Tag: M.W=150-200

Wang, Zhan-Feng published the artcileAn intermediate state of T7 RNA polymerase provides another pathway of nucleotide selection, SDS of cas: 122-20-3, the publication is Chinese Physics B (2017), 26(10), 100203/1-100203/16, database is CAplus.

Phage T7 RNA polymerase is a single-subunit transcription enzyme, transcribing template DNA to RNA. Nucleoside triphosphate (NTP) selection and translocation are two critical steps of the transcription elongation. Here, using all-atom mol. dynamics simulations, we found that between pre- and post-translocation states of T7 RNA polymerase an intermediate state exists, where the O helix C-terminal residue tyrosine 639, which plays important roles in translocation, locates between its pre- and post-translocation positions and the side chain of the next template DNA nucleotide has moved into the active site. NTP selection in this intermediate state was studied, revealing that the selection in the intermediate state can be achieved relying on the effect of Watson-Crick interaction between NTP and template DNA nucleotide, effect of stability of the components near the active site such as the nascent DNA-RNA hybrid and role of tyrosine 639. This indicates that another NTP-selection pathway can also exist besides the main pathway where NTP selection begins at the post-translocation state upon the entry of NTP.

Chinese Physics B published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C15H23BO2, SDS of cas: 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Eriksson, Kjell published the artcileMAb contaminant removal with a multimodal anion exchanger: a platform step to follow protein A, Computed Properties of 101-98-4, the publication is BioProcess International (2009), 7(2), 52-57, database is CAplus.

Monoclonal antibodies (MAbs) constitute approx. 30% of the biopharmaceutical products currently under development. Today, nearly all approved MAb processes include a capture step using protein A. GE Healthcare’s Capto adhere multimodal anion-exchange resin, which has high selectivity for contaminants that remain after protein A separation, represents an addnl. step toward developing highly effective MAb downstream processes. The high purity that follows capture on protein A resins, combined with the multimodal functionality of Capto adhere resin, provides for highly productive, two-step processes.

BioProcess International published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Computed Properties of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hassall, Kathryn published the artcileComparison of Carbon-Silicon Hyperconjugation at the 2- and 4-Positions of the N-Methylpyridinium Cation, Quality Control of 17877-23-5, the publication is Journal of Organic Chemistry (2005), 70(6), 1993-1997, database is CAplus and MEDLINE.

N-Methyl-2-[(trialkylsilyl)methyl]pyridinium cations [R₃ = Me₃ (6a), iso-Pr₃ (6b), Me₂(Me₃C) (6c)] and 4-[(trialkylsilyl)methyl]pyridinium cations (same R₃, 5a–c, resp.) were prepared and studied by using ²⁹Si and ¹³C NMR and single-crystal x-ray crystallog. (for 5b and 6b). Systematic differences in the ²⁹Si chem. shifts and ²⁹Si-¹³C one-bond coupling constants for these cations suggested that the Si-CH₂ bond interacts more strongly at the 2-position of the electron-deficient pyridinium ring than at the 4-position. This result is supported by the x-ray structures of the pyridinium cations 5b and 6b.

Journal of Organic Chemistry published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Quality Control of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zong, Xinlong published the artcileFluoride Anion-Catalyzed Mukaiyama-aldol Reaction: Rapid Access to α-Fluoro-β-Hydroxy Esters, Synthetic Route of 106-25-2, the publication is Journal of Organic Chemistry (2022), 87(10), 6918-6926, database is CAplus and MEDLINE.

A protocol of fluoride anion-mediated Mukaiyama aldol reaction with low catalytic loading in short reaction time to incorporate fluorine at α position into β-hydroxy esters was reported. The method shown good functional-group tolerance and scale-up potential, moreover, was applicable to the late-stage modification of natural products and small mol. drugs.

Journal of Organic Chemistry published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C37H30ClIrOP2, Synthetic Route of 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xu, Xingjian published the artcilePotential biodegradation of phenanthrene by isolated halotolerant bacterial strains from petroleum oil polluted soil in Yellow River Delta, Category: alcohols-buliding-blocks, the publication is Science of the Total Environment (2019), 1030-1038, database is CAplus and MEDLINE.

The Yellow River Delta (YRD), being close to Shengli Oilfield, is at high risk for petroleum oil pollution. The aim of this study was to isolate halotolerant phenanthrene (PHE) degrading bacteria for dealing with this contaminates in salinity environment. Two bacterial strains assigned as FM6-1 and FM8-1 were successfully screened from oil contaminated soil in the YRD. Morphol. and mol. anal. suggested that strains FM6-1 and FM8-1 were belonging to Delftia sp. and Achromobacter sp., resp. Bacterial growth of both strains was not dependent on NaCl, however, grew well under extensive NaCl concentration The optimum NaCl concentration for bacterial production of strain FM8-1 was 4% (m/v), whereas for strain FM6-1, growth was not affected within 2.5% NaCl. Both strains could use the tested aromatic hydrocarbons (naphthalene, phenanthrene, fluoranthene and pyrene) and aliphatic hydrocarbons (C12, C16, C20 and C32) as sole carbon source. The optimized biodegradation conditions for strain FM6-1 were pH 7, 28 °C and 2% NaCl, for strain FM8-1 were pH 8, 28 °C and 2.5% NaCl. The highest biodegradation rate of strains FM6-1 and FM8-1 was found at 150 mg/L PHE and 200 mg/L, resp. In addition, strainsFM8-1 showed a superior biodegradation ability to strain FM6-1 at each optimized condition. The PHE biodegradation process by both strains well fitted to first-order kinetic models and the k₁ values were calculated to be 0.1974 and 0.1070 per day. Strain FM6-1 metabolized PHE via a “phthalic acid” route, while strain FM8-1 metabolized PHE through the “naphthalene” route. This project not only obtained two halotolerant petroleum hydrocarbon degraders but also provided a promising remediation approach for solving oil pollutants in salinity environments.

Science of the Total Environment published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C13H10O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Zhenguo published the artcileMetal-Free Access to (Spirocyclic)Tetrahydro-β-carbolines in Water Using an Ion-Pair as a Superacidic Precatalyst, COA of Formula: C10H18O, the publication is ACS Catalysis (2022), 12(3), 2052-2057, database is CAplus.

The unprecedented triarylcarbonium ion-pair-catalyzed Pictet-Spengler reaction of tryptamines with aromatic aldehydes and cyclic ketones in water was disclosed. Under metal-free conditions, diverse tetrahydro-β-carbolines/spirocyclic tetrahydro-β-carbolines I [R¹ = H, Me, Cl, etc.; R² = H; R³ = Ph, 4-MeC₆H₄, 2-naphthyl, etc.; R²R³ = (CH₂)₅, CH₂CH₂CH(Me)CH₂CH₂, CH₂CH₂N(Boc)CH₂CH₂, etc.] were obtained in good yields with excellent functional group tolerance, including late-stage modification of natural products and small mol. drugs. The practicability of this protocol was also characterized in the gram-scale synthesis of komavine and several other functional compounds Preliminary mechanistic studies indicated that in aqueous media the in situ-generated superacidic species from the carbonium ion pair with water was crucial to promote the Pictet-Spengler reaction.

ACS Catalysis published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C12H10O4S, COA of Formula: C10H18O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fu, Yu published the artcileMandelic Acid as an Interfacial Modifier for High Performance NiO_x-based Inverted Perovskite Solar Cells, HPLC of Formula: 90-64-2, the publication is ChemNanoMat (2022), 8(7), e202200091, database is CAplus.

Nickel oxide (NiO_x) inverted perovskite solar cells have been witnessed as promising solar cells because of the low cast, easy fabrication and negligible hysteresis. However, the inferior interface feature of the link NiO_x and perovskite layer often causes poor device property and repeatability. Here, Mandelic acid (MAD) is introduced to form a modified layer, which could improve the poor interface properties between perovskite layer and NiO_x layer. The contact angel images revels MAD could increase the hydrophobicity and facilitate the growth of perovskite crystal. The X-ray diffraction pattern and Fourier transform IR spectroscopy have confirmed that the MAD small mol. could interact with residual PbI₂ crystal, leading to better interface contact and high crystallinity. This is further demonstrated by the SEM test of NiO_x/MAD/MAPbI₃ film that average grain size is increased from 201.85 nm to 315.17 nm. The space-charge limited current measurement proves the introduction of MAD mol. that result in the decreased trap state d. from 3.58×10¹⁵ cm^-3 to 2.721015 cm^-3. As a consequence, The power conversion efficiency is significantly improved from 14.9% to 18.42% of MAPbI₃-based devices that retained nearly 80% initial PCE after 50 days in N₂ without encapsulation.

ChemNanoMat published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, HPLC of Formula: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Dong-Xing published the artcileStereodivergent Synthesis of Enantioenriched 2,3-Disubstituted Dihydrobenzofurans via a One-Pot C-H Functionalization/Oxa-Michael Addition Cascade, Recommanded Product: 3-Morpholinophenol, the publication is Journal of the American Chemical Society (2021), 143(23), 8583-8589, database is CAplus and MEDLINE.

A one-pot rhodium-catalyzed C-H functionalization/organocatalyzed oxa-Michael addition cascade reaction has been developed. This methodol. enables the stereodivergent synthesis of diverse 2,3-disubstituted dihydrobenzofurans with broad functional group compatibility in good yields with high levels of stereoselectivity under exceptionally mild conditions. The full complement of stereoisomers of chiral 2,3-disubstituted dihydrobenzofurans and 3,4-disubstituted isochromans could be accessed at will by appropriate permutations of the two chiral catalysts. The current work provides a rare example of two chiral catalysts independently controlling two contiguous stereogenic centers subsequently via a two-step reaction in a single operation.

Journal of the American Chemical Society published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C17H14O5, Recommanded Product: 3-Morpholinophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Zhihong published the artcileEffect of aluminum sulfate alkali-free liquid accelerator with compound alkanol lamine on the hydration processes of Portland cement, Recommanded Product: Triisopropanolamine, the publication is Construction and Building Materials (2021), 125101, database is CAplus.

Aluminum sulfate alkali-free liquid accelerator is a kind of shotcrete admixture used in the construction of tunnels and culverts. In order to investigate the influence of alkanol amine in aluminum sulfate alkali-free liquid accelerator on cement hydration and strength, the different proportion of triethanolamine (TEA) and triisopropanolamine (TIPA) mixtures were added to aluminum sulfate alkali-free liquid accelerator. The mortar strength was measured by universal testing machine, and the hydration products were analyzed by XRD SEM and thermogravimetric anal. The results show that TEA can promote the hydration of C3A to form ettringite (AFt) and improve the early strength of cement, and TIPA can promote the hydration of ferrite phase, improve the degree of hydration, and promote the later strength of cement. The synergistic effect of TEA and TIPA in proper proportion can improve both the early strength and late strength of cement at all ages.

Construction and Building Materials published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C17H14N2O2, Recommanded Product: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Yibo published the artcileA high throughput method to screen companion bacterium for 2-keto-L-gulonic acid biosynthesis by co-culturing Ketogulonicigenium vulgare, COA of Formula: C6H10O7, the publication is Process Biochemistry (Oxford, United Kingdom) (2012), 47(9), 1428-1432, database is CAplus.

Bacillus megaterium is widely used as companion bacterium in the two-step biosynthesis of 2-keto-L-gulonic acid (2-KLG) by Ketogulonicigenium vulgare. To screen efficiently target companion strains from large numbers of random mutants, a screen method based on spectrophotometry and 24-well microtiter plates was developed and validated on an integrated library of 450 transposon random insertional mutants and two sporulation-defective mutants. The co-culture processes were classified into three groups (low, intermediate and high performance) by K-mean clustering anal. In addition, mutant m71 was successfully screened out from the library. The substrate conversion ratio of m71 and K. vulgare co-culture process after 72 h was decreased by about 38% compared with that of the wild-type co-culture process in 750 mL flasks. These results indicated that the proposed high throughput method is feasible for screening target companions for the co-culture process of 2-KLG biosynthesis.

Process Biochemistry (Oxford, United Kingdom) published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C38H74Cl2N2O4, COA of Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts