Tag: M.W=150-200

Loska, Rafal published the artcileA three-component synthesis of aryl(heteroaryl)acylamides, Safety of 4,4-Diethoxybutan-1-amine, the publication is Organic & Biomolecular Chemistry (2015), 13(38), 9872-9882, database is CAplus and MEDLINE.

A three-component reaction of azole or azine N-oxides, 1,1-difluorostyrenes and amines gives amides of α-aryl-α-heteroarylacetic or propionic acids. The key step is 1,3-dipolar cycloaddition between N-oxide and difluorostyrene leading to the acyl fluoride intermediate, which has been identified and characterized by NMR spectroscopy. The whole process is an example of selective functionalization of C-H bonds in both 5- and 6-membered heterocyclic systems.

Organic & Biomolecular Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Safety of 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Faverio, Chiara published the artcileAmmonia-Borane-Mediated Reduction of Nitroalkenes, Safety of 2-Methoxy-4-(2-nitroethyl)phenol, the publication is SynOpen (2020), 4(4), 116-122, database is CAplus.

Ammonia-borane was successfully employed in the reduction of nitroalkenes. A variety of nitrostyrenes and alkyl-substituted nitroalkenes were chemoselectively reduced to the corresponding nitroalkanes, in short reaction time, with an atom-economic, simple exptl. procedure that also worked with α- and β-substituted nitroolefins.

SynOpen published new progress about 528594-30-1. 528594-30-1 belongs to alcohols-buliding-blocks, auxiliary class Nitro Compound,Benzene,Phenol,Ether, name is 2-Methoxy-4-(2-nitroethyl)phenol, and the molecular formula is C9H11NO4, Safety of 2-Methoxy-4-(2-nitroethyl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tiollais, Rene published the artcileSeveral physical and chemical properties of aliphatic enamines, Application of 2-Bromo-2-methylpropan-1-ol, the publication is Bulletin de la Societe Chimique de France (1964), 1205-6, database is CAplus.

RR’C:CHNR”₂ prepared by known methods were [R, R’, NR”₂, % yield, b.p. (mm.), density (temperature), and n_D listed]: Me, H, NMe₂, 33, 82° (760), 0.754 (23°), 1.4275; Et, H, NMe₂ 74, 107° (760), 0.768 (20°), 1.4345; Pr, H, NMe₂, 79, 59° (60), 0.776 (20°), 1.4390; Am, H, NMe₂, 71, 67° (15), 0.789 (20°), 1.4440; Et, H, NEt₂, 53, 37° (12), 0.786 (22°), 1.4448; Am, H, NEt₂, 57, 93° (13), 0.800 (16.8°), 1.4500; Et, H, NMeBu, 53, 65° (15), 0.786 (20.4°), 1.4492; Et, H, NMeBu-iso, 76, 82° (51), 0.779 (21°), 1.4460; Me, Me, NMe₂, 64, 87° (760), 0.745 (19.6°), 1.4212; Me, Me, NEt₂, 57, 57° (68), 0.761 (20°), 1.4268; Et, H, morpholino, 65, 72° (12), 0.935 (22°), 1.4750; Me, Me, morpholino, 61, 65° (18), 0.922 (20.4°), 1.4669. Bromination of the enamines in ether gave, after hydrolysis, α-bromo aldehydes (product, % yield, phys. properties, and m.p. 2,4-dinitrophenylhydrazone listed): 2-bromobutanal, 64, b₂₅ 42°, n^21.5_D 1.4595, d_21.5 1.4531, 93-4°; 2-bromo-2-methylpropanol, 60, b₇₀ 47°, n²¹_D 1.4522, d₂₁ 1.389, 115-16°; 2-bromoheptanal, 60, b₁₂ 80-1°, n^22.5_D 1.4621, d_22.5 1.249, 105-6°.

Bulletin de la Societe Chimique de France published new progress about 55376-31-3. 55376-31-3 belongs to alcohols-buliding-blocks, auxiliary class Polymerization Reagents,ATRP Initiators, name is 2-Bromo-2-methylpropan-1-ol, and the molecular formula is C35H35ClN6O5, Application of 2-Bromo-2-methylpropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dumoulin, Hugues published the artcile2-oxo-2-(phenyl-2-pyrrolyl)acetamides as potential anxiolytic agents: synthesis and affinity at the central benzodiazepine receptor, Quality Control of 23351-09-9, the publication is European Journal of Medicinal Chemistry (1998), 33(3), 201-207, database is CAplus.

A series of N-substituted α-hydroxy-N-Ph and α-oxo-N-phenyl-1H-pyrrole-2-acetamides were synthesized and their affinity at the benzodiazepine receptor tested. Isosteric replacement of the indolyl ring in previously described derivatives by a phenylpyrrole led to the synthesis of several compounds having benzodiazepine affinity.

European Journal of Medicinal Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Quality Control of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zizmare, Laimdota published the artcileRoux-En-Y Gastric Bypass (RYGB) Surgery during High Liquid Sucrose Diet Leads to Gut Microbiota-Related Systematic Alterations, Safety of 3-Hydroxyphenylacetic acid, the publication is International Journal of Molecular Sciences (2022), 23(3), 1126, database is CAplus and MEDLINE.

Roux-en-Y gastric bypass (RYGB) surgery has been proven successful in weight loss and improvement of co-morbidities associated with obesity. Chronic complications such as malabsorption of micronutrients in up to 50% of patients underline the need for addnl. therapeutic approaches. We investigated systemic RYGB surgery effects in a liquid sucrose diet-induced rat obesity model. After consuming a diet supplemented with high liquid sucrose for eight weeks, rats underwent RYGB or control sham surgery. RYGB, sham pair-fed, and sham ad libitum-fed groups further continued on the diet after recovery. Notable alterations were revealed in microbiota composition, inflammatory markers, feces, liver, and plasma metabolites, as well as in brain neuronal activity post-surgery. Higher fecal 4-aminobutyrate (GABA) correlated with higher Bacteroidota and Enterococcus abundances in RYGB animals, pointing towards the altered enteric nervous system (ENS) and gut signaling. Favorable C-reactive protein (CRP), serine, glycine, and 3-hydroxybutyrate plasma profiles in RYGB rats were suggestive of reverted obesity risk. The impact of liquid sucrose diet and caloric restriction mainly manifested in fatty acid changes in the liver. Our multi-modal approach reveals complex systemic changes after RYGB surgery and points towards potential therapeutic targets in the gut-brain system to mimic the surgery mode of action.

International Journal of Molecular Sciences published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C9H16BNO2, Safety of 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Abohalaka, Reshed published the artcileThe effects of systemic and local fatty acid amide hydrolase and monoacylglycerol lipase inhibitor treatments on the metabolomic profile of lungs, HPLC of Formula: 526-98-7, the publication is Biomedical Chromatography (2022), 36(1), e5231, database is CAplus and MEDLINE.

The contribution of the endocannabinoid system to both physiol. and pathol. processes in the respiratory system makes it a promising target for inflammatory airway diseases. Previously, we have shown that increasing the tissue endocannabinoid levels by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitors can prevent airway inflammation and hyperreactivity. In this study, the changes in the levels of major metabolites of endocannabinoids by systemic and local FAAH or MAGL inhibitor treatments were evaluated. Mice were treated with either the FAAH inhibitor URB597 or the MAGL inhibitor JZL184 by local (intranasal) or systemic (i.p.) application. Bronchoalveolar lavage (BAL) fluids and lungs were isolated afterward in order to perform histopathol. and metabolomic analyses. There were no significant histopathol. changes in the lungs and neutrophil, and macrophage and lymphocyte numbers in BAL fluid were not altered after local and systemic treatments. However, GC-MS-based metabolomics profile allowed us to identify 102 metabolites in lung samples, among which levels of 75 metabolites were significantly different from the control. The metabolites whose levels were changed by treatments were mostly related to the endocannabinoid system and energy metabolism Therefore, these changes may contribute to the anti-inflammatory effects of URB597 and JZL184 treatments in mice.

Biomedical Chromatography published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, HPLC of Formula: 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ma, Qian published the artcileIntegrated proteomic and metabolomic analysis of a reconstructed three-species microbial consortium for one-step fermentation of 2-keto-L-gulonic acid, the precursor of vitamin C, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Journal of Industrial Microbiology & Biotechnology (2019), 46(1), 21-31, database is CAplus and MEDLINE.

Microbial consortia, with the merits of strong stability, robustness, and multi-function, played critical roles in human health, bioenergy, and food manufacture, etc. On the basis of ‘build a consortium to understand it’, a novel microbial consortium consisted of Gluconobacter oxydans, Ketogulonicigenium vulgare and Bacillus endophyticus was reconstructed to produce 2-keto-L-gulonic acid (2-KGA), the precursor of vitamin C. With this synthetic consortium, 73.7 g/L 2-KGA was obtained within 30 h, which is comparable to the conventional industrial method. A combined time-series proteomic and metabolomic anal. of the fermentation process was conducted to further investigate the cell-cell interaction. The results suggested that the existence of B. endophyticus and G. oxydans together promoted the growth of K. vulgare by supplying addnl. nutrients, and promoted the 2-KGA production by supplying more substrate. Meanwhile, the growth of B. endophyticus and G. oxydans was compromised from the competition of the nutrients by K. vulgare, enabling the efficient production of 2-KGA. This study provides valuable guidance for further study of synthetic microbial consortia.

Journal of Industrial Microbiology & Biotechnology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Manoury, Philippe M. published the artcileSynthesis and antihypertensive activity of a series of 4-amino-6,7-dimethoxyquinazoline derivatives, Application In Synthesis of 101-98-4, the publication is Journal of Medicinal Chemistry (1986), 29(1), 19-25, database is CAplus and MEDLINE.

N²-[(Acylamino)alkyl]-6,7-dimethoxy-2,4-quinazolinediamines I (e.g., R, R¹, R², n = Me, Me, Ph, 2; Me, H, tetrahydro-2-furyl, 3) were synthesized as potential α₁-adrenoceptor antagonists. In rats at 10 mg/kg po, some I (n = 3) showed good antihypertensive activity, whereas I (n = 2) did not.

Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Application In Synthesis of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Perry, Matthew W. D. published the artcileDesign and Synthesis of Soluble and Cell-Permeable PI3Kδ Inhibitors for Long-Acting Inhaled Administration, Category: alcohols-buliding-blocks, the publication is Journal of Medicinal Chemistry (2017), 60(12), 5057-5071, database is CAplus and MEDLINE.

PI3Kδ is a lipid kinase that is believed to be important in the migration and activation of cells of the immune system. Inhibition is hypothesized to provide a powerful yet selective immunomodulatory effect that may be beneficial for the treatment of conditions such as asthma or rheumatoid arthritis. In this work, identification of inhibitors based on a thiazolopyridone core structure and their subsequent optimization for inhalation is described. The initially identified compound I had good potency and isoform selectivity but was not suitable for inhalation. Addition of basic substituents to a region of the mol. pointing to solvent was tolerated (enzyme inhibition pIC₅₀ > 9), and by careful manipulation of the pK_a and lipophilicity, the authors were able to discover compounds II (R = Me or i-Bu) with good lung retention and cell potency that could be taken forward to in vivo studies where significant target engagement could be demonstrated.

Journal of Medicinal Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Altenbach, Robert J. published the artcileDiaryldiamines with Dual Inhibition of the Histamine H3 Receptor and the Norepinephrine Transporter and the Efficacy of 4-(3-(Methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in Pain, Name: 2-(Benzyl(methyl)amino)ethanol, the publication is Journal of Medicinal Chemistry (2010), 53(21), 7869-7873, database is CAplus and MEDLINE.

A series of compounds were designed as dual inhibitors of the H₃ receptor and the norepinephrine transporter. Methylamino phenylpropyl pyrrolidinyl ethoxy naphthalenol I (rNET K_i = 14 nM; rH₃R K_i = 37 nM) was found to be efficacious in a rat model of osteoarthritic pain.

Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Name: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts