Tag: M.W=100-200

Reference of 16308-92-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16308-92-2, name is (2,4-Dimethylphenyl)methanol. A new synthetic method of this compound is introduced below.

Step B. Ethyl 1-(6-{2-[(2,4-dimethylbenzyl)oxy]-3-iodophenyl}pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate; To a solution of the title compound from Example 15 Step A (200 mg, 0.397 mmol), 2,4-dimethylbenzyl alcohol (81.0 mg, 0.596 mmol), and triphenylphosphine (156 mg, 0.596 mmol) in DCM (2 mL) was added diisopropyl azodicarboxylate (0.114 mL, 0.596 mmol), and the resulting mixture was stirred at ambient temperature. After 18 h, the reaction mixture was concentrated in vacuo. Purification by flash chromatography on silica gel (0 to 20% EtOAc in hexanes, then 20 to 100% EtOAc in hexanes) provided the title compound: LCMS m/z 594.8 [M+H]+; 1H NMR (500 MHz, CDCl3) delta 8.17 (s, 1H), 8.02 (d, J=8.0 Hz, 1H), 7.92 (d, J=7.5 Hz, 1H), 7.85-7.81 (m, 2H), 7.60 (d, J=7.5 Hz, 1H), 7.13 (d, J=7.5 Hz, 1H), 7.05 (t, J=7.5 Hz, 1H), 6.95-6.92 (m, 2H), 4.69 (s, 2H), 4.41 (q, J=7.0 Hz, 2H), 2.30 (s, 3H), 2.17 (s, 3H), 1.43 (t, J=7.0 Hz, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,16308-92-2, (2,4-Dimethylphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Bittner, Amy R.; Sinz, Christopher Joseph; Chang, Jiang; Kim, Ronald M.; Mirc, J. W.; Parmee, Emma R.; Tan, Qiang; US2009/209556; (2009); A1;,
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Related Products of 10602-04-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.10602-04-7, name is (4-Ethynylphenyl)methanol, molecular formula is C9H8O, molecular weight is 132.16, as common compound, the synthetic route is as follows.

To a suspension of azide derivative 13 (1 mole eq.) in isopropanol and water (1:1) was added alkyne (2 mole eq.) followed by CuSO4H2O (0.2 mole eq.) and sodium ascorbate (0.4 mole eq.). The reaction mixture was stirred at 40-50 C for 2 h and then evaporated under reduced pressure. To the residue was added H2O and the aqueous mixture was extracted with DCM. The organic phase was washed with H2O, brine, dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The crude product was then purified by column chromatography on silica to obtain the desired C-1 triazole derivative.

Statistics shows that 10602-04-7 is playing an increasingly important role. we look forward to future research findings about (4-Ethynylphenyl)methanol.

Reference:
Article; Bhatt, Beenu; Thomson, Robin J.; Von Itzstein, Mark; Tetrahedron Letters; vol. 52; 21; (2011); p. 2741 – 2743;,
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Adding a certain compound to certain chemical reactions, such as: 623-04-1, (4-Aminophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 623-04-1, blongs to alcohols-buliding-blocks compound. Application In Synthesis of (4-Aminophenyl)methanol

General procedure: To a solution of particular aromatic amine, 1:1 HCl-water was added in small instalments while stirring at 0C. After 10min, 4 equivalents of 3M sodium nitrite in water was added drop wise and after 30min 3 equivalents of 3M sodium azide and sodium acetate in water was added drop wise carefully keeping the reaction mixture at 0C or below (Scheme 2). After completion of addition, reaction was brought to room temperature and allowed to react for one more hour and finally extracted with diethyl ether for at least three times. Organic layers were washed with saturated sodium bicarbonate solution two times, dried over anhydrous sodium sulphate and concentrated to a minimum volume under reduced pressure on rotary evaporator.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,623-04-1, its application will become more common.

Reference:
Article; Dangroo, Nisar A.; Singh, Jasvinder; Dar, Alamgir A.; Gupta, Nidhi; Chinthakindi, Praveen K.; Kaul, Anpurna; Khuroo, Mohmmed A.; Sangwan, Payare L.; European Journal of Medicinal Chemistry; vol. 120; (2016); p. 160 – 169;,
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Application of 83811-73-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 83811-73-8, name is (4-Phenylcyclohexyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Second step Compound (III) (50 g, 0.268 mol) was dissolved in dry pyridine (110 ml) and cooled to 5 C. or lower. To this solution was dropwise added a solution of p-toluenesulfonic chloride (50.1 g, 0.263 mol) dissolved in dry toluene (70 ml), through a dropping funnel in small portions so that the reaction temperature could not exceed 10 C. After completion of the addition, the cooling bath was removed and agitation was carried out at room temperature for 4 hours, followed by adding water (100 ml) and toluene (300 ml) to extract the resulting product, washing the toluene-extraction liquid twice with 6N-HCl (100 ml), then once with water (200 ml), further twice with 2N aqueous solution of NaOH (100 ml), and 4 times with water (200 ml), distilling off the solvent, recrystallizing the residue from toluene (90 ml), filtering off and drying to obtain p-toluenesulfonic acid trans-4-phenylcyclohexyl methyl ester (IV) (77.0 g). M.P. 108.0~108.7 C.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 83811-73-8, (4-Phenylcyclohexyl)methanol.

Reference:
Patent; Chisso Corporation; US4522741; (1985); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 71176-54-0, name is (5-Amino-1,3-phenylene)dimethanol, the common compound, a new synthetic route is introduced below. Formula: C8H11NO2

Compound 101 (923 mg, 1.65 mmol) and (5-amino-1,3-phenylene)dimethanol (240 mg, 1.57 mmol) were dissolved in DMF (5.2 ml). EDC.HCl (601 mg, 3.13 mmol), and DMAP (96 mg, 0.78 mmol) were added at room temperature and the reaction was stirred overnight at room temperature. The reaction was diluted with ethyl acetate and washed with water three times. The organic layer was dried, concentrated in vacuo and purified by silica gel chromatography (DCM/MeOH) to give Compound 102 (150 mg, 20percent yield). LCMS=3.91 min (8 min method). MS (m/z): 472.2 (M+1)+. 1H NMR (400 MHz, MeOD): delta 9.69 (s, 1H), 8.21 (d, 1H, J=6.8 Hz), 8.18 (d, 1H, J=6.8 Hz), 7.52 (s, 2H), 7.12 (s, 1H), 4.58 (s, 4H), 4.44-4.48 (m, 1H), 4.29-4.32 (m, 1H), 3.34 (s, 2H), 2.38 (s, 3H), 2.34-2.40 (m, 2H), 1.90-1.95 (m, 2H), 1.43 (d, 3H, J=7.2 Hz), 1.36 (d, 3H, J=7.2 Hz), 1.30 (s, 6H).

The synthetic route of 71176-54-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IMMUNOGEN, INC.; Chari, Ravi V.J.; Miller, Michael Louis; Shizuka, Manami; (250 pag.)US2016/82114; (2016); A1;,
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Application of 637031-88-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 637031-88-0, name is 3,3-Difluorocyclobutanol, molecular formula is C4H6F2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 7′-methylsulfonylspiro[l,3- dioxolane-2,l’-indane]-4′-ol (2.0 g, 7.4 mmol), triphenylphosphine (8.2 g, 31.1 mmol), and 3,3-difluoro-cyclobutanol (1.04 g, 9.6 mmol) in tetrahydrofuran (50 mL) at 60 C was added diisopropyl azodicarboxylate (2.3 mL, 11.8 mmol). After addition, the reaction mixture was stirred at 60 C overnight. After cooled to ambient temperature, water (50 mL) and MTBE (50 mL) were added. The organic layer was separated, washed with brine, dried (sodium sulfate), filtered and concentrated under reduced pressure. The residue obtained was purified by flash chromatography on silica gel to give 4′-(3,3-difluorocyclobutoxy)-7′-methylsulfonyl- spiro[l,3-dioxolane-2,l’-indane] (1.0 g, 37%) as solid.

According to the analysis of related databases, 637031-88-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PELOTON THERAPEUTICS, INC.; DIXON, Darryl, David; GRINA, Jonas; JOSEY, John, A.; RIZZI, James, P.; SCHLACHTER, Stephen, T.; WALLACE, Eli, M.; WANG, Bin; WEHN, Paul; XU, Rui; YANG, Hanbiao; (237 pag.)WO2016/144825; (2016); A1;,
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Related Products of 637031-88-0 ,Some common heterocyclic compound, 637031-88-0, molecular formula is C4H6F2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of racemic-2′,3′,4′- trifluoro-7′-methylsulfonyl-spiro[l,3-dioxolane-2, -indane] (19.3 mg, 0.063 mmol) and 3,3- difluoro-cyclobutanol (9.8 muEpsilon, 0.10 mmol) in acetonitrile (1.0 mL) at 25 C was treated with potassium hydroxide (5.3 mg, 0.094 mmol) and stirred at 25 C for 1 h. An additional portion of potassium hydroxide (5.3 mg, 0.094 mmol) was added to drive the reaction to completion. Volatiles were removed by concentration under reduced pressure. The reaction mixture was poured into 20 mL of water and extracted with 3 x 20 mL EtOAc. The combined organics were rinsed with 10 mL of brine, dried with MgS04, filtered, and concentrated to dryness. An off-white solid (27.2 mg) was isolated and used without further purification. LCMS ESI (+) [M+H]+ m/z 397.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,637031-88-0, its application will become more common.

Reference:
Patent; PELOTON THERAPEUTICS, INC.; DIXON, Darryl, David; GRINA, Jonas; JOSEY, John, A.; RIZZI, James, P.; SCHLACHTER, Stephen, T.; WALLACE, Eli, M.; WANG, Bin; WEHN, Paul; XU, Rui; YANG, Hanbiao; (237 pag.)WO2016/144825; (2016); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 929-06-6, name is 2-(2-Aminoethoxy)ethanol, the common compound, a new synthetic route is introduced below. Recommanded Product: 2-(2-Aminoethoxy)ethanol

General procedure: To a solution of 2a (or 2b-e, 20 mmol) in a mixture of dioxane (15 mL) and H2O (7 mL), wasadded 5N NaOH (4.8 mL) and a solution of Boc2O (5.0 g, 23 mmol) in dioxane at 0 C. After stirred atrt overnight, the reaction mixture was concentrated in vacuo. The residue was extracted from 10%citric acid with AcOEt, and dried over anhydrous Na2SO4. Evaporation of the solvents gave the pureproduct 3a-e. 3a was obtained as a colorless oil (2.67 g, 83%).

The synthetic route of 929-06-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Li, Xiaoxiao; Hou, Jianjun; Wang, Chao; Liu, Xinjie; He, Hongyan; Xu, Ping; Yang, Zhenjun; Chen, Zili; Wu, Yun; Zhang, Lihe; Molecules; vol. 18; 11; (2013); p. 13957 – 13978;,
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Electric Literature of 42514-50-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 42514-50-1, name is 3-Amino-3-methylbutan-1-ol, molecular formula is C5H13NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

b 3-(N-BOC-amino)-3-methyl-butan-1-ol A solution of 24.88 g (0.114 mol) of di-tert-butyl dicarbonate in 70 ml of methylene chloride is added dropwise to a solution of 11.2 g (0.1086 mol) of 3-amino-3-methyl-butan-1-ol [Z. Naturforsch., Teil B, 38, 1146 (1983)] in 70 ml of methylene chloride and the mixture is stirred at room temperature for 90 hours. After evaporation of the reaction mixture in vacuo, the oily title compound is obtained as a crude product, Rf value=0.52 (silica gel/methylene chloride:methanol (9:1)).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 42514-50-1, 3-Amino-3-methylbutan-1-ol.

Reference:
Patent; Ciba-Geigy Corporation; US5610195; (1997); A;,
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Adding a certain compound to certain chemical reactions, such as: 35106-82-2, (2-Vinylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 35106-82-2, blongs to alcohols-buliding-blocks compound. name: (2-Vinylphenyl)methanol

Step 3: (1,3-dihydroisobenzofuran-1-yl)methanol To a mixture of (2-vinylphenyl)methanol (obtained from step 2) (1.0 g, 7.45 mmol) in DCM (10 mL) was added m-CPBA (1.82 g, 8.94 mmol) in small portions at 0¡ã C. The reaction mixture was stirred at room temperature for overnight, and then the mixture was diluted with DCM (30 mL) and washed with saturated NaHCO3 aqueous solution and brine. The organic layer was dried over sodium sulfate and concentrated under vacuum. The residue was purified by prep-TLC (petroleum ether:ethyl acetate=4:1) to afford (1,3-dihydroisobenzofuran-1-yl) methanol (260 mg, yield: 23percent) as yellow oil. m/z: [M+H]+ 151.1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,35106-82-2, its application will become more common.

Reference:
Patent; SHANGHAI DE NOVO PHARMATECH CO. LTD.; GAO, Daxin; YANG, Heping; WANG, Pei; (84 pag.)US2017/37038; (2017); A1;,
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