Tag: M.W=100-200

Related Products of 148043-73-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 148043-73-6, name is 4,4,5,5,5-Pentafluoropentan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Into a reactor (internal capacity: 200 mL, made of glass) equipped with a stirrer and a dropping funnel, linear C2F5CH2CH2CH2OH (23.6g), triethylamine (16.1 g) and acetone (80 mL) were put and stirred. Then, by an ice bath, the inner temperature of the reactor was adjusted to be at most 10C, and in a nitrogen atmosphere, a solution of 4-(chloromethyl)benzoic acid chloride (25.0 g) in acetone (15 mL) was dropwise added. Further, the temperature was returned to room temperature, and stirring was continued for 2 hours. The obtained reaction crude liquid was transferred to a separating funnel, dichloropentafluoropropane (tradename: AK-225, manufactured by Asahi Glass Company, Limited) (100 mL) was added, followed by washing three times with distilled water (100 mL), and the solvent in the AK-225 phase was distilled off to obtain 40.2 g of a compound (C-2) (pale yellow liquid) represented by the following structural formula (C-2) and classified into the above compound (C). The yield was 93%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 148043-73-6, 4,4,5,5,5-Pentafluoropentan-1-ol.

Reference:
Patent; Asahi Glass Company, Limited; EP2497763; (2012); A1;,
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Electric Literature of 42822-86-6 ,Some common heterocyclic compound, 42822-86-6, molecular formula is C10H20O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: para-Methane-3,8-diol (3, 5.0 g, 0.029 mol) and an appropriatemolar equivalent of acid anhydride were transferred into thereactor concurrently. Both reagents were stirred and heated at60 Cfor 10 minutes. The homogeneous mixture was achievedand 0.3 g of polymer-bound scandium triflate (PS-Sc(OTf)3)catalyst was added into the reaction mixture. The reaction washeated at the appropriate temperature for 24 hours, while followed by sampling at an hourly interval. Upon the completionof the reaction, the catalyst was separated from the product mixture by filtration and the acid byproduct was removed byvacuum distillation. The obtained crude sample was subsequently purified by column chromatography hexane/EtOAc(98:2).Diacetate 9:The reaction was carried out in accordance withthe general procedure using para-menthane-3,8-diol (3, 5.0 g,0.029 mol) and acetic anhydride (5, 7.4 g, 0.073 mol) to givethe title compound 9as viscous colourless oily liquid,bp 288 C, (6.8 g, 91%); 1H NMR (400 MHz, CDCl3, ppm)delta0.78-0.79 (m, 3H), 0.89-1.04 (m, 2H), 1.35 (br d, J= 12 Hz,6H), 1.53-1.60 (m, 3H), 1.72 (d, J= 16 Hz, 1H), 1.82 (d, J= 12Hz, 1H), 1.88 (s, 3H), 1.96 (s, 3H), 2.02-2.08 (m, 1H) and 5.17(br s, 1H); 13C NMR(100 MHz, CDCl3, ppm) delta21.4, 21.9,22.2, 22.3, 24.0, 25.1, 26.6, 34.6, 39.4, 47.3, 69.8, 84.2, 169.9and 170.3; FTIR (cm-1): 2949, 1728, 1180 and 1144; m/z(CI)256 (M+, 1), 197 (78), 137 (71), 95 (62) and 81 (100); GC tR=17.8 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 42822-86-6, 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Mafu, Lubabalo; Zeelie, Ben; Watts, Paul; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 2046 – 2054;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 530-91-6, name is 1,2,3,4-Tetrahydronaphthalen-2-ol, the common compound, a new synthetic route is introduced below. SDS of cas: 530-91-6

A solution of alcohol 13 (262 mg, 1.77 mmol, 1 eq.), nosyl chloride (781.5 mg, 3.53 mmol,2.0 eq.), DMAP (73.2 mg, 0.60 mmol, 0.34 eq.) and Et3N (0.74 mL,540.2 mg, 5.34 mmol, 3.0 eq.) in CH2Cl2 (6 mL) wasstirred vigorously for 16 h at rt. 2M NaOH (6 mL) was added and the reactionmixture was extracted with CH2Cl2 (3 x 5 mL). The organiclayer was washed with 2M NaOH (7 mL), dried (Na2SO4),filtered and concentrated in vacuo. The crude product was purified by fc (d = 3cm, l = 13 cm, v = 25 mL, cyclohexane:EtOAc 8:2, Rf = 0.55) to obtain a colorlessoil, yield 380.0 mg (64 %). C16H15NO5S (333.4g/mol). 1H NMR (400 MHz, CDCl3): delta (ppm) = 2.03 – 2.15(m, 2H, 3-CH2), 2.77 – 2.85 (m, 1H, 1-CH2), 2.92 – 3.02(m, 2H, 4-CH2), 3.08 (dd, J = 16.8/4.9 Hz, 1H, 1-CH2),5.10 – 5.15 (m, 1H, 2-CH), 6.95 (dd, J = 7.3/1.5 Hz, 1H,tetraline), 7.05 – 7.16 (m, 3H, tetraline), 8.08 – 8.14 (m, 2H, nos), 8.35 -8.40 (m, 2H, nos).

The synthetic route of 530-91-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bechthold, Elena; Gawaskar, Sandeep; Robaa, Dina; Schepmann, Dirk; Schreiber, Julian A.; Seebohm, Guiscard; Sippl, Wolfgang; Temme, Louisa; Wuensch, Bernhard; European Journal of Medicinal Chemistry; vol. 190; (2020);,
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Synthetic Route of 311-86-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 311-86-4, name is 2-Bromo-3,3,3-trifluoropropan-1-ol. A new synthetic method of this compound is introduced below.

Adding a moisture content of 4000 ppm in a 50 mL stainless steel autoclave equipped with agitation3,3,3-trifluoropropylene oxide (33.6 g, 0.3 mol), 3-bromo-1,1,1-trifluoro-2-propanol (2.3 g, 12 mol),2,3-dibromo-1,1,1,2,3,3-hexafluoropropane (5.6 g, 18 mol), imidazole (1.6 g, 24 mmol),After sealing, the reactor was replaced twice with CO2, and the stirring was set to a reaction temperature of 120 C.Continuously pass CO2 to maintain the reaction pressure at 2MPa, react for 4h, cool to normal temperature, and slowly releaseTo the excess CO2 gas, 50% water of a molar amount of 3,3,3-trifluoroepoxypropane was added to the reaction solution, and the reaction was stirred at 50 C for about 24 hours to obtain 3,3,3-trifluoro. Crude product of propylene carbonate and 3,3,3-trifluoro-1,2-propanediol, analysis of reaction product distribution by gas chromatography, separation,Refined process to get the target product3,3,3-trifluoropropene carbonate and42.3 g of 3,3,3-trifluoro-1,2-propanediol was used to calculate the yield

At the same time, in my other blogs, there are other synthetic methods of this type of compound,311-86-4, 2-Bromo-3,3,3-trifluoropropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Xi’an Modern Chemical Institute; Lv Jian; Ma Hui; Zhang Wei; Wang Bo; Zeng Jijun; Zhao Bo; Yang Zhiqiang; Qin Yue; Bai Yanbo; Li Fengxian; (10 pag.)CN108178752; (2018); A;,
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Application of 62285-58-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 62285-58-9, name is (2,6-Dimethylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Step B Preparation of N- (2,6-Dimethylbenzyl)phthalimide: To a stirred solution of 2,6-Dimethylbenzyl Alcohol (Step A, 6.59 g, 48.4 mmol) in DMSO (20 ml) was added chlorotrimethylsilane (15.75 ml, 145 mmol) at room temperature, and the mixture was stirred for one hr. To this reaction mixture were added ethyl acetate and water, the organic layer was washed with brine, dried over Na2SO4, filtered and concentrated to give an oil. The oily residue was redissolved in DMF (100 ml) and potassium phthalimide (10.76 g, 58.1 mmol) was added. The reaction mixture was stirred for 16 hours at room temperature, ethyl acetate was added, and the organic layer was washed with 3% Na2CO3, 1 N HCl, dried over Na2SO4, filtered and concentrated to give white solid. The purification was done by flash chromatography on silica gel column (chloroform: methanol 95:5) to provide the title compound as white solid. 1H NMR (270 MHz, DMSO): 2.3 (s, 6H); 4.8 (s, 2H); 7.0 (m, 3H); 7.8 (s, 4H).

According to the analysis of related databases, 62285-58-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sharma, Shalini; von Borstel, Reid W.; US2003/149107; (2003); A1;,
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Reference of 68327-04-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.68327-04-8, name is (1S,2S)-2-Aminocyclopentanol hydrochloride, molecular formula is C5H12ClNO, molecular weight is 137.6079, as common compound, the synthetic route is as follows.

Boc2O (3.49 g, 15.98 mmol) was added to a solution, at 0C, of (1S,2S)-2- aminocyclopentan-1-ol-HC1 (2.0 g, 14.53 mmol) and Et3N (4.05 mL, 29.06 mmol) in methanol (20 mL) and stirred. The reaction was allowed to warm to room temperature and after overnight the reaction was concentrated and the crude was purified by column chromatography to give S 13 (2.87 g) as a white solid.

Statistics shows that 68327-04-8 is playing an increasingly important role. we look forward to future research findings about (1S,2S)-2-Aminocyclopentanol hydrochloride.

Reference:
Patent; REGENTS OF THE UNIVERSITY OF MICHIGAN; WANG, Shaomeng; AGUILAR, Angelo; ZHANG, Ke; XU, Shilin; XU, Tianfeng; BERNARD, Denzil; HUANG, Liyue; (285 pag.)WO2017/192543; (2017); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 29683-23-6, name is Tetrahydro-2H-thiopyran-4-ol, molecular formula is C5H10OS, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 29683-23-6

To a mixture of 4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile (1.00 g), tetrahydro-2H-thiopyran-4-ol (1.18 g), triphenylphosphine (2.62 g) and tetrahydrofuran (30 mL) was added dropwise diisopropyl azodicarboxylate (2.02 g) at room temperature under nitrogen atmosphere, and the mixture was stirred overnight at room temperature. The reaction mixture was diluted with saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted twice with ethyl acetate. The extracts were combined, washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (320 mg). MS (ESI+): [M+H]+ 250.9

With the rapid development of chemical substances, we look forward to future research findings about 29683-23-6.

Reference:
Patent; Takeda Pharmaceutical Company Limited; NAGAMIYA, Hiroyuki; YOSHIDA, Masato; SETO, Masaki; MARUI, Shogo; ODA, Tsuneo; ISHICHI, Yuji; SUZUKI, Hideo; KUSUMOTO, Tomokazu; YOGO, Takatoshi; RHIM, Chul Yun; YOON, Cheolhwan; LEE, Gil Nam; KANG, Hyun Bin; KIM, Kwang Ok; JEON, Hye Sun; EP2818473; (2014); A1;,
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Electric Literature of 558-42-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.558-42-9, name is 1-Chloro-2-methyl-2-propanol, molecular formula is C4H9ClO, molecular weight is 108.5667, as common compound, the synthetic route is as follows.

Example 298 Preparation of Compound Nos. II-84 and II-84a-b (1520) To a solution of 2-(8-methyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-yl)-1-pyridin-4-yl-ethanol (200 mg, 0.651 mmol) in acetonitrile (4 mL), potassium carbonate (270 mg, 1.95 mmol) and 1-chloro-2-methyl-propan-2-ol (105 mg, 0.977 mmol) were added and the reaction mixture was stirred at 100¡ã C. for 12 h. The reaction mixture was diluted with water (10 mL) and extracted with EtOAc (3¡Á20 mL). The combined organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography (Neutral alumina, 1percent MeOH-DCM), to yield 1-[5-(2-hydroxy-2-pyridin-4-yl-ethyl)-8-methyl-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl]-2-methyl-propan-2-ol. 1H NMR (CDCl3, freebase) delta (ppm): 8.6 (d, 2H), 7.27 (m, 2H), 7.2 (m, 2H), 7.0 (d, 1H), 5.08 (t, 1H), 4.19 (m, 2H), 3.9 (bs, 2H), 3.0-3.1 (m, 2H), 2.9 (m, 1H), 2.6 (s, 2H), 2.56 (m, 1H), 2.21 (s, 3H), 1.21 (s, 6H). Separation by chiral HPLC provides enantiomers II-84a-b.

The chemical industry reduces the impact on the environment during synthesis 558-42-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Medivation Technologies, Inc.; PROTTER, Andrew Asher; CHAKRAVARTY, Sarvajit; JAIN, Rajendra Parasmal; GREEN, Michael John; US2015/266884; (2015); A1;,
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Application of 111-32-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 111-32-0, name is 4-Methoxybutan-1-ol. A new synthetic method of this compound is introduced below.

Example A. 22 Preparation of intermediate (66) 4-Methoxy-l-butanol (0. 9 mol) was stirred in DCM (1500 ml) and triethylamine (1.35 mol) was added, then methylsulfonyl chloride (1. 1 mol) was added dropwise (temperature rise up to 40 C) and the reaction mixture was stirred for 2 hours at room temperature. The mixture was washed with water. The organic layer was separated, dried and the solvent was evaporated, then co-evaporated with toluene, yielding 167 g of intermediate (66).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,111-32-0, 4-Methoxybutan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2005/3122; (2005); A1;,
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Reference of 33036-62-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33036-62-3, name is 4-Bromo-1-butanol, molecular formula is C4H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Crude product 4-bromo-butanol was dissolved in DCM (500 ml) and dried over Na2SO4 and p-TosOH (500 mg) was added. Dihydropyran (1181 ml) was added dropwise at 0 C. and during the addition the temperature was kept under 8 C. The reaction was allowed to reach RT overnight, washed with saturated NaHCO3 solution (2¡Á300 ml) and brine (9.3 I). The aqueous layers were washed with TBME (300 ml) and the combined organic layers were dried over anhydrous K2CO3. The mixture was filtered off and the solvent was removed on the rotary evaporator. This yielded 593 g (yield=25% over 2 steps). The obtained 4-bromo-butanol-THP ether was filtrated twice over SiO2 (DCM with 1% MeOH). Finally, the compound was purified by column chromatography (20 I SiO2, DCM with 1% MeOH). This yielded 220.6 g of 2-(4-Bromo-butoxy)-tetrahydro-pyran (yield=9.3% over 2 steps) as a TLC-pure light yellow oil.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 33036-62-3, 4-Bromo-1-butanol.

Reference:
Patent; Solvay Pharmaceuticals GmbH; US2005/192263; (2005); A1;,
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