Tag: M.W=150-200

Nie, Hui-Jun published the artcileRapid and halide compatible synthesis of 2-N-substituted indazolone derivatives via photochemical cyclization in aqueous media, Quality Control of 1043416-40-5, the publication is RSC Advances (2019), 9(23), 13249-13253, database is CAplus and MEDLINE.

A rapid and efficient approach was developed for the synthesis of 2-N-substituted indazolones I [R = H, 5-Br, 6-CF₃, etc.; R¹ = t-Bu, c-pentyl, Bn, etc.] via photochem. cyclization of o-nitrobenzyl alcs. and primary amines in aqueous media at room temperature This straightforward protocol was halide compatible for the synthesis of halogenated indazolones bearing a broad scope of substrates, which suggested a new avenue of great importance to medicinal chem.

RSC Advances published new progress about 1043416-40-5. 1043416-40-5 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Nitro Compound,Benzene,Alcohol, name is (4-Fluoro-2-nitrophenyl)methanol, and the molecular formula is C7H6FNO3, Quality Control of 1043416-40-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Deng, Xiufeng published the artcileEffect of organic alkali on hydration of GGBS-FA blended cementitious material activated by sodium carbonate, Category: alcohols-buliding-blocks, the publication is Ceramics International (2022), 48(2), 1611-1621, database is CAplus.

Sodium carbonate (SC) activated ground granulated blast-furnace slag (GGBS) and fly ash (FA) is a potential substitute of traditional cement with ultra-low carbon footprint. However, its hydration rate and strength growth are limited, owing to the slow leaching of ions during the activation of weak base. In this work, 60% wet-grinded GGBS and 40% FA were blended as the binder, and two organic alkalis, i.e. triethanolamine (TEA) and triisopropanolamine (TIPA), were adopted to facilitate the ions dissolution and pozzolanic reaction of SC activated GGBS-FA blended cementitious material (SCSF). The compressive strength was tested and the hydration kinetics was studied by hydration heat and chem. shrinkage. Besides, ions leaching behavior was characterized by ICP; hydrates and microstructure were also detected by XRD, TG-DTG and SEM. Results indicated that the addition of TEA or TIPA significantly promoted the ions dissolution 0.05% TEA increased the concentration of leached Ca2+, Al3+ and Fe3+ by 36%, 33% and 1545%, resp. This solubilizing effect was also found in TIPA. Moreover, these two chems. could promote the formation of hydrates, such as C-S(A)-H gel, hydrotalcite, calcite and aragonite, especially at the early period; these also activated the hydration process of SCSF effectively, and the compressive strength of the mortar reached above 40.0 MPa at 7 d and 48.0 MPa at 28 d. The carbon emission of the designed system is 85.9% and 55.9% lower than that of PC and strong base activated GGBS system, resp.

Ceramics International published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Donck, Simon published the artcileMild and selective catalytic oxidation of organic substrates by a carbon nanotube-rhodium nanohybrid, Category: alcohols-buliding-blocks, the publication is Catalysis Science & Technology (2015), 5(9), 4542-4546, database is CAplus.

Rhodium nanoparticles were assembled on carbon nanotubes and the resulting nanohybrid was used for the catalytic aerobic oxidation of diverse substrates such as hydroquinones, hydroxylamines, silanes, hydrazines and thiols at room temperature The catalytic system was proved to be very efficient on the investigated substrates and demonstrated high selectivity. Furthermore, the catalyst operates under mild reaction conditions, with excellent yields and could be easily recycled without loss of activity.

Catalysis Science & Technology published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Farah, Joseph published the artcileDirect integration of gold-carbon nanotube hybrids in continuous-flow microfluidic chips: A versatile approach for nanocatalysis, Category: alcohols-buliding-blocks, the publication is Journal of Colloid and Interface Science (2022), 359-367, database is CAplus and MEDLINE.

A carbon nanotube-based packed-bed microreactor was developed for the on-chip oxidation of silanes. The process is catalyzed by a heterogeneous gold-carbon nanotube hybrid that was embedded in the device using a micrometric restriction zone. Integration of the nanohybrid permitted efficient flow aerobic oxidation of the substrates into the corresponding silanols with high selectivity and under sustainable conditions.

Journal of Colloid and Interface Science published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

John, Jubi published the artcileCatalytic Oxidation of Silanes by Carbon Nanotube-Gold Nanohybrids, Computed Properties of 17877-23-5, the publication is Angewandte Chemie, International Edition (2011), 50(33), 7533-7536, S7533/1-S7533/37, database is CAplus and MEDLINE.

Here reported an alternative strategy which has led to the discovery of the most efficient catalytic system to date for silane oxidation The approach involves layer-by-layer (LBL) assembly of gold nanoparticles on carbon nanotubes (CNT₅). Nanotubes provide high sp. surface area and excellent nanoparticle (NP) dispersion. In addition, nanotubes are electronically active and stabilization of transient higher oxidation states of gold are anticipated by collaborative interactions with the metal. To the best of authors knowledge, this is the first report on silane oxidation by CNT-supported catalysts. Thus, gold carbon nanotube catalyzed oxidation of PhSiMe₂H in THF/H₂O in the presence of air gave 98% PhSiMe₂OH in 45m at room temperature

Angewandte Chemie, International Edition published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Computed Properties of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Villemin, Elise published the artcilePolydiacetylene Nanotubes in Heterogeneous Catalysis: Application to the Gold-Mediated Oxidation of Silanes, Synthetic Route of 17877-23-5, the publication is Macromolecular Chemistry and Physics (2015), 216(24), 2398-2403, database is CAplus.

A layer-by-layer approach is used to anchor small gold nanoparticles onto organic nanotubes resulting from the self-assembly and polymerization of diacetylene-containing nitrilotriacetic amphiphiles. The obtained nanotube-gold hybrid is used as a catalyst for the aerobic oxidation of various silanes. With minimal gold loading (0.05 mol%), all substrates are converted into the corresponding silanols with hydrogen gas as the only byproduct. The catalyst operates under mild conditions and can be easily recycled, losing neither activity nor selectivity.

Macromolecular Chemistry and Physics published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C6H8O3, Synthetic Route of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Askey, Hannah E. published the artcilePhotocatalytic Hydroaminoalkylation of Styrenes with Unprotected Primary Alkylamines, Quality Control of 6346-09-4, the publication is Journal of the American Chemical Society (2021), 143(39), 15936-15945, database is CAplus and MEDLINE.

A solution to these problems using organophotoredox catalysis, enabling a direct, modular and sustainable preparation of α-(di)substituted γ-arylamines, including challenging electron-neutral and moderately electron-rich aryl groups was reported. A broad range of functionalities were tolerated, and the reactions was run on multigram scale in continuous flow. The method was applied to a concise, protecting-group-free synthesis of the blockbuster drug Fingolimod, as well as a phosphonate mimic of its in-vivo active form (by iterative α-C-H functionalization of ethanolamine). The reaction was sequenced with an intramol. N-arylation to provided a general and modular access to valuable (spirocyclic) 1,2,3,4-tetrahydroquinolines and 1,2,3,4-tetrahydronaphthyridines. Mechanistic and kinetic studies supportes an irreversible hydrogen atom transfer activation of the alkylamine by the azidyl radical and some contribution from a radical chain. The reaction was photon-limited and exhibits a zero-order dependence on amine, azide, and photocatalyst, with a first-order dependence on styrene.

Journal of the American Chemical Society published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Quality Control of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ghislieri, Diego published the artcileEngineering an Enantioselective Amine Oxidase for the Synthesis of Pharmaceutical Building Blocks and Alkaloid Natural Products, COA of Formula: C8H19NO2, the publication is Journal of the American Chemical Society (2013), 135(29), 10863-10869, database is CAplus and MEDLINE.

The development of cost-effective and sustainable catalytic methods for the production of enantiomerically pure chiral amines is a key challenge facing the pharmaceutical and fine chem. industries. This challenge is highlighted by the estimate that 40-45% of drug candidates contain a chiral amine, fueling a demand for broadly applicable synthetic methods that deliver target structures in high yield and enantiomeric excess. Herein we describe the development and application of a “toolbox” of monoamine oxidase variants from Aspergillus niger (MAO-N) which display remarkable substrate scope and tolerance for sterically demanding motifs, including a new variant, which exhibits high activity and enantioselectivity toward substrates containing the aminodiphenylmethane (benzhydrylamine) template. By combining rational structure-guided engineering with high-throughput screening, it has been possible to expand the substrate scope of MAO-N to accommodate amine substrates containing bulky aryl substituents. These engineered MAO-N biocatalysts have been applied in deracemization reactions for the efficient asym. synthesis of the generic active pharmaceutical ingredients Solifenacin and Levocetirizine as well as the natural products (R)-coniine, (R)-eleagnine, and (R)-leptaflorine. We also report a novel MAO-N mediated asym. oxidative Pictet-Spengler approach to the synthesis of (R)-harmicine.

Journal of the American Chemical Society published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, COA of Formula: C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Matviitsuk, Anastassia published the artcileUnanticipated Silyl Transfer in Enantioselective α,β-Unsaturated Acyl Ammonium Catalysis Using Silyl Nitronates, Application of Triisopropylsilanol, the publication is Organic Letters (2020), 22(1), 335-339, database is CAplus and MEDLINE.

The use of silyl nitronates is reported for the isothiourea-catalyzed synthesis of γ-nitro-substituted silyl esters containing up to two contiguous stereocenters in good yields with excellent enantioselectivities (up to 93% yield and 99:1 er). The serendipitously discovered formation of silyl ester products in this reaction demonstrates a novel platform for catalyst turnover in α,β-unsaturated acyl ammonium catalysis.

Organic Letters published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Application of Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sircar, Ila published the artcileCalcium channel blocking and positive inotropic activities of ethyl 5-cyano-1,4-dihydro-6-methyl-2-[(phenylsulfonyl)methyl]-4-aryl-3-pyridinecarboxylate and analogs. Synthesis and structure-activity relationships, Formula: C10H15NO, the publication is Journal of Medicinal Chemistry (1991), 34(7), 2248-60, database is CAplus and MEDLINE.

A series of 2-[(arylsulfonyl)methyl]-4-aryl-5-cyano-1,4-dihydropyridine-3-carboxylic acid esters and analogs, e.g., I, were prepared via a three component Hantzsch reaction using a substituted benzaldehyde, enamine, and the requisite β-keto ester. These compounds possess unique profile, namely calcium channel blocking and pos. inotropic activities in vitro. Compound I was selected as the best compound in the series and was studied in detail. The synthesis and biol. profiles of enantiomers of I are also reported. The data indicate that although the calcium channel blocking property of I is stereospecific the pos. inotropic activity is not. Examples of 3- and 6-cyano and other closely related 1,4-dihydropyridine derivatives are described and evaluated for comparison and were found to be devoid of dual activities mentioned above.

Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C8H6BrF3S, Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts