Tag: M.W=100-150

You, Yang’en; Ge, Shaozhong published the artcile< Cobalt-Catalyzed One-Pot Asymmetric Difunctionalization of Alkynes to Access Chiral gem-(Borylsilyl)alkanes>, Reference of 10602-04-7, the main research area is cobalt catalyzed one pot asym difunctionalization alkyne chiral borylsilylalkane; gem borylsilylalkane enantioselective preparation reaction cobalt chiral ligand catalyzed; terminal alkyne enantioselective hydrosilylation hydroboration cobalt chiral ligand catalyzed; crystal mol structure gem borylsilylalkane; chiral gem-borylsilylalkanes; cobalt; hydroboration; hydrosilylation; terminal alkynes.

Enantioselective cobalt-catalyzed one-pot hydrosilylation and hydroboration of terminal alkynes has been developed employing a cobalt catalyst generated from Co(acac)2 and (R,R)-Me-Ferrocelane. A variety of terminal alkynes undergo this asym. transformation, affording the corresponding gem-(borylsilyl)alkane products with high enantioselectivity (up to 98% ee). This one-pot reaction combines (E)-selective hydrosilylation of alkynes and consecutive enantioselective hydroboration of (E)-vinylsilanes with one chiral cobalt catalyst. This protocol represents the most straightforward approach to access versatile chiral gem-(borylsilyl)alkanes from readily available alkynes with com. available cobalt salt and chiral ligand.

Angewandte Chemie, International Edition published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Reference of 10602-04-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Larina, Olga V.; Valihura, Karina V.; Kyriienko, Pavlo I.; Vlasenko, Nina V.; Balakin, Dmytro Yu.; Khalakhan, Ivan; Cendak, Tomaz; Soloviev, Sergiy O.; Orlyk, Svitlana M. published the artcile< Successive vapour phase Guerbet condensation of ethanol and 1-butanol over Mg-Al oxide catalysts in a flow reactor>, HPLC of Formula: 104-76-7, the main research area is ethanol butanol Guerbet condensation magnesium aluminum oxide hydrotalcite catalyst.

The successive vapor phase condensation of ethanol and 1-butanol (via Guerbet reaction) in a flow reactor under atm. pressure was studied over catalytic Mg-Al oxide compositions Wherein the vapor phase condensation of 1-butanol to 2-ethyl-1-hexanol in flow has been investigated for the first time. The acid/base capacity ratio, which is determined by the Mg/Al ratio, is an important characteristic for the activity and selectivity of Mg-Al oxide catalysts in the abovementioned processes. The carbon chain length of the reacting alcs., an arrangement of surface active sites and other steric factors also have an impact on Guerbet condensation in the vapor phase. High productivity of Mg-Al oxide system to the Guerbet alcs.: 1-butanol – 25 g/(Lcat·h), 2-ethyl-1-hexanol – 19 g/(Lcat·h), has been achieved. The results have shown a prospect of successive conversion realization: (1) ethanol → 1-butanol; (2) 1-butanol → 2-ethyl-1-hexanol for the production of 2-ethyl-1-hexanol from ethanol.

Applied Catalysis, A: General published new progress about Acidity. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, HPLC of Formula: 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Weifan; Luo, Man; Yao, Weiwei; Ma, Mengtao; Pullarkat, Sumod A.; Xu, Li; Leung, Pak-Hing published the artcile< Catalyst-free and solvent-free hydroboration of ketones>, Electric Literature of 403-41-8, the main research area is catalyst solvent free green hydroboration ketone; boronic ester preparation green chem.

The hydroboration of a wide range of ketones with pinacolborane can be achieved under catalyst-free and solvent-free conditions to provide the corresponding boronic esters in quant. yields. A large gram-scale hydroboration of acetophenone with HBpin under the same conditions was also performed to afford the alc. product in a high yield thus demonstrating the scalability of the newly developed simple protocol.

New Journal of Chemistry published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Electric Literature of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Yaxu; He, Shaopo; Quan, Ziyi; Cai, Huizhuo; Zhao, Yang; Wang, Bo published the artcile< Mild palladium-catalysed highly efficient hydrogenation of CN, C-NO2, and C=O bonds using H2 of 1 atm in H2O>, COA of Formula: C8H9FO, the main research area is amine preparation green chem; nitro compound hydrogenation palladium nanocatalyst; nitrile hydrogenation palladium nanocatalyst; alc preparation green chem; aldehyde hydrogenation palladium nanocatalyst; ketone hydrogenation palladium nanocatalyst.

The first example of a mild and high-efficiency protocol enabling a process in water using 1 atm of H2 for the efficient and selective hydrogenation of nitriles RCN [R = CH3(CH2)2, 4-FC6H4, naphthalen-1-yl, etc.], nitro compounds 4-R1C6H4NO2 (R1 = H, F, Cl, Br, OH, Me, MeO, NH2), ketones R2C(O)R3 [R2 = CH3(CH2)2, 3-FC6H4, 2-H3CC6H4, etc.; R3 = Me, CF3] and aldehydes R4CHO [R4 = 4-(H3C)2CHC6H4, 3,4,5-(H3CO)3C6H2, naphthalen-1-yl, etc.], to yield primary amines RCH2NH2, 4-R1C6H4NH2 and alcs. R2CH(OH)CH3, R4CH2OH with satisfactory yields of up to >99% has been presented. Several palladium-based nanoparticle catalysts were prepared from K2PdCl4 and ligands, and one of them was found to be the best and most suitable for the hydrogenation of CN, C-NO2 and C=O bonds. In addition, the catalyst Pd-NPs can be easily recycled and reused without losing their activity and selectivity. A plausible mechanism for the hydrogenation of a CN bond was also proposed, representing the first example that possesses great potential for sustainable industrial purposes.

Green Chemistry published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, COA of Formula: C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Fengxiao; Zhu, Changyin; Zhou, Dongmei; Gao, Juan published the artcile< Fate of di (2-ethylhexyl) phthalate and its impact on soil bacterial community under aerobic and anaerobic conditions>, Safety of 2-Ethylhexan-1-ol, the main research area is di 2ethylhexylphthalate Clostridiales Bacillus Actinobacteria Proteobacteria Gemmatimonadaceae soil pollution; Bacterial community; High-throughput sequencing; Metabolite; Oxygen; Phthalate ester.

In this study, we examined the influence of oxygen on the degradation of di (2-ethylhexyl) phthalate (DEHP), the accumulation of its monoester metabolite mono (2-ethylhexyl) phthalate (MEHP) and their impact on soil bacterial communities. Soil microcosms artificially contaminated with DEHP (0, 100 and 1000 mg kg-1) were incubated under aerobic and anaerobic flooded conditions, and sacrificed after 0, 21 and 42 days. The results indicated that DEHP degradation proceeded at similar rates in aerobic and anaerobic flooded soils, but accumulation of metabolite MEHP was more likely to occur in anaerobic soils. Moreover, MEHP generated from DEHP degradation seemed to be readily released into the water phase, which may arouse health concerns. Illumina Miseq sequencing showed that MEHP had a greater impact on soil bacterial community than DEHP at the same dosage, and a wide range of bacterial phylotypes were inhibited by MEHP under anaerobic conditions. High DEHP contamination (1000 mg kg-1) significantly reduced bacterial diversity and altered bacterial community structure under anaerobic conditions, but not under aerobic conditions. Firmicutes was constantly inhibited by DEHP under both aerobic (Bacillus) and anaerobic (unclassified Clostridiales Family_XVIII) conditions. On the other hand, bacterial phylotypes belonging to Actinobacteria, β-Proteobacteria and Gemmatimonadaceae were constantly enriched by DEHP in anaerobic soils, however no such a clear pattern existed in aerobic soils. This work greatly expanded our understanding of the fate of DEHP and its modifying effect on bacterial communities under different environmental conditions.

Chemosphere published new progress about Actinobacteria. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Safety of 2-Ethylhexan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jantunen, Niklas; Virolainen, Sami; Latostenmaa, Petri; Salminen, Justin; Haapalainen, Mika; Sainio, Tuomo published the artcile< Removal and recovery of arsenic from concentrated sulfuric acid by solvent extraction>, Name: 2-Ethylhexan-1-ol, the main research area is arsenic sulfuric acid tributyl phosphate phase equilibrium solvent extraction.

Arsenic-contaminated sulfuric acid solutions are produced in large quantities as byproduct during pyrometallurgical processing of sulfide minerals. Options for re-using such acid solutions are increased if the arsenic is removed and recovered as a product. The performances of tri-Bu phosphate and a mixture of 6 wt-% 1,2-octanediol in 2-ethylhexanol were studied in liquid-liquid extraction of arsenic from an industrial solution containing 10.4 M H2SO4. It was found that, due to the complex phase equilibrium, a process design based on conventional batch equilibrium data did not describe the countercurrent processes accurately. A countercurrent flowsheet utilizing undiluted tri-Bu phosphate was investigated by pseudo-countercurrent extractions 83.7% extraction of arsenic and 31.4% coextn. of H2SO4 was obtained in three-stage countercurrent extraction operated at a solvent-to-feed ratio of 0.79. Two-stage countercurrent scrubbing with pure water at O/A = 4.03 back-extracted 83.6% of H2SO4 and 24.9% of arsenic. 100% and 89.7% back-extraction was achieved in four-stage stripping at O/A = 2.01 for H2SO4 and arsenic, resp. The effects of varying the flowsheet and operating parameters on separation efficiency are discussed.

Hydrometallurgy published new progress about Phase equilibrium Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PROC (Process). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Name: 2-Ethylhexan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dahatonde, Dipak J.; Ghosh, Aritra; Batra, Sanjay published the artcile< Metal-Free Synthesis of Alkenylazaarenes and 2-Aminoquinolines through Base-Mediated Aerobic Oxidative Dehydrogenation of Benzyl Alcohols>, Electric Literature of 5344-90-1, the main research area is alkyl azaarene arylmethanol base promoter diastereoselective dehydrogenative olefination; alkenyl azaarene preparation; aminobenzyl alc arylacetonitrile base promoter dehydrogenative cyclocondensation; aminoquinoline preparation.

A metal-free, base-mediated, and atom-efficient oxidative dehydrogenative coupling of substituted phenylmethanols (benzyl alcs.) with Me azaarenes or phenylacetonitriles to afford substituted alkenylazaarenes or 2-aminoquinolines, resp. was described. CsOH. H2O was discovered to be the base of choice for obtaining optimal yields of the title compounds, although the reaction proceeded with KOH as well. The protocol that worked efficiently in the presence of air was amenable over broad range of substrates.

European Journal of Organic Chemistry published new progress about Acetonitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Electric Literature of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Prathima, A.; Karthikeyan, S.; Radhi Devi, K.; Usha, K.; Shanthi, M. published the artcile< Environmental effect of lubricity additives through dielectric molecular parameters>, Synthetic Route of 104-76-7, the main research area is caprylic valeric acid additive lubricity.

Lubricant additives are chems., nearly always-organic or organometallic, that are added to oils in quantities of a few weight percent to improve the lubricating capacity and durability of the oil. Specific purposes of lubricant additives are improving the wear and friction characteristics by provision for adsorption and extreme pressure lubrication, improving the oxidation resistance, control of corrosion, control of contamination by reaction products, wear a and other debris, reducing excessive decrease of lubricant viscosity at high temperatures, enhancing lubricant characteristics by reducing the pour point and inhibiting the generation of foam. These properties depend upon the mol. interactions between the chem. additives. So that, this study target on investigating the mol. interactions through the dielec. parameters such as Kirkwood correlation factor, Excess permittivity, Bruggemann factor and Dipolar excess free energy in the lubricative binary mixtures,(1) caprylic acid + 2-ethyl-1-hexanol and (2) valeric acid + 2-ethyl-1-hexanol. The above dielec. parameters have been calculated from the exptl. measured values of capacitance and refractive index of mixtures, at temperatures 303 K, 313 K and 323 K. In the above studied systems, existence of short and long range, homo and hetero interactions are identified. The hetero interaction results in the formation linear as well as closed multimers in the mixture Due to the existing interactions, structural changes are found to take place.

Materials Today: Proceedings published new progress about Helmholtz free energy. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Synthetic Route of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rothemund, Matthias; Baer, Sofia I.; Rehm, Tobias; Kostrhunova, Hana; Brabec, Viktor; Schobert, Rainer published the artcile< Antitumoral effects of mitochondria-targeting neutral and cationic cis-[bis(1,3-dibenzylimidazol-2-ylidene)Cl(L)]Pt(II) complexes>, Electric Literature of 10602-04-7, the main research area is melanoma antitumoral platinum complexes DNA cell cycle cytotoxicity ROS.

Recently, we opened a synthetic access to antitumoral platinum complexes of the type cis-[(NHC)1(NHC)2PtIICl(L)] which interact with DNA in a way correlated to the complex charge and to the sterical accessibility of the leaving chlorido ligand. We now identified mitochondria rather than nuclei as the cellular target of the neutral dichlorido complex 1 (L = Cl) and the delocalized lipophilic cationic phosphine complex 2 (L = PPh3), both carrying the same cis-bis(1,3-dibenzylimidazol-2-ylidene) ligands. Their uptake into 518A2 melanoma cells was concentration-dependent and distinctly greater for complex 2 which was also more cytotoxic against sensitive cancer cell lines with submicromolar IC50 values. Both complexes interfered strongly with various forms of DNA in vitro, but only complex 2 caused a melanoma cell cycle arrest in G1-phase, setting both apart from the S-phase arresting drug cisplatin. Studies of the intracellular localisation of 1 and 2 were carried out with their alkyne-tagged analogs 6 and 7, which showed identical patterns of cancer cell cytotoxicity, cell cycle interference and effects on mitochondria. Click reactions with 7-hydroxycoumarin azide, colocalisation with Mitotracker and confocal microscopy, proved complexes 6 and 7 to accumulate mainly in the mitochondria rather than the nuclei of melanoma cells. Complex 1 and even more so complex 2 reduced the mitochondrial membrane potential and also increased the cellular ROS levels. As a consequence, both complexes caused stress fiber formation in the F-actin cytoskeleton of melanoma cells, most distinctly so complex 2 which also activated the apoptotic cascade mediated by capases-3 and -7.

Dalton Transactions published new progress about Antitumor agents. 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Electric Literature of 10602-04-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kumar, Gujjenahalli Ramalingaiah Yogesh; Begum, Noor Shahina published the artcile< Mn(III)-mediated cascade cyclization of 1-(azidomethyl)-2-isocyanoarenes with organoboronic acids: construction of quinazoline derivatives>, COA of Formula: C7H9NO, the main research area is quinazoline preparation; azidomethyl isocyanoarene organoboronic acid cascade cyclization catalyst manganese acetate.

A novel and efficient Mn(III)-mediated oxidative radical cascade reaction of 1-(azidomethyl)-2-isocyanoarenes with organoboronic acids was reported. The single electron oxidation of a com. available organo boronic acid in the presence of a mild oxidant, Mn(OAc)3.2H2O, resulted in moderate yields of the corresponding quinazoline derivatives I [R1 = H, 6-F, 8-Br, 5-Me, 5-MeO; R2 = Me, iso-Pr, Ph, etc.].

New Journal of Chemistry published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, COA of Formula: C7H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts