Tag: M.W=150-200

Skorenski, Marcin published the artcilePhosphonate inhibitors of West Nile virus NS2B/NS3 protease, Application of 4,4-Diethoxybutan-1-amine, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2019), 34(1), 8-14, database is CAplus and MEDLINE.

West Nile virus (WNV) is a member of the flavivirus genus belonging to the Flaviviridae family. The viral serine protease NS2B/NS3 has been considered an attractive target for the development of anti-WNV agents. Although several NS2B/NS3 protease inhibitors have been described so far, most of them are reversible inhibitors. Herein, we present a series of α-aminoalkylphosphonate di-Ph esters and their peptidyl derivatives as potent inhibitors of the NS2B/NS3 protease. The most potent inhibitor identified was Cbz-Lys-Arg-(4-GuPhe)^P(OPh)₂ displaying K_i and k₂/K_i values of 0.4 μM and 28 265 M^-1s^-1, resp., with no significant inhibition of trypsin, cathepsin G, and HAT protease.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C15H14O3, Application of 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Adam, Waldemar published the artcileHost-Guest Chemistry in a Urea Matrix: Catalytic and Selective Oxidation of Triorganosilanes to the Corresponding Silanols by Methyltrioxorhenium and the Urea/Hydrogen Peroxide Adduct, Recommanded Product: Triisopropylsilanol, the publication is Journal of the American Chemical Society (1999), 121(10), 2097-2103, database is CAplus.

The oxidation of silanes to silanols, catalyzed by methyltrioxorhenium (MTO), proceeds in high conversions and excellent selectivities in favor of the silanol (no disiloxane product) when the urea/hydrogen peroxide adduct (UHP) is used as oxygen source instead of 85% aqueous H₂O₂. It is proposed that this novel Si-H oxidation takes place in the helical urea channels, in which the urea matrix serves as host for the silane substrate, the H₂O₂ oxygen source, and the MTO metal catalyst as guests. In this confined environment, the metal catalyst is stabilized against decomposition, and this enhances higher conversions while condensation of the silanol to its disiloxane is avoided for steric reasons. The oxidation of the optically active silane (S)-(α-Np)PhMeSiH proceeds with retention of configuration in excellent yield. To date, no catalytic Si-H oxygen insertion has been reported for the preparation of optically active silanols. In analogy with the stereoselectivity in the dioxirane oxidation of (+)-(α-Np)PhMeSiH to (+)-(α-Np)PhMeSiOH, a concerted spiro-type transition-state structure is proposed for this novel Si-H oxidation Herewith, a valuable synthetic method for the preparation of silanols has been made available through catalytic and selective oxidation of silanes to silanols by the MTO/UHP system.

Journal of the American Chemical Society published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Recommanded Product: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Urayama, Teppei published the artcileO₂-enhanced catalytic activity of gold nanoparticles in selective oxidation of hydrosilanes to silanols, Recommanded Product: Triisopropylsilanol, the publication is Chemistry Letters (2015), 44(8), 1062-1064, database is CAplus.

O₂ acts as a nonconsumed activator for gold nanoparticles (AuNPs) in the oxidation of hydrosilanes to silanols with water under O₂ atm, providing an acceleration of more than 200 times relative to the reaction rate under Ar atm. The AuNP catalyst under aerobic conditions exhibits high activity in the oxidation with high turnover numbers (1230000). Various hydrosilanes including less-reactive bulky ones can be converted to the corresponding silanols in excellent yields. Moreover, the present AuNP catalyst is reusable while maintaining the high performance.

Chemistry Letters published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C22H18Cl2N2, Recommanded Product: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ghavtadze, Nugzar published the artcileConversion of 1-alkenes into 1,4-diols through an auxiliary-mediated formal homoallylic C-H oxidation, Synthetic Route of 17877-23-5, the publication is Nature Chemistry (2014), 6(2), 122-125, database is CAplus and MEDLINE.

The ubiquitous nature of C-H bonds in organic mols. makes them attractive as a target for rapid complexity generation, but brings with it the problem of achieving selective reactions. In developing new methodologies for C-H functionalization, alkenes are an attractive starting material because of their abundance and low cost. Here we describe the conversion of 1-alkenes into 1,4-diols. The method involves the installation of a new Si,N-type chelating auxiliary group on the alkene followed by iridium-catalyzed C-H silylation of an unactivated δ-C(sp³)-H bond to produce a siloxane intermediate. Oxidation of the C-Si bonds affords a 1,4-diol. The method is demonstrated to have broad scope and good functional group compatibility by application to the selective 1,4-oxygenation of several natural products and derivatives

Nature Chemistry published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Synthetic Route of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Azzena, Ugo published the artcileReductive cleavage of N-substituted 2-aryl-1,3-oxazolidines: generation of α-amino-substituted carbanions, SDS of cas: 101-98-4, the publication is Journal of Organic Chemistry (1993), 58(24), 6707-11, database is CAplus.

The behavior of N-substituted 2-aryl-1,3-oxazolidines I (R = H, Me, Ph, R¹ = aryl, R² = Me, Et) have been investigated under conditions of electron transfer from alkali metals in aprotic solvents. The reduction led to the regioselective cleavage of the benzylic carbon-oxygen bond, with formation of the corresponding N-substituted benzylamino alcs. RR¹CHNR²CH₂CH₂OH in good yields. Investigation of the mechanism of this reductive cleavage, with the aid of labeling experiments, showed the intermediate formation of α-tertiary amino-substituted carbanions.

Journal of Organic Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, SDS of cas: 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kun, Jirui published the artcileCharacterization of the key compounds responsible for the fermented soybean-like cup aroma of raw Pu-erh tea using instrumental and sensory methods, Product Details of C10H18O, the publication is LWT–Food Science and Technology (2022), 113458, database is CAplus.

Cup aroma refers to the volatiles emitted from an empty cup after tea infusion. In this study, gas chromatog.-olfactometry (GC-O) and the odor activity value (OAV) approach were employed to investigate the composition of fermented soybean-like cup aroma from raw Pu-erh tea. Further, the aroma recombination and omission tests were performed, and the results demonstrated that 2-methylbutyric acid, acetic acid, 4-methyl-3-penten-2-one, Et isobutyrate, nonanoic acid, and phenylacetic acid exhibited relatively high aroma intensities (AI) and OAVs among the 12 odor-active compounds that were detected in the fermented soybean-like cup aroma. The aroma recombination, which was performed employing the 12 odorants with AI ≥1 successfully mimicked the overall aroma profile of the fermented soybean-like cup aroma. The omission test revealed that 2-methylbutyric acid contributed significantly to the fermented soybean-like cup aroma. And the enantiomeric ratio (ER) of the (S)- to (R)-forms of 2-methylbutyric acid was 67:33.

LWT–Food Science and Technology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Product Details of C10H18O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nannini, Giulia published the artcileFecal metabolomic profiles: a comparative study of patients with colorectal cancer vs adenomatous polyps, COA of Formula: C8H8O3, the publication is World Journal of Gastroenterology (2021), 27(38), 6430-6441, database is CAplus and MEDLINE.

BACKGROUND Colorectal cancer (CRC), the third most common cause of death in both males and females worldwide, shows a pos. response to therapy and usually a better prognosis when detected at an early stage. However, the survival rate declines when the diagnosis is late and the tumor spreads to other organs. Currently, the measures widely used in the clinic are fecal occult blood test and evaluation of serum tumor markers, but the lack of sensitivity and specificity of these markers restricts their use for CRC diagnosis. Due to its high sensitivity and precision, colonoscopy is currently the gold-standard screening technique for CRC, but it is a costly and invasive procedure. Therefore, the implementation of custom-made methodologies including those with minimal invasiveness, protection, and reproducibility is highly desirable. With regard to other screening methods, the screening of fecal samples has several benefits, and metabolomics is a successful method to classify the metabolite shift in living systems as a reaction to pathophysiol. influences, genetic modifications, and environmental factors. AIM To characterize the variation groups and potentially recognize some diagnostic markers, we compared with healthy controls (HCs) the fecal NMR (NMR) metabolomic profiles of patients with CRC or adenomatous polyposis (AP). METHODS Proton NMR spectroscopy was used in combination with multivariate and univariate statistical approaches, to define the fecal metabolic profiles of 32 CRC patients, 16 AP patients, and 38 HCs well matched in age, sex, and body mass index. RESULTS NMR metabolomic analyses revealed that fecal sample profiles differed among CRC patients, AP patients, and HCs, and some discriminatory metabolites including acetate, butyrate, propionate, 3-hydroxyphenylacetic acid, valine, tyrosine and leucine were identified. CONCLUSION In conclusion, we are confident that our data can be a forerunner for future studies on CRC management, especially the diagnosis and evaluation of the effectiveness of treatments.

World Journal of Gastroenterology published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, COA of Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Schmidt, Sebastian F. M. published the artcileSMM behaviour and magnetocaloric effect in heterometallic 3d-4f coordination clusters with high azide : metal ratios, Recommanded Product: Triisopropanolamine, the publication is Dalton Transactions (2017), 46(45), 15661-15665, database is CAplus and MEDLINE.

