Tag: M.W=150-200

Velu, Sadanandan E. published the artcileTethered Dimer Inhibitors of NAD Synthetase: Parallel Synthesis of an Aryl-Substituted SAR Library, Recommanded Product: 3-Morpholinophenol, the publication is Journal of Combinatorial Chemistry (2005), 7(6), 898-904, database is CAplus and MEDLINE.

The authors previously reported that tethered dimers containing indoles on one end and a permanent pos. charge on the other, using a 6-9 carbon polymethylene tether, provided NAD synthetase inhibitors with impressive antibacterial activities against Gram-positives. Here, the authors report that the Ph ring is a good substitute for indole, and the authors utilize solution-phase parallel synthesis to explore structure-activity relationships for substituents on that ring. General conclusions are that nonpolar substituents are more effective than polar ones and that different positional isomers often have very different enzyme inhibition activities. This latter observation reveals that enzyme activity is sensitive to minor structural changes and suggests that nonspecific detergent actions are not important for the observed effects.

Journal of Combinatorial Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C7H6Cl2, Recommanded Product: 3-Morpholinophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Blundell, Toby J. published the artcileEnantiopure and racemic radical-cation salts of B(mandelate)₂^– and B(2-chloromandelate)₂^– anions with BEDT-TTF, Related Products of alcohols-buliding-blocks, the publication is Dalton Transactions (2022), 51(12), 4843-4852, database is CAplus and MEDLINE.

Authors report the first examples of radical-cation salts of BEDT-TTF with spiroborate anions [B(mandelate)₂]^– and [B(2-chloromandelate)₂]^–, synthesized from either enantiopure or racemic bidentate mandelate or chloromandelate ligands. In the salts prepared using enantiopure ligands only one of two diastereoisomers of the spiroborate anion is incorporated, with the boron center having the same stereochem. as the enantiopure ligand. For the racemic salts one racemic pair of spiroborate anions containing an R and an S mandelate ligand is incorporated. In certain solvents helical crystals were obtained when using spiroborate anions with enantiopure ligands. Elec. and magnetic properties, and band structure calculations are reported.

Dalton Transactions published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Llorente, Briardo published the artcileDownregulation of polyphenol oxidase in potato tubers redirects phenylpropanoid metabolism enhancing chlorogenate content and late blight resistance, Related Products of alcohols-buliding-blocks, the publication is Molecular Breeding (2014), 34(4), 2049-2063, database is CAplus.

Land plants synthesize phenolic compounds involved in plant defense against invading pathogens through the phenylpropanoid pathway. Although not considered as part of the phenylpropanoid pathway, plant polyphenol oxidases (PPOs) are enzymes that catalyze cresolase and catecholase reactions on several phenolic compounds Here, transgenic potato (Solanum tuberosum) tubers with downregulated PPO genes (-PPO) were challenged with the oomycete pathogen Phytophthora infestans to investigate the interactions between PPO, phenylpropanoid metabolism, and disease resistance. We found that pathogen invasiveness was reduced in -PPO lines, while microscopic evidences suggested that the mechanism underlying the defense response involved the participation of phenolic compounds Detailed metabolite-profiling analyses demonstrated that the concentration of metabolites related to the phenylpropanoid pathway and chlorogenate in particular was largely altered in PPO-downregulated tubers. Silencing of PPO caused a shift in metabolism from phenylpropanoid precursors to downstream phenylpropanoid products. The presented results suggest that downregulation of PPO redirects the phenylpropanoid metabolism leading to the accumulation of defensive phenolic compounds in the plant cells, consequently enhancing resistance to the pathogen. These results emphasize the importance of components acting in parallel to canonical metabolic pathway constituents in influencing plant metabolism and reveal new scenarios for modulating the levels of phenolics in crops.

Molecular Breeding published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dotsikas, Yannis published the artcileEffect of the luminol signal enhancer selection on the curve parameters of an immunoassay and the chemiluminescence intensity and kinetics, Application of 4-(1H-Pyrrol-1-yl)phenol, the publication is Talanta (2007), 71(2), 906-910, database is CAplus and MEDLINE.

In the present study, three luminol signal enhancers {4-methoxyphenol, 4-hydroxybiphenyl and 4-(1H-pyrrol-1-yl)phenol} were utilized in the chemiluminescence (CL) substrate solution of horseradish peroxidase (HRP). The latter was applied in a heterogeneous enzyme immunoassay that has been previously described. The employment of these mols. greatly affected important assay parameters, such as detection limit and the range of the calibration curve and the results were compared with those obtained from other two similar enhancers that have been described from the authors’ group. Practically, the use of a novel enhancer, even if this is a slightly changed 4-substituted phenol derivative, can affect assay properties so dramatically, one can assume that another substrate/enzyme system was applied. Furthermore, the use of different luminol signal enhancers in the luminol/HRP/H₂O₂ system affected not only the intensity of the obtained signal, which is well known, but also its kinetics. It was monitored that the stronger intensity was combined with a more rapid decrease of the CL signal.

Talanta published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kritikos, Nikolaos published the artcileQuantitative structure-chemiluminescence intensity relationships of 4-substituted phenols acting as luminol signal enhancers, Computed Properties of 23351-09-9, the publication is Chemometrics and Intelligent Laboratory Systems (2015), 478-484, database is CAplus.

The addition of a forth compound into this system has been thoroughly explored over the years, namely an enhancer promoting potency in the signal attained. Improvements in this regard serve to increase sensitivity and applicability of various biochem. methods. Studies exploring the ability of compounds to act as enhancers have proposed several chem. groups as possible candidates, amongst which 4-substituted phenols have been widely employed. Although some studies have explored the effect of the substituent on enhancer potency, no quant. structure – property relationships employing mol. descriptors for this group of compounds have been presented. Current study provides two such cross- and externally validated models, constructed by the projection to latent structures by means of partial least squares (PLS) multivariate linear regression method: i) a PLS-DA model contributing to the classification of such compounds into classes (relative to the signal), and ii) a PLS model for predicting the signal acquired. Validation was based on statistical metrics Q²ext(F3) for the test set and Roy’s metrics r²m(Av) & r²m(δ), assessing both predictive stability and internal validity. Applied in tandem, those models can assist in the recognition of available compounds as potential enhancers or inspire the synthesis of novel analogs. The significance of some characteristics governing the compounds’ behavior are also discussed based on the mol. descriptors chosen.

Chemometrics and Intelligent Laboratory Systems published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Computed Properties of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Afonso, Carlos A. M. published the artcileSynthesis of 2,4,6-tri-substituted-1,3,5-triazines, Synthetic Route of 101-98-4, the publication is Molecules (2006), 11(1), 81-102, database is CAplus and MEDLINE.

Several specific synthetic protocols were developed for the preparation of a range of sym. and non-sym. di- and tri-substituted 1,3,5-triazines containing alkyl, aromatic, hindered, chiral and achiral hydroxyalkyl, ester and imidazole groups , e.g., I (R = H or Me) via sequential nucleophilic substitution of the C-Cl bond by C-O, C-N and C-S bonds, starting from cyanuric chloride.

Molecules published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Synthetic Route of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Simon-Manso, Yamil published the artcileMetabolite Profiling of a NIST Standard Reference Material for Human Plasma (SRM 1950): GC-MS, LC-MS, NMR, and Clinical Laboratory Analyses, Libraries, and Web-Based Resources, Application of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Analytical Chemistry (Washington, DC, United States) (2013), 85(24), 11725-11731, database is CAplus and MEDLINE.

Recent progress in metabolomics and the development of increasingly sensitive anal. techniques have renewed interest in global profiling, i.e., semiquant. monitoring of all chem. constituents of biol. fluids. In this work, we have performed global profiling of NIST SRM 1950, “Metabolites in Human Plasma”, using GC-MS, LC-MS, and NMR. Metabolome coverage, difficulties, and reproducibility of the experiments on each platform are discussed. A total of 353 metabolites have been identified in this material. GC-MS provides 65 unique identifications, and most of the identifications from NMR overlap with the LC-MS identifications, except for some small sugars that are not directly found by LC-MS. Also, repeatability and intermediate precision analyses show that the SRM 1950 profiling is reproducible enough to consider this material as a good choice to distinguish between anal. and biol. variability. Clin. laboratory data shows that most results are within the reference ranges for each assay. Inhouse computational tools have been developed or modified for MS data processing and interactive web display. All data and programs are freely available online at http://peptide.nist.gov/ and http://srmd.nist.gov/.

Analytical Chemistry (Washington, DC, United States) published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H7BClNO3, Application of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sciukaite, Agne published the artcileContents of some bioactive compounds in Norway spruce needles as affected by short-term storage at different conditions and implications for their industrial use, Category: alcohols-buliding-blocks, the publication is Industrial Crops and Products (2022), 114919, database is CAplus.

The main aim of the research was to evaluate changes in contents of essential oils and pigments in Norway spruce needles as affected by short-term storage under different conditions as well as to assess the potential resources of winter-harvested foliage obtainable from byproducts of forest felling as a natural source of these bioactives. One- and two-year-old needles were taken for the analyses fresh (control) and after five-week storage at three different conditions: at 4°C in fridge, at -24°C in freezer and in the forest of their origin. Essential oils were isolated from needles by hydrodistillation and analyzed by gas chromatog.-mass spectrometry. Analyses of chlorophylls and carotenoids were performed spectrophotometrically. The study showed that none of the tested storage conditions of P. abies needles had significant influence on the total amounts of essential oils in them varying from 0.16% to 0.20% per dry matter (v/w) in two- and one-year-old needles, resp. Bornyl acetate was the main compound identified in the essential oils amounting to 14.47-40.04%. The mean total contents of chlorophylls amounted to 1.10 mg/g in one-year-old needles and to 1.28 mg/g in two-year-old ones measured in fresh weight Statistically significant differences were established in the levels of all the pigments analyzed between fresh material, and stored under controlled, -24°C and 4°C, conditions both of 1-yr-old and 2-yr-old needles. The highest contents of the pigments were obtained after the storage at 4°C as well as under the natural forest condition. Based on the above data and the national forestry statistics, potential yields of essential oils (6.45 kg), total chlorophylls (9.27 kg) and total carotenoids (1.32 kg) were assessed per ha of a mature sprucewood stand in Lithuania.

Industrial Crops and Products published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C15H18BF3O4, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gao, Lili published the artcileEfficient optimization of Gluconobacter oxydans based on protein scaffold-trimeric CutA to enhance the chemical structure stability of enzymes for the direct production of 2-keto-L-gulonic acid, Quality Control of 526-98-7, the publication is Journal of Chemistry (2020), 5429409, database is CAplus.

2-Keto-L-gulonic acid (2-KLG), the direct precursor of vitamin C, is produced by a two-step fermentation route from D-sorbitol in industry. However, this route is a complicated mix-culture system which involves three bacteria. Thus, replacement of the conventional two-step fermentation process with a one-step process could be revolutionary in vitamin C industry. The one-step fermentation of 2-keto-L-gulonic acid (2-KLG) has been achieved in our previous study; 32.4 g/L of 2-KLG production was obtained by the one-step strain G. oxydans/pGUC-tufB-sdh-GGGGS-sndh after 168 h. In this study, L-sorbose dehydrogenase (SDH) and L-sorbosone dehydrogenase (SNDH) were expressed in G. oxydans after the codon optimization. Furthermore, the trimeric protein CutA was used to improve the chem. structure stability of SDH and SNDH. The recombinant strain G. oxydans/pGUC-tufB-SH3-sdh-GGGGS-sndh-tufB-SH3lig-(GGGGS)2-cutA produced 40.3 g/L of 2-KLG after 168 h. In addition, the expression levels of the cofactor PQQ were enhanced to further improve 2-KLG production With the stepwise metabolic engineering of G. oxydans, the final 2-KLG production was improved to 42.6 g/L. The efficient one-step production of 2-KLG was achieved, and the final one-step industrial-scale production of 2-KLG is drawing near.

Journal of Chemistry published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Quality Control of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Chen published the artcileHeat-cured concrete: Improving the early strength and pore structure by activating aluminosilicate internal curing agent with triisopropanolamine, Recommanded Product: Triisopropanolamine, the publication is Journal of the American Ceramic Society (2019), 102(10), 6227-6238, database is CAplus.

Although heat-cured concrete (HCC) has received extensive research interests in recent years, it still suffers from problems including coarsened microstructure and low cement hydration degrees, which limited its application. Some of these problems can be solved by internal curing method resulting in low early strength of HCC and low-production efficiency. This study addressed this issue by activating the aluminosilicate internal curing agent (lightweight fine aggregate, LWFA) with triisopropanolamine (TIPA). More Al³⁺ and Fe³⁺ ions were dissolved from LWFA by TIPA, which assisted the formation of hydrates with cement ions in interfacial transition zone (ITZ), and enhanced the d. of ITZ in the early stage. The introduction of TIPA increased the early compressive strength of HCC, by ∼15.3%, 25.9%, and 28.0%, resp. for the cement cured for 1, 3, and 7 days compared with control samples. Moreover, the results of rapid chloride migration and water absorption depth also suggested that coupling the aluminosilicate internal curing agent with TIPA improved the pore structure of HCC.

Journal of the American Ceramic Society published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Recommanded Product: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts