Tag: M.W=150-200

Maya, R. J. published the artcileA bentonite-gold nanohybrid as a heterogeneous green catalyst for selective oxidation of silanes, Safety of Triisopropylsilanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(70), 10625-10628, database is CAplus and MEDLINE.

A highly efficient, environmentally benign and reusable heterogeneous bentonite-gold nanohybrid catalyst was designed and synthesized. This heterogeneous catalyst could efficaciously catalyze the oxidation of organosilanes to silanols. The reaction is 98.7% atom economical and the products were obtained in excellent yield without the formation of disiloxanes as byproducts. The catalyst was also well applicable for the gram scale preparation of silanols.

Chemical Communications (Cambridge, United Kingdom) published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Safety of Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dashti, Amir published the artcileQuantitative structure property relationship schemes for estimation of autoignition temperatures of organic compounds, Synthetic Route of 122-20-3, the publication is Journal of Molecular Liquids (2020), 111797, database is CAplus.

We have extended a quant. structure-property relationship (QSPR) scheme to estimate the auto-ignition temperatures (AIT) of organic compounds by employing GA-ANFIS, PSO-ANFIS, DE-ANFIS and GP methods. The average absolute relative deviations (%AARD) are 7.96, 6.29, 8.85 and 8.26, resp. The range of these values appears to match that of exptl. error in AIT measurements, suggesting strong models. For organic compounds, the AIT can be estimated using the above-mentioned methods, from mol. structure. This goal is possible using only 9 theor. descriptors.

Journal of Molecular Liquids published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Synthetic Route of 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Jingwu published the artcileReaction-activated palladium catalyst for dehydrogenation of substituted cyclohexanones to phenols and H₂ without oxidants and hydrogen acceptors, Computed Properties of 27292-49-5, the publication is Chemical Science (2015), 6(8), 4674-4680, database is CAplus and MEDLINE.

It was widely believed that the dehydrogenation of organic compounds was a thermodynamically unfavorable process, and thus required stoichiometric oxidants such as dioxygen and metal oxides or sacrificial hydrogen acceptors to remove the hydrogen from the reaction mixture to drive the equilibrium towards the products. A previously unappreciated combination of common com. Pd/C and H₂ which dehydrogenated a wide range of substituted cyclohexanones and 2-cyclohexenones to their corresponding phenols with high isolated yields, with H₂ as the only byproduct was reported. The reaction requires no oxidants or hydrogen acceptors because instead of removing the generated hydrogen with oxidants or hydrogen acceptors, it was used as a cocatalyst to help power the reaction. The method for phenol synthesis manifested a high atom economy, and was inherently devoid of the complications normally associated with oxidative dehydrogenations.

Chemical Science published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C38H24F4O4P2, Computed Properties of 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Martinez-Hernandez, Gabriela Belen published the artcileA mixture of quercetin 4′-O-rhamnoside and isoquercitrin from Tilia americana var. mexicana and its biotransformation products with antidepressant activity in mice, Quality Control of 621-37-4, the publication is Journal of Ethnopharmacology (2021), 113619, database is CAplus and MEDLINE.

The present study aims to focus on the evaluation of the antidepressant effect of the mixture of two flavonoids (FMix), and its interaction with serotonergic drugs. One of the fractions contained FMix wich is constituted of the mixture of quercetin 4′-O-rhamnoside y isoquercitrin. The mice were divided into the several following groups: FMix; FMix (1.0 mg/kg) and agonist DOI (2.0 mg/kg); FMix (1.0 mg/kg) and antagonist ketanserin (KET, 0.03 mg/kg) of 5-HT2A receptors; FMix (1.0 mg/kg) and selective agonist 8-OH-DPAT (8-OH, 0.01 mg/kg); FMix (1.0 mg/kg) and antagonist WAY100635 (WAY, 0.5 mg/kg) of 5HT1 receptors; PHL; DOPAC; p-HPAA; and m-HPAA were tested in FST or OFT. FMix induced dependent-dose antidepressant activity and, at the highest dose administered, a sedative effect was also observed The 8-OH-DPAT, or the DOI, or the KET combination with FMix (1.0 mg/kg) induced a higher antidepressant effect than compounds alone; there was no effect exerted with WAY. The activity on OFT increased only with the FMix and KET combination. At the same time, the products of the aglycon metabolism of quercetin, i.e., DOPAC and p-HPAA, decreased the immobility time of the mice in FST at 1.0 mg/kg, and a dose-curve was formed for these. The antidepressant effect of FMix could depend, at least in part, on the degradation products of quercetin and with a possible action mode through interaction with the serotoninergic system.

Journal of Ethnopharmacology published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Quality Control of 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fan, Weihua published the artcileDegradation of phenanthrene by consortium 5H under hypersaline conditions, Product Details of C11H8O3, the publication is Environmental Pollution (Oxford, United Kingdom) (2022), 119730, database is CAplus and MEDLINE.

PAHs have been widely detected to accumulate in saline and hypersaline environments. Moderately halophilic microbes are considered the most suitable player for the elimination of PAHs in such environments. In this study, consortium 5H was enriched under 5% salinity and completely degraded phenanthrene in 5 days. By high-throughput sequencing, consortium 5H was identified as being mainly composed of Methylophaga, Marinobacter and Thalassospira. Combined with the investigation of intermediates and enzymic activities, the degradation pathway of consortium 5H on phenanthrene was proposed. Consortium 5H was identified as having the ability to tolerate a wide range of salinities (1%-10%) and initial PAH concentrations (50 mg/L to 400 mg/L). It was also able to function under neutral to weak alk. conditions (pH from 6 to 9) and the phytotoxicity of the produced intermediates showed no significant difference with distilled water. Furthermore, the metagenome of consortium 5H was measured and analyzed, which showed a great abundance of catabolic genes contained in consortium 5H. This study expanded the knowledge of PAH-degradation under hypersaline environments and consortium 5H was proposed to have good potential for the elimination of PAH pollution in saline/hypersaline environments.

Environmental Pollution (Oxford, United Kingdom) published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Product Details of C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kopriva, Ivica published the artcileNon-negative Least Squares Approach to Quantification of ¹H Nuclear Magnetic Resonance Spectra of Human Urine, Formula: C8H8O3, the publication is Analytical Chemistry (Washington, DC, United States) (2021), 93(2), 745-751, database is CAplus and MEDLINE.

Because of its quant. character and capability for high-throughput screening, ¹H NMR (NMR) spectroscopy is used extensively in the profiling of biofluids such as urine and blood plasma. However, the narrow frequency bandwidth of ¹H NMR spectroscopy leads to a severe overlap of the spectra of components present in the complex mixtures such as biofluids. Therefore, ¹H NMR-based metabolomics anal. is focused on targeted studies related to concentrations of the small number of metabolites. Here, we propose a library-based approach to quantify proportions of overlapping metabolites from ¹H NMR mixture spectra. The method boils down to the linear non-neg. least squares (NNLS) problem, whereas proportions of the pure components contained in the library stand for the unknowns. The method is validated on an estimation of the proportions of (i) the 78 pure spectra, presumably related to type 2 diabetes mellitus (T2DM), from their synthetic linear mixture; (ii) metabolites present in 62 ¹H NMR spectra of urine of subjects with T2DM and 62 ¹H NMR spectra of urine of control subjects. In both cases, the inhouse library of 210 pure component ¹H NMR spectra represented the design matrix in the related NNLS problem. The proposed method pinpoints 63 metabolites that in a statistically significant way discriminate the T2DM group from the control group and 46 metabolites discriminating control from the T2DM group. For several T2DM-discriminative metabolites, we prove their presence by independent anal. determination or by pointing out the corresponding findings in the published literature.

Analytical Chemistry (Washington, DC, United States) published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bachovchin, Daniel A. published the artcileSuperfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening, Quality Control of 23351-09-9, the publication is Proceedings of the National Academy of Sciences of the United States of America (2010), 107(49), 20941-20946, S20941/1-S20941/172, database is CAplus and MEDLINE.

Serine hydrolases (SHs) are-one of the largest and most diverse enzyme classes in mammals. They play fundamental roles in virtually all physiol. processes and are targeted by drugs to treat diseases such as diabetes, obesity, and neurodegenerative disorders. Despite this, we lack biol. understanding for most of the 110+ predicted mammalian metabolic SHs, in large part because of a dearth of assays to assess their biochem. activities and a lack of selective inhibitors to probe their function in living systems. We show here that the vast majority (>80%) of mammalian metabolic SHs can be labeled in proteomes by a single, active site-directed fluorophosphonate probe. We exploit this universal activity-based assay in a library-vs.-library format to screen 70+ SHs against 140+ structurally diverse carbamates. Lead inhibitors were discovered for ∼40% of the screened enzymes, including many poorly characterized SHs: Global profiles identified carbamate inhibitors that discriminate among highly sequence-related SHs and, conversely, enzymes that share inhibitor sensitivity profiles despite lacking sequence homol. These findings indicate that sequence relatedness is not a strong predictor of shared pharmaol. within the SH superfamily. Finally, we show that lead carbamate inhibitors can be optimized into pharmacol. probes that inactivate individual SHs with high specificity in vivo.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Quality Control of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Yang published the artcilePorous organic cage for enantiomeric fluorescence recognition of amino acid and hydroxy acid, COA of Formula: C8H8O3, the publication is Luminescence (2021), 36(8), 2022-2027, database is CAplus and MEDLINE.

A new method based on the enantioselective recognition of porous organic cages CC3-R was established for the first time. Porous organic cages are widely used for separation, adsorption and host-guest interaction sensing, but are rarely used for fluorescence sensing. Based on the inherent chiral environment of CC3-R and the inherent fluorescence properties of the organic ligands constituting the cage, when different chiral monomers diffuse into the cage, different effects occur to produce changes in fluorescence. We found for the first time that the fluorescence of CC3-R can be enhanced and quenched by tyrosine and mandelic acid, resp., and that different chiral monomers are enhanced or quenched differently at the same concentration Unlike the chiral recognition of other composite luminescent materials, the chiral porous organic cage not only utilizes its own host-guest effect for chiral recognition, but also utilizes the organic ligands constituting the cage for luminescence recognition. This work provides an alternative method to accomplish chiral recognition other than chromatog., that is using porous organic cages (POC), but it can show the advantages of simplicity, low cost and high sensitivity. We believe this work could provide valuable thoughts in the exploration of POC in chiral recognition as new FL probes for the future.

Luminescence published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, COA of Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xin, Zhuo published the artcileRu-Catalyzed Switchable N-Hydroxyethylation and N-Acetonylation with Crude Glycerol, SDS of cas: 101-98-4, the publication is ChemSusChem (2020), 13(8), 2007-2011, database is CAplus and MEDLINE.

Highly efficient Ru-catalyzed selective C-C or C-O bond cleavage of polyols (e.g., crude glycerol) for N-hydroxyethylation or N-acetonylation of amines to give β-amino alcs. RR¹N(CH₂)₂OH [R = Ph, 2-MeC₆H4, 4-ClC₆H₄, etc.; R¹ = Me, Et, Bn, etc.] and β-amino ketones ArNR₂CH₂C(O)Me [Ar = Ph, 2-MeC₆H₄, 4-BrC₆H₄, etc.; R² = Me, Bn, etc.] in moderate-to-excellent yields was achieved through the hydrogen-borrowing approach. The use of new redox-active catalysts containing bisphosphine/thienylmethylamine ligands allowed this hydrogen-borrowing system to be operated selectively under both basic and acidic conditions.

ChemSusChem published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C4H4N2O2, SDS of cas: 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Si published the artcileFitness analysis between the L-sorbosone dehydrogenase modules and Ketogulonigenium vulgare chassis, Synthetic Route of 526-98-7, the publication is Shengwu Gongcheng Xuebao (2016), 32(9), 1224-1232, database is CAplus and MEDLINE.

Ketogulonigenium vulgare is an acid-producing strain in the process of two-step vitamin C fermentation L-sorbosone dehydrogenase (SNDH) is one of the key enzymes during the biosynthesis of 2-keto-L-gulonic acid (2-KGA), the precursor of vitamin C. However, the catalytic mechanism of SNDH is unclear. According to the whole genome sequencing of K. vulgare, two genes encoding sorbosone dehydrogenases, one derived from the chromosome (named as sndhg) and one from plasmid (named as sndhp), were introduced into an industrial strain K. vulgare. The overexpression of gene sndhg had hardly effect on 2-KGA production, and the overexpression of gene sndhp produced an obvious byproduct in the fermentation broth. Combinational expression of sndhg/sndhp with pqqA (obtaining sndhg-pqqA and sndhp-pqqA modules) in K. vulgare resulted in the similar fermentation phenotype to two previous strains. After serial sub-cultivation of co-cultured Bacillus endophyticus with each engineered K. vulgare for 50 d, the conversion rate of 2-KGA increased by 15.4%, 179%, 0.65% and 125% compared with that of the parental K. vulgare with B. endophyticus. This study shows that adaptive evolution of microbial consortium is an effective strategy to increase the fitness between functional modules and chassis, thus quickly getting better strains for production of 2-KGA.

Shengwu Gongcheng Xuebao published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Synthetic Route of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts