Tag: M.W=150-200

Wang, Yekai published the artcileMetabolic signature of the aging eye in mice, HPLC of Formula: 86-48-6, the publication is Neurobiology of Aging (2018), 223-233, database is CAplus and MEDLINE.

Aging is a major risk factor for age-related ocular diseases including age-related macular degeneration in the retina and retinal pigment epithelium (RPE), cataracts in the lens, glaucoma in the optic nerve, and dry eye syndrome in the cornea. We used targeted metabolomics to analyze metabolites from young (6 wk) and old (73 wk) eyes in C57 BL6/J mice. Old mice had diminished electroretinogram responses and decreased number of photoreceptors in their retinas. Among the 297 detected metabolites, 45-114 metabolites are significantly altered in aged eye tissues, mostly in the neuronal tissues (retina and optic nerve) and less in cornea, RPE/choroid, and lens. We noted that changes of metabolites in mitochondrial metabolism and glucose metabolism are common features in the aged retina, RPE/choroid, and optic nerve. The aging retina, cornea, and optic nerve also share similar changes in NAD (NAD), 1-methylnicotinamides, 3-methylhistidine, and other methylated metabolites. Metabolites in taurine metabolism are strikingly influenced by aging in the cornea and lens. In conclusion, the aging eye has both common and tissue-specific metabolic signatures. These changes may be attributed to dysregulated mitochondrial metabolism, reprogrammed glucose metabolism and impaired methylation in the aging eye. Our findings provide biochem. insights into the mechanisms of age-related ocular changes.

Neurobiology of Aging published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C12H14O2, HPLC of Formula: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wahlang, Banrida published the artcileAssociations between residential exposure to volatile organic compounds and liver injury markers, HPLC of Formula: 90-64-2, the publication is Toxicological Sciences (2022), 185(1), 50-63, database is CAplus and MEDLINE.

Occupational exposures to volatile organic compounds (VOCs) have been associated with numerous health complications including steatohepatitis and liver cancer. To address this knowledge gap, the objective of this cross-sectional study is to investigate associations between VOCs and liver injury biomarkers in community residents. Subjects were recruited from six Louisville neighborhoods, and informed consent was obtained. Exposure biomarkers included 16 creatinine-adjusted urinary metabolites corresponding to 12 parent VOCs. Serol. disease biomarkers measured included cytokertain-18 (K18 M65 and M30), liver enzymes, and direct bilirubin. The population comprised of approx. 60% females and 40% males; White persons accounted 78% of the population; with more nonsmokers (n = 413) than smokers (n = 250). In the overall population, metabolites of acrolein, acrylonitrile, acrylamide, 1,3-butadiene, crotonaldehyde, styrene, and xylene were pos. associated with alk. phosphatase. These associations persisted in smokers, with the exception of crotonaldehyde, and addition of N,N-dimethylformamide and propylene oxide metabolites. Although no pos. associations were observed for K18 M30, the benzene metabolite was pos. associated with bilirubin, irresp. of smoking status. Taken together, the results demonstrated that selected VOCs were pos. associated with liver injury biomarkers. These findings will enable better risk assessment and identification of populations vulnerable to liver disease.

Toxicological Sciences published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C5H5BrN2, HPLC of Formula: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Andorfer, Mary C. published the artcileUnderstanding Flavin-Dependent Halogenase Reactivity via Substrate Activity Profiling, Safety of 4-(1H-Pyrrol-1-yl)phenol, the publication is ACS Catalysis (2017), 7(3), 1897-1904, database is CAplus and MEDLINE.

The activity of four native FDHs and four engineered FDH variants on 93 low mol. weight arenes was used to generate FDH substrate activity profiles. These profiles provided insights into how substrate class, functional group substitution, electronic activation, and binding impact FDH activity and selectivity. The enzymes studied could halogenate a far greater range of substrates than previously recognized, but significant differences in their substrate specificity and selectivity were observed Trends between the electronic activation of each site on a substrate and halogenation conversion at that site were established, and these data, combined with docking simulations, suggest that substrate binding can override electronic activation even on compounds differing appreciably from native substrates. These findings provide a useful framework for understanding and exploiting FDH reactivity for organic synthesis.

ACS Catalysis published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Safety of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yetisen, Mehmet published the artcileElucidation of key aroma enhancement in cloudy lemon juices by the addition of peel oil using GC-MS-Olfactometry, Related Products of alcohols-buliding-blocks, the publication is International Journal of Food Science and Technology (2022), 57(8), 5280-5288, database is CAplus.

Volatile substances play a crucial role in the consumer preference of lemon juices. The effects of heat treatment and addition of lemon peel oil to lemon juice (Citrus limon Burm. cv. Kutdiken) on the aroma compounds were elucidated for the first time. Total phenolic, antioxidant activity, acidity, pH and color properties were also studied. Results revealed that the aroma of the juice samples comprised mostly the terpene compounds Limonene, γ-terpinene, β-pinene and α-pinene were the influential terpenes responsible for the distinctive odor of the lemon juice. The addition of the lemon peel oil increased the amounts of the aroma and aroma-active compounds Besides, the heat treatment had a pos. effect on the total phenolics and the antioxidant activity but it caused significant reduction of the aroma compounds Sensory anal. revealed that the most preferred sample was the juice with lemon peel oil added after pasteurization.

International Journal of Food Science and Technology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C14H7F3OS, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hidalgo-Liberona, Nicole published the artcileIncreased intestinal permeability in older subjects impacts the beneficial effects of dietary polyphenols by modulating their bioavailability, Formula: C8H8O3, the publication is Journal of Agricultural and Food Chemistry (2020), 68(44), 12476-12484, database is CAplus and MEDLINE.

Polyphenols have great potential in regulating intestinal health and ameliorating pathol. conditions related to increased intestinal permeability (IP). However, the efficacy of dietary interventions with these phytochems. may significantly be influenced by interindividual variability factors affecting their bioavailability and consequent biol. activity. In the present study, urine samples collected from older subjects undergoing a crossover intervention trial with polyphenol-rich foods were subjected to metabolomics anal. for investigating the impact of increased IP on the bioavailability of polyphenols. Interestingly, urinary levels of phase II and microbiota-derived metabolites were significantly different between subjects with healthier intestinal barrier integrity and those with increased IP disruption. Our results support that this IP-dependent impaired bioavailability of polyphenols could be attributed to disturbances in the gut microbial metabolism and phase II methylation processes. Furthermore, we also observed that microbiota-derived metabolites could be largely responsible for the biol. activity elicited by dietary polyphenols against age-related disrupted IP.

Journal of Agricultural and Food Chemistry published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gonzalez-Calderon, Davir published the artcileA Novel Chemoselective Cleavage of (tert-Butyl)(dimethyl)silyl (TBS) Ethers Catalyzed by Ce(SO₄)₂.4 H₂O, Recommanded Product: Triisopropylsilanol, the publication is Helvetica Chimica Acta (2014), 97(7), 965-972, database is CAplus.

(tert-Butyl)(dimethyl)silyl (tBuMe₂Si; TBS) phenyl/alkyl ethers were efficiently cleaved to the corresponding parent hydroxy compounds in good yields using catalytic amounts of Ce(SO₄)₂.4 H₂O by microwave-assisted or conventional heating in MeOH. Intramol. and competitive experiments demonstrated the chemoselective deprotection of TBS ethers in the presence of triisopropylsilyl (ⁱPr₃Si; TIPS) and (tert-butyl)(diphenyl)silyl (tBuPh₂Si; TBDPS) ethers.

Helvetica Chimica Acta published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Recommanded Product: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kumar, Naresh published the artcileExtrapolation of hydroxytyrosol and its analogues as potential anti-inflammatory agents, COA of Formula: C8H8O3, the publication is Journal of Biomolecular Structure and Dynamics (2021), 39(15), 5588-5599, database is CAplus and MEDLINE.

Discovery of potential lead mol. is a challenging, and complex process which require lots of money, patience, and manpower. Human beings are using natural products, predominantly secondary metabolites, for this purpose since ancient time and they are still working on them as a potent source for drug discovery due to their wide structural diversity. Phenolic phytochems. such as hydroxytyrosol and tyrosol are natural antioxidant and involved in many biol. disease cure. Herein, we have carried out the quantum chem. calculations for conformational anal., geometry optimization and computation of electronic as well as optical properties of hydroxytyrosol and its analogs (1a-1k) in terms of d. functional theory by using Gaussian 09 program suite. The eventual charge transfer within the mols. has been confirmed by the anal. of frontier MOs. The mol. docking studies of 1a-1k with cyclooxygenase-2 showed the noticeable binding affinity as compared to other nonsteroidal anti-inflammatory drugs viz. aspirin, naproxen and celecoxib. Computation of pharmacokinetics and pharmacol. properties confirmed the lead/drug like potential of these screened mols. Furthermore, the mol. dynamics simulation of best three docked ligands (1f, 1h and 1k)-receptor complex and their binding free energy calculations reveals that these mols. bind in the catalytic cavity of cyclooxygenase-2 and found stable during the 100 ns of simulation.

Journal of Biomolecular Structure and Dynamics published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, COA of Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kirpichenok, M. A. published the artcileSynthesis of 4-chloro-7-(dialkylamino)coumarins, Related Products of alcohols-buliding-blocks, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1990), 830-5, database is CAplus.

The title coumarins I (R = Et, R₂N = piperidino, morpholino, R¹ = H, Et, cyclohexyl, benzyl) and II were prepared in 15-42% yields by heating aminophenols III or benzoquinolizinol IV with R¹CH(CO₂H)₂ in excess POCl₃. Treating I (R = Et, R¹ = H) with NaOEt, Bu₂NH, and N₂H₄.H₂O gave 45, 63, and 17% coumarins V (R² = OEt, Bu₂N, NHNH₂).

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kirschenlohr, Heide L. published the artcileEstimation of systolic and diastolic free intracellular Ca²⁺ by titration of Ca²⁺ buffering in the ferret heart, COA of Formula: C6H3F2NO3, the publication is Biochemical Journal (2000), 346(2), 385-391, database is CAplus.

Spectroscopic Ca²⁺-indicators are thought to report values of free intracellular Ca²⁺ concentration ([Ca²⁺]_i) that may differ from unperturbed values because they add to the buffering capacity of the tissue. To check this for the heart we have synthesized a new ¹⁹F-labeled NMR Ca²⁺ indicator, 1,2-bis-[2-bis-(carboxymethyl)amino-4,5-difluorophenoxy]ethane (“4,5FBAPTA”), with a low affinity (K_d 2950 nM). The new indicator and four previously described ¹⁹F-NMR Ca²⁺ indicators 1,2-bis-[2-(1-carboxyethyl)(carboxymethyl)amino-5-fluorophenoxy]ethane (“DiMe-5FBAPTA”), 1,2-bis-[2-(1-carboxyethyl)(carboxymethyl)-amino-4-fluorophenoxy]ethane (“DiMe-4FBAPTA”), 1,2-bis-[2-bis(carboxymethyl)amino-5-fluorophenoxy]ethane (“5FBAPTA”) and 1,2-bis-[2-bis(carboxymethyl)amino-5-fluoro-4-methylphenoxy]ethane (“MFBAPTA”), with dissociation constants for Ca²⁺ ranging from 46 to 537 nM, have been used to measure [Ca²⁺]_i, over the range from less than 100 nM to more than 3 μM, in Langendorff-perfused ferret hearts (30°C, pH 7.4, paced at 1.0 Hz) by ¹⁹F-NMR spectroscopy. Loading hearts with indicators resulted in buffering of the Ca²⁺ transient. The measured end-diastolic and peak-systolic [Ca²⁺]_i were both pos. correlated with indicator K_d. The pos. correlations between indicator K_d and the measured end-diastolic and peak-systolic [Ca²⁺]_i were used to estimate the unperturbed end-diastolic and peak-systolic [Ca²⁺]_i by extrapolation to K_d = 0 (diastolic) and to K_d = ∞ (systolic) resp. The extrapolated values in the intact beating heart were 161 nM for end-diastolic [Ca²⁺]_i and 2650 nM for peak-systolic [Ca²⁺]_i, which agree well with values determined from single cells and muscle strips.

Biochemical Journal published new progress about 55346-97-9. 55346-97-9 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Nitro Compound,Benzene,Phenol, name is 4,5-Difluoro-2-nitrophenol, and the molecular formula is C6H3F2NO3, COA of Formula: C6H3F2NO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Armbruster, Michael R. published the artcileIsobaric 4-Plex Tagging for Absolute Quantitation of Biological Acids in Diabetic Urine Using Capillary LC-MS/MS, Application In Synthesis of 621-37-4, the publication is ACS Measurement Science Au (2022), 2(3), 287-295, database is CAplus and MEDLINE.

Isobaric labeling in mass spectrometry enables multiplexed absolute quantitation and high throughput, while minimizing full scan spectral complexity. Here, we use 4-plex isobaric labeling with a fixed pos. charge tag to improve quantitation and throughput for polar carboxylic acid metabolites. The isobaric tag uses an isotope-encoded neutral loss to create mass-dependent reporters spaced 2 Da apart and was validated for both single- and double-tagged analytes. Tags were synthesized inhouse using deuterated formaldehyde and Me iodide in a total of four steps, producing cost-effective multiplexing. No chromatog. deuterium shifts were observed for single- or double-tagged analytes, producing consistent reporter ratios across each peak. Perfluoropentanoic acid was added to the sample to drastically increase retention of double-tagged analytes on a C18 column. Excess tag was scavenged and extracted using hexadecyl chloroformate after reaction completion. This allowed for removal of excess tag that typically causes ion suppression and column overloading. A total of 54 organic acids were investigated, producing an average linearity of 0.993, retention time relative standard deviation (RSD) of 0.58%, and intensity RSD of 12.1%. This method was used for absolute quantitation of acid metabolites comparing control and type 1 diabetic urine. Absolute quantitation of organic acids was achieved by using one isobaric lane for standards, thereby allowing for anal. of six urine samples in two injections. Quantified acids showed good agreement with previous work, and six significant changes were found. Overall, this method demonstrated 4-plex absolute quantitation of acids in a complex biol. sample.

ACS Measurement Science Au published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Application In Synthesis of 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts