Tag: M.W=100-200

Synthetic Route of 4704-94-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4704-94-3, name is 2-(Hydroxymethyl)propane-1,3-diol, molecular formula is C4H10O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step A. To a solution of 2-(hydroxymethyl)-1,3-propanediol (1 g, 9.4 mmol) in pyridine (7.5 mL) at 0 C. was added acetic anhydride (0.89 mL, 9.4 mmol) slowly. The resulting solution was warmed to room temperature and stirred for 16 h. The reaction was concentrated under reduced pressure and chromatographed by eluding with methanol-dichloromethane (1:9) to give 510 mg of pure 2-acetoxymethyl-1,3-propanediol.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4704-94-3, 2-(Hydroxymethyl)propane-1,3-diol.

Reference:
Patent; Metabasis Therapeutics, Inc.; US6054587; (2000); A;,
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Reference of 16308-92-2 , The common heterocyclic compound, 16308-92-2, name is (2,4-Dimethylphenyl)methanol, molecular formula is C9H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 7 Synthesis of Dmb protected 6-mercaptohexanoic acid 7 Compound 7 was synthesized according to the following scheme: To a solution of 6-mercaptohexanoic acid (7.10 g, 47.90 mmol) in trifluoroacetic acid (20 mL), 2,4-dimethylbenzyl alcohol (13.5 g, 95.80 mmol) was added. The mixture was stirred at rt for 60 min and then the trifluoroacetic acid was removed in vacuo. The residue was dissolved in a mixture of 95.8 mL LiOH (3 M) and THF (81 mL) and stirred at rt for 60 min. The solvent was removed in vacuo and the aqueous residue was extracted 3x with EtOAc (200 mL). The combined organic phases were dried over MgSO4, and the solvent was removed in vacuo.7 was purified by RP-HPLC. Yield: 2.27 g (8.52 mmol, 18 %) MS: m/z 267.01 = [M+H]+ , (calculated monoisotopic mass = 266.13).

The synthetic route of 16308-92-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASCENDIS PHARMA GROWTH DISORDERS A/S; SPROGØE, Kennett; RAU, Harald; CLEEMANN, Felix; HERSEL, Ulrich; RASMUSSEN, Caroline Elisabeth; (244 pag.)WO2017/118703; (2017); A1;,
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Related Products of 2240-88-2, Adding some certain compound to certain chemical reactions, such as: 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol,molecular formula is C3H5F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2240-88-2.

c) Methyl 4-bromo-3-(3,3,3-trifluoropropoxy)benzoate3,3,3-Trifluoro-l-propanol (0.294 mL, 3.33 mmol) was added to a stirred solution of diisopropyl azodicarboxylate (1.21 mL, 6.15 mmol), triphenylphosphine (1.346 mL, 6.16 mmol) and methyl 4-bromo-3-hydroxybenzoate (0.9489 g, 4.11 mmol) in tetrahydrofuran (40 mL) and the mixture was stirred at room temperature for 2 days. Water and ethyl acetate was added and the aqueous phase was washed with ethyl acetate. The aqueous phase was acidified (pH~l) using hydrochloric acid (2 M) and extracted with ethyl acetate. The combined organic phases were washed with water and brine, dried over magnesium sulfate and the solvent was evaporated to give 0.894 g (67percent yield) of the title compound. 1H NMR (500 MHz, CDCl3) delta ppm 7.64 (d, 1 H) 7.53 – 7.58 (m, 2 H) 4.32 (t, 2 H) 3.94 (s, 3 H) 2.74 (dt, 2 H); GC MS (EI) m/z 326, 328 [M]+*.

According to the analysis of related databases, 2240-88-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; BYLUND, Johan; EK, Maria, E; HOLENZ, Joerg; KERS, Annika; OeHBERG, Liselotte; WO2010/132016; (2010); A1;,
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Synthetic Route of 627-18-9, Adding some certain compound to certain chemical reactions, such as: 627-18-9, name is 3-Bromopropan-1-ol,molecular formula is C3H7BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-18-9.

To a flask, appropriate halide (1b5 and 1b6,0.70 g) was dissolved in 15mL of acetone and then NaN3 (3-5 eq)(plus 0.1 eq of KI, when the halide was 3-Bromo-1-propanol) and5mL of H2O was added. The mixture was stirred bath at 50 C for12 h. After the reaction, the solvent was removed by rotary evaporation,and 15 mL of water was added. The solution was thenextracted by ethyl acetate for three times. The organic phase wascombined, dried and concentrated to yield the crude product whichwas used for the next step without further purification. Thismethod was applied in the preparation of 2b5 and 2b6.

According to the analysis of related databases, 627-18-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Tian, Ye; Liu, Zhaoqiang; Liu, Jinghan; Huang, Boshi; Kang, Dongwei; Zhang, Heng; De Clercq, Erik; Daelemans, Dirk; Pannecouque, Christophe; Lee, Kuo-Hsiung; Chen, Chin-Ho; Zhan, Peng; Liu, Xinyong; European Journal of Medicinal Chemistry; vol. 151; (2018); p. 339 – 350;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 945-24-4, name is (2,4-Diaminopteridin-6-yl)methanol. A new synthetic method of this compound is introduced below., Formula: C7H8N6O

To a solution of triphenylphosphene (408 mg, 1 .03 mmol) in anhydrous DMA ( 1 mL) is added bromine dropwise at 0 0C (0.08 mL, 1 .03 mmol) under N2 atmosphere. After stirring for 5 additional minutes, (2,4-diaminopteridin-6-yl)methanol (100 mg, 0.33 mmol) is added at once and the reaction mixture is stirred at RT for 18 h. Barium oxide ( 100 mg, 0.65 mmol) is then added to the reaction mixture followed by 3-aminobenzoic acid (107 mg, 0.78 mmol) at RT. The reaction mixture is then heated at 56 0C and stirred at that temperature for 24 h and cooled to RT. The mixture is diluted with methylene chloride (5 mL) and the resulting brownish precipitate is filtered. The solids are washed with water and methanol. The solids are then taken in methanol and heated at reflux for 2 h. After cooling to RT, the solids are filtered again and dried overnight in a heated vacuum oven to give 45 mg product (Yield: 26.9%) as a brownish yellow solid. 1 H NMR (500 MHz, DMSOd6) delta 4.6 (br s, 2H), 6.7 (s, 1 H), 6.9-7.0 (d, 1 H), 7.15-7.3 (m, 2H), 7.38 (br s, 2H), 8.6-8.7 (br s, I H), 8.9 (s, I H), 9.3-9.4 (m, 2H), 12.8 (br s, I H); LC-MS m/z 312 (MH+), retention time 1 1 .48 min., HPLC Method B.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 945-24-4, (2,4-Diaminopteridin-6-yl)methanol.

Reference:
Patent; BIORELIX, INC.; COISH, Philip, D., G.; WICKENS, Phil; DIXON, Brian; OSTERMAN, David; KHIRE, Uday, R.; NAVIA, Manuel; BERMAN, Judd; KAUR, Harpreet; WILSON, Jeffrey; UNDERWOOD, Dennis; WO2010/110907; (2010); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 627-18-9, name is 3-Bromopropan-1-ol, the common compound, a new synthetic route is introduced below. Formula: C3H7BrO

To a stirring solution of concentrated sulfuric acid (30 mmol) was slowly added concentrated nitric acid (30 mmol) dropwise at 0 C under nitrogen, and stirred for 10 min followed by the addition of 3-bromopropanol 3 (3.5 g, 25 mmol) in anhydrous dichloromethane (5 mL) dropwise while keeping the temperature below 5 C. After 3 h, the reaction was quenched with water (10 mL), followed by addition of dichloromethane (40 mL). The organic phase was separated, washed with water (15 mL), dried (MgSC ) and concentrated to give bromopropyl nitrate 4, which was used in the next step without further purification.

The synthetic route of 627-18-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; VIRGINIA COMMONWEALTH UNIVERSITY; SAFO, Martin, K.; DANSO-DANQUAH, Richmond; GHATGE, Mohini; VENITZ, Jurgen; MANGINO, Martin; WARD, Kevin, R.; WO2015/100235; (2015); A1;,
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Adding a certain compound to certain chemical reactions, such as: 1004-24-6, (4-Methylenecyclohexyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1004-24-6, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C8H14O

PREPARATION 8 4-Methylenecyclohexane-1-carbaldehyde To pydridinium dichromate (223 g., 0.59 mole) in 1 liter CH2 Cl2, stirring under N2, was added dropwise 4-methylene-1-cyclohexanemethanol (50 g., 0.40 mole) in 75 ml. CH2 Cl2 over a few minutes. After stirring for 21 hours at room temperature, the reaction mixture was heated at 60 C. for 24 hours. The reaction mixture was cooled, diluted with 400 ml. ether and decanted from solids. The solids were slurried with 400 ml. of fresh ether and decanted. The combined organic decants were filtered over fluorasil and diatomaceous earth and the filtrate concentrated in vacuo to an oil (41 g.) and distilled to yield title product, 13.6 g., b.p. 82-90/15-20 mm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1004-24-6, its application will become more common.

Reference:
Patent; Pfizer Inc.; US4430337; (1984); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16369-21-4, name is 2-(Propylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 16369-21-4

General procedure: [HEA][HCO2], [HEPA][HCO2], [BHEA][HCO2], and [DEHEA][HCO2] were prepared by dropping the stoichiometric amount of formic acid to corresponding amino alcohol at 0 C. The reaction mixture was stirred at rt for 2 h under argon atmosphere. After completion of the reaction, the ionic liquid was washed with EtOAc and Et2O. The ionic liquid was dried in vacuo at 40 C.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 16369-21-4, 2-(Propylamino)ethanol.

Reference:
Article; Suzuki, Hideyuki; Yoshioka, Seiki; Igesaka, Ami; Nishioka, Hiromi; Takeuchi, Yasuo; Tetrahedron; vol. 69; 31; (2013); p. 6399 – 6403;,
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Electric Literature of 5299-60-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5299-60-5, name is Ethyl 6-hydroxyhexanoate. A new synthetic method of this compound is introduced below.

General procedure: According to a modified literature procedure,[2] a flame-dried Schlenk flask is charged withpoly(4-vinylpyridine) (2.1 equiv) in CH2Cl2. At 0 C, Tf2O (1.1 equiv) is added dropwisefollowed by the addition of the corresponding primary alcohol in CH2Cl2. The reaction mixtureis then allowed to warm to room temperature. After completion of reaction (TLC monitoring),the reaction mixture is filtered under gravity, and the residue is washed with CH2Cl2.Evaporation of the solvents at room temperature (due to decomposition of the triflates athigher temperatures) affords the crude title compounds. Purification by vacuum filtration oversilica gel using a sintered funnel (grade 4) with the indicated eluent affords the analyticallypure alkyltriflates.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5299-60-5, its application will become more common.

Reference:
Article; Scharfbier, Jonas; Oestreich, Martin; Synlett; vol. 27; 8; (2016); p. 1274 – 1276;,
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Synthetic Route of 2568-33-4, Adding some certain compound to certain chemical reactions, such as: 2568-33-4, name is 3-Methylbutane-1,3-diol,molecular formula is C5H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2568-33-4.

Step 1: 4-Chloro-2-methyl-butan-2-ol 10.0 g (96.0 mmol)_3-methyl-1 ,3-butandiol is dissolved in 30.0 ml toluene and 10.7 g (106 mmol) TEA is added. The funnel is rinsed with 10.0 ml toluene. The mixture is heated to 80C and a mixture of 1 1 .6 g (101 mmol) methanesulfonyl chloride and 3.00 ml toluene is added. After complete addition, the funnel is rinsed with 7.00 ml toluene and the reaction mixture is heated to reflux for approx. 3h. After full conversion (GC) the mixture is cooled to 20 C and 40.0 ml water is added. Stirring is continued for a short period and the aqueous phase is separated. Then, approx. 10 ml of the organic phase is distilled off in vacuum. The crude toluene solution of the product is used for the next step.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2568-33-4, 3-Methylbutane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; DAHMANN, Georg; WAGNER, Holger; ECKHARDT, Matthias; FRANK, Markus; SANTAGOSTINO, Marco; SCHNAUBELT, Juergen; STERTZ, Uwe; PACHUR, Thorsten; WO2015/44073; (2015); A1;,
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