Tag: M.W=150-200

Zhou, Dejian; Li, Peipei; Dong, Zhe; Wang, Teng; Sun, Kunlai; Zhao, Yuqin; Wang, Bin; Chen, Yin published the artcile< Structure and immunoregulatory activity of β-D-galactofuranose-containing polysaccharides from the medicinal fungus Shiraia bambusicola>, SDS of cas: 3458-28-4, the main research area is galactofuranose polysaccharide immunoregulation macrophage Shiraia; Galactofuranose; Macrophages; Medical fungi; Polysaccharide; Structure.

To explore bioactive polysaccharides from medicinal fungi, a homogeneous heteropolysaccharide SB1-1 was extracted from the stroma of Shiraia bambusicola by enzyme assisted extraction, ethanol precipitation, anion-exchange and size-exclusion chromatogs. Chem. and spectroscopic analyses showed that SB1-1 was a neutral polysaccharide composed of mannose, glucose and galactose at a molar ratio of 1.1:1.9:1.0, and had a mol. weight of 18.3 kDa. SB1-1 was composed of a mannan core and glucose and galactose side chains. The mannan core was composed of (1 → 2)-α-Manp substituted by the side chains (1 → 6)-α-D-Manp, (1 → 4)- α-D-Glcp and (1 → 6)-α-D-Glcp with different ds.p. at the C-6. The galactose side chains had the backbone of (1 → 6)-β-D-Galf. There were two branch sites on every five sugars on average at the O-2 of →6)-β–Galf(1→, and the branches consisted of (→2)-β-D-Galf(1→ and terminal β-D-Galf) 1→. The potential immunomodulatory activities of SB1-1 on RAW264.7 macrophages were investigated. The results showed that SB1-1 could activate macrophage and significantly improve its phagocytic ability by neutral red uptake assay. Addnl., SB1-1 enhanced the productions of IL-1, IL-6, IL-12 and TNF-α in the RAW264.7 macrophages by stimulation of SB1-1, while significantly increased the production of inducible nitric oxide synthase (iNOS) production This study demonstrated that the galactofuranose-containing polysaccharide SB1-1 from S. bambusicola which is a novel mannogalactoglucan, could enhance the activation of macrophages.

International Journal of Biological Macromolecules published new progress about Acid hydrolysis. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, SDS of cas: 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fakhfakh, Jawhar; Athmouni, Khaled; Mallek-Fakhfakh, Hanen; Ayedi, Habib; Allouche, Noureddine published the artcile< Polysaccharide from Lycium arabicum: Structural Features, in Vitro Antioxidant Activities and Protective Effect against Oxidative Damage in Human Erythrocytes>, Product Details of C6H12O6, the main research area is Lycium polysaccharide antioxidant erythrocyte; Lycium arabicum; antioxidant potential; human erythrocytes; polysaccharide.

In this research work, a water-soluble polysaccharide (LAP) isolated from the fruits of Lycium arabicum was investigated. LAP contains carbohydrates (82.45±1.23%), protein (1.56±0.21%), and uronic acids (3.56±0.34%). The anal. of the monosaccharide composition revealed the presence of rhamnose, arabinose, galactose, glucose and mannose in a molar ratio of 4.7 : 1.5 : 1 : 8.7 : 16.4 : 5.6. The extracted polysaccharide (PS) was considered as heterogeneous and highly branched by interpreting its GC/MS, FT-IR and NMR data. Crystallinity of LAP was inferred from its X-ray diffractometry (XRD) and SEM (SEM) anal. LAP exhibited an interesting stability at high temperatures (∼254°C) and in a wide range of pH (3-9) deduced, resp., from its DSC and zeta potential anal. LAP displayed a strong antioxidant activity at low concentrations evaluated by the 2,2-diphenyl-1-picrylhydrazyl (DPPH)-radical scavenging, ferric reducing activity power (FRAP), free radical scavenging ability, superoxide radical-scavenging and hydroxyl radical-scavenging abilities. Inhibition of erythrocyte hemolysis and lipid peroxidation was also assessed. In 5 h, LAP treatment allowed the protection of the damaged erythrocytes caused by AAPH (2,2-azobis(2-amidinopropane) dihydrochloride), to reduce the level of malondialdehyde (MDA) as well as to increase the reduced glutathione (GSH) level.

Chemistry & Biodiversity published new progress about Antioxidants. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kang, Suyoung; Yan, Han; Zhu, Yin; Liu, Xu; Lv, Hai-Peng; Zhang, Yue; Dai, Wei-Dong; Guo, Li; Tan, Jun-Feng; Peng, Qun-Hua; Lin, Zhi published the artcile< Identification and quantification of key odorants in the world's four most famous black teas>, Application In Synthesis of 78-70-6, the main research area is odorant black tea gas chromatog mass spectrometry; Black teas; GC-O; GC × GC-TOFMS; Key odorants; OAV.

Keemun, Assam, Darjeeling and Ceylon black teas are honored as the world’s four most famous black teas, and their excellent aroma qualities are well received by people around the world. In this study, aroma components in these four types of teas were analyzed by comprehensive two-dimensional gas chromatog. time-of-flight mass spectrometry (GC × GC-TOFMS) and gas chromatog.-olfactometry (GC-O) technologies. A total of 42 aroma-active compounds were ultimately identified, especially benzeneacetaldehyde, geraniol, (Z)-3-hexen-1-yl hexanoate, trans-β-ionone, cis-linalool oxide (pyranoid), hotrienol, and Me salicylate presented the strongest aroma strengths with pleasant scents in all tested teas. The quantification results indicated that 19 compounds including (Z)-3-hexenol, 1-octen-3-ol, linalool, phenylethyl alc., hexanal, benzeneacetaldehyde, limonene, heptanoic acid, (Z)-3-hexen-1-ol, acetate, benzyl alc., trans-linalool oxide (furanoid), hotrienol, 1-octen-3-one, 2-nonanone, (E)-2-octenal, nonanal, β-myrcene, 2-pentylfuran, and methylpyrazine were identified as the key compounds with odor activity values (OAVs) higher than 1.0 in the world’s four most famous black teas. Notably, the comparison of GC-O and OAV calculation results showed that Me salicylate (Ceylon), (E)-2-octenal (Assam), benzeneacetaldehyde (Keemun) and linalool and trans-linalool oxide (furanoid) (Darjeeling) might be the most definitive odorants in the corresponding tea categories.

Food Research International published new progress about Black tea beverages. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Application In Synthesis of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Duan, Xiaohui; Zhang, Mina; Du, Huan; Gu, Xiu; Bai, Caihong; Zhang, Liuqiang; Chen, Kaixian; Hu, Kaifeng; Li, Yiming published the artcile< Effect of Different Processing Methods on the Chemical Constituents of Scrophulariae Radix as Revealed by 2D NMR-Based Metabolomics>, Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, the main research area is Scrophularia metabolomics steaming chem markers; 2D NMR; Scrophulariae Radix; chemical markers; processing methods; “sweating” processing.

Scrophulariae Radix (SR) is one of the oldest and most frequently used Chinese herbs for oriental medicine in China. Before clin. use, the SR should be processed using different methods after harvest, such as steaming, “”sweating””, and traditional fire-drying. In order to investigate the difference in chem. constituents using different processing methods, the two-dimensional (2D) 1H-13C heteronuclear single quantum correlation (1H-13C HSQC)-based metabolomics approach was applied to extensively characterize the difference in the chem. components in the extracts of SR processed using different processing methods. In total, 20 compounds were identified as potential chem. markers that changed significantly with different steaming durations. Seven compounds can be used as potential chem. markers to differentiate processing by sweating, hot-air drying, and steaming for 4 h. These findings could elucidate the change of chem. constituents of the processed SR and provide a guide for the processing. In addition, our protocol may represent a general approach to characterizing chem. compounds of traditional Chinese medicine (TCM) and therefore might be considered as a promising approach to exploring the scientific basis of traditional processing of TCM.

Molecules published new progress about Amino acids Role: ANT (Analyte), BSU (Biological Study, Unclassified), PUR (Purification or Recovery), THU (Therapeutic Use), ANST (Analytical Study), BIOL (Biological Study), PREP (Preparation), USES (Uses). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gao, Yuan; Wang, Gang-Qiang; Wei, Kun; Hai, Ping; Wang, Fei; Liu, Ji-Kai published the artcile< Isolation and biomimetic synthesis of (±)-guajadial B, a novel meroterpenoid from Psidium guajava>, Electric Literature of 4396-13-8, the main research area is guajadial B Psidium.

(±)-Guajadial B (I), an unusual humulene-based meroterpenoid, was isolated as a racemate from the leaves of Psidium guajava, collected from Vietnam. The structure of this novel secondary metabolite was established on the basis of extensive anal. of NMR spectra and confirmed by biomimetic synthesis in a domino three-component coupling reaction.

Organic Letters published new progress about Guava. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Electric Literature of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shi, Xiao-Dan; Yin, Jun-Yi; Zhang, Liu-Jing; Huang, Xiao-Jun; Nie, Shao-Ping published the artcile< Studies on O-acetyl-glucomannans from Amorphophallus species: Comparison of physicochemical properties and primary structures>, Name: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Amorphophallus O acetylglucomannan physicochem property primary structure.

Plants in Amorphophallus genus are rich in soluble dietary fibers and have long been used as food and traditional medicine in Asian countries. In the present investigation, natural O-acetyl-glucomannans were extracted from tubers of Amorphophallus rivirei (konjac), A. albus and two local types of A. bulbifer (wild type M and wild type B), which were designated as KGM, AGM, MGM, and BGM, successively. Comparative studies were conducted on their physicochem. properties and primary structures. The four AcGMs had about 90% (weight/weight) neutral sugar, 11% (weight/weight) moisture, and 1%-2% (weight/weight) ash. Relatively high contents of acetyl groups (17%-24%, weight/weight) were detected. Mannose and glucose as the main components existed in molar ratios of 1.41, 1.41, 1.21, and 1.58 for KGM, AGM, MGM, and BGM, resp. Relative mol. weights of AcGMs increased in the order of: KGMName: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Yubao; Antonietti, Markus published the artcile< Visible-Light-Driven Conversion of Alcohols into Iodide Derivatives with Iodoform>, Product Details of C8H10OS, the main research area is iodoalkane green preparation; alc photochem iodination.

A mild, cost effective, operationally simple and environmentally benign visible-light-driven alc. iodination reaction system for the synthesis of iodoalkanes was developed. In this reaction system, visible light and iodoform were employed as the energy source and iodination reagent, resp. The reaction begins with the homolytic fission of the C-I bond in iodoform induced by visible-light irradiation, produced active radicals. The following steps involved as radical trapping by DMF, nucleophilic substitution, Vilsmeier-type reagent formation, and the final iodination of the alc. The excellent performance of the model reaction in the flow photoreactor demonstrated the potential of this system for practical application.

ChemPhotoChem published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Product Details of C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Hong; Sun, Jian; Liu, Jun; Gou, Yarun; Zhang, Xin; Wu, Xiaonan; Sun, Rui; Tang, Sixue; Kan, Juan; Qian, Chunlu; Zhang, Nianfeng; Jin, Changhai published the artcile< Structural characterization and anti-inflammatory activity of alkali-soluble polysaccharides from purple sweet potato>, Reference of 3458-28-4, the main research area is purple sweet potato polysaccharide structural property antiinflammatory; Alkali-soluble polysaccharide; Anti-inflammation activity; Purple sweet potato; Structural characterization.

In this study, the structural characterization and anti-inflammation effect of dilute alkali-soluble polysaccharides from purple sweet potato were investigated. Three fractions (F-1, F-2 and F-3) were obtained by purifying crude polysaccharides on DEAE-52 cellulose column. The main fraction (F-1) was further purified on Sephadex G-200 column to afford purified alkali-soluble sweet potato polysaccharide (ASPP). The chem. structure of ASPP was analyzed by gas chromatog., Fourier transform IR spectroscopy, methylation anal. and NMR spectroscopy. Monosaccharide compositional anal. showed ASPP was composed of rhamnose, arabinose, xylose, mannose and glucose in the molar ratio of 2.8:1.9:1.0:7.6:53.3. Moreover, the backbone of ASPP was composed of 1,4-linked Glcp with side chains attached to the O-6 position. The anti-inflammation effect of ASPP was further investigated by in vitro and in vivo experiments Results showed ASPP could inhibit the levels of nitric oxide, interleukin (IL)-6, IL-1β and TNF-α but increase the production of IL-10 in lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells. In addition ASPP could reduce the secretion of IL-6, IL-1β and TNF-α in LPS-treated mice. Our results suggest ASPP can be developed as a novel anti-inflammation agent.

International Journal of Biological Macromolecules published new progress about Anti-inflammatory agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Reference of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kajiki, Takahito; Komba, Shiro; Iwaura, Rika published the artcile< Supramolecular Organogelation Directed by Weak Noncovalent Interactions in Palmitoylated 1,5-Anhydro-D-Glucitol Derivatives>, COA of Formula: C6H12O6, the main research area is palmitoylated anhydro glucitol supramol organogelation noncovalent interaction; carbohydrates; gelators; hydrogen bonding; nanofibers; self-assembly.

We synthesized a series of novel alicyclic compounds by modifying 1,5-anhydro-D-glucitol with two to four palmitoyl chains, and we explored their self-assembly and gelation behaviors in paraffin. The obtained organogels were studied by field emission SEM, at. force microscopy, variable-temperature Fourier transform IR spectroscopy, X-ray diffraction anal., polarized optical microscopy, and transmission spectroscopy. While all the palmitoylated derivatives spontaneously formed fibrous networks and gelated the paraffin, an acetylated derivative of 1,5-anhydro-D-glucitol did not gelatinize the solvent, thus indicating the importance of aliphatic chains for gelation. Interestingly, α- and β- D-glucopyranose with five palmitoyl chains neither gelatinized the solvent nor formed fibrous networks, thus suggesting that the absence of C-1 substitution in 1,5-anhydro-D-glucitol is important for gelation. Fourier transform IR spectroscopy suggested that the formation of weak hydrogen bonds between the carbonyl groups and the C-H groups was the driving force for formation of the supramol. fibers and for gelation of the solvent.

ChemPlusChem published new progress about Gelation. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Chun-Ping; Li, Xiong; Lai, Ge-Na; Li, Jin-Hua; Jia, Wen-Yu; Cao, Ying-Ying; Xu, Wen-Xing; Tan, Qing-Long; Zhou, Chang-Yuan; Luo, Min; Zhang, Xue-Ying; Yuan, Dao-Qing; Tian, Jin-Ying; Zhang, Xian; Zeng, Xing published the artcile< Mechanisms of macrophage immunomodulatory activity induced by a new polysaccharide isolated from Polyporus umbellatus (Pers.) Fries>, Related Products of 492-62-6, the main research area is Polyporus extract polysaccharide anticancer immunomodulator NFkB NLRP3 bladder cancer; NF-κB pathway; NLR P3 inflammasome; Polyporus umbellatus; immunomodulatory activity; polysaccharide.

Bladder cancer is one of the most malignant tumors closely associated with macrophage immune dysfunction. The Chinese medicine polyporus has shown excellent efficacy in treating bladder cancer, with minimal side effects. However, its material basis and mechanism of action remain unclear. A new water-soluble polysaccharide (HPP) with strong immunomodulatory activity was isolated from the fungus Polyporus umbellatus (Pers.) Fries. HPP had an average mol. weight of 6.88 kDa and was composed mainly of an <-(1→ 4)-linked D-galactan backbone. The immunomodulatory activity of HPP was determined in vitro, and the results revealed that it could obviously increase the secretion of immune factors by IFN-γ-stimulated macrophages, including nitric oxide (NO), interleukin-6 (IL-6), interleukin-1β (IL-1β), RANTES and interleukin-23 (IL-23), and the expression of the cell membrane mol. CD80. In addition, HPP was recognized by Toll-like receptor 2 (TLR2) and activated the signaling pathways of NF-κB and NLRP3 in a bladder cancer microenvironment model, indicating that HPP could enhance host immune system function. These findings demonstrated that HPP may be a potential immune modulator in the treatment of immunol. diseases or bladder cancer therapy. Frontiers in Chemistry (Lausanne, Switzerland) published new progress about Antitumor agents. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts