Tag: M.W=150-200

Moubri, K. published the artcileDiscovery of a recombinant Babesia canis supernatant antigen that protects dogs against virulent challenge infection, Category: alcohols-buliding-blocks, the publication is Veterinary Parasitology (2018), 21-29, database is CAplus and MEDLINE.

Soluble parasite antigens (SPA) in supernatants of in vitro cultures of Babesia canis can be used to vaccinate dogs against virulent B. canis infection. The moment that immunity becomes apparent coincides with the appearance of antibodies against SPA in the serum of the vaccinated animals. This so-called vaccination-challenge serum (VC-serum) was used to precipitate antigens from B. canis culture supernatants in agarose gels. This antigen preparation was then used to analyze the reactivity of sera from vaccinated dogs on western blots showed that the first appearance of antibody reactivity against a protein that migrated at the 39 kDa position in SDS-PAGE gels was associated with the moment vaccinated dogs started to recover from a virulent challenge infection. In addition, pulse-chase experiments revealed that a 39-40 kDa doublet was released into the supernatant of B. canis cultures starting 15 min after the chase. This doublet was specifically precipitated by VC-serum, thus corroborating that the 39-40 kDa doublet in SPA preparations was of parasite origin. Partial amino acid sequencing allowed the discovery of the gene that encoded the 39-40 kDa doublet (canine Babesia antigen; CBA). The full-length gene was cloned and expressed in E. coli. The recombinant CBA protein (rCBA) was recognized by VC-serum, and antibodies against rCBA precipitated the 39 kDa antigen of SPA preparations and of merozoites of B. canis. In addition, anti-rCBA serum reacted with the surface of B. canis merozoites (but not with B. rossi merozoites) in immunofluorescence. Vaccination of dogs with rCBA induced antibodies against rCBA, which recognized B. canis merozoites. Vaccinated dogs were protected against virulent challenge infection by limiting parasite proliferation. As a result, the development of clin. signs was prevented and the animals self-cured. In contrast, six out of seven non-vaccinated control dogs developed relatively high parasitemia and serious clin. signs associated with poor tissue perfusion. This antigen can be used to replace the SPA antigen in the conventional B. canis vaccines, which eliminates the need for dog blood and serum for vaccine production

Veterinary Parasitology published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gajic, Mihajlo published the artcileRepurposing of 8-Hydroxyquinoline-Based Butyrylcholinesterase and Cathepsin B Ligands as Potent Nonpeptidic Deoxyribonuclease I Inhibitors, Formula: C11H8O3, the publication is ChemMedChem (2022), 17(5), e202100694, database is CAplus and MEDLINE.

A library of 31 butyrylcholinesterase (BChE) and cathepsin B (CatB) inhibitors was screened in vitro for inhibition of DNase I (DNase I). Compounds 22, 8 and 7 are among the most potent synthetic non-peptide DNase I inhibitors reported to date. Three 8-hydroxyquinoline analogs inhibited both DNase I and BChE with IC50 values below 35 μM and 50 nM, resp., while two nitroxoline derivatives inhibited DNase I and Cat B endopeptidase activity with IC50 values below 60 and 20 μM. Selected derivatives were screened for various co-target binding affinities at dopamine D2 and D3, histamine H3 and H4 receptors and inhibition of 5-lipoxygenase. Compound 8 bound to the H3 receptor and is highlighted as the most promising multifunctional ligand with a favorable pharmacokinetic profile and one of the most potent non-peptide DNase I inhibitors. The present study demonstrates that 8-hydroxyquinoline is a structural fragment critical for DNase I inhibition in the presented series of compounds

ChemMedChem published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Formula: C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Shih-Wei published the artcilePilot production of a sensitive ELISA kit and an immunochromatographic strip for rapid detecting citrinin in fermented rice, Category: alcohols-buliding-blocks, the publication is RSC Advances (2022), 12(31), 19981-19989, database is CAplus and MEDLINE.

Citrinin (CTN) is a mycotoxin primarily produced by Monascus species. Excess consumption of CTN may lead to nephrotoxicity and hepatotoxicity. A pilot study for com. production of competitive direct ELISA (cdELISA) kit and an immunochromatog. strip (immunostrip) for screening CTN in red yeast rice is established in this study. The coating antibody and the CTN-horse radish peroxidase (HRP) concentrations were optimized to increase the sensitivity and specificity of cdELISA kit. The conjugation methods/ratios of CTN to HRP as well as the long-term stability of kit components were also evaluated. The IC50 and detection limit of the ELISA kit were determined to be 4.1 and 0.2 ng mL-1, resp. Anal. of 20 red yeast rice samples using ELISA kits revealed the contamination levels of CTN from 64 to 29 404 ng g-1. The on-site rapid detection of CTN with the immunostrip showed that CTN levels in seven samples exceeded the regulatory limit of 5 ppm. Addnl., the coefficient correlation between the results of HPLC and ELISA kits of 20 samples was 0.96. Sensitive and convenient tools at com. levels for detection of CTN contamination in food are established herein to protect the health of the public.

RSC Advances published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C8H11BO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sripahco, Teerapong published the artcileChemical composition, antioxidant, and antimicrobial activity of Elsholtzia beddomei C. B. Clarke ex Hook. f. essential oil, HPLC of Formula: 106-25-2, the publication is Scientific Reports (2022), 12(1), 2225, database is CAplus and MEDLINE.

The essential oil of Elsholtzia beddomei C. B. Clarke ex Hook. f. was investigated for its chem. composition and tested for antioxidant and antimicrobial activities. The E. beddomei essential oil was extracted using hydrodistillation for 4 h (yield of 1.38% weight/weight). Forty-three volatile compounds were identified in the E. beddomei essential oil, including linalool (83.67%), perillaldehyde (4.68%), neral (3.68%), perillene (1.65%), E-caryophyllene (1.55%), and α-zingiberene (1.06%) as the major compounds The antioxidant activity of the E. beddomei essential oil was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical and 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation scavenging activity. The IC₅₀ values calculated using the DPPH and ABTS methods were 148.31 and 172.22μg/mL, resp. In addition, using disk diffusion and broth microdilution methods, the antimicrobial activities of the E. beddomei essential oil against Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogenes, Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, and Candida albicans were evaluated. The E. beddomei essential oil possessed an inhibitory effect with the min. inhibitory concentration in the range of 31.25-250.00μg/mL among these pathogens. The results indicated that E. beddomei essential oil is an alternative raw material of food, and medicinal products for use in pharmaceutical applications.

Scientific Reports published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C18H10F3NO3S2, HPLC of Formula: 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kang, Seok Hee published the artcilePLGA Microsphere Addition to 1-Hydroxy-2-naphthoic Acid Enhances the Sustained Release of Escitalopram, Related Products of alcohols-buliding-blocks, the publication is Bulletin of the Korean Chemical Society (2019), 40(8), 791-795, database is CAplus.

Escitalopram (ET), a selective serotonin reuptake inhibitor, has been utilized for the treatment of depression and anxiety.However, ET has serious side effects such as nausea, leading to an increased therapeutic dose, needing multiple administrations.Therefore, to overcome these issues, we developed ET encapsulated poly (d,l-lactic-co-glycolic acid) (PLGA) microspheres (PLGA-MS) as a sustained release carrier to maintain therapeutic efficacy.The mean particle size of the PLGA-MSs was measured by microscopy.Loading efficiency was measured by high performance liquid chromatog. (HPLC). Morphologies were determined by microscopy and SEM (SEM).Differential scanning calorimetry (DSC) was used for thermal anal. and glass transition temperature determinationMean particle size of the ET-loaded PLGA-MSs was 129 ± 14μm, loading efficiency was 36.8 ± 9.1%, and encapsulation efficiency was up to 70.6 ± 6.8%.Loading efficiency and encapsulation efficiency were increased by the addition of 1-hydroxy-2-naphthoic acid (HNA).ET was released from PLGA-MS for 4 wk, which was longer than ET release from PLGA-MS without the addition of HNA.Taken together, we demonstrate the optimum condition for sustained release of ET from PLGA-MS with the addition of HNA, and that this approach may be useful for depression therapy.

Bulletin of the Korean Chemical Society published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kwon, Yongseok published the artcilePlatinum-Catalyzed Synthesis of Substituted Phenanthrenes from Biphenyl Propargyl Alcohols via a Carbene Intermediate, COA of Formula: C8H19NO2, the publication is Organic Letters (2014), 16(18), 4936-4939, database is CAplus and MEDLINE.

An efficient synthesis for phenanthrenes via a Pt-carbene intermediate is described. Using Pt as a catalyst, the readily accessible biphenyl propargyl alc. substrate can be transformed to the vinylphenanthrene system through a cascade involving electrophilic cyclization, dehydration, and 1,2-H migration. The synthetic utility and efficiency of this protocol were demonstrated via the concise total synthesis of antofine.

Organic Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, COA of Formula: C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Van Houten, Kelly A. published the artcileA New Strategy for the Design of Monoamine Oxidase Inactivators. Exploratory Studies with Tertiary Allylic and Propargylic Amino Alcohols, SDS of cas: 101-98-4, the publication is Journal of the American Chemical Society (1998), 120(24), 5864-5872, database is CAplus.

A new strategy for the design of monoamine oxidase (MAO) inhibitors is proposed. The strategy is based on the premise that tertiary amine-containing MAO inactivators which operate by alkylation of active site nucleophiles are activated in situ by single electron transfer (SET) to the MAO-flavin cofactor to form aminium cation radicals which undergo secondary fragmentation reactions to produce reactive electrophiles. The purpose of the current work was to assess the feasibility and applicability of this proposal for the design of new families of MAO inactivators. Based on the documented retro-aldol type fragmentation reactivity of β-amino alc. cation radicals, tertiary β-allylic and propargylic β-amino alcs. were expected to serve as precursors of conjugated ketones in SET-promoted processes. Evidence supporting this hypothesis was gained from studies of model SET-photoreactions of members of this amino alc. family with 3-methyllumiflavin. The efficient production of 4a- and 4a,5-flavin adducts in these excited-state reactions demonstrates that aminium radicals, arising by SET-oxidation of tertiary β-allylic and -propargylic β-amino alcs., fragment to generate α,β-unsaturated ketones which react rapidly with the simultaneously formed 3MLF-hydroflavin anion. The second feature of the MAO-inactivator design strategy pathway was tested by examining reactions of the MAOs with substances which contain electrophilic, conjugated enone and ynone moieties tethered to amine functions to ensure delivery to the enzyme active sites. The covalent modification of active site cysteine thiol residues by the unsaturated ketone groups in these substances was confirmed by demonstrating that they serve as active site-directed, time-dependent, nonredox based, inactivators of MAO-A and MAO-B. In the key test of the feasibility of the new MAO-inactivator design strategy, it was shown that selected tertiary β-allylic and -propargylic β-amino alcs. undergo redox reactions in the MAO-A active site which result in inactivation of the enzyme via covalent modification of a single cysteine residue. The exptl. results which support the conclusions stated above are presented and discussed in this paper.

Journal of the American Chemical Society published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C4H10O2, SDS of cas: 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ha, Eun Kyo published the artcilePersonal exposure to total VOC is associated with symptoms of atopic dermatitis in schoolchildren, Formula: C8H8O3, the publication is Journal of Korean Medical Science (2022), 37(8), e63, database is CAplus and MEDLINE.

The urinary levels of volatile organic compound (VOC) metabolites provide individual exposure levels compared to data obtained by measuring these compounds in ambient air. We aimed to investigate the association between personal urinary concentrations of VOC metabolites and symptoms of atopic dermatitis in schoolchildren. Nine urinary VOC metabolites were analyzed from urine samples of 149 children. Diagnosis of atopic dermatitis was determined using standardized questionnaires. Pediatricians visited the schools and rated the severity of symptoms using the SCORing Atopic Dermatitis (SCORAD) in all children. Forty-five children (30.2%) had atopic dermatitis based on the International Study of Asthma and Allergies in Childhood (ISAAC) results and 35 children (23.8%) had symptoms of atopic dermatitis with pos. SCORAD index values (defined as SCORAD �5). Children with benzylmercapturic acid detected in personal urines were associated with presence of atopic dermatitis and pos. SCORAD index values. Children in the highest quartile of mandelic acid concentration were associated with presence of atopic dermatitis and pos. SCORAD results. Conclusion: Personal exposure to VOCs, as indicated by urinary levels of VOC metabolites, was associated with presence of atopic dermatitis and the SCORAD index value.

Journal of Korean Medical Science published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shim, Young Key published the artcileUtilization of 1-[(methanesulfonyl)oxy]-6-(trifluoromethyl)benzotriazole (FMS) as a coupling agent for the esterification of dihydropyridine-3-carboxylic acid, Name: 2-(Benzyl(methyl)amino)ethanol, the publication is Bulletin of the Korean Chemical Society (1988), 9(3), 187-8, database is CAplus.

Dihydropyridinedicarboxylates I [R = Et, CHMe₂, (CH₂)₁₀H, CH₂CH₂OMe, CH₂CH₂NMeCH₂Ph, cyclohexyl, CH₂Ph, Ph] were prepared from monoester I (R = H) via benzotriazolyl Me dihydropyridinedicarboxylate II. Thus, I (R = H) was treated with FMS to give II, which was heated with EtOH to give I (R = Et).

Bulletin of the Korean Chemical Society published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C6H17NO3Si, Name: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kim, Hanseol published the artcileA single amino acid substitution in aromatic hydroxylase (HpaB) of Escherichia coli alters substrate specificity of the structural isomers of hydroxyphenylacetate, Safety of 3-Hydroxyphenylacetic acid, the publication is BMC Microbiology (2020), 20(1), 109, database is CAplus and MEDLINE.

A broad range of aromatic compounds can be degraded by enteric bacteria, and hydroxyphenylacetic acid (HPA) degrading bacteria are the most widespread. Majority of Escherichia coli strains can use both the structural isomers of HPA, 3HPA and 4HPA, as the sole carbon source, which are catabolized by the same pathway whose associated enzymes are encoded by hpa gene cluster. Previously, we observed that E. coli B REL606 grew only on 4HPA, while E. coli B BL21(DE3) grew on 3HPA as well as 4HPA. In this study, we report that a single amino acid in 4-hydroxyphenylacetate 3-hydroxylase (HpaB) of E. coli determines the substrate specificity of HPA isomers. Alignment of protein sequences encoded in hpa gene clusters of BL21(DE3) and REL606 showed that there was a difference of only one amino acid (position 379 in HpaB) between the two, viz., Arg in BL21(DE3) and Cys in REL606. REL606 cells expressing HpaB having Arg379 could grow on 3HPA, whereas those expressing HpaB with Gly379 or Ser379 could not. Structural anal. suggested that the amino acid residue at position 379 of HpaB is located not in the active site, but in the vicinity of the 4HPA binding site, and that it plays an important role in mediating the entrance and stable binding of substrates to the active site. The arginine residue at position 379 of HpaB is critical for 3HPA recognition. Information regarding the effect of amino acid residues on the substrate specificity of structural isomers can facilitate in designing hydoxylases with high catalytic efficiency and versatility.

BMC Microbiology published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Safety of 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts