Tag: M.W=150-200

Osman, Maged A. published the artcileEpoxy-Layered Silicate Nanocomposites and Their Gas Permeation Properties, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Macromolecules (2004), 37(19), 7250-7257, database is CAplus.

Epoxy-OM (organo-montmorillonite) nanocomposites have been synthesized, and their permeability to oxygen and water vapor has been measured. The chem. structure of the organic monolayer ionically bonded to the montmorillonite surface has been varied, and its influence on the swelling, intercalation, and exfoliation behavior of the OM has been studied. Exfoliated aluminosilicate layers build a barrier for the permeating gas mols., while the polymer intercalated tactoids do not contribute much to the permeation barrier performance. The gas permeation through the composites was correlated to the volume fraction of the impermeable inorganic part of the OM. The incorporation of small volume fractions of the platelike nanoparticles in the polymer matrix decreased its permeability coefficient when the interface between the two heterogeneous phases was properly designed. Long alkyl chains enhanced the polymer intercalation but increased the permeability coefficient probably due to phase separation at the interface between the polymer and the inclusions. Matching the surface energy of the OM with that of the matrix as well as tethering polymer mols. to the silicate layers surface enhanced the exfoliation and decreased the permeation coefficient The exfoliation process is governed by interplay of entropic and energetic factors. A macroscopic volume average of the aspect ratio of montmorillonite platelets was deducted from the relative permeability of the nanocomposites by comparing the measured values to numerical predictions of gas permeation through composites of misaligned disk-shaped inclusions. The permeability coefficient of the epoxy matrix was reduced to one-fourth at 5 vol % Bz1OH loading, and the reduction was attributed to the tortuous pathway the gas mols. have to cover during their random walk to penetrate the composite. The transmission rate of water vapor through the composites is more influenced by the permeant-composite interactions and hence the hydrophobicity of the monolayer covering the inclusions surface. At 5 vol % BzC16 loading, the relative vapor transmission rate was reduced to half.

Macromolecules published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Irie, Raku published the artcileStructure Revision of Protoaculeine B, a Post-translationally Modified N-Terminal Residue in the Peptide Toxin Aculeine B, Name: 4,4-Diethoxybutan-1-amine, the publication is Journal of Natural Products (2021), 84(4), 1203-1209, database is CAplus and MEDLINE.

The structure of protoaculeine B, the N-terminal residue of the marine peptide toxin aculeine B, is revised to the cis-1,3-disubstituted tetrahydro-β-carboline framework. We prepared two truncated model compounds that lack a long-chain polyamine using the one-step Pictet-Spengler reaction of tryptophan and compared their NMR, mass spectra, and chem. reactivity with those of the natural protoaculeine B. The synthetic models reproduced the profiles of the natural product well, which confirmed the appropriateness of the structure revision.

Journal of Natural Products published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Name: 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Miyoshi, Norikazu published the artcilePractical method for hydroxyl-group protection using strontium metal and readily available silyl chlorides, Category: alcohols-buliding-blocks, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(43), 6312-6315, database is CAplus and MEDLINE.

Smooth O-silylation of secondary aliphatic alcs. R¹CH(OH)R² was achieved by coupling with silyl chlorides R₃SiCl (R₃ = ^tBuMe₂, Et₃, ⁱPr₃, ^tBuPh₂, Ph₃) promoted by strontium metal in DMA, instead of use the expensive, yet more reactive, and commonly used silyl triflate. The reaction occurred almost completely with various alcs., giving silyl ethers R¹CH(OSiR₃)R².

Chemical Communications (Cambridge, United Kingdom) published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Haga, Yuji published the artcileDiscovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Bioorganic & Medicinal Chemistry (2011), 19(2), 883-893, database is CAplus and MEDLINE.

The design, synthesis and structure-activity relationships of a novel class of N-phenylpyridone MCH1R antagonists are described. The core part of the N-phenylpyridone structure was newly designed and the side chain moieties that were attached to the core part were extensively explored. As a result of optimization of the N-phenylpyridone leads, we successfully developed the orally available, and brain-penetrable MCH1R selective antagonist 7c (I), exhibiting excellent anti-obese effect in diet-induced obese (DIO) mice.

Bioorganic & Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Stojanovic, Nikola M. published the artcileLemon balm (Melissa officinalis L.) essential oil and citronellal modulate anxiety-related symptoms – In vitro and in vivo studies, Application of cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Journal of Ethnopharmacology (2022), 114788, database is CAplus and MEDLINE.

Besides psyche-related symptoms, patients with anxiety disorders can have a large number of somatic symptoms as well. Although the treatment of these disorders is mainly focused on resolving their mental component, one cannot neglect the need for the treatment of accompanying somatic symptoms. Melissa officinalis L. (lemon balm), in various formulations, has been extensively used as an ethnomedicinal remedy for the treatment of different psyche-related symptoms, and its use is considered relatively safe. Aim of the study: In the present study, the activity of M. officinalis (MO) essential oil was evaluated in several in vitro and in vivo models mimicking or involving anxiety-related somatic symptoms. To address the effect of MO essential oil on the gastrointestinal and heart-related symptoms accompanying anxiety disorders, in vitro models were utilized that follow the function of the isolated mouse ileum and atria tissues, resp., after exposure to MO essential oil. Effects of MO essential oil on BALB/c mice motor activity was estimated using the open field, rota-rod, and horizontal wire tests. Addnl., the essential oil was assayed for its potential in inhibiting acetylcholinesterase activity. The performance of mice treated with 25 mg/kg of the oil showed a statistically significant decrease in the motor impairment arising from acute anxiety (open field test), while there was a prolonged latency and a reduction of the frequency of falling from a rotating rod and/or a horizontal wire (signs of muscle weakness/spasms). Concentrations of the essential oil higher than 1 μg/mL were found to inhibit both spontaneous and induced ileum contractions. Moreover, the essential oil and citronellal were found to decrease isolated mouse atria contraction frequency, as well as contraction force. However, the oil was found to be a very weak acetylcholinesterase inhibitor. The modulation of anxiety-related symptoms by the oil was found not to be mediated through the inhibition of the acetylcholinesterase, nonetheless, the mechanistic studies involving the ileum and cardiac tissues, revealed that the activity of MO and citronellal might be related to the modification of either voltage-gated Ca2+ channels or muscarinic receptors. Mice locomotion, balance, and muscle strength were not impacted by the essential oil; however, its main constituent, citronellal, was found to exert a certain degree of muscle function inhibition. All these results suggest that the activity of MO essential oil arises from synergistic and/or antagonistic interactions of its constituents, and is not completely dependent on the oil main constituent.

Journal of Ethnopharmacology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C9H9NO, Application of cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Rui published the artcileFluorometric/electrochemical dual-channel sensors based on carbon quantum dots for the detection and information anti-counterfeiting, Synthetic Route of 90-64-2, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (2022), 114118, database is CAplus.

Sensors used to detect Fe³⁺ and Cys are generally a single method. In this work, two methods of fluorescence and electrochem. are innovatively combined to detect Fe³⁺ and Cys, and the obtained Lod is basically the same. Carbon quantum dots (CQDs) with blue fluorescence were successfully prepared by hydrothermal methods using tryptophan (Trp) as carbon source, which can be used for fluorescence and electrochem. dual-channel probe quickly detecting iron ion (Fe³⁺) and cysteine (Cys). A series of studies have been carried out on its morphol., chem. structure, and optical properties through TEM, XRD, FT-IR, XPS, UV-vis absorption spectrum, and photoluminescence spectra. And the quantum yield of CQDs was up to 52.64%. It was also analyzed in the real sample, demonstrating the feasibility and reliability of detecting Fe³⁺ and Cys in the real sample. Furthermore, CQDs can also be used as fluorescent ink for information anti-counterfeiting due to their excellent fluorescent properties.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C5H10O2S, Synthetic Route of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sheykhan, Mehdi published the artcileNovel access to carbonyl and acetylated compounds: the role of the tetra-n-butylammonium bromide/sodium nitrite catalyst, HPLC of Formula: 101-98-4, the publication is RSC Advances (2016), 6(56), 51347-51355, database is CAplus.

A novel aerobic oxidation of alcs. ArCH(OH)R (Ar = C₆H₅, 2-O₂N-3-CH₃-C₆H₃, 2-carbaldehydefuran-5-yl, etc.; R = H, CH₃) without the use of any oxidants was developed. An equimolar catalytic mixture of tetra-n-butylammonium bromide and sodium nitrite catalyzes the aerobic selective oxidation of benzylic alcs. under oxidant-free, base-free and metal-free conditions. The mild reaction conditions allow oxidation of a wide range of benzylic alcs., chemo-selectively to their carbonyl compounds ArC(O)R (68-93% isolated yields). More importantly, high selectivity among different kinds of alcs. (aromatic vs. aliphatic alcs., primary vs. secondary alcs. as well as alcs. having neutral rings vs. electron-deficient rings) is available by this approach. The method surprisingly switched over to be an efficient acetylation approach in the case of aliphatic alcs. without the use of any transition metal, phosphorus or other toxic reagents or any need for using toxic acyl halides, sulfonyl halides, anhydrides, etc. by the use of only acetic acid as a reagent.

RSC Advances published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C16H24BF4Ir, HPLC of Formula: 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nelson, Jade D. published the artcilePhoto-induced ring expansion of 1-triisopropylsilyloxy-1-azidocyclohexane: preparation of ε-caprolactam, Recommanded Product: Triisopropylsilanol, the publication is Organic Syntheses (2003), 165-175, database is CAplus.

The synthesis of lactams has attracted considerable attention in recent years. Despite the wide range of methodologies that have been examined for the synthesis of lactams, the Beckmann and Schmidt rearrangements still remain by far the most convenient and general methods. The strongly acidic conditions required for the Schmidt rearrangement often lead to undesired byproducts. This is a major limitation particularly with acid-labile substrates. A convenient and environmentally benign Schmidt rearrangement is reported in which the azidohydrin is prepared using a recyclable acid catalyst and trimethylsilyl azide. Photolysis of the azidocyclohexane results in the ring expansion, probably through the formation of a reactive nitrene. The byproducts from this reaction are gases or innocuous silanes. The main limitation with the method is that at present the ring expansion is not regioselective.

Organic Syntheses published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Recommanded Product: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Khajavi-Shojaei, Shila published the artcileBiodegradation and phytotoxicity assessment of phenanthrene by biosurfactant-producing Bacillus pumilus 1529 bacteria, Product Details of C11H8O3, the publication is Chemistry and Ecology (2020), 36(5), 396-409, database is CAplus.

Phenanthrene is a toxic and mutagenic pollutant that can cause severe environmental and human health issues. The bioremediation of these polyaromatic hydrocarbons (PAHs) is possible with a biosurfactant by enhancing hydrophobicity. In this study, the production of a biosurfactant by Bacillus pumilus 1529 and its effects on the phenanthrene biodegradation pathway were examined Biosurfactant production was determined using hemolytic activity, emulsification index, and surface tension. For phenanthrene metabolite detection, samples at 0, 7, 14, and 21 incubation days were analyzed by gas chromatog.-mass (GC-mass) spectrometry. The results showed that Bacillus pumilus 1529 can reduce surface tension to 22.83 ± 1.1 mN m-1. Furthermore, the GC-mass spectrometry anal. showed that 1-hydroxy-2-naphthoic acid, benzaldehyde, o-phthalic acid, and phenylacetic acid were notable phenanthrene metabolites produced during phenanthrene biodegradation Biodegraded phenanthrene and its metabolites have a less toxic effect on the germination of safflower seeds than non-biodegraded phenanthrene. The IC50 of phenanthrene on seed germination after biodegradation was increased to approx. 113 mg L-1. In general, biodegradation aided by biosurfactant producing bacteria contributed to turning the toxic phenanthrene into less harmful metabolites with lower phytotoxicity effects, indicating that its application in the bioremediation of PAHs is promising.

Chemistry and Ecology published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Product Details of C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kinosita, Yoshiaki published the artcileMotile ghosts of the halophilic archaeon, Haloferax volcanii, Application of Triisopropanolamine, the publication is Proceedings of the National Academy of Sciences of the United States of America (2020), 117(43), 26766-26772, database is CAplus and MEDLINE.

Archaea swim using the archaellum (archaeal flagellum), a reversible rotary motor consisting of a torque-generating motor and a helical filament, which acts as a propeller. Unlike the bacterial flagellar motor (BFM), ATP (adenosine-5a²-triphosphate) hydrolysis probably drives both motor rotation and filamentous assembly in the archaellum. However, direct evidence is still lacking due to the lack of a versatile model system. Here, we present a membrane-permeabilized ghost system that enables the manipulation of intracellular contents, analogous to the triton model in eukaryotic flagella and gliding Mycoplasma. We observed high nucleotide selectivity for ATP driving motor rotation, neg. cooperativity in ATP hydrolysis, and the energetic requirement for at least 12 ATP mols. to be hydrolyzed per revolution of the motor. The response regulator CheY increased motor switching from counterclockwise (CCW) to clockwise (CW) rotation. Finally, we constructed the torque-speed curve at various [ATP]s and discuss rotary models in which the archaellum has characteristics of both the BFM and F1-ATPase. Because archaea share similar cell division and chemotaxis machinery with other domains of life, our ghost model will be an important tool for the exploration of the universality, diversity, and evolution of biomol. machinery.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Application of Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts