Tag: M.W=150-200

Zhang, Feng published the artcileSynthetic studies towards atkamine, Product Details of C8H19NO2, the publication is Chinese Chemical Letters (2021), 32(2), 668-671, database is CAplus.

Atkamine (I) is a complex marine pyrroloiminoquinone alkaloid that comprises a heptacyclic scaffold bearing five different heterocycles and four contiguous stereocenters, and therefore it is a highly challenging target for synthetic chemists. We herein reported a modular synthetic strategy toward this alkaloid, featuring a formal [5 + 2] annulation and an asym. Michael addition The efficient synthesis of the long-chain aliphatic aldehyde and chiral amino acetal fragments have been achieved. A simplified tetracyclic intermediate bearing the core structure of atkamine has been successfully constructed through the formal [5 + 2] annulation.

Chinese Chemical Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H8O2, Product Details of C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Asadov, Ziyafaddin H. published the artcileEffects of head group on the properties of cationic surfactants containing hydroxyethyl- and hydroxyisopropyl fragments, SDS of cas: 122-20-3, the publication is Journal of Molecular Liquids (2019), 125-132, database is CAplus.

Cationic surfactants containing different head-groups have been synthesized by interaction of tetradecyl bromide and amines having hydroxyalkyl group (monoethanolamine, diethanolamine, triethanolamine, methylethanolamine, methyldiethanolamine, diethanolisopropanolamine, ethanoldiisopropanolamine, triisopropanolamine). Surfactivity parameters of the synthesized cationic surfactants have been determined by measurements of surface tension and electroconductance. The character of change of the colloidal-chem. parameters with an increase of the number of hydroxyethyl and hydroxyisopropyl groups in the head-group of the cationic surfactants has been established. The synthesized cationic surfactants possess effective antibacterial and antifungal properties.

Journal of Molecular Liquids published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, SDS of cas: 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tomas-Navarro, Maria published the artcileNovel urinary biomarkers of orange juice consumption, interindividual variability, and differences with processing methods, Formula: C8H8O3, the publication is Journal of Agricultural and Food Chemistry (2021), 69(13), 4006-4017, database is CAplus and MEDLINE.

Untargeted metabolomics identified urinary biomarkers able to discriminate between the intake of fresh hand-squeezed and industrially processed orange juices. Processing led to an upregulation in the excretion of hydroxy-polymethoxyflavone sulfates, abscisic acid, and sinapic acid 4′-glucuronide. The demethylated polymethoxyflavone metabolites were produced with a significant interindividual variability suggesting that they could originate from gut microbiota metabolism No correlation between the excretion levels of flavanone and polymethoxyflavone metabolites was observed, showing that gut microbiota metabolism differences could be behind the interindividual variability. Subjects with a high excretion level of hesperetin conjugates could be low or high polymethoxyflavone excretors. Flavanone phase II metabolites were primarily glucuronides, while those of demethylated polymethoxyflavones were mainly sulfates. A comparative study with the available demethylated polymethoxyflavone standards suggested that the metabolites produced in humans could be tentatively 4′-hydroxy- and/or 3′-hydroxy-polymethoxyflavone sulfates. This study is the first to describe the bioavailability and metabolism of citrus juice polymethoxyflavones in humans.

Journal of Agricultural and Food Chemistry published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C11H10N4, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Park, Hwalkee published the artcileA novel morpholine-based rhodamine fluorescent chemosensor for the rapid detection of Hg²⁺ ions, Quality Control of 27292-49-5, the publication is Journal of Nanoscience and Nanotechnology (2019), 19(11), 6893-6898, database is CAplus and MEDLINE.

A novel rhodamine-based receptor bearing a morpholine (RDM) was developed as a fluorescent chemosensor with high selectivity toward Hg²⁺. After the addition of Hg²⁺ to RDM, the color of the solution changed from colorless to pink, and the new absorption band appears at 580 nm. The fluorescent of RDM appears to orange color in the presence of Hg²⁺. Upon the addition of Hg²⁺, ring-opening of the corresponding spirolactam gives rise to fluorescence, and a 1:1 metal-ligand complex formed.

Journal of Nanoscience and Nanotechnology published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Quality Control of 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shen, Xiao published the artcileAlkyl Aryl Ether Bond Formation with PhenoFluor, COA of Formula: C10H13NO2, the publication is Angewandte Chemie, International Edition (2015), 54(19), 5662-5665, database is CAplus and MEDLINE.

An alkyl aryl ether bond formation reaction between phenols and primary and secondary alcs. with PhenoFluor has been developed. The reaction features a broad substrate scope and tolerates many functional groups, and substrates that are challenging for more conventional ether bond forming processes may be coupled. A preliminary mechanistic study indicates reactivity distinct from conventional ether bond formation.

Angewandte Chemie, International Edition published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C8H10S, COA of Formula: C10H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Xiao-Feng published the artcileA General and Efficient Palladium-Catalyzed Alkoxycarbonylation of Phenols To Form Esters through In Situ Formed Aryl Nonaflates, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol, the publication is Chemistry – A European Journal (2012), 18(13), 3831-3834, S3831/1-S3831/27, database is CAplus and MEDLINE.

A novel process for the palladium catalyzed alkoxycarbonylation of phenols is presented. Activation of the phenols occurs via convenient in situ generation of aryl nonaflates. Electron-withdrawing or electron-donating substituents on the aryl or ester moiety are tolerated amongst the varied functional groups. Notably, not only homoesterification, but also cross-coupling of two different phenols (alcs.) are possible under these conditions.

Chemistry – A European Journal published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C22H18O2, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Patel, Jayendra Z. published the artcileOptimization of 1,2,5-Thiadiazole Carbamates as Potent and Selective ABHD6 Inhibitors, Product Details of C6H9N3O2S, the publication is ChemMedChem (2015), 10(2), 253-265, database is CAplus and MEDLINE.

At present, inhibitors of α/β-hydrolase domain 6 (ABHD6) are viewed as a promising approach to treat inflammation and metabolic disorders. This article describes the development of 1,2,5-thiadiazole carbamates as ABHD6 inhibitors. Altogether, 34 compounds were synthesized, and their inhibitory activity was tested using lysates of HEK293 cells transiently expressing human ABHD6 (hABHD6). Among the compound series, 4-morpholino-1,2,5-thiadiazol-3-yl cyclooctyl(methyl)carbamate I (JZP-430) potently and irreversibly inhibited hABHD6 (IC₅₀=44 nM) and showed ∼230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL), the main off-targets of related compounds Addnl., activity-based protein profiling indicated that I displays good selectivity among the serine hydrolases of the mouse brain membrane proteome. I has been identified as a highly selective, irreversible inhibitor of hABHD6, which may provide a novel approach in the treatment of obesity and type II diabetes.

ChemMedChem published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C6H9N3O2S, Product Details of C6H9N3O2S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Guo-Ying published the artcileApplication of Fragment-Based Drug Discovery against DNA Gyrase B, SDS of cas: 23351-09-9, the publication is ChemPlusChem (2015), 80(8), 1250-1254, database is CAplus and MEDLINE.

Bacterial resistance to antibiotics remains a serious threat to global health. The gyrase B enzyme is a well-validated target for developing antibacterial drugs. Despite being an attractive target for antibiotic development, there are currently no gyrase B inhibitory drugs on the market. A fragment screen using 1,800 compounds identified 14 fragments that bind to Escherichia coli (E. coli) gyrase B. The detailed characterization of binding is described for all 14 fragments. With the aid of X-ray crystallog., modifications on a low-affinity fragment (K_D=253 μΜ, IC₅₀=634 μΜ) has led to the development of a new class of potent Ph aminopyrazole inhibitors against E. coli gyrase B (IC₅₀=160 nΜ). The study presented here combines the use of a set of biophys. techniques including differential scanning fluorimetry, NMR, isothermal titration calorimetry, and X-ray crystallog. to methodically identify, quantify, and optimize fragments into new chem. leads.

ChemPlusChem published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, SDS of cas: 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Williamson, Alice E. published the artcileRapid Generation of Complex Molecular Architectures by a Catalytic Enantioselective Dearomatization Strategy, Application In Synthesis of 6346-09-4, the publication is Synlett (2016), 27(1), 116-120, database is CAplus.

A catalytic enantioselective dearomatization strategy can be used to convert readily assembled phenols into complex polycyclic architectures. By combining oxidative dearomatization of phenols bearing a pendent nucleophile with enantioselective secondary amine catalysis, high enantiomeric excesses were obtained for the natural product-like products.

Synlett published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C17H14F3N3O2S, Application In Synthesis of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nakamura, Itaru published the artcileThermally induced [2+2] cycloadditions of (benzyloxymethylene)cyclopropane with alkylidenemalononitriles, Computed Properties of 50915-29-2, the publication is European Journal of Organic Chemistry (2007), 4479-4482, database is CAplus.

The reaction of [(benzyloxy)methylene]cyclopropane (I) with alkylidenemalononitriles at ambient pressure afforded the corresponding spiro cyclobutane derivatives in good to high yields. For example, the reaction of I with benzylidenemalononitrile, [(2-naphthyl)methylene]malononitrile, and (tert-butylmethylene)malononitrile in acetonitrile at 80 °C gave the corresponding spiro[2.3]hexanes in 96, 96, and 91% yields, resp. Control experiments proved that the reaction proceeds via a well-stabilized zwitterionic intermediate.

European Journal of Organic Chemistry published new progress about 50915-29-2. 50915-29-2 belongs to alcohols-buliding-blocks, auxiliary class Cyclopropanes, name is (1-Bromocyclopropyl)methanol, and the molecular formula is C4H7BrO, Computed Properties of 50915-29-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts