Tag: M.W=150-200

Gao, Lili published the artcileStepwise metabolic engineering of Gluconobacter oxydans WSH-003 for the direct production of 2-keto-L-gulonic acid from D-sorbitol, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Metabolic Engineering (2014), 30-37, database is CAplus and MEDLINE.

2-Keto-L-gulonic acid (2-KLG), the direct precursor of vitamin C, is currently produced by a two-step fermentation route from D-sorbitol. However, this route involves three bacteria, making the mix-culture system complicated and redundant. Thus, replacement of the conventional two-step fermentation process with a one-step process could be revolutionary in vitamin C industry. In this study, different combinations of five L-sorbose dehydrogenases (SDH) and two L-sorbosone dehydrogenases (SNDH) from Ketogulonicigenium vulgare WSH-001 were introduced into Gluconobacter oxydans WSH-003, an industrial strain used for the conversion of D-sorbitol to L-sorbose. The optimum combination produced 4.9 g/L of 2-KLG. In addition, 10 different linker peptides were used for the fusion expression of SDH and SNDH in G. oxydans. The best recombinant strain (G. oxydans/pGUC-k0203-GS-k0095) produced 32.4 g/L of 2-KLG after 168 h. Furthermore, biosynthesis of pyrroloquinoline quinine (PQQ), a cofactor of those dehydrogenases, was enhanced to improve 2-KLG production With the stepwise metabolic engineering of G. oxydans, the final 2-KLG production was improved to 39.2 g/L, which was 8.0-fold higher than that obtained using independent expression of the dehydrogenases. These results bring us closer to the final one-step industrial-scale production of vitamin C.

Metabolic Engineering published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cheng, Rui published the artcileA nucleotide-sensing endonuclease from the Gabija bacterial defense system, Name: Triisopropanolamine, the publication is Nucleic Acids Research (2021), 49(9), 5216-5229, database is CAplus and MEDLINE.

The arms race between bacteria and phages has led to the development of exquisite bacterial defense systems including a number of uncharacterized systems distinct from the well-known restriction-modification and CRISPR/Cas systems. Here, we report functional analyses of the GajA protein from the newly predicted Gabija system. The GajA protein is revealed as a sequence-specific DNA nicking endonuclease unique in that its activity is strictly regulated by nucleotide concentration NTP and dNTP at physiol. concentrations can fully inhibit the robust DNA cleavage activity of GajA. Interestingly, the nucleotide inhibition is mediated by an ATPase-like domain, which usually hydrolyzes ATP to stimulate the DNA cleavage when associated with other nucleases. These features suggest a mechanism of the Gabija defense in which an endonuclease activity is suppressed under normal conditions, while it is activated by the depletion of NTP and dNTP upon the replication and transcription of invading phages. This work highlights a concise strategy to utilize a DNA nicking endonuclease for phage resistance via nucleotide regulation.

Nucleic Acids Research published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Name: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Parnes, Howard published the artcileSynthesis of [¹⁴C]-labeled dihydropyridine calcium channel-entry blockers: nicardipine-[4-¹⁴C] and RS-93522-[4-¹⁴C], Synthetic Route of 101-98-4, the publication is Journal of Labelled Compounds and Radiopharmaceuticals (1988), 25(6), 621-6, database is CAplus.

The Hantzsch synthesis was used to prepare title compounds I [R = CH₂CH₂NMeCH₂Ph, CH₂CH₂C₆H₄[OCH₂CH(OH)CH₂OH]-p] from m-O₂NC₆H₄¹⁴CHO (II), H₂NCMe:CHCO₂Me, and MeCOCH₂CO₂R. II was prepared in high yield from PhBr and ¹⁴CO₂ in 4 steps.

Journal of Labelled Compounds and Radiopharmaceuticals published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Synthetic Route of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liao, Xia-ling published the artcileMicrostructural characterization of cement in the presence of alkanolamines, Product Details of C9H21NO3, the publication is Materials Today Communications (2021), 102386, database is CAplus.

In order to understand the potential issues regarding the cement performance over time in the presence of alkanolamines, such as triethanolamine (TEA) and triisopropanolamine (TIPA), this investigation provided a series of quant. phase characterization to monitor the hydration and microstructure of cement pastes. The addition of 0.02% alkanolamines to cement promoted the strength development and altered the hydration kinetics at early ages. The aluminate reaction was greatly promoted, which resulted in the formation of hydrosulfoaluminates with a high monosulfoaluminate-to-ettringite ratio due to the facilitated dissolution of the intermediate phase. The morphol. and chem. composition of the hydrates, as well as the porosity of the pastes, were also influenced by the altered hydration kinetics. Particularly, TIPA markedly reduced Si/Ca ratio (from 0.61 to 0.51) and increased Fe/Ca ratio (from 0.016 to 0.036) in the C-S-H gel at the early stage of hydration. Based on the variations in microstructural features subjected to the alkanolamines, the durability and long-term performance of the cement, including the phase variation, resistance to sulfate or chloride ingression and volume stability, were discussed.

Materials Today Communications published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Product Details of C9H21NO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yin, Xia published the artcileIdentification of volatile and odor-active compounds in Hunan black tea by SPME/GC-MS and multivariate analysis, Synthetic Route of 106-25-2, the publication is LWT–Food Science and Technology (2022), 113656, database is CAplus.

Hunan black tea is well-known for its floral-honey aroma, but the volatile components responsible for the fragrance have not been elucidated yet. In this study, the volatile compounds in Hunan black tea were identified and quantified by the headspace solid-phase microextraction coupled with gas chromatog.-mass spectrometry (HS-SPME-GC-MS). The results showed that 88 compounds were extracted and determined in Hunan black tea, including the dominant components Geraniol, phenethyl alc., phenylacetaldehyde, linalool, nonanal and other 5 aromatic compounds Furthermore, the aroma-active compounds were identified by odor activity value (OAV). It was found that 24 aroma compounds, including geraniol with an OAV≥1 were regarded as the primary active aromatic compounds in Hunan black tea. Finally, partial least squares (PLS) regression anal. was employed and results revealed that Nonanal, trans-nerolidol, benzyl alc., and phenylethanol exhibit a pos. correlation with the intensity of floral and sweet honey aromas. Overall, this study identified the volatile compounds responsible for the dominant floral-honey aroma in Hunan black tea.

LWT–Food Science and Technology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H12O5, Synthetic Route of 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ma, Xiao-Yan published the artcileConcise and efficient syntheses of methyl 4-(1-methylpyrrolidin-2-yl)-3-oxobutanoate and hygrine, Synthetic Route of 6346-09-4, the publication is Canadian Journal of Chemistry (2020), 98(4), 191-193, database is CAplus.

Me 4-(1-methylpyrrolidin-2-yl)-3-oxobutanoate and hygrine are important biosynthetic intermediates for tropane alkaloids. A concise method to synthesize these two compounds from the key intermediate N-methylpyrrolinium cation has been developed. Me 4-(1-methylpyrrolidin-2-yl)-3-oxobutanoate and hygrine were obtained in four and six steps from com. available 4,4-diethoxybutylamine with overall yields of 42% and 25%, resp.

Canadian Journal of Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Synthetic Route of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pappenberger, Gunter published the artcileIndustrial Production of l -Ascorbic Acid (Vitamin C) and d -Isoascorbic Acid, Category: alcohols-buliding-blocks, the publication is Advances in Biochemical Engineering/Biotechnology (2014), 143-188, database is CAplus and MEDLINE.

A review. L -ascorbic acid (vitamin C) was first isolated in 1928 and subsequently identified as the long-sought antiscorbutic factor. Industrially produced l -ascorbic acid is widely used in the feed, food, and pharmaceutical sector as nutritional supplement and preservative, making use of its antioxidative properties. Until recently, the Reichstein-Grüssner process, designed in 1933, was the main industrial route. Here, d -sorbitol is converted to l -ascorbic acid via 2-keto- l -gulonic acid (2KGA) as key intermediate, using a bio-oxidation with Gluconobacter oxydans and several chem. steps. Today, industrial production processes use addnl. bio-oxidation steps with Ketogulonicigenium vulgare as biocatalyst to convert d -sorbitol to the intermediate 2KGA without chem. steps. The enzymes involved are characterized by a broad substrate range, but remarkable regiospecificity. This puzzling specificity pattern can be understood from the preferences of these enzymes for certain of the many isomeric structures which the carbohydrate substrates adopt in aqueous solution Recently, novel enzymes were identified that generate l -ascorbic acid directly via oxidation of l -sorbosone, an intermediate of the bio-oxidation of d -sorbitol to 2KGA. This opens the possibility for a direct route from d -sorbitol to l -ascorbic acid, obviating the need for chem. rearrangement of 2KGA. Similar concepts for industrial processes apply for the production of d -isoascorbic acid, the C5 epimer of l -ascorbic acid. d -isoascorbic acid has the same conformation at C5 as d -glucose and can be derived more directly than l -ascorbic acid from this common carbohydrate feed stock.

Advances in Biochemical Engineering/Biotechnology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Limin published the artcileCharacterization of bitter-tasting and antioxidant activity of dry-hopped beers, Application of cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Journal of the Science of Food and Agriculture (2022), 102(11), 4843-4853, database is CAplus and MEDLINE.

Bitter flavors and antioxidant activities are critical characteristics and indicators, resp., of beer quality. To gain a better understanding of dry-hopped beer′s bitterness, this work comprehensively evaluated the perceived bitterness intensity and bitterness attributes from aspects of beer aroma and non-volatile bitter compounds using sensory anal. under two conditions: (i) with and (ii) without nose clips. To quantify bitter and volatile compounds, the work conducted chromatog. analyses: high-performance liquid chromatog. (HPLC), ultra-performance liquid chromatog.-mass spectrometry (UPLC-MS) and gas chromatog.-mass spectrometry (GC-MS). Simultaneously, this work assessed the antioxidant activity of com. dry-hopped beers. First, dry-hopped beer in this study contained abundant non-volatile bitter compounds (hop bitter acids, polyphenols and flavonoids), and aroma was validated using HPLC, UPLC-MS and GC-MS methods. Moreover, the bitter-tasting perception test findings demonstrated that many dry-hopped beers had a higher bitterness intensity when evaluated without a nose clip, whereas this phenomenon was adverse in several ale beers. Addnl., the ′lingering′ and ′harsh′ characteristics were diminished when beer aroma was blocked out (with nose clip) for dry-hopped beer. Meanwhile, most dry-hopped beers had greater antioxidant activity than ale beers (P < 0.05). This work revealed the bitterness complexity of dry-hopped beer; besides non-volatile bitter compounds, beer aroma had an impact on the perceived bitterness intensity and attributes, and dry-hopped beer had a relatively intense antioxidant capacity. This study facilitated the development of a detailed knowledge about the assessment of bitter-tasting perceptions in dry-hopped beers and provided a basis for the development of functional beer benefiting human health. 2022 Society of Chem. Industry.

Journal of the Science of Food and Agriculture published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C38H74Cl2N2O4, Application of cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kucinski, K. published the artcileChemoselective and Catalyst-Free O-Borylation of Silanols: A Facile Access to Borasiloxanes, Recommanded Product: Triisopropylsilanol, the publication is ChemSusChem (2017), 10(23), 4695-4698, database is CAplus and MEDLINE.

This paper demonstrates the 1st highly chemoselective syntheses of various borasiloxanes from hydroboranes and silanols, achieved through catalyst-free dehydrogenative coupling at room temperature This green protocol, which uses easily accessible reagents, allows for the obtaining of borasiloxanes under air atm. and solvent-free conditions.

ChemSusChem published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Recommanded Product: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kazmierczak, Joanna published the artcileNafion as effective and selective heterogeneous catalytic system in O-metalation of silanols and POSS silanols, Quality Control of 17877-23-5, the publication is Journal of Catalysis (2018), 95-103, database is CAplus.

Herein, we demonstrate the first use of Nafion as heterogeneous catalyst in O-metalation of compounds containing Si-OH moiety (silanols and POSS silanols). Our methodol. permits efficient and highly selective formation of Si-O-E bonds (E = Si, Ge, B) within mols., under mild conditions with excellent yields. This approach allows syntheses of various unsym. disiloxanes, germasiloxanes and borasiloxanes, as well as introduction of a wide range of functional groups into silsesquioxanes. It is worth noting that Nafion can be reused for further experiments and its catalytic activity in this process is well-maintained for more than 10 recycling steps, without a decrease in yield or selectivity.

Journal of Catalysis published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Quality Control of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts