Tag: M.W=150-200

Ulaszewska, Maria M. published the artcileTwo apples a day modulate human:microbiome co-metabolic processing of polyphenols, tyrosine and tryptophan., Synthetic Route of 621-37-4, the publication is European Journal of Nutrition (2020), 59(8), 3691-3714, database is CAplus and MEDLINE.

Methods: Using an untargeted metabolomics approach, we aimed to identify biomarkers of long-term apple intake and explore how apples impact on the human plasma and urine metabolite profiles. Forty mildly hypercholesterolemic volunteers consumed two whole apples or a sugar and energy-matched control beverage, daily for 8 wk in a randomized, controlled, crossover intervention study. The metabolome in plasma and urine samples was analyzed via untargeted metabolomics. Results: We found 61 urine and 9 plasma metabolites being statistically significant after the whole apple intake compared to the control beverage, including several polyphenol metabolites that could be used as BFIs. Furthermore, we identified several endogenous indole and phenylacetyl-glutamine microbial metabolites significantly increasing in urine after apple consumption. The multiomic dataset allowed exploration of the correlations between metabolites modulated significantly by the dietary intervention and fecal microbiota species at genus level, showing interesting interactions between Granulicatella genus and phenyl-acetic acid metabolites. Phloretin glucuronide and phloretin glucuronide sulfate appeared promising biomarkers of apple intake; however, robustness, reliability and stability data are needed for full BFI validation. Conclusion: The identified apple BFIs can be used in future studies to assess compliance and to explore their health effects after apple intake.

European Journal of Nutrition published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8BFO2, Synthetic Route of 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gago-Ferrero, Pablo published the artcileSuspect Screening and Regulatory Databases: A Powerful Combination To Identify Emerging Micropollutants, Product Details of C9H21NO3, the publication is Environmental Science & Technology (2018), 52(12), 6881-6894, database is CAplus and MEDLINE.

This study demonstrates that regulatory databases combined with the latest advances in high resolution mass spectrometry (HRMS) can be efficiently used to prioritize and identify new, potentially hazardous pollutants being discharged into the aquatic environment. Of the approx. 23000 chems. registered in the database of the National Swedish Product Register, 160 potential organic micropollutants were prioritized through quant. knowledge of market availability, quantity used, extent of use on the market, and predicted compartment-specific environmental exposure during usage. Advanced liquid chromatog. (LC)-HRMS-based suspect screening strategies were used to search for the selected compounds in 24 h composite samples collected from the effluent of three major wastewater treatment plants (WWTPs) in Sweden. In total, 36 tentative identifications were successfully achieved, mostly for substances not previously considered by environmental scientists. Of these substances, 23 were further confirmed with reference standards, showing the efficiency of combining a systematic prioritization strategy based on a regulatory database and a suspect-screening approach. These findings show that close collaboration between scientists and regulatory authorities is a promising way forward for enhancing identification rates of emerging pollutants and expanding knowledge on the occurrence of potentially hazardous substances in the environment.

Environmental Science & Technology published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Product Details of C9H21NO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kamal, Ahmed published the artcileLipase-catalyzed resolution of 1-chloro-3-[(4-morpholin-4-yl-1,2,5-thiadiazole-3-yl)oxy]propan-2-ol, COA of Formula: C6H9N3O2S, the publication is Journal of Molecular Catalysis B: Enzymatic (2008), 54(1-2), 55-59, database is CAplus.

Lipase-catalyzed resolution of 1-chloro-3-[(4-morpholin-4-yl-1,2,5-thiadiazole-3-yl)oxy]propan-2-ol (5) is described using vinyl acetate as acyl donor. The effect of different lipases from various sources in several solvents has been studied. This intermediate 5 is utilized in the preparation of enantiomerically enriched (R) and (S)-timolol.

Journal of Molecular Catalysis B: Enzymatic published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C6H9N3O2S, COA of Formula: C6H9N3O2S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Borkowski, Olivier published the artcileLarge scale active-learning-guided exploration for in vitro protein production optimization, Computed Properties of 122-20-3, the publication is Nature Communications (2020), 11(1), 1872, database is CAplus and MEDLINE.

Abstract: Lysate-based cell-free systems have become a major platform to study gene expression but batch-to-batch variation makes protein production difficult to predict. Here we describe an active learning approach to explore a combinatorial space of ~4,000,000 cell-free buffer compositions, maximizing protein production and identifying critical parameters involved in cell-free productivity. We also provide a one-step-method to achieve high quality predictions for protein production using minimal exptl. effort regardless of the lysate quality.

Nature Communications published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Computed Properties of 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zyakun, A. M. published the artcileApplication of High-Performance Liquid Chromatography/High Resolution Mass Spectrometry to the Investigation of the Biodegradation and Transformation of Phenanthrene by a Plasmid Bearing Rhizosphere Bacteria Pseudomonas aureofaciens, SDS of cas: 86-48-6, the publication is Journal of Analytical Chemistry (2019), 74(13), 1355-1361, database is CAplus.

Mass spectrometry identified metabolites and estimated the efficiency of phenanthrene biodegradation and transformation by the rhizospheric bacteria, Pseudomonas aureofaciens BS1393. P. aureofaciens strains BS1393(pOV17) and BS1393(NPL-41) with various naphthalene biodegradation plasmids were used. Strain BS1393(pOV17) contained the pOV17 wild-type naphthalene biodegradation plasmid which determined naphthalene oxidation Krebs cycle metabolites. Strain BS1393(NPL-41) contained the mutant plasmid, NPL-41, governing the initial stages of naphthalene oxidation to salicylic acid. Phenanthrene biodegradation limiting stages in bacteria with various plasmids was identified according to intermediates accumulation. When bacteria were grown on phenanthrene, main metabolites were: 2-hydroxy-2H-benzo[h]chromene-2-carboxylic acid/trans-4-(1-hydroxynaph-2-yl)-2-oxobut-3-enoic acid; 1-hydroxy-2-naphthoic acid; and salicylic acid. For strain BS1393(pOV17), 2-hydroxy-2H-benzo[h]chromene-2-carboxylic acid/trans-4-(1-hydroxynaph-2-yl)-2-oxobut-3-enoic acid was observed during 1-14 days of cultivation. For strain BS1393(NPL-41), an insignificant amount of this metabolite was observed after only 14 days. Availability of 1-hydroxy-2-naphthoic acid in the growth of both strains showed the limited rate of its further decarboxylation. Salicylic acid as final biodegradation product was obsd for BS1393(NPL-41) growth. For strain BS1393(pOV17), this metabolite was not observed, indicating phenanthrene complete oxidation

Journal of Analytical Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C6H8O6, SDS of cas: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bacher, Emily P. published the artcileA Phosphine-Mediated Dearomative Skeletal Rearrangement of Dianiline Squaraine Dyes, Synthetic Route of 27292-49-5, the publication is Organic Letters (2021), 23(8), 2853-2857, database is CAplus and MEDLINE.

A phosphorus(III)-mediated dearomatization of ortho-substituted dianiline squaraine dyes results in an unusual skeletal rearrangement to provide exotic, highly conjugated benzofuranone and oxindole scaffolds bearing a C3 side chain comprised of a linear conflagration of an enol, a phosphorus ylide, and 2,4-disubstituted aniline. Employing exptl. and computational anal., a mechanistic evaluation revealed a striking dependence on the acidity of the aniline ortho substituent. Notably, the rearrangement adducts underwent rapid and complete reversion to the parent squaraine in the presence of a Bronsted acid.

Organic Letters published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Synthetic Route of 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Murayama, Eigoro published the artcileMetal-catalyzed organic photoreactions. Evidence for the long-range electron-transfer mechanism in the uranyl- or iron(III)-catalyzed photoreactions of olefins, Safety of 2-Methyl-3-bromo-2-butanol, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1980), 947-9, database is CAplus.

A mechanism for the title reaction was proposed involving interligand electron transfer from the electron-donating ligand (OH^– or Cl^–) to O₂ through the metal ion and olefin mol. This was verified for the UO₂²⁺-catalyzed photochem. formation of bromohydrins from olefins and polyhalogenated compounds by correlation of the reactivities and product ratios with the half-wave reduction potentials of the polyhalogenated compounds

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 2588-77-4. 2588-77-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 2-Methyl-3-bromo-2-butanol, and the molecular formula is C5H11BrO, Safety of 2-Methyl-3-bromo-2-butanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Limnios, Dimitris published the artcileOrganocatalytic Oxidation of Organosilanes to Silanols, Synthetic Route of 17877-23-5, the publication is ACS Catalysis (2013), 3(10), 2239-2243, database is CAplus.

The oxidation of organosilanes to silanols constitutes an attractive transformation for both industry and academia. Bypassing the need for stoichiometric oxidants or precious metal catalytic complexes, the first organocatalytic oxidation of silanes has been accomplished. Catalytic amounts of 2,2,2-trifluoroacetophenone, in combination with the green oxidant H₂O₂, lead to excellent to quant. yields in a short reaction time. A variety of alkyl, aryl, alkenyl, and alkynyl substituents can be tolerated, providing an easy, cheap, efficient, and practical solution to a highly desirable transformation.

ACS Catalysis published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Synthetic Route of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Jing published the artcileEnantioselective synthesis of an octahydroindolizine (indolizidine) alcohol using an enzymatic resolution, Synthetic Route of 6346-09-4, the publication is Organic & Biomolecular Chemistry (2017), 15(14), 2953-2961, database is CAplus and MEDLINE.

A homo-chiral synthesis of (7R,8aS)-octahydro-5,5-dimethylindolizin-7-amine 8 and (7S, 8aS)-octahydro-5,5-dimethylindolizin-7-ol 9, amine building blocks which have found applications within the pharmaceutical industry, is presented. The approach uses a Novozym 435-mediated kinetic resolution of racemic octahydroindolizine (indolizidine) alc. 13 as a key step (up to 100 g scale).

Organic & Biomolecular Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H5F3O2S, Synthetic Route of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kadnikova, O. Yu. published the artcileSynthesis and structures of tris(2-hydroxypropyl)amine complexes with Ni^II, Zn^II, Cu^II, and Co^II salts of biologically active carboxylic acids, Recommanded Product: Triisopropanolamine, the publication is Russian Chemical Bulletin (2020), 69(5), 958-964, database is CAplus.

New trimethylhydrometallatranes, tris(2-hydroxypropyl)amine complexes with Ni^II, Zn^II, Cu^II, and Co^II salts of biol. active carboxylic acids (benzoic, cinnamic, salicylic, succinic), were synthesized. The structure of the tris(2-hydroxypropyl)amine complex with nickel(II) cinnamate was determined by single-crystal x-ray diffraction. Thermal stability of the synthesized tris(2-hydroxypropyl)amine complexes was compared with that of tris(2-hydroxyethyl)- amine complexes. Zinc(II) benzoate, zinc(II) cinnamate, copper(II) cinnamate, copper(II) salicylate, copper(II) succinate, nickel(II) cinnamate, nickel(II) benzoate, cobalt(II) cinnamate, cobalt(II) succinate, and cobalt(II) chloride.

Russian Chemical Bulletin published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Recommanded Product: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts