Tag: M.W=100-150

Sharma, Hemant K. published the artcileSiloxymethylamines as aminomethylation reagents for amines leading to labile diaminomethanes that can be trapped as their [Mo(CO)₄] complexes, Computed Properties of 597-52-4, the publication is Chemistry – A European Journal (2016), 22(22), 7363-7366, database is CAplus and MEDLINE.

Compound Et₃SiOCH₂NMe₂ transfers the aminomethyl group, Me₂NCH₂ to R₂NH (R₂ = Et₂, PhMe, [Cr(η⁶-C₆H₅)(CO)₃]Me, PhH) giving previously unknown diaminomethanes, Me₂NCH₂NR₂ and, in the case of R₂ = PhH, the triamine Me₂NCH₂N(Ph)CH₂NMe₂. The diaminomethanes exhibit an unreported disproportionation to a mixture of (R₂N)₂CH₂, (Me₂N)₂CH₂, and Me₂NCH₂NR₂, which can be trapped as their [Mo(CO)₄(diamine)] complexes. Whereas PhMeNCH₂NMe₂ is a labile compound, the metal-substituted [(η⁶-C₆H₅)Cr(CO)₃]MeNCH₂NMe₂ is a stable material. The triamine Me₂NCH₂N(Ph)CH₂NMe₂ is unstable with respect to transformation to 1,3,5-triphenyltriazine, but is readily trapped as the bidentate-triamine Mo(CO)₄ complex. All metal complexes were characterized by single-crystal x-ray diffraction.

Chemistry – A European Journal published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C4H6O3, Computed Properties of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Song, Fengqin published the artcileGas chromatography-mass spectrometry profiling of volatile compounds reveals metabolic changes in a non-aflatoxigenic Aspergillus flavus induced by 5-azacytidine, SDS of cas: 622-40-2, the publication is Toxins (2020), 12(1), 57, database is CAplus and MEDLINE.

Aspergillus flavus is one of the most opportunistic pathogens invading many important oilseed crops and foodstuffs with such toxic secondary metabolites as aflatoxin (AF) and Cyclopiazonic acid. We previously used the DNA methylation inhibitor 5-azacytidine to treat with an AF-producing A. flavus A133 strain, and isolated a mutant (NT) of A. flavus, which displayed impaired abilities of AF biosynthesis and fungal development. In this study, gas chromatog.-mass spectrometry (GC-MS) anal. was used to reveal the metabolic changes between these two strains. A total of 1181 volatiles were identified in these two strains, among which 490 volatiles were found in these two strains in vitro and 332 volatiles were found in vivo. The NT mutant was found to produce decreasing volatile compounds, among which most of the fatty acid-derived volatiles were significantly downregulated in the NT mutant compared to the A133 strain, which are important precursors for AF biosynthesis. Two antioxidants and most of the amino acids derived volatiles were found significantly upregulated in the NT mutant. Overall, our results reveal the difference of metabolic profiles in two different A. flavus isolates, which may provide valuable information for controlling infections of this fungal pathogen.

Toxins published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C8H7NaO4S, SDS of cas: 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gokel, George W. published the artcileSulfur heterocycles. I. Use of 4,4-dimethyl-1,3-oxathiolane-3,3-dioxide as a carbonyl anion equivalent, Recommanded Product: 2-Methyl-2-sulfanylpropan-1-ol, the publication is Tetrahedron Letters (1979), 3375-8, database is CAplus.

The oxathiolane I (R = H), acting as a carbonyl anion equivalent, was alkylated with BuLi and the appropriate reagent to give I [R = D, Me, PhCH₂, CH₂:CHCH₂, Me(CH₂)₅, 1-hydroxycyclopentyl, 1-hydroxycyclohexyl, 1-hydroxycyclododecyl, PhCH(OH), PhC(OH)Me, Me₃Si, Ph]. Thermal demasking of I (R ≠ H, D), with loss of Me₂C:CH₂ and SO₂, gave the corresponding aldehyde or α-silyl ketone. E.g., pyrolysis of I (R = PhCH₂) gave 100% PhCH₂CHO.

Tetrahedron Letters published new progress about 73303-88-5. 73303-88-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Alcohol, name is 2-Methyl-2-sulfanylpropan-1-ol, and the molecular formula is C4H10OS, Recommanded Product: 2-Methyl-2-sulfanylpropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gokel, George W. published the artcileSulfur heterocycles. 3. Heterogeneous, phase-transfer, and acid-catalyzed potassium permanganate oxidation of sulfides to sulfones and a survey of their carbon-13 nuclear magnetic resonance spectra, Name: 2-Methyl-2-sulfanylpropan-1-ol, the publication is Journal of Organic Chemistry (1980), 45(18), 3634-9, database is CAplus.

Nineteen low-mol.-weight and heterocyclic sulfides were oxidized by variations of a technique using KMnO₄ and various catalysts. In addition, the NMR spectra of these compounds and other sulfones are reported.

Journal of Organic Chemistry published new progress about 73303-88-5. 73303-88-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Alcohol, name is 2-Methyl-2-sulfanylpropan-1-ol, and the molecular formula is C4H10OS, Name: 2-Methyl-2-sulfanylpropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Oliveira, Marilene Silva published the artcileMechanism of Photochemical O-Atom Exchange in Nitrosamines with Molecular Oxygen, SDS of cas: 4543-95-7, the publication is Journal of Organic Chemistry (2015), 80(12), 6119-6127, database is CAplus and MEDLINE.

The detection of an oxygen-atom photoexchange process of N-nitrosamines is reported. The photolysis of four nitrosamines (N-nitrosodiphenylamine 1, N-nitroso-N-methylaniline 2, N-butyl-N-(4-hydroxybutyl)nitrosamine 3, and N-nitrosodiethylamine 4) with UV light was examined in an ¹⁸O₂-enriched atm. in solution HPLC/MS and HPLC-MS/MS data show that ¹⁸O-labeled nitrosamines were generated for 1 and 2. But nitrosamines 3 and 4 do not exchange the ¹⁸O label and instead decomposed to amines and/or imines under the conditions. For 1 and 2, the ¹⁸O atom was found not to be introduced by moisture or by singlet oxygen [¹⁸(¹O₂¹Δ_g)] produced thermally by ¹⁸O-¹⁸O labeled endoperoxide of N,N’-di(2,3-hydroxypropyl)-1,4-naphthalene dipropanamide (DHPN¹⁸O₂) or by visible-light sensitization. A d. functional theory study of the structures and energetics of peroxy intermediates arising from reaction of nitrosamines with O₂ is also presented. A reversible head-to-tail dimerization of the O-nitrooxide to the 1,2,3,5,6,7-hexaoxadiazocane (30 kcal/mol barrier) with extrusion of O=¹⁸O accounts for exchange of the oxygen atom label. The unimol. cyclization of O-nitrooxide to 1,2,3,4-trioxazetidine (46 kcal/mol barrier) followed by a retro [2 + 2] reaction is an alternative, but higher energy process. Both pathways would require the photoexcitation of the nitrooxide.

Journal of Organic Chemistry published new progress about 4543-95-7. 4543-95-7 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 4-(Butylamino)butan-1-ol, and the molecular formula is C8H19NO, SDS of cas: 4543-95-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Zhuming published the artcileGut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer, COA of Formula: C3H5F3O, the publication is Journal of Medicinal Chemistry (2021), 64(15), 11570-11596, database is CAplus and MEDLINE.

Selective cyclooxygenase (COX)-2 inhibitors have been extensively studied for colorectal cancer (CRC) chemoprevention. Celecoxib has been reported to reduce the incidence of colorectal adenomas and CRC but is also associated with an increased risk of cardiovascular events. Here, we report a series of gut-restricted, selective COX-2 inhibitors characterized by high colonic exposure and minimized systemic exposure. By establishing acute ex vivo ¹⁸F-FDG uptake attenuation as an efficacy proxy, we identified a subset of analogs that demonstrated statistically significant in vivo dose-dependent inhibition of adenoma progression and survival extension in an APC^min/+ mouse model. However, in vitro-in vivo correlation anal. showed their chemoprotective effects were driven by residual systemic COX-2 inhibition, rationalizing their less than expected efficacies and highlighting the challenges associated with COX-2-mediated CRC disease chemoprevention.

Journal of Medicinal Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is 0, COA of Formula: C3H5F3O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Price, David A. published the artcileHigh throughput synthesis of functionalized 1,3-diones and subsequent heterocycle formation, Recommanded Product: 3,3,3-Trifluoropropan-1-ol, the publication is Synlett (2002), 1170-1172, database is CAplus.

Treatment of 3,5-heptanedione with iodosylbenzene followed by reaction with aliphatic and benzylic alcs. ROH [R = F₃CCH₂CH₂, EtCMe₂, 3-MeOC₆H₄CH₂, PhO(CH₂)₃, cyclopropylmethyl, etc.] gave the corresponding 4-alkoxy-3,5-heptanediones, which in situ underwent heterocyclization with hydrazine to afford alkoxy-substituted pyrazoles I in 10-40% total yields.

Synlett published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Recommanded Product: 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Andrieux, Claude P. published the artcileEvidence for Inverted Region Behavior in Proton Transfer to Carbanions, Application of 3,3,3-Trifluoropropan-1-ol, the publication is Journal of the American Chemical Society (2003), 125(33), 10119-10124, database is CAplus and MEDLINE.

The diphenylmethane-diphenylmethyl anion acid/base couple in N,N-dimethylformamide is taken as an example for investigating the dynamics of proton transfer at carbon in a system where the acid is not activated by an electron-withdrawing group or by removal of an electron. The laser flash electron photoinjection technique is applied to the determination of the rate constant for the protonation of diphenylmethyl anion by an extended series of acids that offers a range of driving forces encompassing over 1.2 eV. The plot of the rate constant vs. the pK_a difference between diphenylmethane and the acids or of the activation free energy vs. the standard free energy of the reaction exhibits clear “inverted region” behavior (by a factor of 80 in terms of rate constants). While such behaviors have been predicted and observed for outer-sphere electron-transfer reactions, previous evidence for proton-transfer reactions was scarce. Entropic factors, derived from an investigation of the temperature dependence of the exptl. rate constants, are also discussed.

Journal of the American Chemical Society published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Application of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Forni, Jose A. published the artcileCarbonylative Hydroacylation of Styrenes with Alkyl Halides by Multiphoton Tandem Photoredox Catalysis in Flow, Name: Pentane-1,5-diol, the publication is ACS Catalysis (2022), 12(16), 10018-10027, database is CAplus.

The photocatalytic carbonylative hydroacylation of styrenes (R¹)R²C=CH₂ (R¹ = H, Ph, Me, Et; R² = Ph, naphthalen-2-yl, pyridin-2-yl, thiophen-2-yl, etc.) with inactivated alkyl halides RX (R = Cyclohexyl, cyclopentyl, n-Bu, i-Pr, etc.; X = Br, I) was reported. This protocol unifies the visible-light multiphoton catalytic cycle of [Ir(ppy)₂(dtb-bpy)]⁺ with flow chem. to engage energy-demanding alkyl bromides and iodides at moderate pressures of carbon monoxide. The mild and practical methodol. was employed to prepare a diverse array of 43 unsym. dialkyl ketones RC(O)CH₂CH(R¹)R² from primary, secondary, and tertiary inactivated alkyl halides. The application of flow chem. technol. to achieve spatially resolved chemoselectivity and broad functional group tolerance for the mild generation of functionalized C(sp³)-rich ketone products was demonstrated.

ACS Catalysis published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Name: Pentane-1,5-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Barik, Chandan Kr published the artcileRuthenacyclic Carbamoyl Complexes: Highly Efficient Catalysts for Organosilane Hydrolysis, Safety of Triethylsilanol, the publication is European Journal of Inorganic Chemistry (2018), 2018(46), 4982-4986, database is CAplus.

The ruthenacyclic carbamoyl complexes [RuX{2-NHC(O)C₅H₃NR}(CO)₂(NCMe)] (R = H and Me; X = Br and SC₆H₃-o,o-Me₂) are excellent catalysts for the hydrolysis of organosilanes, particularly towards primary silanes, generating H under ambient conditions within seconds. These complexes are structural mimics of the [Fe]-hydrogenase active site and like the natural enzyme, a labile ligand at the 6th coordination site is essential to the catalytic activity.

European Journal of Inorganic Chemistry published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Safety of Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts