Tag: M.W=150-200

Hamaguchi, Wataru published the artcileDesign and synthesis of novel benzimidazole derivatives as phosphodiesterase 10A inhibitors with reduced CYP1A2 inhibition, Category: alcohols-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry (2013), 21(24), 7612-7623, database is CAplus and MEDLINE.

A novel class of phosphodiesterase 10A (PDE10A) inhibitors with reduced CYP1A2 inhibition were designed and synthesized starting from 2-{[(1-phenyl-1H-benzimidazol-6-yl)oxy]methyl}quinoline I. Introduction of an iso-Pr group at the 2-position and a methoxy group at the 5-position of the benzimidazole ring of lead compound 1 resulted in the identification of 2-{[(2-isopropyl-5-methoxy-1-phenyl-1H-benzimidazol-6-yl)oxy]methyl}quinoline II, which exhibited potent PDE10A inhibitory activity with reduced CYP1A2 inhibitory activity compared to compound 1.

Bioorganic & Medicinal Chemistry published new progress about 120103-18-6. 120103-18-6 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Nitro Compound,Benzene,Phenol, name is 2,5-Difluoro-4-nitrophenol, and the molecular formula is C6H3F2NO3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Reddy, Kumbam Lingeshwar published the artcileMandelic acid appended chiral gels as efficient templates for multicolour circularly polarized luminescence, Application of 2-Hydroxy-2-phenylacetic acid, the publication is Nanoscale (2022), 14(13), 4946-4956, database is CAplus and MEDLINE.

Mandelic acid is a medicinally important chiral mol. that is widely used as a vital component in antibiotics, antiseptics and cosmetics. While the medicinal properties of mandelic acid are well known, its aggregation and gelation characteristics, which are crucial to finding applications as cosmetics and ointments, are least explored. We have designed and synthesized a pair of mandelic acid derivatives and investigated their aggregation properties in binary solvent mixtures The compounds undergo self-assembly through various noncovalent interactions, leading to the formation of robust chiral gels. Strong birefringence could be visualised from the individual structures constituting the gel. The large rod-like chiral structures are utilized as efficient templates for the assembly of ultra-small luminescent achiral carbon nanodots. The transfer of optical activity from the chiral host matrix to the fluorescent guest nanoparticles resulted in the generation of circularly polarized luminescence signals from the hybrid nanocomposites. The use of blue, green and red-emitting nanodots led to the fabrication of multicolor chiral light-emitting materials capable of covering the entire visible range. Considering the numerous medicinal benefits offered by mandelic acid and carbon nanodots, the materials constituting the nanocomposites, the distinct dimensions presented in the current work open new avenues for chiral light emitting materials to be used in biomedical research.

Nanoscale published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Application of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tharmalingam, Balamurugan published the artcileNitrogen rich triaminoguanidine-pyrrole conjugate as supramolecular synthon for the construction of charge-assisted hydrogen bonded network with various carboxylic acids, Application of 1-Hydroxy-2-naphthoic acid, the publication is Journal of Solid State Chemistry (2022), 122637, database is CAplus.

In this paper, we report the construction of hydrogen bonded supramol. assemblies of salt obtained from novel nitrogen rich C₃-sym. star-shaped triaminoguanidine-pyrrole conjugate and various carboxylic acids. Different types of supramol. assembly were achieved by using a variety of carboxylate anions. Formation of all compounds were confirmed by single crystal anal. The hydrogen bonded three-dimensional supramol. network assemblies (1-6) are harvested by utilizing traditional N-H···O, O-H···O, and weak C-H···π interactions. Among all salts, heterosynthons R¹₂(10) containing traditional N-H···O interactions are commonly observed The thermal stability of salt 1-6 has been examined by thermogravimetric anal. (TGA).

Journal of Solid State Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C3H7BrO2S, Application of 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pohodylo, N. T. published the artcileSynthesis of 1-(1-aryl-1H-1,2,3-triazol-4-yl)-β-carboline derivatives, Application In Synthesis of 6346-09-4, the publication is Russian Journal of Organic Chemistry (2014), 50(2), 275-279, database is CAplus.

Reaction of 5-methyl-1-aryl-1H-1,2,3-triazole-4-carbonyl chlorides with tryptamines afforded 1-aryl-N-[2-(1H-indol-3-yl)ethyl]-5-methyl-1H-1,2,3-triazole-4-carboxamides. Subsequent Bischler-Napieralski cyclization by heating in toluene in the presence of POCl₃ and P₂O₅ gave 1-(1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)-4,9-dihydro-3H-β-carbolines, which were transformed into β-carbolines and tetrahydro-β-carbolines.

Russian Journal of Organic Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Application In Synthesis of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hasegawa, Minoru published the artcileSynthesis and properties of antimony compounds of the type Sb(OSiR₃)₃, Product Details of C9H22OSi, the publication is Nippon Kagaku Kaishi (1995), 550-6, database is CAplus.

Novel organoantimony compounds Sb(OSiR₃)₃ [1, R¹ = R² = R³ = Me; 2, R¹ = R² = R³ = Pr; 3, R¹ = R² = R³ = i-Pr;4, R¹ = R² = Me, R³ = t-Bu; 5, R¹ = R² = R³ = Ph] were prepared in 41-81% yields by the reaction of SbCl₃ with NaOSiR₃ (1:3 mol ratio) in toluene. These compounds were characterized by IR, ¹H, ¹³C, and ²⁹Si-NMR, and MS spectroscopy. According to MS and NMR spectral data, each compound appears to be a monomer. They are subject to hydrolysis at room temperature Thus, treatment of 1–4 with a large excess of H₂O under slightly forced conditions gave the corresponding silanols and Sb trioxides. IR and XPD data suggest the resulting Sb trioxides are two polymorphs; the 1st polymorph is senarmontite obtained by hydrolysis of 1–4 in H₂O/MeOH and the 2nd polymorph is valentinite given by hydrolysis of 3 and 4 in H₂O/acetone.

Nippon Kagaku Kaishi published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Product Details of C9H22OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Igarashi, Masayasu published the artcileNonhydrolytic synthesis of silanols by the hydrogenolysis of benzyloxysilanes, Safety of Triisopropylsilanol, the publication is Chemistry Letters (2014), 43(4), 429-431, database is CAplus.

The hydrogenolysis of benzyloxysilanes was smoothly catalyzed by Pd/C in THF to give corresponding silanols under nonhydrolytic conditions. The reaction proved to be applicable to various benzyloxysilanes giving silanemonools, diol, and triol.

Chemistry Letters published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Safety of Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nakanishi, Masako published the artcileDietary walnut supplementation alters mucosal metabolite profiles during DSS-induced colonic ulceration, Application of Triisopropanolamine, the publication is Nutrients (2019), 11(5), 1118, database is CAplus and MEDLINE.

Walnuts contain a complex array of natural compounds and phytochems. that exhibit a wide range of health benefits, including protection against inflammation and colon cancer. In this study, we assess effect of dietary supplementation with walnuts on colonic mucosal injury induced in mice by ulcerogenic agent, dextran sodium sulfate (DSS). C57Bl/6J mice were started on the Total Western Diet supplemented with freshly-ground whole walnuts (0, 3.5, 7 and 14% g/kg) 2 wk prior to a 5-day DSS treatment and walnut diets were continued throughout the entire exptl. period. In a sep. study, a discovery-based metabolite profiling anal. using liquid chromatog. tandem mass spectrometry was performed on fecal samples and colonic mucosa following two weeks of walnut supplementation. Dietary walnut supplementation showed significant effects in the 10-day post-DSS recovery-phase study, in which the extent of ulceration was significantly reduced (7.5% vs. 0.3%, p < 0.05) with 14% walnuts. In the metabolite-profiling anal., walnuts caused a significant increase in several polyunsaturated fatty acids, including docosahexaenoic acid and 9-oxo-10(E),12(E)-octadecadienoic acid (9-oxoODA), as well as kynurenic acid. In colon tissue samples, walnuts caused a significant increase in the levels of S-adenosylhomocysteine and betaine, important components of fatty acid β-oxidation These metabolite changes may contribute in part to the observed protection against DSS-induced inflammatory tissue injury.

Nutrients published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Application of Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mathis-Noel, Raymonde published the artcileSpectroscopic studies of hydrogen bonding in aliphatic and aromatic amino alcohols, Application of 2-(Benzyl(methyl)amino)ethanol, the publication is Bulletin de la Societe Chimique de France (1970), 3047-56, database is CAplus.

Inter- and intramol. H bonds were studied for a series of amino alcs., which included some aromatic substituted compounds The ir frequencies of the OH and NH bonds were observed for the pure compound and for several dilutions in CCl4. Further, the NMR shifts of these bonds were observed All compounds studied, with the one exception of 1-phenyl-2-N-methyl-N-ethylaminoethanol, showed various intermol. H-bonds in the pure phase, i.e., OH..A, NH…O, NH…N. Compounds with electron donor substituents on N showed intramol. H bonds (C. F. Douberet and Pariand, 1962). Such bonds are also observed for primary amines; they increase as the number of electron donors on the adjacent C increases. Substitution of an electron source or sink for a H on the C bearing the OH will always favor intramol. association Chelation will be suppressed by substitution of a H atom on N; this increases the H-bonding to the π-electrons of an aromatic system, observed at about 3541 cm-1.

Bulletin de la Societe Chimique de France published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Application of 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sindhu, S. published the artcileGC-MS determination of bioactive components of Polycarpaea corymbosa Lams. (Caryophyllaceae), Application of Triisopropylsilanol, the publication is Hygeia (2013), 5(1), 5-9, database is CAplus.

Plan: The investigation was carried out to determine the possible chem. components from Polycarpaea corymbosa Lam. root and aerial parts. Methodol.: GC-MS was analyzed using Agilent (Model 5975C) Gas Chromatog.-Mass Spectrometry. Outcome: GC-MS anal. of methanolic extract of root and aerial part led to identification of 30 and 24 compounds resp. The components were identified by comparing their retention indexes and mass spectra fragmentation patterns with those stored in the National Institute of Standards and Technol. (NIST) library. The major constituents reported are n-Hexadecanoic acid in methanolic aerial extract and 5-Hydroxymethyl furfural in methanolic root extract

Hygeia published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C5H5N3S, Application of Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Paalasmaa, Sanna published the artcileSynthesis and characterization of three homoleptic bismuth silanolates: [Bi(OSiR₃)₃] (R = Me, Et, iPr), Quality Control of 17877-23-5, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (2005), 631(12), 2433-2438, database is CAplus.

The bismuth tris(triorganosilanolates) [Bi(OSiR₃)₃] (1, R = Me; 2, R = Et; 3, R = iPr) were prepared by reaction of R₃SiOH with [Bi(OtBu)₃]. Compound 1 crystallizes in the triclinic space group P1̅ with Z = 2 and a 10.323(1), b 13.805(1), c 21.096(1) Å and α 91.871(4), β 94.639(3), γ 110.802(3)°. In the solid state compound 1 is a trimer as result of weak intermol. bismuth-oxygen interactions with Bi-O distances in the range 2.686(6)-3.227(3) Å. The coordination at the bismuth atoms Bi(1) and Bi(3) is best described as 3 + 2 coordination whereas Bi(2) shows a 3 + 3 coordination. The intramol. Bi-O distances fall in the range 2.041(3)-2.119(3) Å. Compound 3 crystallizes in the orthorhombic space group Pbcm with Z = 4 and a 7.201(1), b 23.367(5) and c 20.893(1) Å whereas the triethylsilyl-derivative 2 is liquid In contrast to [Bi(OSiMe₃)₃] (1), compound 3 is monomeric in the solid state, but shows similar intramol. Bi-O distances in the range 1.998(2)-2.065(5) Å. The bismuth silanolates are highly soluble in common organic solvents and strongly moisture sensitive. Compound 1 shows the lowest thermal stability.

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Quality Control of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts