral compounds synthesis or construction of new metabolic pathways. In this paper, the physiol. significance and the existing range of the mandelic acid degradation pathway were introduced first. Then each of the enzymes in the pathway is reviewed one by one, including the researches on enzymic properties and the applications in biotechnol. as well as efforts that have been made to modify the substrate specificity or improving catalytic activity by enzyme engineering to adapt different applications. The composition of the important metabolic pathway of bacterial mandelic acid degradation pathway as well as the researches and applications of pathway enzymes is summarized in this review for the first time.

Journal of Applied Microbiology published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C17H14N2O2, Quality Control of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ekrami, Ali published the artcileDevelopment and evaluation of Zhumeria majdae essential oil-loaded nanoliposome against multidrug-resistant clinical pathogens causing nosocomial infection, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Journal of Drug Delivery Science and Technology (2022), 103148, database is CAplus.

In this study, we used Zhumeria majdae essential oil (ZMEO) loaded nanoliposome (NLP) to control several multidrug-resistant clin. pathogens (MDRs) that cause nosocomial infections using thin-layer hydration. Initially, ZMEO was extracted and analyzed by GC-MS, and then NLP-ZMEO was examined with different ratios of ZMEO to lecithin. Based on evaluation of release profile and phys. stability, size distribution, and particle size, using dynamic light scattering (DLS) results, the most stable NLP-ZMEO were prepared from ZMEO to lecithin ratio 1:3 that relative to pure ZMEO presented more potent antioxidant, anti-quorum sensing, and anti-biofilm activities. The morphol. results (AFM and SEM) also agreed with DLS anal. Also, the results of structural properties (DSC and FTIR) approved interaction between ZMEO and NLP. Comparing the cytotoxic effect on fibroblasts cell lines and antibacterial activity (MIC, MBC, and agar disk diffusion method), it was found that the antimicrobial activity in NLP-ZMEO was higher than ZMEO against multidrug-resistant clin. pathogens that cause nosocomial infection. The subcytotoxic values of the tested NLP-ZMEO were higher than MICs and MBCs for MDR bacteria and chlorhexidine doses.

Journal of Drug Delivery Science and Technology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Clerici, Angelo published the artcileA New One-Pot, Four-Component Synthesis of 1,2-Amino Alcohols: TiCl₃/t-BuOOH-Mediated Radical Hydroxymethylation of Imines, Computed Properties of 101-98-4, the publication is Organic Letters (2008), 10(21), 5063-5066, database is CAplus and MEDLINE.

An amine, an aldehyde, and methanol can be readily assembled in one pot under very mild conditions through a free-radical multicomponent reaction by using an aqueous acidic TiCl₃/t-BuOOH system to afford 1,2-amino alcs. in fair to excellent yields.

Organic Letters published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Computed Properties of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wasson, B. K. published the artcileβ-Adrenergic blocking agents. 3-(3-Substituted-amino-2-hydroxypropoxy)-4-substituted-1,2,5-thiadiazoles, Category: alcohols-buliding-blocks, the publication is Journal of Medicinal Chemistry (1972), 15(6), 651-5, database is CAplus and MEDLINE.

A number of 3-(3-substitute-amino-2-hydroxypropoxy)-4-substituted-1,2,5-thiadiazoles were prepared by 3 general procedures: (a) by condensation of the appropriate 3-hydroxy-4-substituted-1,2,5-thiadiazole with epichlorohydrin, then formation of the epoxide, and condensation with an amine, (b) by treatment of 4-chloro-3-(3-substituted-amino-2-hydroxypropoxy)-1,2,5-thiadiazole with a heterocyclic compound containing a secondary N, or (c) by formation of a bromohydrin of a 3-substituted-4-allyloxy-1,2,5-thiadiazole, followed by treatment with an amine. A number of I containing 4-Cl, 4-Et, or 4-EtO such as (+)-3-(3-tert-butylamino-2-hydroxypropoxy)-4-chloro-1,2,5-thiadiazole-HCl [(+)-I, R = Cl, R1 = H, R2 = tert-Bu] [26791-14-0], 3-(3-isopropylamino-2-hydroxypropoxy)-4-ethyl-1,2,5-thiadiazole-HCl (I, R = Et, R1 = H, R2 = iso-Pr) [26670-38-2] and 3-(3-isopropylamino-2-hydroxypropoxy)-4-ethoxy-1,2,5-thiadiazole-HCl (I, R = EtO, R1 = H, R2 = iso-Pr) [26852-60-8] were potent β-adrenergic blocking agents but short acting (ED50 0.023, 0.04 and 0.035 mg/kg i.v., resp., dose required to inhibit by 50% the cardioaccelerator response to 0.12 mg/kg i.v. isoproterenol in the ganglion-blocked anesthetized rat). A number of 1,2,5-thiadiazoles possessing a bulky group in the 4-position were long acting, the outstanding member being (+-)-3-(3-tert-butylamino-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole-HCl [(+-)-II -HCl] [26670-02-0] with an ED50 of 0.013. Resolution of (+-)-II showed the bulk of activity resided in the (+)-form, (+)-3-(3-tert-butylamino-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole hydrogen maleate [(+)-II H maleate] [26839-77-0] the ED50 being 0.0066. The optimal activity in the thiadiazoles was achieved by the presence of an iso-Pr or tert-Bu group in the aminoisopropanoloxy side chain and inclusion of a bulky substituent in the 4 position.

Journal of Medicinal Chemistry published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C42H63O3P, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts