Tag: M.W=150-200

Ren, Guilin published the artcileStudy of the volatilization rules of volatile oil and the sustained-release effect of volatile oil solidified by porous starch, Category: alcohols-buliding-blocks, the publication is Scientific Reports (2022), 12(1), 8153, database is CAplus and MEDLINE.

Volatile oil from traditional Chinese medicine has various biol. activities and has pharmacol. activities in the central nervous system, digestive system, cardiovascular system, respiratory system, etc. These oils are widely used in clin. practice. However, the development of their clin. applications is restricted due to the disadvantages of volatile oils, such as high stimulation, high volatility and poor stability. To improve the stability of a volatile oil in the preparation process, its volatilization and stable release must be controlled. In this paper, porous starch was used as a solid carrier material, and liquid volatile oil was solidified by phys. adsorption. GC-MS was used to determine the chem. constituents of the volatile oil, solidified powder and tablets, and the volatilization rules of 34 chem. constituents were analyzed statistically. The solidified volatile oil/porous starch powder was characterized by XRD, TGA and DSC, and the VOCs of the volatile oil before and after solidification were analyzed by portable GC-MS. Finally, the stable release of the volatile oil could be optimized by changing the porous starch ratio in the formulation. Volatilization was shown to be closely related to the peak retention time and chem. composition, which was consistent with the theory of flavor. The phys. properties and chem. composition of the volatile oil did not change after curing, indicating that the adsorption of the volatile oil by porous starch was phys. adsorption. In this paper, the porous starch-solidified volatile oil had a slow-release effect, and the production process is simple, easy to operate, and has high application value.

Scientific Reports published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Boehme, Thomas M. published the artcileStructure-Activity Relationships of Dimethindene Derivatives as New M₂-Selective Muscarinic Receptor Antagonists, Quality Control of 101-98-4, the publication is Journal of Medicinal Chemistry (2003), 46(5), 856-867, database is CAplus and MEDLINE.

2,3-Disubstituted indenes, such as I [R = (Me₂CH)₂N, (FCH₂CH₂)MeN; n = 2], analogs of the widely used histamine H₁ receptor antagonist dimethindene, are prepared as potential M₂-selective muscarinic receptor antagonists. (-)-I [R = (Me₂CH)₂N; n = 2] has comparable affinity for M₂ receptors to (S)-dimethindene with 5-275-fold selectivities for the M₂ muscarinic receptor over other muscarinic receptor subtypes and over histamine H₁ receptors. I [R = (FCH₂CH₂)MeN; n = 2] also has high affinity for the muscarinic M₂ receptor and is selective for the M₂ receptor over other muscarinic receptors but possesses high affinity for histamine H₁ receptors. I (R = Me₂N; n = 1) has the highest affinity of the tested indenes for M₂ muscarinic receptors but low selectivity for M₂ muscarinic receptors over other muscarinic receptor subtypes.

Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Quality Control of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Chuangxing published the artcileDiscovery of 3-aryloxy-lactam analogs as potent androgen receptor full antagonists for treating castration resistant prostate cancer, COA of Formula: C4H9BrO, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(2), 1230-1236, database is CAplus and MEDLINE.

High throughput cell-based screening led to the identification of 3-aryloxy lactams as potent androgen receptor (AR) antagonists. Refinement of these leads to improve the ADME profile and remove residual agonism led to the discovery of 12, a potent full antagonist with greater oral bioavailability. Improvements in the ADME profile were realized by designing more ligand-efficient mols. with reduced mol. weights and lower lipophilicities.

Bioorganic & Medicinal Chemistry Letters published new progress about 55376-31-3. 55376-31-3 belongs to alcohols-buliding-blocks, auxiliary class Polymerization Reagents,ATRP Initiators, name is 2-Bromo-2-methylpropan-1-ol, and the molecular formula is C4H9BrO, COA of Formula: C4H9BrO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kennedy, Sean published the artcileSuperacid-promoted synthesis of indolizidine derivatives, Recommanded Product: 4,4-Diethoxybutan-1-amine, the publication is Tetrahedron Letters (2018), 59(20), 1932-1935, database is CAplus.

A series of amido-acetals were reacted with the Bronsted superacid, CF₃SO₃H, to provides indolizidine derives by a cyclization cascade. A mechanism is proposed involving formation of a vinylogous enol which undergoes a 6π-electrocyclization reaction with an adjacent N-acyl iminium ion group. With aryl substituents, there is a strong tendency for the N-acyl iminium ion group to undergo Friedel-Crafts type cyclizations with the aryl group. The synthetic methodol. was used to prepare the alkaloid natural product, ipalbidine.

Tetrahedron Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Recommanded Product: 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gazizov, Mukattis B. published the artcileO, o-Dialkyl-S-(1,1-dimethyl-2-oxoethyl)dithiophosphates: Synthesis and Reactions with N-Nucleophiles, Category: alcohols-buliding-blocks, the publication is Heteroatom Chemistry (2015), 26(6), 436-440, database is CAplus.

Hydrolysis of the new types of iminium salts was used to synthesize O,O-dialkyl-S-(1,1-dimethyl-2-oxoethyl)dithiophosphates or 2-dialkoxythiophosphorylthio-substituted aldehydes with C isochain. Reactions of aldehydes with N-, N,N-, and O,N-nucleophiles gave new phosphorylated imines containing an acetal group at different positions, perhydro-1,3-diazol and oxazol with the diisopropoxythiophosphorylthio group in a side chain, and hydrazone of this aldehyde and diphenylphosphinylacetic acid hydrazide.

Heteroatom Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Khan, Atta Ullah published the artcileIron-doped zinc oxide nanoparticles-triggered elicitation of important phenolic compounds in cell cultures of Fagonia indica, Product Details of C8H8O3, the publication is Plant Cell, Tissue and Organ Culture (2021), 147(2), 287-296, database is CAplus and MEDLINE.

The callus cultures of Fagonia indica could prove as factories for the production of important phytochems. when triggered through different types of stress. In this study, we initiated callus cultures from healthy stem explants in the presence of iron-doped zinc oxide nanoparticles (Fe-ZnO-NPs). We performed experiments with the callus cultures of F. indica to determine the impact of Fe-ZnO-NPs in concentrations (15.62-250μg/mL) on biomass accumulation, production of important phenolic and flavonoids, and antioxidative potential. Our results showed that maximum callus biomass [Fresh weight (FW) = 13.6 g and Dry weight (DW) = 0.58 ± 0.01] was produced on day 40 when the media was supplemented with 250μg/mL Fe-ZnO-NPs. Similarly, maximum total phenolic content (268.36μg GAE/g of DW) was observed in 40 days old callus added with 125μg/mL Fe-ZnO-NPs. Maximum total flavonoid content (78.56μg QE/g of DW) was recorded in 20 days old callus grown in 62.5μg/mL Fe-ZnO-NPs containing media. Maximum total antioxidant capacity (390.74μg AAE/g of DW) was recorded in 40 days old callus with 125μg/mL Fe-ZnO-NPs treated cultures, resp. Similarly, the highest free radical scavenging activity (93.02%) was observed in callus derived from media having 15.62μg/mL Fe-ZnO-NPs. The antioxidant potential was observed to have pos. correlation with TPC (r = 0.44). HPLC anal. showed that Fe-ZnO-NPs produced compounds (e.g., Epigallocatechin gallate) that were either absent or in lesser quantities in the control group. These results showed that Fe-ZnO-NPs elicitors could increase the biomass and activate secondary metabolism in F. indica cells.

Plant Cell, Tissue and Organ Culture published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Product Details of C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gazizov, A. S. published the artcileSynthesis of new polyphenols containing sym-triazine fragment, SDS of cas: 6346-09-4, the publication is Russian Journal of General Chemistry (2016), 86(3), 761-763, database is CAplus.

Synthesis of 2-[4,4-bis(3-methyl-2,4-dihydroxyphenyl)alkylamino]-4,6-dimorpholino-1,3,5-trazines by the condensation of a sym-triazine acetals and 2-methylresocinol and the effect of the length of the methylene spacer between the acetal group and sym-triazine moiety on the reaction were presented.

Russian Journal of General Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, SDS of cas: 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gazizov, Almir S. published the artcileFacile synthesis of 2-(2-arylpyrrolidin-1-yl)pyrimidines via acid-catalyzed reaction of N-(4,4-diethoxybutyl)pyrimidin-2-amine with phenols, Category: alcohols-buliding-blocks, the publication is Monatshefte fuer Chemie (2015), 146(11), 1845-1849, database is CAplus.

N-(4,4-diethoxybutyl)pyrimidin-2-amine undergoes acid-catalyzed intramol. cyclization in the presence of phenols leading to the formation of 2-(2-arylpyrrolidin-1-yl)pyrimidine derivatives Target compounds were obtained with moderate to good yields by operationally simple one-step procedure.

Monatshefte fuer Chemie published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vozhdaeva, Margarita Yu. published the artcileMonitoring and statistical analysis of formation of organochlorine and organobromine compounds in drinking water of different water intakes, Product Details of C5H11BrO, the publication is Molecules (2021), 26(7), 1852, database is CAplus and MEDLINE.

The main drawback of drinking water chlorination involves the formation of quite hazardous disinfection byproducts (DBPs), represented mainly by halogenated species. Based on the authors’ monitoring data since 2002, the prevalence of chlorine over bromine in the composition of volatile DBPs was shown for the drinking water in Ufa (Russia). However, the situation was completely reversed in the case of semi-volatile DBPs. The principal goal of the present study involved rationalization of the results of the long-term monitoring. Gas chromatog.-mass spectrometry (GC-MS) was used for the qual. and quant. anal. of volatile DBPs. Identification of semi-volatile compounds was carried out with GC-MS, while gas chromatog. with an at. emission detector (GC-AED) was used for their quantification. A significant contribution of oxygen to the composition of semi-volatile compounds proves the decisive role of the dissolved organic matter oxidative destructive processes. Statistical anal. revealed notable linear correlations for trihalomethane and haloacetic acid formation vs. chlorine dose. On the contrary, halogenated semi-volatile products do not demonstrate any correlations with the water quality parameters or chlorine dose. Principal component anal. (PCA) placed them into sep. groups. The results allow for proposing that formation of the organohalogenated species involved the fast penetration of bromine into the humic matter mols. and, further, their oxidative destruction by active chlorine.

Molecules published new progress about 2588-77-4. 2588-77-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 2-Methyl-3-bromo-2-butanol, and the molecular formula is C14H10O4S2, Product Details of C5H11BrO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lhotska, Ivona published the artcilePreparation of citrinin-selective molecularly imprinted polymer and its use for on-line solid-phase extraction coupled to liquid chromatography, Quality Control of 86-48-6, the publication is Analytical and Bioanalytical Chemistry (2019), 411(11), 2395-2404, database is CAplus and MEDLINE.

A new selective molecularly imprinted polymer has been prepared and used for extraction in online SPE-HPLC to achieve the selective determination of citrinin. Four different imprinted polymers varying in combinations of components were prepared by bulk polymerization and evaluated in terms of binding capacity and selectivity. Imprinted polymer prepared from a mixture comprising 1-hydoxy-2-naphtoic acid as the template mol., acrylamide as the structural monomer, ethylene dimethacrylate as the cross-linker (in a molar ratio of 1:4:16), and acetonitrile as the porogenic solvent exhibited the best properties. The selectivity of this sorbent was confirmed by comparison with the non-imprinted counterpart prepared using the same polymerization carried out in the absence of template. Imprinted polymer was packed in a 20 × 3 mm i.d. steel cartridge and coupled to the online SPE-HPLC system through a six-port switching valve. The method for determination of citrinin including the online extraction step was then developed and validated. The sample in the form of methanolic extract was loaded, cleaned, and preconcd. in the imprinted SPE cartridge. Subsequent separation of citrinin from residual interferences was achieved using the anal. column Kinetex Biphenyl 100 × 4.6 mm i.d., 5 μm particle size, and fluorescence detection (Ex 335, Em 500 nm). The total anal. time was only 9.50 min. Our fully validated method was also applied to anal. of food supplements based on red yeast rice extracts, the control of which is implemented in European legislation. Only minor yet acceptable contamination was found in tested samples.

Analytical and Bioanalytical Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Quality Control of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts