Tag: M.W=100-150

Su, Xinluona published the artcileDiffusion of phenolic compounds within high-silica MFI-type zeolite in the mesitylene solution, Category: alcohols-buliding-blocks, the publication is Microporous and Mesoporous Materials (2021), 111044, database is CAplus.

The intracrystalline diffusivity of phenolic compounds (phenol, p-propylphenol and m-cresol) and toluene within silicalite-1 and MFI-type zeolite with Si/Al = 303 (H-MFI) in the liquid phase (solvent: mesitylene) in the temperature range from 313 to 353 K were measured by using the constant volumetric method. The amounts of phenol, p-propylphenol, and toluene adsorbed onto silicalite-1 at 313, 323 and 353 K were approx. the same, whereas less m-cresol was adsorbed because of its larger kinetic diameter Unlike adsorbed toluene, adsorbed of phenol displayed stronger interactions in H-MFI than in silicalite-1, indicating that hydrogen bonding between the OH group of phenol and Bronsted acid sites in H-MFI enhanced the adsorption of phenol. Whereas the intracrystalline diffusivity of phenol, p-propylphenol, and toluene within silicalite-1 are approx. the same, m-cresol exhibited lower intracrystalline diffusivity, indicating that the intracrystalline diffusivity was governed by geometrical limitation. The intracrystalline diffusivity of phenol was lower within H-MFI with acid sites than within silicalite-1. The residence time of phenol on the acid sites became longer than that of toluene, which led to a difference in the intracrystalline diffusivity between phenol and toluene within H-MFI.

Microporous and Mesoporous Materials published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C20H17FO4S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Munakala, Anandarao published the artcileSteric and Electronic Control Intramolecular [2 + 2]-Cycloaddition of Cyclohexadienone-Containing 1,7-Enynes, Category: alcohols-buliding-blocks, the publication is Organic Letters (2022), 24(3), 892-896, database is CAplus and MEDLINE.

Herein, authors have developed silver-catalyzed an electronic and steric control intramol. formal [2 + 2]-cycloaddition of alkyne-tethered cyclohexadienones. Substrates with electron-rich alkynes and less hindered quaternary carbon center afford tricyclic fused-cyclobutenes through 1,7-enyne cyclization. In contrast, the formation of dihydrofurans was observed from electron-deficient alkynes via proton abstraction/C-O bond cleavage. The synthetic potential of this method was also broadened with a gram-scale reaction and various transformations on cyclobutene.

Organic Letters published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lunsford, Carl D. published the artcilePreparation of 4-amino-1-butanols and some derivatives of pharmacological interest, Synthetic Route of 4543-95-7, the publication is Journal of Organic Chemistry (1957), 1225-8, database is CAplus.

The 4-alkylamino (I) and 4-dialkylamino-1-butanols (II) were prepared by LiAlH₄ reduction of the product from equimolar amounts of butyrolactone (III) and a primary or secondary amine. Use of 2 moles amine resulted in N,N’-symmetrically substituted putrescines. The 3-aminopropanols were prepared similarly by the substitution of propiolactone (IV) for III. The 3,4,5-trimethoxybenzoates, the diphenylacetates, and the benzhydryl ethers of some of the II and of N-3-hydroxypropylpiperidine (V) and their quaternary salts were prepared and their pharmacol. activity examined III (68.8 g.) and 104 g. NHBu₂ heated 4 hrs. at 150°, the mixture in Et₂O added dropwise to 25.1 g. LiAlH₄ in 300 ml. Et₂O, refluxed 1 hr., the excess hydride decomposed with H₂O, the mixture filtered, the filtrate concentrated, and the residue fractionated gave 97.4 g. II (di-Bu derivative), b₄₀ 172-5°. When the starting amine refluxed below 150°, the reaction with III was carried out at reflux until the pot temperature reached 150° where it was kept 4 hrs.; when the starting amine was NHMe₂ or NHEt₂ the reaction was run in a sealed tube at 150°. The following results were obtained in preparing I and II, RR’N(CH₂)₄OH (RR’N, b.p./mm., % yield, n²⁵_D, and d. given): BuNH, 80-0.5°/0.2, 44, 1.4503, 0.8900; PhCH₂NH, 137-40°/0.8, 56, 1.5288, -; Me₂N, 98°/22, 56, 1.4390, 0.8798; Et₂N, 83-5°/0.8, 80, 1.4460, 0.8653; Pr₂N, 114°/4.3, 77, 1.4472, 0.8723; Bu₂N, 135°/0.3, 62, 1.4502, 0.8616; (CH₂)₅N, 75°/0.2, 71, 1.4733, 0.9471. III (172 g.) and 180 g. NHMe₂ heated 4 hrs. at 200° in 2 sealed tubes, the mixture heated to 125° in vacuo, and reduced with 125 g. LiAlH₄ gave 86 g. N,N,N’,N’-tetramethylputrescine, b₂₈ 78-80°, n²⁵_D 1.4261, d₂₇ 0.7864; dipicrate, m. 203-5°. There was also a higher-boiling fraction which proved to be II (di-Me derivative). Similarly, 17.2 g. III, 34 g. piperidine, and 11.4 g. LiAlH₄ gave 25 g. 1,4-piperidinobutane, b_0.3 117-18°; HCl salt, m. above 300°. IV (28.4 g.) added dropwise to 34 g. piperidine at 5-10° and towards the end of the addition the temperature allowed to rise to 20°, the sirup dissolved in 100 ml. tetrahydrofuran and reduced as above with 11.4 g. LiAlH₄, and the product fractionally distilled gave 31 g. V, b₂₅ 117-22°, n²⁵_D 1.4750, d²⁹₂₅ 0.9585; 3,4,5-trimethoxybenzoate hydrochloride, 51% yield, m. 169-71°; diphenylacetate nitrate, 90% yield, m. 115-16°(H₂O); diphenylacetate-MeI, m. 144.5-46° (alc.); diphenylacetate-MeBr, m. 165-6° (iso-PrOH). The 3,4,5-trimethoxybenzoic acid and diphenylacetic acid esters of I and II were prepared from the acid chloride with I or II. 3,4,5-Trimethoxybenzoyl chloride (23 g.) in 50 ml. CHCl₃ refluxed 2 hrs. with 11.7 g. II (di-Me derivative), the residue partitioned between dilute HCl and Et₂O, the acid extract made alk. and extracted with Et₂O, dried, and separated gave 26 g. II 3,4,5-trimethoxybenzoate-HCl, m. 122-4°. The quaternary salts of both the esters and the ethers were prepared by addition of MeI or MeBr to the base in Et₂O. When crystallization did not occur spontaneously the Et₂O was decanted and the oil crystallized from a suitable solvent. The following RCO₂(CH₂)NR”R’₂X were thus formed (R, R’, R”, X, m.p., and % yield given): 3,4,5-(MeO)₃C₆H₂, Me, H, Cl, 122-4°, 75; 3,4,5-(MeO)₃C₆H₂, Et, H, Cl, 140-1°, 97; 3,4,5-(MeO)₃C₆H₂, Et, Me, I, 142.5-44°, 78; 3,4,5-(MeO)₃C₆H₂, Pr, H, Cl, 118-19°, 35; 3,4,5-(MeO)₃C₆H₂, Pr, Me, I, 115-17°, 37; 3,4,5-(MeO)₃C₆H₂, [R’₂ = (CH₂)₅], H, Cl, 156.5-57°, 83; 3,4,5-(MeO)₃C₆H₂, [R’₂ = = (CH₂)₅], Me, I, 171-3°, 35; Ph₂CH, [R’₂ = (CH₂)₅], H, Cl, 148-50°, 53; Ph₂CH, [R’₂ = (CH₂)₅], Me, I, 69-72°, 34; Ph₂CH, [R’₂ = (CH₂)₅], Me, Br, 144-6°, 61. Benzhydryl bromide (49.3 g.) and 69.2 g. 4-dipropylamino-1-butanol in 200 ml. PhMe refluxed 15 hrs., concentrated in vacuo, partitioned between 5% NaOH and Et₂O, the extract then extracted with 5% HCl, this made alk. with 20% NaOH, and extracted with Et₂O gave 39 g. unchanged II (alkyl = Pr) and 26 g. N-(4-benzhydryloxybutyl)-N,N-dipropylamine, b_1.5 175-7°. The following PhRCHO(CH₂)₄NR’R’ were similarly prepared (R, R’R’N, salt, b.p./mm., or m.p., and % yield given): Ph, Et₂N, -, 202-5°/1.4, 68; Ph, Et₂N, HBr, 109-11.5°, -; Ph, Et₂N, MeBr, 120-1°, 81; Ph, Bu₂N, -, 192-4°/1.5, 38; Ph, (CH₂)₅N, -, 217-20°/2.0, 46; Ph, (CH₂)₅N, HCl, 135.5-37°, -; Ph, (CH₂)₅N, MeI, 126-6.5°, 73; p-ClC₆H₄, Et₂N, citrate, 123-4°, 62.

Journal of Organic Chemistry published new progress about 4543-95-7. 4543-95-7 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 4-(Butylamino)butan-1-ol, and the molecular formula is C8H19NO, Synthetic Route of 4543-95-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Park, Jaeyong published the artcileTotal chemocatalytic cascade conversion of lignocellulosic biomass into biochemicals, Recommanded Product: 4-Propylphenol, the publication is Applied Catalysis, B: Environmental (2022), 121280, database is CAplus.

Because of its complexity, selective conversion of lignocellulosic biomass into platform chems. presents significant challenges. Herein, we converted birch wood into high-yield lignin-derived phenolic monomers and dimers and holocellulose-derived polyols and monocarboxylic acids via a two-step cascade reaction using 0.1 wt% Pd on N-doped carbon (Pd_0.1/CN_x) and passivated alumina-coated Ni on activated carbon (Ni₂ @Al₂O₃/AC) catalysts. The catalytic fractionation of birch sawdust using Pd_0.1/CN_x produced 11.1 wt% monomers, 5.6% dimers, and 63.4 wt% pulp-rich solid (PRS) based on feed weight The subsequent conversion of PRS over passivated Ni₂ @Al₂O₃/AC produced 21.6 wt% C₂-C₆ polyols and 7.9 wt% monocarboxylic acids. After the whole biomass conversion reaction, the Pd_0.1/CN_x and Ni₂ @Al₂O₃/AC catalysts were separated using their different magnetic responses and reused three times without activity loss. The structure-performance relationships of the Pd_0.1/CN_x catalysts synthesized using different methods and effect of passivation on the performance of the Ni₂ @Al₂O₃/AC catalyst were analyzed.

Applied Catalysis, B: Environmental published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Recommanded Product: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Styler, Sarah A. published the artcileHeterogeneous Photooxidation of Fluorotelomer Alcohols: A New Source of Aerosol-Phase Perfluorinated Carboxylic Acids, SDS of cas: 2240-88-2, the publication is Environmental Science & Technology (2013), 47(12), 6358-6367, database is CAplus and MEDLINE.

Little is known of the atm. fate(s) of fluorotelomer alcs. (FTOHs), a class of high-production-volume chems. used in the production of H₂O- and oil-repelling surface coatings and which have been detected in a wide variety of urban and remote environmental matrixes. We studied the uptake and photochem. of FTOHs at the surface of TiO₂, Fe₂O₃, Mauritanian sand, and Icelandic volcanic ash. Gas-phase 3,3,3-trifluoropropanol, 4:2 FTOH, and 6:2 FTOH exhibited significant uptake to each of the surfaces under study. The sand- and ash-catalyzed heterogeneous photooxidation of 6:2 FTOH resulted in the rapid production and subsequent slow degradation of surface-sorbed perfluorinated carboxylic acids (PFCAs). We suggest that this transformation, which proceeds via saturated and unsaturated fluorotelomer carboxylic acid intermediates (6:2 FTCA/FTUCA), is catalyzed by Fe and Ti contained within the samples. These results provide the 1st evidence that the heterogeneous oxidation of FTOHs at metal-rich atm. surfaces may provide a significant loss mechanism for these chems. and also act as a source of aerosol-phase PFCAs close to source regions. Subsequent long-range transport of these aerosol-sorbed PFCAs has the potential to join oceanic transport and local gas-phase FTOH oxidation as a source of PFCAs to Arctic regions.

Environmental Science & Technology published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C12H19BrS, SDS of cas: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rival, Jose V. published the artcileLight-Emitting Atomically Precise Nanocluster-Based Flexible QR Codes for Anticounterfeiting, Application In Synthesis of 4410-99-5, the publication is ACS Applied Materials & Interfaces (2021), 13(8), 10583-10593, database is CAplus and MEDLINE.

Despite tremendous progress in the field of fluorescence-based anticounterfeiting, the advanced anticounterfeiting techniques are still posing challenges all over the world due to their cost and reliability. Recently, light-emitting atomically precise nanoclusters have emerged as attractive building blocks because of their well-defined structure, function, and stable photoluminescence. Herein, we report the room temperature fabrication of a stable, flexible, nontoxic, and low-cost precision nanocluster-based luminescent ink for the stencil printing of an optically unclonable security label. Nanocluster-based printing ink shows brilliant photoluminescence owing to its extended C-H···π/π···π interactions. Spectroscopic and microscopic investigations show that intercalated nanoclusters in the printed security labels are highly stable as their optical features and mol. compositions are unaffected. The exceptional mech., thermal, photo, and aqueous stabilities of the printed security labels endorse to demonstrate the printing and smartphone-based electronic reading of the quick response code on a currency. Finally, confidential information protection and decryption under a precise window of light have been achieved by adopting the optical contrast illusion. The overall cost of the security label is found to be approx. 0.013 USD per stamp.

ACS Applied Materials & Interfaces published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Application In Synthesis of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Collins, Ian published the artcileN-alkenyl nitrone dipolar cycloaddition routes to piperidines and indolizidines. Part 6. Allylic stereocontrol in the intramolecular cyclization of monosubstituted nitrones, Related Products of alcohols-buliding-blocks, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1994), 2205-15, database is CAplus.

The intramol., thermal dipolar cycloadditions of the (Z)-N-alk-4-enyl nitrones I (R = OMe, MeOCH₂O, alkylsiloxy) bearing a single, allylic substituent were investigated. Certain alkoxy substituted nitrones I showed a remarkable preference for the formation of axially substituted isoxazolidines II (same R), whereas the Pr and trifluoromethyl substituted nitrones I (R = F₃C, Pr) gave equatorially substituted cycloadducts resp., consistent with the involvement of chair-like transition states.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 83706-94-9. 83706-94-9 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is (E)-4,4,4-Trifluorobut-2-en-1-ol, and the molecular formula is C4H5F3O, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Iio, Takuya published the artcileFine-Bubble-Slug-Flow Hydrogenation of Multiple Bonds and Phenols, Product Details of C9H12O, the publication is Synlett (2020), 31(19), 1919-1924, database is CAplus.

A promising method for the continuous hydrogenation of alkenes or alkynes by using a newly developed fine-bubble generator is described. The fine-bubble-containing slug-flow system was up to 1.4 times more efficient than a conventional slug-flow method. When applied in the hydrogenation of phenols to the corresponding cyclohexanones, the fine bubble-slug-flow method suppressed over-reduction As this method does not require the use of excess gas, it is expected to be widely applicable in improving the efficiency of gas-mediated flow reactions.

Synlett published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Product Details of C9H12O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kikugawa, Yasuo published the artcileIntramolecular Cyclization with Nitrenium Ions Generated by Treatment of N-Acylaminophthalimides with Hypervalent Iodine Compounds: Formation of Lactams and Spiro-Fused Lactams, Safety of 3,3,3-Trifluoropropan-1-ol, the publication is Journal of Organic Chemistry (2003), 68(17), 6739-6744, database is CAplus and MEDLINE.

In hexafluoroisopropyl alc., N-phthalimido-N-acylnitrenium ions, generated from N-acylamino phthalimides I [X = O, CH₂, (CH₂)₂, (CH₂)₃, OCH₂, etc.; R = H, 4-Me, 2-Cl, 4-MeO, 2,4-F₂, etc.] by treatment with hypervalent iodine compounds, phenyliodine bis(trifluoroacetate) (PIFA) or its 4-chloro-substituted derivative, underwent intramol. electrophilic substitution reactions to afford N-phthalimido azaheterocycles II in high yields. Treatment of I [X = OCH₂, (CH₂)₂, (CH₂)₃] with PIFA or [hydroxy(tosyloxy)iodo]benzene (HTIB) in 2,2,2-trifluoroethanol gave spirodienones, e.g. III, as a result of ipso attack of the intermediate nitrenium ion.

Journal of Organic Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Safety of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gorb, L. G. published the artcileRelation between activity and selectivity in electrophilic substitution reactions of five-membered heteroaromatic compounds. 3. Electronic effects of substituents, Application In Synthesis of 17236-59-8, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1983), 828-35, database is CAplus.

The activity and selectivity of the electrophilic reactions of monosubstituted benzenes, thiophenes, furans, and pyrrole were studied by calculating localization energies by the CNDO/2 MO method. Anal. of theor. and exptl. reactivity indexes indicated a difference in the transfer of substituent effects from the α and β positions of the 5-membered heterocycles. Orbital interactions must be calculated to explain the selectivity of electrophilic reactions of the 5-membered heterocycles.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Application In Synthesis of 17236-59-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts