Tag: M.W=100-200

Synthetic Route of 25055-82-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 25055-82-7, name is 2-(3-Methyl-3H-diazirin-3-yl)ethanol. A new synthetic method of this compound is introduced below.

A solution of 2-(3-methyl-3H-diazirin-3-yl)ethan-i-ol (100 mg, 1.0 mmol) and triethylamine (160 mu, 1.15 mmol) in dichloromethane (5 mL) was cooled in an ice bath. To the cooled solution was added methanesulfonyl chloride (93 mu, 1.2 mmol). The reaction mixture was stirred for 1.5 hours in the ice bath, then saturated ammonium chloride was added and the organic layer was separated. The aqueous layer was extracted once with dichloromethane. The organic layers were combined, dried over sodium sulfate, filtered and then concentrated in vacuo to afford the title compound (178 mg, quantitative yield) which was used without further purification. (1292) NMR (CDC13): delta = 4.13 (t, 2 Eta), 3.05 (s, 3 Eta), 1.79 (t, 2 Eta), 1.09 (s, 3 Eta).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,25055-82-7, its application will become more common.

Reference:
Patent; INFLAZOME LIMITED; COOPER, Matthew; MILLER, David; MACLEOD, Angus; VAN WILTENBURG, Jimmy; THOM, Stephen; ST-GALLAY, Stephen; SHANNON, Jonathan; (352 pag.)WO2019/8025; (2019); A1;,
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Reference of 71176-54-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.71176-54-0, name is (5-Amino-1,3-phenylene)dimethanol, molecular formula is C8H11NO2, molecular weight is 153.18, as common compound, the synthetic route is as follows.

Aniline compound 7 (100 mg, 0.653 mmol) and acid compound 6 (227 mg, 0.685 mmol) were suspended in CH2Cl2/MeOH (4.35 mL/2.2 mL) at rt. EEDQ (323 mg, 1.306 mmol) was added and the reaction was stirred at rt overnight. The solvent was concentrated and the residue was slurried in EtOAc (15 mL) and filtered. The solids were washed with EtOAc (2×15 mL) and was dried under vacuum/N2 to obtain compound 8 as a white solid (260 mg, 85percent yield). 1H NMR (400 MHz, DMSO-d6): delta 9.74 (s, 1H), 8.21-8.19 (m, 2H), 8.11-8.08 (m, 1H), 7.45 (s, 2H), 6.96 (s, 1H), 5.17 (t, 2H, J=5.7 Hz), 4.45 (d, 4H, J=5.6 Hz), 3.87 (d, 2H, J=5.8 Hz), 3.75 (dd, 4H, J=5.7, 13.4 Hz), 3.58 (s, 3H), 2.31-2.27 (m, 2H), 2.16-2.13 (m, 2H), 1.52-1.48 (m, 4H). LCMS=0.886 min (15 min method). Mass observed (ESI+): 489.3 (M+Na).

Statistics shows that 71176-54-0 is playing an increasingly important role. we look forward to future research findings about (5-Amino-1,3-phenylene)dimethanol.

Reference:
Patent; IMMUNOGEN, INC.; Chari, Ravi V.J.; Miller, Michael Louis; Shizuka, Manami; (250 pag.)US2016/82114; (2016); A1;,
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Application of 15852-73-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15852-73-0, name is (3-Bromophenyl)methanol, molecular formula is C7H7BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of compound 8a (1.08 g, 10 mmol) and Et3N (1.52g, 15 mmol) in anhydrous DCM (100 mL) was added dropwisemethanesulfonyl chloride (1.36 g, 12 mmol) in anhydrous DCM(20 mL). The mixture was stirred for 12 h while being cooled withan ice-water bath. DCM was evaporated under vacuum. The residuewas dissolved in EtOAc (100 mL) and washed with 10percent HCl(3 100 mL), saturated NaHCO3 (3 100 mL) and brine (3 100mL), and then dried over MgSO4 overnight. EtOAc was evaporatedto give 11a as yellow oil (1.77 g, yield: 95percent). ESI-MS m/z 187.4 [M+H]+. The crude product was used directly in the next reactionwithout further purification.Compounds 11b?11w, 11aa?11ff and 23a?23h were preparedusing the same procedure described above.

According to the analysis of related databases, 15852-73-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Cao, Jiangying; Ma, Chunhua; Zang, Jie; Gao, Shuai; Gao, Qianwen; Kong, Xiujie; Yan, Yugang; Liang, Xuewu; Ding, Qin’ge; Zhao, Chunlong; Wang, Binghe; Xu, Wenfang; Zhang, Yingjie; Bioorganic and Medicinal Chemistry; vol. 26; 12; (2018); p. 3145 – 3157;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-90-0, name is Diethylene Glycol Monoethyl Ether. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 111-90-0

General procedure: To a solution of 4 (50 mg, 0.08 mmol, 1 equiv) in DMF (2 mL), N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) (39.6 mg, 0.16 mmol, 2 equiv) was added and the mixture was stirred for 10 minutes at room temperature. N,N-Diisopropylethylamine (DIEA) (20.7 mg, 0.16 mmol, 2 equiv) was added to the reaction at room temperature. In a separate flask, alkyl amine or alcohol (0.12 mmol, 1.5 equiv) was dissolved in DMF (2 mL) and added to the reaction mixture. The reaction was then heated to 60 C and continued for 12 hours. The reaction progress was monitored by TLC until completion. The productwas extracted in DCM (10 mL) and washed with H2O (3 x 10 mL) and brine (10 mL). The organic layer was dried with Na2SO4, filtered and concentrated in vacuo prior to purification by silica gel column chromatography.

With the rapid development of chemical substances, we look forward to future research findings about 111-90-0.

Reference:
Article; Patel, Pradeepkumar; Hanawa, Emi; Yadav, Reeta; Samuni, Uri; Marzabadi, Cecilia; Sabatino, David; Bioorganic and Medicinal Chemistry Letters; vol. 23; 18; (2013); p. 5086 – 5090;,
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Reference of 702-23-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.702-23-8, name is 2-(4-Methoxyphenyl)ethanol, molecular formula is C9H12O2, molecular weight is 152.19, as common compound, the synthetic route is as follows.

Reactant: 6. To a stirred solution of compound 6 (1.0 g, 6.57 mmol) in toluene (40 mL) triethylamine(2.0 mL, 19.71 mmol) was added at 0 C. TsCl (1.5 g, 7.88 mmol) was added slowly and the reaction mixture stirred 48 h at RT. The solution was diluted with diethyl ether and washed with saturatedaqueous NaHCO3 (20 mL). The residue of unreacted precipitated TsCl was filtered out and organiclayer was dried, filtered and concentrated to give light yellow crystals: 29 (2.0 g, 99 %).

The chemical industry reduces the impact on the environment during synthesis 702-23-8, I believe this compound will play a more active role in future production and life.

Reference:
Article; Blaess, Markus; Bibak, Nelly; Claus, Ralf A.; Kohl, Matthias; Bonaterra, Gabriel A.; Kinscherf, Ralf; Laufer, Stefan; Deigner, Hans-Peter; European Journal of Medicinal Chemistry; vol. 153; (2018); p. 73 – 104;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 55414-72-7, name is (2-Amino-5-methoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 55414-72-7

A mixture of compound 6 (0.081 g, 0.35 mmol) and thionyl chloride (1.12 mL, 15.4 mmol) was stirred at reflux for 5 h. The excess thionyl chloride was removed and the residue was cooled to 0 C. Aqueous saturated sodium bicarbonate solution (10 mL) and a solution of compound 4 (0.046 g, 0.30 mmol) in methanol (2 mL) were added slowly with rapid stirring. The mixture was stirred at room temperature overnight and the resultant pink-orange solid was collected and washed with aqueous HCl (1 M, 5 mL), water (5 mL), diethyl ether (5 mL) and hexane (5 mL). The solid was dried to obtain the title compound as a sticky orange powder (0.063 g, 58%); 1H NMR (300 MHz, CDCl3): delta 3.81 (s, 3H), 3.82 (s, 3H), 4.71 (s, 2H), 6.82-6.93 (m, 3H), 7.17 (d, J = 3.1 Hz, 1H), 7.49 (d, J = 8.8 Hz, 1H), 7.91 (d, J = 8.8 Hz, 1H), 8.57 (br s, 1H); this material was carried forward to the next step without further purification.

With the rapid development of chemical substances, we look forward to future research findings about 55414-72-7.

Reference:
Article; Lizarme, Yuvixza; Wangsahardja, Jonatan; Marcolin, Gabriella M.; Morris, Jonathan C.; Jones, Nicole M.; Hunter, Luke; Bioorganic and Medicinal Chemistry; vol. 24; 7; (2016); p. 1480 – 1487;,
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Application of 3391-86-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3391-86-4, name is Oct-1-en-3-ol, molecular formula is C8H16O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: In a sealed tube, under nitrogen atmosphere, the ruthenium complex [RuCl2( 6-C6H6)(PTA-Me)] (3a) (0.02-0.1 mmol; 0.5-2.5 mol% of Ru) and K2CO3 (0.05-0.25 mmol; 1.25-6.25 mol%) were added to a solution of the corresponding allylic alcohol 4a-o (4 mmol) in tetrahydrofuran (4 mL), and the resulting mixture stirred at 75 C for the indicated time (see Table 4 and Scheme 3). The course of the reaction was monitored by taking regularly samples of ca. 10 L which after dilution with dichloromethane (3 mL) were analyzed by GC. After the reaction was finished, the mixture was cooled to room temperature leading to the partial precipitation of 3a. The solid was separated by filtration and the reaction product isolated by solvent removal and chromatographic workup of the residue on silica-gel using a mixture of EtOAc-hexane (1:10) as eluent. The identity of the resulting carbonyl compounds 5a-o was assessed by comparison of their retention times with those of commercially available pure samples (Sigma-Aldrich or Acros Organics), by their fragmentation in GC/MS, and/or NMR spectroscopy.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3391-86-4, Oct-1-en-3-ol.

Reference:
Article; Menendez-Rodriguez, Lucia; Crochet, Pascale; Cadierno, Victorio; Journal of Molecular Catalysis A: Chemical; vol. 366; (2013); p. 390 – 399;,
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Application of 599-67-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 599-67-7, name is 1,1-Diphenylethanol, molecular formula is C14H14O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A solvent (5 mL) was placed in a 10 mL round bottom-flask equipped with a magnetic stirrerunder reflux, NXS (1.1 mmol) was then added and, after being dissolved, the substrate (1 mmol) wasadded and the solution was stirred for 4-24 h. The progress of the reaction mixture was monitoredby TLC, whilst the consumption of NXS was tested by KI (0.1 M). Upon completion of the reaction,the crude reaction mixture was cooled down at room temperature, diluted with EtOAc (15 mL),washed with aqueous Na2S2O3 (6 mL), NaHCO3 (6 mL), and water (10 mL), and dried over anhydrousNa2SO4. The solvent was evaporated under reduced pressure and the crude product obtained wasanalyzed by 1H-NMR. The pure final products were obtained after flash chromatography, columnchromatography or preparative thin layer chromatography.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 599-67-7, 1,1-Diphenylethanol.

Reference:
Article; Ajvazi, Njomza; Stavber, Stojan; Molecules; vol. 21; 10; (2016);,
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Electric Literature of 769-30-2, Adding some certain compound to certain chemical reactions, such as: 769-30-2, name is Benzo[d][1,3]dioxol-4-ylmethanol,molecular formula is C8H8O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 769-30-2.

General procedure: A mixture of corresponding alcohol (1, 1 mmol) and 3,4-dihydro-2H-pyran (2, 100 mg, 1.2 mmol) was stirred in the presence of zwitterionic-salt A (10 mg, 10 mol%) at 60-80 C (oil bath) for 10-12 h in a seal tube. After completion of the reaction (TLC), the reaction mixture was cooled to room temperature and diluted with water (10 mL) and extracted with ethyl acetate (20 mL). Organic layer was dried over anhydrous Na2SO4. After evaporation of solvent the crude product was purified by column chromatography on silica gel using petroleum ether/ethyl acetate (4-5%) as eluent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 769-30-2, Benzo[d][1,3]dioxol-4-ylmethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Mahato, Sachinta; Chatterjee, Rana; Chakraborty Ghosal, Nirnita; Majee, Adinath; Synthetic Communications; vol. 47; 20; (2017); p. 1905 – 1915;,
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Electric Literature of 15852-73-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15852-73-0, name is (3-Bromophenyl)methanol, molecular formula is C7H7BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: In a round-bottom flask, benzylic alcohol 1a (10 mmol, 2.0 equiv.), benzenesulfonyl chloride 2a (13 mmol, 1.3 equiv.) and NMP (2.5 equiv.). Then, DCE (3 mL) were added. The mixture was stirred at 80 C for 1.5 h. After completion of the reaction (monitoredby TLC), water (10 mL) was added and the mixture was extracted with ethyl acetate (3*10 mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, and evaporated under reduced pressure. The crude product was purified by flash chromatography on silica gel to give the desired alkyl chlorides 3.

According to the analysis of related databases, 15852-73-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zheng, Dagui; Mao, Liu-Liang; Zhu, Xian-Hong; Zhou, An-Xi; Synthetic Communications; vol. 48; 21; (2018); p. 2793 – 2800;,
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