The authors present the synthesis and characterization of heterometallic compounds with a very large azide to metal ratio, (TBA)₃[Fe₃Gd₂(N₃)₁₅(OH)₃(tipaH₃)₂] (1) and (TBA)₂[Mn₄Dy₂(N₃)₁₂(teaH₂)₄] (2) (TBA = tetrabutylammonium, tipaH₃ = triisopropanolamine, teaH₃ = triethanolamine). Their interesting structures give rise to fascinating magnetic properties.

Dalton Transactions published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Recommanded Product: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Driess, Matthias published the artcileSynthesis and structure of siloxy-substituted ZnO aggregates having (ZnO)_n (n = 2, 4) and Zn₃O₄ cores, Application of Triisopropylsilanol, the publication is European Journal of Inorganic Chemistry (2000), 2517-2522, database is CAplus.

Convenient syntheses and x-ray crystallog. characterizations of the first bis(trimethylsilyl)amido-, Me-, and iodozinc triorganosiloxide aggregates 1–5 are described. They are accessible by the simple reaction of ZnR’₂ [R = Me, N(SiMe₃)₂] with the resp. silanols R₃SiOH (R = Me, Et, iPr), which affords the dimeric [(Me₃Si)₂NZnOSiR₃]₂ (1a: R = iPr; 1b: R = Et), trinuclear [(MeZn)₂Zn(OSiPrⁱ₃)₄] (2a), {[(Me₃Si)₂NZn]₂Zn(OSiR₃)₄} (2b: R = Et; 2c: R = Me), and tetranuclear heterocubanes [MeZnOSiR₃]₄ (3a: R = Me; 3b: R = Et), resp. The latter were oxidized with four equivalent of elemental I₂ to form the tetraiodo derivatives [IZnOSiR₃]₄ (4a: R = Me; 4b: R = Et) in 82 and 88% yield, resp. Due to the higher polarity of the Zn-I vs. Zn-C σ-bond, the Zn-O distances of the almost regular Zn₄O₄ core in 4a are 2-6 pm shorter than those observed in the less Lewis-acidic cluster 3b. However, the Zn-O distances in 3b and 4a are ∼10-15 pm longer than those in 1a, 2a, and 2c, due to different coordination numbers at Zn and the effects of ring strain. Remarkably, the iodo derivatives 4a,b undergo dissociation in THF to give the resp. dimeric THF solvates [IZn(THF)OSiR₃]₂ (5a: R = Me; 5b: R = Et), whereas the Zn₄O₄ cores in 3a and 3b are retained even in aprotic polar solvents.

European Journal of Inorganic Chemistry published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Application of Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Odoardi, Sara published the artcileMetabolism study and toxicological determination of mephtetramine in biological samples by liquid chromatography coupled with high-resolution mass spectrometry, Recommanded Product: 1-Hydroxy-2-naphthoic acid, the publication is Drug Testing and Analysis (2021), 13(8), 1516-1526, database is CAplus and MEDLINE.

The emerging market of new psychoactive substances (NPSs) is a global-scale phenomenon, and their identification in biol. samples is challenging because of the lack of information about their metabolism and pharmacokinetic. In this study, we performed in silico metabolic pathway prediction and in vivo metabolism experiments, in order to identify the main metabolites of mephtetramine (MTTA), an NPS found in seizures since 2013. MetaSite software was used for in silico metabolism predictions and subsequently the presence of metabolites in the blood, urine, and hair of mice after MTTA administration was verified. The biol. samples were analyzed by liquid chromatog. coupled with high-resolution mass spectrometry (LC-HRMS) using a benchtop Orbitrap instrument. This confirmed the concordance between software prediction and exptl. results in biol. samples. The metabolites were identified by their accurate masses and fragmentation patterns. LC-HRMS anal. identified the dehydrogenated and demethylated-dehydrogenated metabolites, together with unmodified MTTA in the blood samples. Besides unmodified MTTA, 10 main metabolites were detected in urine. In hair samples, only demethyl MTTA was detected along with MTTA. The combination of Metasite prediction and in vivo experiment was a powerful tool for studying MTTA metabolism This approach enabled the development of the anal. method for the detection of MTTA and its main metabolites in biol. samples. The development of anal. methods for the identification of new drugs and their main metabolites is extremely useful for the detection of NPS in biol. specimens. Indeed, high throughput methods are precious to uncover the actual extent of use of NPS and their toxicity.

Drug Testing and Analysis published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Recommanded Product: 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts