Tag: M.W=150-200

Chen, Si published the artcileComparative analysis of L-sorbose dehydrogenase by docking strategy for 2-keto-L-gulonic acid production in Ketogulonicigenium vulgare and Bacillus endophyticus consortium, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Journal of Industrial Microbiology & Biotechnology (2016), 43(11), 1507-1516, database is CAplus and MEDLINE.

Improving the yield of 2-keto-L-gulonic acid (2-KGA), the direct precursor of vitamin C, draws more and more attention in industrial production In this study, we try to increase the 2-KGA productivity by computer-aided selection of genes encoding L-sorbose dehydrogenases (SDH) of Ketogulonicigenium vulgare. First, six SDHs were modeled by docking strategy to predict the binding mode with co-factor PQQ. The binding energy between SSDA1-H/SSDA1-L and PQQ was the highest, followed by SSDA3/SSDA2. The binding energy between SSDA1-P/SSDB and PQQ was the lowest. Then, these genes were overexpressed, resp., in an industrial strain K. vulgare HKv604. Overexpression of ssda1-l and ssda1-h enhanced the 2-KGA production by 7.89 and 12.56 % in mono-cultured K. vulgare, and by 13.21 and 16.86 % when K. vulgare was co-cultured with Bacillus endophyticus. When the engineered K. vulgare SyBE_Kv000116013 (overexpression of ssda1-p) or SyBE_Kv000116016 (overexpression of ssdb) was co-cultured with B. endophyticus, the 2-KGA production decreased significantly. The docking results were in accordance with the exptl. data, which indicated that computer-aided modeling is an efficient strategy for screening more efficient enzymes.

Journal of Industrial Microbiology & Biotechnology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Joshi, Suraj R. published the artcileConstruction, analysis and validation of co-expression network to understand stress adaptation in Deinococcus radiodurans R1, Related Products of alcohols-buliding-blocks, the publication is PLoS One (2020), 15(6), e0234721, database is CAplus and MEDLINE.

In the current study, we have performed system-level anal. for Deinococcus radiodurans R1 by constructing a gene co-expression network based on several microarray datasets available in the public domain. This condition-independent network was constructed by Weighted Gene Co-expression Network Anal. (WGCNA) with 61 microarray samples from 9 different exptl. conditions. We identified 13 co-expressed modules, of which, 11 showed functional enrichments of one or more pathway/s or biol. process. Comparative anal. of differentially expressed genes and proteins from radiation and desiccation stress studies with our co-expressed modules revealed the association of cyan with radiation response. We obtained 7 TFs for radiation and desiccation responsive modules. The expressions of 3 TFs were validated in response to gamma radiation using qRT-PCR. Along with the TFs, selected close neighbor genes of two important TFs, viz., DR_0997 (CRP) and DR_2287 (AsnC family transcriptional regulator) in the darkgreen module were also validated. In our network, among 13 hub genes associated with 13 modules, the functionality of 5 hub genes which are annotated as hypothetical proteins (hypothetical hub genes) in D. radiodurans genome has been revealed. Overall the study provided a better insight of pathways and regulators associated with relevant DNA damaging stress response in D. radiodurans.

PLoS One published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vana, Lubomir published the artcileSynthesis of Aza[n]helicenes (n = 4-7) via Photocyclodehydrochlorination of 1-Chloro-N-aryl-2-naphthamides, Quality Control of 86-48-6, the publication is Journal of Organic Chemistry (2022), 87(11), 7150-7166, database is CAplus and MEDLINE.

A series of 5-aza[4]helicene, e.g., I was synthesized using a photocyclodehydrochlorination of 1-chloro-N-aryl-2-naphthamides, e.g., 1-chloro-N-phenyl-2-naphthamide as a general synthetic procedure introducing the nitrogen atom to the third ring of the helicene framework. The effect of the nitrogen presence in the helicene skeleton on the physicochem. properties of the prepared 5-aza[4]helicene was studied and compared to those of the parent carbo-analogs. The insertion of a nitrogen atom into the outer edge of the helicene mol. has a severe impact on certain physicochem. properties such as optical rotation, electrostatic potentials, and intermol. interactions. On the other hand, some other properties such as UV/vis, fluorescence, and phosphorescence spectra remained almost unaffected when compared to the parent carbohelicenes. A nitrogen atom can be also used for further derivatization, which can lead to further modification of helicene properties, as manifested here in the fluorescence changes induced by protonation.

Journal of Organic Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C10H9ClN2O, Quality Control of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Al-Shaikh, Aminah Jeza published the artcileBioaugmentation of halophilic consortia for the degradation of petroleum hydrocarbons and petroleum wastewater treatment, Related Products of alcohols-buliding-blocks, the publication is International Journal of Advanced Research in Biological Sciences (2020), 7(9), 97-112, database is CAplus.

The present study, details about a halophilic bacterial consortium enriched from water and sediment samples from Red sea, Jeddah, Saudi Arabia analyzed for PAHs degradation potential under saline condition (40 g/L NaCl concentration). The bacterial consortium was able to growth in halophilic mineral salt medium with PAHs (Polycyclic Aromatic Hydrocarbons) as sole carbon source. Different types of selected LMW (Low Mol. Weight) PAHs such as phenathrene (PHN) and fluorine (FLU) at different concentrations (25, 50, 100, 200, 500 ppm) and pyrene (PY) from HMW(High Mol. Weight) PAH at 50 and 100 ppm concentrations was used in the study under saline condition. The results recorded 90% degradation of phenanthrene and fluoreneupto 500 ppm. HMW pyrene revealed 79% and 69% degradation at 50 ppm and 100 ppm concentration under saline condition by the halophilic consortium. Addition of FLU (100 ppm) along with the PY (50 ppm) recorded 85% of PY degradation in 8 days and 98% degradation in 12 days. Addition of yeast extract during PY degradation recorded complete degradation of PY (50 ppm) in 12 days. Lab Scale reactor study with CSTR (continuous stirred tank reactor) used to investigate the PAHs degradation and petroleum refinery wastewater treatment efficiency of in thehalophilic bacterial consortium. The results recorded 95% COD removal in 32 days with complete degradation of LMW PAHs in 12 days under saline condition. Bacterial strains in the consortium were identified by using mol. techniques such as DNA isolation and next generation sequencing.

International Journal of Advanced Research in Biological Sciences published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Al-Joufi, Fakhria A. published the artcileAnabasis articulata (Forssk.) Moq: A Good Source of Phytochemicals with Antibacterial, Antioxidant, and Antidiabetic Potential, SDS of cas: 90-64-2, the publication is Molecules (2022), 27(11), 3526, database is CAplus and MEDLINE.

Anabasis articulata is medicinally used to treat various diseases. In this study, A. articulata was initially subjected to extraction, and the resultant extracts were then evaluated for their antimicrobial, antioxidant, and antidiabetic potentials. After obtaining the methanolic extract, it was subjected to a silica gel column for separation, and fractions were collected at equal intervals. Out of the obtained fractions (most rich in bioactive compounds confirmed through HPLC), designated as A, B, C, and D as well hexane fraction, were subjected to GC-MS anal., and a number of valuable bioactive compounds were identified from the chromatograms. The preliminary phytochem. tests were pos. for the extracts where fraction A exhibited the highest total phenolic and flavonoid contents. The hexane fraction as antimicrobial agent was the most potent, followed by the crude extract, fraction A, and fraction D. DPPH and ABTS assays were used to estimate the free radical scavenging potential of the extracts Fraction C was found to contain potent inhibitors of both the tested radicals, followed by fraction D. The potential antidiabetic extracts were determined using α-glucosidase and amylase as probe enzymes. The former was inhibited by crude extract, hexane, and A, B, C and D fractions to the extent of 85.32 ± 0.20, 61.14 ± 0.49, 62.15 ± 0.84, 78.51 ± 0.45, 72.57 ± 0.92 and 70.61 ± 0.91%, resp., at the highest tested concentration of 1000 μg/mL with their IC50 values 32, 180, 200, 60, 120 and 140 μg/mL correspondingly, whereas α-amylase was inhibited to the extent of 83.98 ± 0.21, 58.14 ± 0.75, 59.34 ± 0.89, 81.32 ± 0.09, 74.52 ± 0.13 and 72.51 ± 0.02% (IC50 values; 34, 220, 240, 58, 180, and 200 μg/mL, resp.). The observed biol. potentials might be due to high phenolic and flavonoid content as detected in the extracts The A. articulata might thus be considered an efficient therapeutic candidate and could further be investigated for other biol. potentials along with the isolation of pure responsible ingredients.

Molecules published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, SDS of cas: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Traeff, A. M. published the artcileC-F bond substitution via aziridinium ion intermediates, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2015), 51(68), 13260-13263, database is CAplus and MEDLINE.

Aliphatic 1,2-aminofluorides undergo extremely fast substitution reactions under the influence of lanthanum tris(hexamethyldisilazide). The substitution proceeds via an in situ generated aziridinium ion intermediate, which subsequently undergoes ring opening by addition of a nucleophile, yielding various β-substituted amines.

Chemical Communications (Cambridge, United Kingdom) published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C13H19N5OS, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Al-Oudat, Buthina A. published the artcileDesign, synthesis and biological evaluation of novel glyoxalase I inhibitors possessing diazenylbenzenesulfonamide moiety as potential anticancer agents, HPLC of Formula: 86-48-6, the publication is Bioorganic & Medicinal Chemistry (2020), 28(16), 115608, database is CAplus and MEDLINE.

The enzyme glyoxalase-I (Glo-I) is an essential therapeutic target in cancer treatment. Significant efforts have been made to discover competitive inhibitors of Glo-I as potential anticancer agents. Herein, the synthesis of a series of diazenylbenzenesulfonamide derivatives 3-R-4-R¹-C₆H₃N=NR² (R = H, sulfamoyl, carboxy; R¹ = H, Me, carboxy, sulfo; R² = 4-amino-6-hydroxynaphthalen-1-yl, 8-hydroxyquinolin-5-yl, 4-hydroxyphenyl, etc.) and their in vitro evaluation against Glo-I and the resulting structure-activity relationships were reported. Among the compounds tested, compounds 3-R-4-R¹-C₆H₃N=NR² (R = sulfamoyl, R¹ = Me, R² = 8-hydroxyquinolin-5-yl) and (R = sulfamoyl, R¹ = Me, R² = 3-carboxy-4-hydroxynaphthalen-1-yl) exhibited the highest activity with IC₅₀ 1.28μM and 1.13μM, resp. Docking studies to explore the binding mode of the compounds identified the key moieties that may contribute to the observed activities. The active compounds will serve as suitable leads for further chem. optimization.

Bioorganic & Medicinal Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, HPLC of Formula: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Miller, Eric J. published the artcileDiscovery of Tetrahydroisoquinoline-Containing CXCR4 Antagonists with Improved in Vitro ADMET Properties, HPLC of Formula: 6346-09-4, the publication is Journal of Medicinal Chemistry (2018), 61(3), 946-979, database is CAplus and MEDLINE.

CXCR4 is a seven-transmembrane receptor expressed by hematopoietic stem cells and progeny, as well as by ≥48 different cancers types. CXCL12, the only chemokine ligand of CXCR4, is secreted within the tumor microenvironment, providing sanctuary for CXCR4⁺ tumor cells from immune surveillance and chemotherapeutic elimination by (1) stimulating prosurvival signaling and (2) recruiting CXCR4⁺ immunosuppressive leukocytes. Addnl., distant CXCL12-rich niches attract and support CXCR4⁺ metastatic growths. Accordingly, CXCR4 antagonists can potentially obstruct CXCR4-mediated prosurvival signaling, recondition the CXCR4⁺ leukocyte infiltrate from immunosuppressive to immunoreactive, and inhibit CXCR4⁺ cancer cell metastasis. Current small mol. CXCR4 antagonists suffer from poor oral bioavailability and off-target liabilities. Herein, we report a series of novel tetrahydroisoquinoline-containing CXCR4 antagonists designed to improve intestinal absorption and off-target profiles. Structure-activity relationships regarding CXCR4 potency, intestinal permeability, metabolic stability, and cytochrome P 450 inhibition are presented.

Journal of Medicinal Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, HPLC of Formula: 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Asao, Naoki published the artcileNanostructured Materials as Catalysts: Nanoporous-Gold-Catalyzed Oxidation of Organosilanes with Water, Quality Control of 17877-23-5, the publication is Angewandte Chemie, International Edition (2010), 49(52), 10093-10095, S10093/1-S10093/4, database is CAplus and MEDLINE.

Oxidation of organosilanes R_4-nSiH_n (n = 1, R = Et, Bu, Me₂CH, Ph; n = 2, 3, R = Ph; n = 1, R₃ = PhMe₂, CH₂:CHMePh, PhCCMe₂) with n H₂O (same n) in acetone over nanoporous gold catalyst at room temperature for 1-9 h gave 80-100% of the corresponding silanols R_4-nSi(OH)_n (same R, n).

Angewandte Chemie, International Edition published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Quality Control of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Barfoot, Katie Louise published the artcileEffects of daily consumption of wild blueberry on cognition and urinary metabolites in school-aged children: a pilot study, Formula: C8H8O3, the publication is European Journal of Nutrition (2021), 60(8), 4263-4278, database is CAplus and MEDLINE.

Acute intervention with wild blueberry (WBB) has previously revealed pos. cognitive and mood effects in typically developing children; however, it is unclear whether effects persist after daily supplementation. In addition, no data have been published exploring the metabolite profiles of children following berry consumption, to our knowledge. A study of this kind could provide insight into a mechanism of action for the cognitive and mood improvements observed previously in children. The aim of this pilot study was to assess cognitive performance and urinary metabolite concentrations in healthy 7-10-yr-old children across a 4 wk daily WBB drink intervention. This pilot study examined the effects of daily WBB consumption for 4 wk (766 mg total polyphenols; 253 mg anthocyanins; equivalent to 240 g fresh blueberries per day) on cognition and mood in 15 healthy 7-10-yr-old children. Polyphenol metabolites were measured in 24 h urine before and after the 4 wk intervention. Chronic WBB-related benefits were seen on cognitively demanding trials on the modified attention network task, a task measuring executive functioning. Specifically, the WBB group maintained significantly higher accuracy on incongruent trials (96%; SE 0.03) compared with placebo participants (85%; SE 0.03; p = 0.038) after the 4 wk intervention, suggesting WBB was of most benefit on the more difficult aspects of the task. No significant WBB-related effects were observed on the auditory verbal learning task or the childs version of the pos. and neg. affect schedule. Urinary metabolite analyses indicated significant increases in different metabolites in WBB and placebo groups after 4 wk consumption. The research demonstrates 24 h WBB bioavailability in a child cohort for the first time with increases in urinary hippuric acid excretion during 2 wk daily WBB consumption. This study highlights the importance of conducting a larger study in children investigating the mechanism of action behind cognitive effects using bioavailability data.

European Journal of Nutrition published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts