Tag: M.W=150-200

Shahrivari, Saba published the artcileA comprehensive study on essential oil compositions, antioxidant, anticholinesterase and antityrosinase activities of three Iranian Artemisia species, Quality Control of 106-25-2, the publication is Scientific Reports (2022), 12(1), 7234, database is CAplus and MEDLINE.

Artemisia is one of the most diverse genera in the Asteraceae family. The genus is wildly distributed in Irano-Turanian habitats and includes 34 species in Iran. Here, for the first time the essential oil variability, antioxidants and anti-cholinesterase and anti-tyrosinase activities of extracts of three Artemisia species (A. tournefortiana, A. khorassanica, A. haussknechtii), from different regions of Iran were evaluated. Based on GC-MS analyses, 81.84% to 98.70% of the total oils were identified. Cluster anal. grouped the studied populations in three different chemotypes. The highest and the lowest essential oil contents were observed in A. khorassanica and A. haussknechtii species, resp. Camphor, en-in-dicycloether, 1,8-cineole and (Z)-β-farnesene were the dominant components of essential oil in investigated ecotypes. The results revealed that the total phenol content was higher in A. tournefortiana collected from Kerman and A. haussknechtii collected from Chaharmahal and Bakhtiari. However, the lowest phenol content was recorded for A. haussknechtii collected from Isfahan province. The highest flavonoids content was found in A. tournefortiana collected from West Azerbaijan and A. khorassanica collected from North Khorasan. The highest FRAP antioxidant activity was observed in A. tournefortiana (Kerman) and the lower amount was in A. haussknechtii collected from Kohgiluyeh and Boyer-Ahmad. The highest antioxidant activity by DPPH method was in A. khorassanica collected from South Khorasan and the lowest activity was in Isfahan’s A. haussknechtii. The acetycholine esterase inhibitory activity was higher in A. tournefortiana collected from West Azerbaijan; and the lowest activity was in A. haussknechtii collected from Chaharmahal and Bakhtiari province. The highest tyrosinase inhibitory activity was in A. khorassanica collected from North Khorasan; and the lowest was in A. haussknechtii collected from Chaharmahal and Bakhtiari.

Scientific Reports published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C40H35N7O8, Quality Control of 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Storz, Michael P. published the artcileFrom in vitro to in cellulo: structure-activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa, Recommanded Product: 4,4-Diethoxybutan-1-amine, the publication is Organic & Biomolecular Chemistry (2014), 12(32), 6094-6104, database is CAplus and MEDLINE.

Recent studies have shown that compounds based on a (2-nitrophenyl)methanol scaffold are promising inhibitors of PqsD, a key enzyme of signal mol. biosynthesis in the cell-to-cell communication of Pseudomonas aeruginosa. The most promising mol. displayed anti-biofilm activity and a tight-binding mode of action. Herein, the authors report on the convenient synthesis and biochem. evaluation of a comprehensive series of (2-nitrophenyl)methanol derivatives The in vitro potency of these inhibitors against recombinant PqsD as well as the effect of selected compounds on the production of the signal mols. HHQ and PQS in P. aeruginosa were examined The gathered data allowed the establishment of a structure-activity relationship, which was used to design fluorescent inhibitors, and finally, led to the discovery of (2-nitrophenyl)methanol derivatives with improved in cellulo efficacy providing new perspectives towards the application of PqsD inhibitors as anti-infectives.

Organic & Biomolecular Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C10H18O, Recommanded Product: 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Al-Ghannam, Sheikha M. published the artcileStability-indicating HPLC method for the determination of nicardipine in capsules and spiked human plasma. Identification of degradation products using HPLC/MS, Category: alcohols-buliding-blocks, the publication is Arabian Journal of Chemistry (2019), 12(8), 1983-1993, database is CAplus.

In this stability-indicating, reversed-phase high-performance liquid chromatog. method for nicardipine (NIC), forced degradation has been employed and the formed degradants were separated on a C18 (150 mm × 3.9 mm, 5μm) anal. column using a mobile phase consisted of 70% methanol: acetic acid containing 0.01 M triethylamine with pH 4. The flow rate was 1.0 mL/min and the photodiode array detection wavelength was 353 nm. Forced degradation of the drug was carried out under acidic, basic, photolytic, and oxidative stress conditions. Chromatog. peak purity data indicated no co-eluting peaks with the main peaks. This method resulted in the detection of seven degradation products. Among these, two major degradation products from basic hydrolysis, one from oxidation by H₂O₂ and four from photolytic stress were identified by mass spectral data. A good linear response was achieved over the range of 0.5-40μg/mL with a limit of detection (LOD) of 0.011μg/mL and limit of quantification (LOQ) of 0.036μg/mL. The suggested method was successfully applied for the anal. of NIC in its com. capsules, with mean% recovery value of 100.11 ± 2.26%. The method was extended to the in vitro determination on NIC in spiked human plasma samples with mean% recovery of 99.04 ± 5.67%. The suggested method was utilized to investigate the kinetics of photolytic induced degradation

Arabian Journal of Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ford, Russell L. published the artcileIntramolecular Pd-Catalyzed Reductive Amination of Enolizable sp³-C-H Bonds, Product Details of C7H6FNO3, the publication is Organic Letters (2019), 21(21), 8827-8831, database is CAplus and MEDLINE.

A palladium-catalyzed reductive cyclization of nitroarenes has been designed to construct sp³-C-NHAr bonds from sp³-C-H bonds by using an enolizable nucleophile to intercept a nitrosoarene intermediate. Exposure of ortho-substituted nitroarenes to 5 mol % of Pd(OAc)₂ and 10 mol % of phenanthroline under 2 atm of CO constructs partially saturated 5-, 6-, or 7-membered N-heterocycles I (R¹ = H, Cl, Me, etc.; R² = H, F, Me, etc.; R³ = H, Me) using α-pyridyl carboxylates, malonates, 1,3-dimethylbarbituric acid, 1,3-diones, or difurans as the nucleophile.

Organic Letters published new progress about 1043416-40-5. 1043416-40-5 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Nitro Compound,Benzene,Alcohol, name is (4-Fluoro-2-nitrophenyl)methanol, and the molecular formula is C7H6FNO3, Product Details of C7H6FNO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Toprak, Nurettin Alper published the artcileThe effects of grinding aids on modelling of air classification of cement, Related Products of alcohols-buliding-blocks, the publication is Construction and Building Materials (2018), 564-573, database is CAplus.

Until so far, several studies have been performed on grinding aids which have discussed the influences. However, the evaluations were all based on closed circuited grinding operations where the milling and the classification operations were integrated and had effect with each other. The novelty of this paper comes from its comprehensive test works with only on air classifier and development of grinding aid-specific model structure that has not been performed. Within the scope, laboratory scale air classifier was utilized and triethanolamine (TEA), triisopropanolamine (TIPA), and diethylenglycol (DEG) were mixed with cement at various dosage rates. The exptl. tests were performed at different wheel speed and air flow rates then the performance of the air classification was evaluated by plotting the Tromp curves. As a result, the limited change was observed for cut size and sharpness parameters however, bypass and fish hook parameters changed significantly. Among the grinding aids tested, TIPA type aid was found to be more effective on both bypass and fish hook parameters. Finally, the air classifier was modelled by using Whiten’s equation and the relations between dosage rate, type and model parameters were investigated. The results concluded that different types of grinding aids had varied influences and the model structures needed to be developed accordingly.

Construction and Building Materials published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C18H17NO8, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Castrosanto, Melvin A. published the artcileBarnyard grass [ Echinochloa crus-galli (L.) Beauv] leaves extract against tomato pests, COA of Formula: C8H8O3, the publication is Journal of the Science of Food and Agriculture (2021), 101(15), 6289-6299, database is CAplus and MEDLINE.

Tomato is one of the widely cultivated crops worldwide that is affected by several pests, such as fungi (Fusarium oxysoporum, Alternaria solani), bacteria (Pectobacterium carotovorum) and weeds (Cyperus iria L., Amaranthus spinosus). A growing interest has emerged for developing plant-derived pesticidal compounds to counteract these pests. One attractive alternative is to use barnyard grass (Echinochloa crus-galli), known to be widely resistant to synthetic herbicides, as a potential biopesticide compound source. Phytochem. screening of the crude extract showed that phenolic compounds were the most abundant component present in barnyard grass. The crude extract was evaluated for antifungal, antibacterial and herbicidal activities. Bioassays showed inhibition against F. oxysporum (10.73 ± 1.30%) and A. solani (20.47 ± 3.51%), the causative agent of Fusarium rot and early blight disease in tomato, resp. Antibacterial activity against P. carotovorum gave a mean zone of inhibition (paper disk diffusion assay) of 17.00 ± 1.00 mm and an IC50 (dose-response assay) of 2.26 mg mL-1 was observed Dose-responsive herbicidal activity on the lettuce seed germination bioassay produced an IC50 of 459.30 ppm. Selectivity studies showed inhibition towards C. iria and A. spinosus with no effect on tomato. Lastly, bioassay-guided fractionation coupled with untargeted metabolomics studies using ultra-performance liquid chromatog. with diode array detection-tandem mass spectrometry mass analyses revealed loliolide and tricin as the putative metabolites present in barnyard grass. To date, this is the first reported study on using barnyard grass as a potential alternative biopesticide against tomato pests such as fungi, bacteria and weeds. 2021 Society of Chem. Industry.

Journal of the Science of Food and Agriculture published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, COA of Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sanchez-Martinez, Jose David published the artcileNeuroprotective potential of terpenoid-rich extracts from orange juice by-products obtained by pressurized liquid extraction, Name: cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Food Chemistry: X (2022), 100242, database is CAplus and MEDLINE.

The agri-food industry plays a key role in many countries and economies, such as in Spain. Mong the different sectors, Spain is the largest producer of citrus juice in the European Union (EU) and one of the largest in the world. However, several environmental problems are associated to these activities, such as food waste generation. In 2013, the global citrus industry generated 24.3 million tons of waste, of which 1.3 million tons corresponded to Spain (mainly from the orange juice production). The recovery of bioactive compounds from plant material or agri – cultural waste through conventional techniques (such as maceration) involves several environmental constrains due to the important amount of organic solvents, large extraction times and high energy consumption requirements. In this sense, the use of advanced environmentally friendly extraction techniques such as pressurized liquid extraction (PLE), which uses high temperatures (above the b.p. and below the critical point) and pressures enough to maintain the solvent in the liquid state, presents some advantages, like the reduction of organic solvents volume and extraction times, and the improvement of the extraction yield of bioactive compounds through the increase of mass transfer rate between the solvent and the biomass. Hence, the aim of the present work is to optimize the PLE conditions to obtain terpenoids enriched extracts with neuroprotective properties from an orange juice byproduct and to characterize these extracts by using gas chromatog. coupled to high-resolution mass spectrometry (GC-q-TOF-MS) in order to increase the recovery of these compounds Moreover, the neuroprotective potential of the PLE orange extracts is explored and confirmed by a pool of in-vitro assays including anti-enzymic (AChE, BChE and LOX) and antioxidant (ABTS, ROS and RNS) tests. Finally, in-vitro cytotoxicity is evaluated by using different human cell culture models (HK-2, THP-1 and SH-SY5Y cells), as well as the potential anti-inflammatory capacity and neuroprotective activity against Aβ 1-42 and L-glutamic acid insults. Moreover, in-silico mol. docking is also applied to better understand the interaction between target mono- and sesquiterpenoids with acetylcholinesterase, butyrylcholinesterase and lipoxygenase active sites.

Food Chemistry: X published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Name: cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Silva-Santos, A. Rita published the artcileSeparation of plasmid DNA topoisomers by multimodal chromatography, Category: alcohols-buliding-blocks, the publication is Analytical Biochemistry (2016), 68-70, database is CAplus and MEDLINE.

The ability to analyze the distribution of topoisomers in a plasmid DNA sample is important when evaluating the quality of preparations intended for gene therapy and DNA vaccination or when performing biochem. studies on the action of topoisomerases and gyrases. Here, the authors describe the separation of supercoiled (s.c.) and open circular (oc) topoisomers by multimodal chromatog. A medium modified with the ligand N-benzyl-N-Me ethanolamine and an elution scheme with increasing NaCl concentration were used to accomplish the baseline separation of s.c. and oc plasmid. The utility of the method is demonstrated by quantitating topoisomers in a purified plasmid sample.

Analytical Biochemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H16Br3N, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Durig, Wiebke published the artcileApplication of a novel prioritisation strategy using non-target screening for evaluation of temporal trends (1969-2017) of contaminants of emerging concern (CECs) in archived lynx muscle tissue samples, Application In Synthesis of 122-20-3, the publication is Science of the Total Environment (2022), 153035, database is CAplus and MEDLINE.

Most environmental monitoring studies of contaminants of emerging concern (CECs) focus on aquatic species and target specific classes of CECs. Even with wide-scope target screening methods, relevant CECs may be missed. In this study, non-target screening (NTS) was used for tentative identification of potential CECs in muscle tissue of the terrestrial top predator Eurasian lynx (Lynx lynx). Temporal trend anal. was applied as a prioritisation tool for archived samples, using univariate statistical tests (Mann-Kendall and Spearman rank). Pooled lynx muscle tissue collected from 1969 to 2017 was analyzed with an eight-point time series using a previously validated screening workflow. Following peak detection, peak alignment, and blank subtraction, 12,941 features were considered for statistical anal. Prioritisation by time-trend anal. detected 104 and 61 features with statistically significant increasing and decreasing trends, resp. Following probable mol. formula assignment and elucidation with MetFrag, two compounds with increasing trends, and one with a decreasing trend, were tentatively identified. These results show that, despite low expected concentration levels and high matrix effects in terrestrial species, it is possible to prioritise CECs in archived lynx samples using NTS and univariate statistical approaches.

Science of the Total Environment published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Application In Synthesis of 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gundogdu-Hizliates, Cevher published the artcileSynthesis of new ibuprofen derivatives with their in silico and in vitro cyclooxygenase-2 inhibitions, Quality Control of 6346-09-4, the publication is Bioorganic Chemistry (2014), 8-15, database is CAplus and MEDLINE.

Cyclooxygenase-2 (COX-2) is one of the important targets for treatment of inflammation related diseases. In the literature, most of drug candidates are first synthesized and then their COX-2 inhibitory activities are tested by in vitro and in vivo experiments However, synthesis of dozens of drug analogs without any interpretations on their inhibitory activity can result in loss of time and chems. Therefore, synthetic drug designs with mol. modeling are of importance to synthesize selective drug candidates against inflammatory diseases. The synthesis of the novel ibuprofen derivatives through their in silico and in vitro COX-2 inhibitory activities were investigated in the present study. Starting from ibuprofen, ibuprofen amide and ibuprofen acyl hydrazone derivatives were synthesized. According to the results of the in silico mol. docking and in vitro enzyme inhibition studies, the synthesized novel ibuprofen derivatives have selective COX-2 inhibition, and mol. 3a and 3c were showed higher inhibition compared to ibuprofen. In conclusion, the newly synthesized ibuprofen derivatives can be used in model in vivo studies.

Bioorganic Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Quality Control of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts