Tag: M.W=100-200

Electric Literature of 62058-03-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 62058-03-1, name is trans-4-Aminoadamantan-1-ol, molecular formula is C10H17NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example B .4 a) Preparation of compound 4; A mixture of 2-[(4-chlorophenyl)thio]-2-methylpropanoic acid [17413-74-0] (0.0007 mol) in dichloromethane (5 ml), DMF (5 ml) and DIPEA (0.5 ml) was stirred and l-[bis(dimethylamino)methylene]-lH-benzotriazolium, hexafluorophosphate(l-), 3-oxide (EtaBTU)(0.0075 mol) was added. After stirring for 15 minutes (lalpha,3alpha,4alpha,5beta,7alpha) -4-aminotricyclo[3.3.1.13’7]decan-l-ol [62058-03-1] (0.00075 mol) was added. The reaction mixture was stirred overnight at 40°C and the solvent was evaporated. The residue was dissolved in dichloromethane and then the solution was washed with a 15 percent citric acid solution and with a sodium carbonate solution. The organic layer was separated, dried, filtered off and the solvent was evaporated. The obtained residue was purified by column chromatography over silica gel (Supelco) (eluent: dichloromethane). The product fractions were collected and the solvent was evaporated, yielding 0.164 g of compound 4.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 62058-03-1, trans-4-Aminoadamantan-1-ol.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2006/24627; (2006); A2;,
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Adding a certain compound to certain chemical reactions, such as: 7287-82-3, 1-(2-Methylphenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 1-(2-Methylphenyl)ethanol, blongs to alcohols-buliding-blocks compound. Safety of 1-(2-Methylphenyl)ethanol

General procedure: In a typical process, into a 5ml two-necked, round-bottom flask equipped with a magnetic stirrer and a thermometer were added the ruthenium complex [Ru(pymieb)(pydic)] (0.002mmol) and the substrate alcohol (2mmol) successively. The mixture was heated to 40C under stirring. Then t-butyl hydroperoxide (TBHP) was added dropwise to the mixture and the temperature was kept at 40C until completion of the reaction. The reaction samples were analyzed on a Shandong Lunan Ruihong Gas Chromatograph (SP-6800A) equipped with a FID detector and a SE 30 column (30m×0.5mm). The conditions used in gas chromatography were temperature of the detector 280C, column temperature 130-220C (varying with alcohols), pressure of the carrier gas 0.05-0.07MPa (varying with alcohols).

The synthetic route of 7287-82-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Yuecheng; Liu, Liu; Cao, Xiaohui; Zhao, Jiquan; Polyhedron; vol. 105; (2016); p. 170 – 177;,
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Electric Literature of 431-38-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 431-38-9 as follows.

2-(3-Fluorophenyl)-3-oxo-6-[4-(trifluoromethyl)phenyl]-2,3-dihydropyridazine-4-carboxylic acid (100 mg, 0.26 mmol) was dissolved in anhydrous DMF (2 mL). (2RS)-3-Amino-1 ,1 ,1 – trifluoropropan-2-ol (68 mg, 0.53 mmol), N-ethyl-N-isopropylpropan-2-amine (0.207 mL, 1.19 mmol), and propane phosphonic acid anhydride (T3P, 231 muIota_, 50% in DMF, 397 muetaetaomicronIota) were successively added. It was stirred at rt overnight. The crude reaction mixture was purified by RP-HPLC (column: X-Bridge C18 5muetaiota 100x30mm, mobile phase: (water + 0.1 vol% formic acid (99%)) / acetonitril gradient) to yield 73.9 mg (57%) of the title compound. 1H-NMR (400MHz, DMSO-de): delta [ppm] = 3.48 (ddd, 1 H), 3.71 – 3.80 (m, 1 H), 4.17 – 4.29 (m, 1 H), 6.67 (d, 1 H), 7.37 – 7.44 (m, 1 H), 7.55 – 7.59 (m, 1 H), 7.60 – 7.67 (m, 2H), 7.89 (d, 2H), 8.20 (d, 2H), 8.74 (s, 1 H), 9.62 (t, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,431-38-9, its application will become more common.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ); SCHMEES, Norbert; GUTCHER, Ilona; IRLBACHER, Horst; BADER, Benjamin; ZHAO, Na; PLATTEN, Michael; (437 pag.)WO2017/202816; (2017); A1;,
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Synthetic Route of 4084-38-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4084-38-2, name is 2,3,5,6-Tetrafluorobenzyl alcohol, molecular formula is C7H4F4O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2,3,5,6-tetrafluorobenzyl alcohol (30 mg, 0.17 mmol) and(1 R) -trans-3 – [(E) -2-methoxy-1-ethenyl]-2,2-dimethylcyclopropanecarboxylic acid (43 mg, 0.25 mmol)1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (48 mg, 0.25 mmol) and 4-dimethylaminopyridine (3 mg) were added to a chloroform solution (2 mL).After stirring at room temperature for 20 hours, water was poured into the reaction solution,This was extracted with ethyl acetate. After drying the organic layer with magnesium sulfate,Concentrate under reduced pressure, The residue was subjected to silica gel column chromatography,Represented by the following formula (X)2,3,5,6-tetrafluorobenzyl (1 R) -trans-3-[(E) -2-methoxy-1-ethenyl]-2,2-dimethylcyclopropanecarboxylate (hereinafter referred to as “This compound is referred to as the compound 9 of the present invention. ) 18 mg.

According to the analysis of related databases, 4084-38-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DAINIHON JOCHUGIKU COMPANY LIMITED; MATSUO, NORITADA; KOUTANI, YASUYUKI; NAKAYAMA, KOJI; (27 pag.)JP2018/43961; (2018); A;,
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Related Products of 1562-00-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1562-00-1, name is Sodium isethionate. This compound has unique chemical properties. The synthetic route is as follows.

N-[(3S,4S)-6-Acetyl-3-hydroxy-2,2-di methyl-3,4-di hydro-2H- 1 -benzopyran-4-yl]-3-chloro-4- fluorobenzamide (3.92g, 10.Ommol) and pyridine (2.5mL) were dissolved in DCM (125mL) and triphosgene (980mg, 3.33mmol) was added. The reaction mixture was stirred for 2h. Sodium isethionate (1.48g, 10.Ommol) was added and the reaction mixture was stirred overnight. The rection mixture was diluted with DCM (50mL) and EtOAc (100mL) and washed with brine, dried (Mg504) and concentrated in vacuo. The residue was dissolved in EtOAc (50mL), filtered and passed through a plug of silica. The residue was triturated from diisopropyl ether then hexane to give the title compound (133mg, 2.3%) as a cream solid.LCMS (ESj: 544.0 [MH].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1562-00-1, Sodium isethionate.

Reference:
Patent; PROXIMAGEN LIMITED; SAVORY, Edward; HILL, Daniel; KOCIAN, Oldrich; WO2014/140510; (2014); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3319-15-1, name is 1-(4-Methoxyphenyl)ethanol. A new synthetic method of this compound is introduced below., COA of Formula: C9H12O2

General procedure: In a typical reaction, alcohol (0.4 mmol) was mixed with AlCl3 (0.02 mmol, 5 mol%) and triphenylphosphine (PPh3, 0.02 mmol, 5 mol%) in nitromethane (1.0 mL). Thereafter the mixture was stirred at 80 C for 2 h. After the reaction, the mixture was cooled to room temperature, and the product was isolated using preparative thin layer chromatography (TLC, eluting solution: petroleum ether/ethyl acetate, 5/1 (v/v)). Tests for substrate scope were all performed with an analogous procedure.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3319-15-1, 1-(4-Methoxyphenyl)ethanol.

Reference:
Article; Liu, Changhui; Pan, Bin; Gu, Yanlong; Cuihua Xuebao/Chinese Journal of Catalysis; vol. 37; 6; (2016); p. 979 – 986;,
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Related Products of 2240-88-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, molecular formula is C3H5F3O, molecular weight is 114.07, as common compound, the synthetic route is as follows.

A mixture of Description 3 (100 mg, 0.325 mmol), 3,3,3-trifluoropropanol (74 mg, 0.649 mmol) and K2CO3 (134 mg, 0.974 mmol) in MeCN (3 mL) was stirred at 50 0C for 16 h. Additional 3,3,3- trifluoropropanol (30 mg) was added, the temperature raised to 60 0C and the reaction stirred for another 24 h. The reaction was condensed and partitioned between water and dichloromethane. The organic layer was dried over MgSO4 and evaporated. The crude product was purified firstly by preparative thin layer chromatography, eluting with 10 percent methanol in dichloromethane and then by flash column chromatography, eluting with ethyl acetate/dichloromethane [1:1] then ethyl acetate/dichloromethane/ methanol [50:47.5:2.5] to give the title compound (43 mg, 34 percent). 1H NMR (400 MHz, CDCl3) delta 7.67 (1 H, s), 7.45 (2 H, d, J8.6), 7.14 (2 H, d, J 8.7), 4.59 (2 H, t, J6.2), 4.16 (2 H, q, /7.3), 2.53-2.45 (2 H, m), 1.53 (3 H, m). M/z (ES+) 387, 389 (MH-H+).

The chemical industry reduces the impact on the environment during synthesis 2240-88-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2006/120481; (2006); A2;,
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Application of 702-82-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 702-82-9, name is 3-Aminoadamantan-1-ol, molecular formula is C10H17NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of 1-aminoadamantane-3-ol (2.00 g, 12.0 mmol) and potassium carbonate (2.48 g,18.0 mmol, 1.5 equiv) in 60 mL of tetrahydrofuran is added benzyl chloroformate (1.88 mL, 13.2mmol, 1,1 equiv) in dropwise fashion over a 10-minute period. The mixture is then stirred at room temperature for 2 h and then partitioned between ethyl acetate and water. The product is then extracted into the ethyl acetate and the aqueous layer is washed twice with ethyl acetate (100 ml). The combined organic layers are then washed successively with 100 mL of aqueous 2 N sodium hydroxide, water and brine, dried over sodium sulfate, filtered and concentrated to provide 1-benzylcarbamoyladamantane-3-ol as a white solid (3.32g, 92% yield). This compound was used without further purification.1H NMR (500 MHz, CDCl3): delta 7.36-7.28 (m, 5H), 5.02 (s, 2H), 4.78 (br s, 1H), 2.25 (s, 2H), 2.00(br s, 1H), 1.92 (s, 2H), 1.84 (s, 4H), 1.67 (s, 4H), 1.52 (q, J = 12.7 Hz, 2H) ppm.13C NMR (125 MHz, CDCl3): delta 154.2, 136.5, 128.4, 128.0, 126.9, 69.1, 66.0, 65.1, 53.2, 49.2,43.9, 40.4, 34.7, 30.5 ppm. Spectroscopic data matches with previously reported data.8

According to the analysis of related databases, 702-82-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Gonzalez-Esguevillas, Maria; Miro, Javier; Jeffrey, Jenna L.; MacMillan, David W.C.; Tetrahedron; vol. 75; 32; (2019); p. 4222 – 4227;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22436-06-2, name is (S)-2-Methyl-3-phenylpropan-1-ol, the common compound, a new synthetic route is introduced below. Formula: C10H14O

General procedure: To a CH2Cl2 solution (2 mL) of the (Sax)-chloride 1a (429 mg,1.0 mmol) was added a solution of 2-methyl-1-hexanol (2a)(119 mg, 1.0 mmol) in CH2Cl2 (1 mL) and Et3N (0.14 mL,1.0 mmol) at room temperature under an Ar atmosphere. Theresulting solution was stirred at reflux in CH2Cl2 for 6.5 h.The reaction mixture was poured into water and extracted withCH2Cl2. The organic layer was dried over MgSO4, filtered, concentrated,and purified by column chromatography on silicagel (CH2Cl2:hexane = 1:5) to give the corresponding ester 3a(429 mg, 84%, 54 : 46) as a white solid.

The synthetic route of 22436-06-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Murai, Toshiaki; Itoh, Hikaru; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 191; 2; (2016); p. 163 – 173;,
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Reference of 52273-77-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52273-77-5, name is 2-(3-Aminophenyl)ethanol, molecular formula is C8H11NO, molecular weight is 137.179, as common compound, the synthetic route is as follows.

A solution of 2-(3-aminophenyl)ethanol (1.8 mmol), 2-chloro-5-(4-difluoromethoxy- phenyl)-pyrimidine 30 (1.8 mmol) and p-TSA (1.8 mmol) in dioxane (10 mL) is heated at 100 0C for 12 h then cooled to rt. The reaction mixture is slowly added to water (100 mL) with stirring. The resulting precipitate is collected by filtration, washed with water and air dried. The crude precipitate of 2-(3-(5-(4-(difluoromethoxy)phenyl)pyrimidin-2-ylamino)phenyl)ethanol 42a is used without further purification. MS (m/z) (M+l)+: 357.9.

The chemical industry reduces the impact on the environment during synthesis 52273-77-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; IRM LLC; WO2009/26276; (2009); A1;,
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