Tag: M.W=150-200

Zhao, Kang-He published the artcileRefractory organic compounds in coal chemical wastewater treatment by catalytic ozonation using Mn-Cu-Ce/Al₂O₃, Application In Synthesis of 2588-77-4, the publication is Environmental Science and Pollution Research (2021), 28(30), 41504-41515, database is CAplus and MEDLINE.

A composite Mn-Cu-Ce tri-metal oxide supported on γ-Al₂O₃ (Mn-Cu-Ce/Al₂O₃) catalyst was prepared by an impregnation-calcination method and investigated in the catalytic ozonation treatment of real coal chem. wastewater (CCW). The catalyst was characterized by XRD, SEM, TEM, XRF, BET, and XPS techniques. The results showed that Mn, Cu, and Ce metal oxides were evenly distributed on the Al₂O₃ surface and the catalyst maintained a large surface area and a high pore volume compared with the pristine Al₂O₃. The synergy between Mn, Cu, and Ce oxides greatly enriched the catalytic active sites and enhanced the ozonation performance. The catalytic ozonation process with Mn-Cu-Ce/Al₂O₃ increased the removal rate of total organic carbon (TOC) by 31.6% compared with ozonation alone. The ketones, aromatic compounds, phenols, and nitrogen-containing heterocyclic compounds in CCW have been effectively degraded and mineralized by Mn-Cu-Ce/Al₂O₃ catalytic ozonation process, and its biodegradability has also been significantly improved. The exptl. results of ·OH scavengers revealed that the mechanism of Mn-Cu-Ce/Al₂O₃ catalytic ozonation was to promote the generation of ·OH radicals. The catalytic activity of Mn-Cu-Ce/Al₂O₃ was only a slight decrease in six consecutive catalytic ozonation treatments, showing good stability. Therefore, Mn-Cu-Ce/Al₂O₃ can be used as a candidate catalyst for the advanced treatment of refractory organic wastewaters upon catalytic ozonation.

Environmental Science and Pollution Research published new progress about 2588-77-4. 2588-77-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 2-Methyl-3-bromo-2-butanol, and the molecular formula is C24H20Ge, Application In Synthesis of 2588-77-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Belhachemi, Asma published the artcileGC-MS and GC-FID analyses of the essential oil of Eucalyptus camaldulensis grown under greenhouses differentiated by the LDPE cover-films, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Industrial Crops and Products (2022), 114606, database is CAplus.

The chem. composition of essential oils (EOs) can vary from one plant to another of the same species and can be affected by several factors including the environment of growth. The research was carried out on the EOs of Eucalyptus camaldulensis leaves grown in three sep. greenhouses differentiated by their low-d. polyethylene (LDPE) covering material. This study aimed to compare the impact of the type of the greenhouse cover film on the internal microclimate, light intensity, and chem. composition of E. camaldulensis EOs. Eucalyptus species was initially cultivated from the seeds and the EOs were extracted from the leaves of 14 wk aged trees. The extraction was performed by hydrodistillation using a Clevenger-type apparatus Qual. and quant. analyses of the extracted EOs were performed using gas chromatog. coupled with mass spectrometry (GC-MS) and gas chromatog. coupled with a flame ionization detector (GC-FID). The analyzed samples were rich in terpenes with a total of 66 identified compounds The oxygenated monoterpenes pinocarvone and -carvone were only identified in the essential oils from multilayered greenhouses. cis-1-Methyl-4-(1-methylethyl-)-2-cyclohexen-1-ol was absent in eucalyptus EOs from the three-layer greenhouse, unlike the others that had it. Different compound contents were detected in the extracted essential oils, according to their greenhouse cover conditions. 1,8-Cineol was the compound present in a higher amount as expected, with the highest value of c.a 164.78 mg/gdw from the leaves of E. camaldulensis cultivated in the ordinary greenhouse. Contents of 51.55 mg/gdw and 42.11 mg/gdw were obtained from E. camaldulensis cultivated in the three-layers and monolayer greenhouses, resp. In contrast, the EOs of E. camaldulensis grown under the monolayer greenhouse presented the highest content of some aromadendranes family compounds This study shows that the greenhouse cover-film should be chosen thoughtfully because it plays a major function regarding its effect on the chem. composition of the EOs of E. camaldulensis cultivated in greenhouse environments.

Industrial Crops and Products published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shareef, Afzaal M. published the artcileComparison of RNA synthesis initiation properties of non-segmented negative strand RNA virus polymerases, SDS of cas: 122-20-3, the publication is PLoS Pathogens (2021), 17(12), e1010151, database is CAplus and MEDLINE.

It is generally thought that the promoters of non-segmented, neg. strand RNA viruses (nsNSVs) direct the polymerase to initiate RNA synthesis exclusively opposite the 3′ terminal nucleotide of the genome RNA by a de novo (primer independent) initiation mechanism. However, recent studies have revealed that there is diversity between different nsNSVs with pneumovirus promoters directing the polymerase to initiate at positions 1 and 3 of the genome, and ebolavirus polymerases being able to initiate at position 2 on the template. Studies with other RNA viruses have shown that polymerases that engage in de novo initiation opposite position 1 typically have structural features to stabilize the initiation complex and ensure efficient and accurate initiation. This raised the question of whether different nsNSV polymerases have evolved fundamentally different structural properties to facilitate initiation at different sites on their promoters. Here we examined the functional properties of polymerases of respiratory syncytial virus (RSV), a pneumovirus, human parainfluenza virus type 3 (PIV-3), a paramyxovirus, and Marburg virus (MARV), a filovirus, both on their cognate promoters and on promoters of other viruses. We found that in contrast to the RSV polymerase, which initiated at positions 1 and 3 of its promoter, the PIV-3 and MARV polymerases initiated exclusively at position 1 on their cognate promoters. However, all three polymerases could recognize and initiate from heterologous promoters, with the promoter sequence playing a key role in determining initiation site selection. In addition to examining de novo initiation, we also compared the ability of the RSV and PIV-3 polymerases to engage in back-priming, an activity in which the promoter template is folded into a secondary structure and nucleotides are added to the template 3′ end. This anal. showed that whereas the RSV polymerase was promiscuous in back-priming activity, the PIV-3 polymerase generated barely detectable levels of back-primed product, irresp. of promoter template sequence. Overall, this study shows that the polymerases from these three nsNSV families are fundamentally similar in their initiation properties, but have differences in their abilities to engage in back-priming.

PLoS Pathogens published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C4H10BBrO2, SDS of cas: 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Caliskan, Burcu published the artcilePyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils, Application of 4-(1H-Pyrrol-1-yl)phenol, the publication is European Journal of Medicinal Chemistry (2011), 46(10), 5021-5033, database is CAplus and MEDLINE.

Thirty-six title compounds were synthesized and led to potent inhibition of leukotriene (LT) biosynthesis in activated human neutrophils. Some examples showed IC₅₀ values in the range of 1.6-3.5 μM. Moreover, several compounds showed a substantial inhibition of platelet COX-1 activity with IC₅₀ of 2.5, 0.041, 0.3, 0.9 and 0.014 μM, resp., leading up to dual acting inhibitors. On the basis of their high potency in cellular environment, these straightforward pyrazole-3-propanoic acid derivatives may possess potential in the design of more potent compounds for intervention with inflammatory and allergic diseases.

European Journal of Medicinal Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liang, YaoYao published the artcileDirected evolution of PobR allosteric transcription factor to generate biosensor for 4-hydroxymandelic acid, Formula: C8H8O3, the publication is World Journal of Microbiology & Biotechnology (2022), 38(6), 104, database is CAplus and MEDLINE.

Hydroxy-mandelic acid (HMA) is widely applied in pharmaceuticals, food and cosmetics. In this study, we aimed to develop an allosteric transcription factors (aTFs) based biosensor for HMA. PobR, an aTF for HMA analog 4-hydroxybenzoic acid, was used to alter its selectivity and create novel aTFs responsive to HMA by directed evolution. We established a PobR mutant library with a capacity of 550,000 mutants using error-prone PCR and Megawhop PCR. Through our screening, two mutants were obtained with responsiveness to HMA. Anal. of each missense mutation indicating residues 122-126 were involved in its PobR ligand specificity. These results showed the effectiveness of directed evolution in switching the ligand specificity of a biosensor and improving HMA production

World Journal of Microbiology & Biotechnology published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Liang published the artcileMetal- and solvent-free conditions for the acylation reaction catalyzed by carbon tetrabromide (CBr₄), Computed Properties of 27292-49-5, the publication is Green Chemistry (2007), 9(9), 1022-1025, database is CAplus.

An efficient and useful catalyst, carbon tetrabromide (CBr₄), was discovered to be highly effective for the acylation of phenols, alcs., and thiols under metal- and solvent-free conditions.

Green Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C9H6F3NO, Computed Properties of 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cipriani, Andreza published the artcilePhenolic compounds of Eugenia involucrata (Myrtaceae) extracts and associated antioxidant and inhibitory effects on acetylcholinesterase and α-glucosidase, Category: alcohols-buliding-blocks, the publication is Natural Product Research (2022), 36(4), 1134-1137, database is CAplus and MEDLINE.

Eugenia involucrata DC. (Myrtaceae), popularly known as “cereja-do-Rio-Grande”, is a native tree from Brazil, popularly used as a hypoglycemiant. Crude hydroalcoholic extract (CHE) and fractions (insoluble (FI), dichloromethane (FDM), Et acetate (FEA) and butanol (FBu)) of leaves were assessed to determine the phenolic chem. composition by HPLC-ESI-MS/MS. 10 compounds were identified, being 7 new for this species: rutin, isoquercitrin, luteolin-7-O-rutinoside, mandelic acid, naringenin, luteolin-7-O-glucoside and salicylic acid. Extract and fractions showed inhibitory activity on acetylcholinesterase (AchE) enzyme (best result: IC50 = 44.19μg mL-1, for FEA) and α-glucosidase (α-Glu) (best result: IC50 = 31.25 ± 0.15μg mL-1, for CHE). The observed antioxidant and inhibitory activity on the AchE and α-Glu is due to, at least in part, the presence of phenolic compounds in the samples.

Natural Product Research published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ouyang, Mi published the artcileStudy on electrochromic performance of the copolymer based on 4-(1H-pyrrol-1-yl) phenyl 4-(1H-pyrrol-1-yl) butanoate with 3,4-ethylenedioxythiophene, Safety of 4-(1H-Pyrrol-1-yl)phenol, the publication is Advanced Materials Research (Durnten-Zurich, Switzerland) (2011), 335-336(Pt. 2), 929-933, database is CAplus.

A new polypyrrole derivative 4-(1H-pyrrol-1-yl) Ph 4-(1H-pyrrol-1-yl) butanoate (NPB) was synthesized by chem. method and characterized by ¹H and ¹³C NMR spectroscopy. A new copolymer based on NPB and 3,4-ethylenedioxythiophene(EDOT) was electrochem. synthesized. Cyclic voltammogram and spectroelectrochem. characterization showed that the copolymer film had a well-defined reversible redox process as well as electrochromic behavior. Moreover, the copolymer film exhibited a multicolor electrochromism at different potentials, fast switching time of 0.8 s at 365 nm and an optical contrast of 17% at 1100nm.

Advanced Materials Research (Durnten-Zurich, Switzerland) published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Safety of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gao, Ming published the artcileOptimization of fermentation conditions for two-step fermentation of vitamin C, Synthetic Route of 526-98-7, the publication is Shipin Gongye Keji (2012), 33(14), 235-238, database is CAplus.

The conversion process from L-sorbose to 2-keto-L-gulonic acid in vitamin C two-step fermentation was mixed culture fermentation by acid-producing strain (Gluconobacter oxydans) and companion bacterium (Bacillus subtilis). In order to promote the coordination between the two strains and make it reach the best state, the nutrient condition and the culture conditions were researched by orthogonal test and single factor experiment The result showed that the optimal conditions were as follows: 8% L-sorbose, 1.4% corn steep liquor, 1.2% urea, 0.5% CaCO₃, 0.02% MgSO₄, liquid volume in 100 mL flask with 10 mL, culture temperature 29°C, inoculation amount 15%. The yield of 2-KGA increased by 2.45% under the optimized culture medium conditions compared with the original medium. It reached the fermentation end after 60 h which was shortened by 16 h than before and the fermentation efficiency improved by 0.29 g/L·h.

Shipin Gongye Keji published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Synthetic Route of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Xin published the artcileSmall molecule-mediated upregulation of CCR7 ameliorates murine experimental autoimmune encephalomyelitis by accelerating T-cell homing, Formula: C9H21NO3, the publication is International Immunopharmacology (2017), 33-41, database is CAplus and MEDLINE.

Impairing the infiltration of immune cells into the CNS is a promising target for suppressing the development of multiple sclerosis (MS) and its animal model exptl. autoimmune encephalomyelitis (EAE). Here, we found that oral administration of a synthetic small mol. compound Fc24 showed potential preventive effects on the development of EAE, including the reduction in EAE severity and a delay in the onset of the disease. Fc24 facilitated the accumulation of both CD4⁺ and CD8⁺ T cells within spleen and lymph nodes, while having no effect on MOG-specific T cell responses. Furthermore, CCR7 expression was upregulated by Fc24 on activated T cells in vivo and in vitro, accompanied by ERK activation in the treated T cells in response to CCL19. These findings demonstrate that small mol.-mediated CCR7 upregulation might ameliorate EAE by facilitating T cell homing into and within lymphoid organs, and that Fc24 may be a potential candidate for modifying the development of EAE.

International Immunopharmacology published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Formula: C9H21NO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts