Tag: M.W=100-150

Hosseiny Davarani, Saied Saeed; Pourahadi, Ahmad; Ghasemzadeh, Peivand published the artcile< Quantification of controlled release leuprolide and triptorelin in rabbit plasma using electromembrane extraction coupled with HPLC-UV>, Application In Synthesis of 104-76-7, the main research area is HPLC UV plasma determination controlled release leuprolide triptorelin pharmacokinetics; electromembrane extraction HPLC controlled release leuprolide triptorelin; Electromembrane extraction; Leuprolide; Pharmacokinetic; Rabbit plasma; Triptorelin.

An electromembrane extraction followed by HPLC-UV technique was developed and validated for quantification of leuprolide and triptorelin in rabbit plasma. The influencing parameters on the extraction efficiency were optimized using exptl. design methodol. The optimized conditions were found to be; supported liquid membrane: a mixture of 1-octanol and 2-Et hexanol (1:1) containing 10% volume/volume di(2-ethylhexyl) phosphate, applied voltage: 5 V, extraction time: 5 min, pH of the donor phase: 4.5 and pH of the acceptor phase: 1.0. The optimized method was validated for linearity, intraday and interday precision, and accuracy in rabbit plasma. The range of quantification for both peptides was 0.5-1000 ng/mL with regression coefficients higher than 0.994. Relative recoveries of leuprolide and triptorelin were found to be 80.3 and 75.5%, resp. Limits of quantification and detection for both peptides were found to be 0.5 and 0.15 ng/mL, resp. The validated method was successfully applied to pharmacokinetic study of the 1-mo depot formulations of each peptide after s.c. administration to rabbits.

Electrophoresis published new progress about Blood analysis. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Application In Synthesis of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cavallo, Marzia; Arnodo, Davide; Mannu, Alberto; Blangetti, Marco; Prandi, Cristina; Baratta, Walter; Baldino, Salvatore published the artcile< Deep eutectic solvents as H2-sources for Ru(II)-catalyzed transfer hydrogenation of carbonyl compounds under mild conditions>, Related Products of 52160-51-7, the main research area is aldehyde ketone transfer hydrogenation ruthenium catalyst deep eutectic solvent.

The employment of easily affordable ruthenium(II)-complexes as pre-catalysts in the transfer hydrogenation of carbonyl compounds in deep eutectic media is described for the first time. The eutectic mixture tetrabutylammonium bromide/formic acid = 1/1 (TBABr/HCOOH = 1/1) acts both as reaction medium and hydrogen source. The addition of a base is required for the process to occur. An extensive optimization of the reaction conditions has been carried out, in terms of catalyst loading, type of complexes, H2-donors, reaction temperature and time. The combination of the dimeric complex [RuCl(p-cymene)-μ-Cl]2 (0.01-0.05 equivalent) and the ligand dppf (1,1′-ferrocenediyl-bis(diphenylphosphine)ferrocene) in 1/1 molar ratio has proven to be a suitable catalytic system for the reduction of several and diverse aldehydes and ketones to their corresponding alcs. under mild conditions (40-60°) in air, showing from moderate to excellent tolerability towards different functional groups (halogen, cyano, nitro, phenol). The reduction of imine compounds to their corresponding amine derivatives was also studied. In addition, the comparison between the results obtained in TBABr/HCOOH and in organic solvents suggests a non-innocent effect of the DES medium during the process.

Tetrahedron published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Related Products of 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dubey, Abhishek; Rahaman, S. M. Wahidur; Fayzullin, Robert R.; Khusnutdinova, Julia R. published the artcile< Transfer Hydrogenation of Carbonyl Groups, Imines and N-Heterocycles Catalyzed by Simple, Bipyridine-Based MnI Complexes>, Application In Synthesis of 403-41-8, the main research area is bipyridine manganese complex preparation UV visible spectra crystal structure; carbonyl compound bipyridine manganese complex transfer hydrogenation; benzylideneaniline bipyridine manganese complex transfer hydrogenation; azaarene bipyridine manganese complex transfer hydrogenation.

A simple bipyridine-based Mn catalysts were developed that act as active catalysts for transfer hydrogenation of ketones, aldehydes and imines. For the first time, Mn-catalyzed transfer hydrogenation of N-heterocycles was reported. The highest catalytic activity among complexes with variously substituted ligands was observed for the complex bearing two OH groups in bipyridine. Deuterium labeling experiments suggested a monohydride pathway.

ChemCatChem published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Application In Synthesis of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Maier, Thomas M.; Gawron, Martin; Coburger, Peter; Bodensteiner, Michael; Wolf, Robert; van Leest, Nicolaas P.; de Bruin, Bas; Demeshko, Serhiy; Meyer, Franc published the artcile< Low-Valence Anionic α-Diimine Iron Complexes: Synthesis, Characterization, and Catalytic Hydroboration Studies>, Synthetic Route of 403-41-8, the main research area is iron diimine low valent complex preparation ketone hydroboration catalyst; crystal mol structure iron diimine low valent ferrate complex.

The synthesis of rare anionic heteroleptic and homoleptic α-diimine iron complexes is described. Heteroleptic BIAN complexes [(cod)Fe(BIAN)][K([18]c-6)(thf)0.5] (1) and [(dnbe)Fe(BIAN)][K([18]c-6)(thf)2] (2; H2BIAN = N,N’-Dipp2-1,2-acenaphtylenediamine, cod = 1,5-cyclooctadiene, dnbe = 5,5′-dinorbornene-6,6′-diyl)were synthesized by reduction of the [(BIAN)FeBr2] precursor complex using stoichiometric amounts of potassium graphite in the presence of the corresponding olefin. The electronic structure of these paramagnetic species was investigated by numerous spectroscopic analyses (NMR, EPR, 57Fe Mossbauer, UV-vis), magnetic measurements (Evans NMR method, SQUID), and theor. techniques (DFT, CASSCF). Whereas anion 1 is a low-spin complex, anion 2 consists of an intermediate-spin Fe(III) center. Both complexes are efficient precatalysts for the hydroboration of carbonyl compounds under mild reaction conditions. The reaction of bis(anthracene) ferrate(1-) gave the homoleptic BIAN complex 3-[K([18]c-6)(thf)], which is less catalytically active. The electronic structure was elucidated with the same techniques as described for complexes 1-[K([18]c-6)(thf)0.5] and 2-[K([18]c-6)(thf)2] and revealed an Fe(II) species in a quartet ground state. Highly reduced ferrate anions were synthesized and structurally characterized. The mol. structures were elucidated by X-ray crystallog. Because of the presence of redox-active α-diimine ligands, the electronic situation was thoroughly analyzed using high-level quantum chem. calculations 57Fe-Mossbauer, EPR, NMR, and UV-vis spectroscopies and SQUID magnetization measurements were employed to characterize the spectroscopic and magnetic properties. Two of the new complexes prepared are precatalysts for the hydroboration of carbonyl compounds requiring low catalyst loadings.

Inorganic Chemistry published new progress about Crystal structure. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Synthetic Route of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Plestina, R.; Stoner, H. B.; Jones, Glenys; Butler, W. H.; Mattocks, A. R. published the artcile< Vascular changes in the lungs of rats after the intravenous injection of pyrrole carbamates>, Application of C6H9NO, the main research area is lung pathol pyrrole carbamate; monocrotaline derivative lung toxicity; alkaloid pyrrolizidine derivative lung.

Acute pulmonary edema was produced in mice and rats, after injection into a systemic vein, of 1-methyl-2-(N-ethylcarbamoyloxymethyl)pyrrole (I) [62435-67-0] and 1-methyl-2,3-bis(N-ethylcarbamoyloxymethyl)pyrrole (II) [36504-91-3], 2 synthetic compounds related to monocrotaline pyrrole. 1-Methyl-2-hydroxymethylpyrrole (III) [52160-51-7] and Et N-ethylcarbamate [623-78-9] had no such effect and although 3-(N-ethylcarbamoyloxymethyl)furan (IV) [50884-33-8] did not cause pleural effusion in rats it did in mice. Like monocrotaline pyrrole, the pyrrole carbamates, when injected into other vessels, produced edema in the region of the 1st capillary bed encountered. S labeling occurred in both the postcapillary venules and the capillaries of the lungs when colloidal C was injected i.v. after the pyrrole carbamates. Venular labeling occurred before capillary labeling, which occurred optimally when C was injected >4 h after the pyrrole. No C labeling was observed after IV injection. The effects of the synthetic pyrrole esters were similar to those of monocrotaline pyrrole. The pyrrole carbamates were less active on a mol. basis, but they had a broader action on the pulmonary vasculature, causing both venular and capillary labeling. The compounds required the pyrrole ring structure and ≥1 ester side-chain to affect the lungs acutely.

Journal of Pathology published new progress about Lung. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Application of C6H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hosseiny Davarani, Saied Saeed; Pourahadi, Ahmad; Ghasemzadeh, Peivand published the artcile< Quantification of controlled release leuprolide and triptorelin in rabbit plasma using electromembrane extraction coupled with HPLC-UV>, Application In Synthesis of 104-76-7, the main research area is HPLC UV plasma determination controlled release leuprolide triptorelin pharmacokinetics; electromembrane extraction HPLC controlled release leuprolide triptorelin; Electromembrane extraction; Leuprolide; Pharmacokinetic; Rabbit plasma; Triptorelin.

An electromembrane extraction followed by HPLC-UV technique was developed and validated for quantification of leuprolide and triptorelin in rabbit plasma. The influencing parameters on the extraction efficiency were optimized using exptl. design methodol. The optimized conditions were found to be; supported liquid membrane: a mixture of 1-octanol and 2-Et hexanol (1:1) containing 10% volume/volume di(2-ethylhexyl) phosphate, applied voltage: 5 V, extraction time: 5 min, pH of the donor phase: 4.5 and pH of the acceptor phase: 1.0. The optimized method was validated for linearity, intraday and interday precision, and accuracy in rabbit plasma. The range of quantification for both peptides was 0.5-1000 ng/mL with regression coefficients higher than 0.994. Relative recoveries of leuprolide and triptorelin were found to be 80.3 and 75.5%, resp. Limits of quantification and detection for both peptides were found to be 0.5 and 0.15 ng/mL, resp. The validated method was successfully applied to pharmacokinetic study of the 1-mo depot formulations of each peptide after s.c. administration to rabbits.

Electrophoresis published new progress about Blood analysis. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Application In Synthesis of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Dianfeng; Wang, Jinguo; Xu, Fengxia; Zhang, Nianchen; Men, Yong published the artcile< Mesoporous (001)-TiO2 nanocrystals with tailored Ti3+ and surface oxygen vacancies for boosting photocatalytic selective conversion of aromatic alcohols>, Safety of 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is mesoporous anatase catalyst morphol aromatic alc oxidation.

Selective conversion of aromatic alcs. to value-added chems. is becoming an emerging research hotspot in heterogeneous photocatalysis, but its critical challenge is how to construct highly efficient photocatalysts. Herein, mesoporous (001)-TiO2 nanocrystals with tailored Ti3+ and surface oxygen vacancies have been fabricated by a facile hydrothermal route, showing remarkably boosted photoactivity for selective conversion of aromatic alcs. to carbonyl compounds in water medium under visible-light irradiation Results attest that the remarkably boosted photoactivity was mainly correlated with the strong synergetic effect of exposed (001) facets, Ti3+ self-doping, and surface oxygen vacancies, leading to the enhanced reactant (aromatic alcs. and O2) activation via the high surface energy of (001) facets, the improved visible-light absorbance via the intrinsic band gap narrowing, and the escalated photoelectron-hole separation efficiency via Ti3+ and surface oxygen vacancies acting as electron sinks. Meanwhile, a plausible photocatalytic mechanism for selective conversion of aromatic alcs. to carbonyl compounds has been elucidated in detail based on active species identified by capture experiments It is hoped that this work can deliver some new insights into the rational design of highly efficient photocatalysts applied in future green organic selective transformation reactions.

Catalysis Science & Technology published new progress about Crystallinity. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Safety of 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cao, Fei; Mao, Anruo; Yang, Bobin; Ge, Chenyang; Wang, Dawei published the artcile< The preparation of a Co@C3N4 catalyst and applications in the synthesis of quinolines from 2-aminobenzyl alcohols with ketones>, Electric Literature of 5344-90-1, the main research area is cobalt doped carbon nitride catalyst quinoline synthesis aminobenzenemethanol ketone.

An unsym. diphenylphosphino-pyridinyl-triazole ligand was synthesized and characterized through IR, NMR and MS and the corresponding earth-abundant metal complex (cobalt) was prepared Considering energy consumption and environmental friendliness, it is necessary to turn this diphenylphosphino-pyridinyl-triazole cobalt complex into a recyclable catalyst, which could easily be reused. Therefore, a heterogeneous catalyst was synthesized through Co-doping of C3N4, and the Co-nanoparticles on C3N4 revealed high catalytic activity for the synthesis of quinolines with good recovery performance.

New Journal of Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Electric Literature of 5344-90-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pingitore, Valeria; Martinez-Bailen, Macarena; Carmona, Ana T.; Meszaros, Zuzana; Kulik, Natalia; Slamova, Kristyna; Kren, Vladimir; Bojarova, Pavla; Robina, Inmaculada; Moreno-Vargas, Antonio J. published the artcile< Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars>, SDS of cas: 10602-04-7, the main research area is mol modeling docking pyrrolidine iminosugar preparation hexosaminidase human acetylglucosaminidase; click alkyne azide triazole cycloaddition catalyst preparation thiourea; enzyme active site human lysosomal hexosaminidase inhibitor; human lysosomal hexosaminidase inhibitor combinatorial library pyrrolidine iminosugar synthesis; Click reaction; Glycosidase inhibitors; Hexosaminidases; Iminosugars; In situ screening; Multivalency.

Two libraries of mono- and dimeric pyrrolidine iminosugars were synthesized by CuAAC and (thio)urea-bond-forming reactions from the resp. azido/aminohexylpyrrolidine iminosugar precursors. The resulting monomeric and dimeric compounds were screened for inhibition of β-N-acetylglucosaminidase from Jack beans, the plant ortholog of human lysosomal hexosaminidases. A selection of the best inhibitors of these libraries was then evaluated against human lysosomal β-N-acetylhexosaminidase B (hHexB) and human nucleocytoplasmic β-N-acetylglucosaminidase (hOGA). This evaluation identified a potent (nM) and selective monomeric inhibitor of hOGA compound I that showed a 6770-fold higher affinity for this enzyme than for hHexB. The corresponding dimeric derivative II further remarkably improved the selectivity in the inhibition of hOGA (2.7 x 104 times more selective for hOGA over hHexB) and the inhibition potency (by one order of magnitude). Docking studies were performed to explain the selectivity of inhibition observed in I.

Bioorganic Chemistry published new progress about 1,3-Dipolar cycloaddition reaction. 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, SDS of cas: 10602-04-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Maji, Ankur; Singh, Anshu; Singh, Neetu; Ghosh, Kaushik published the artcile< Efficient Organoruthenium Catalysts for α-Alkylation of Ketones and Amide with Alcohols: Synthesis of Quinolines via Hydrogen Borrowing Strategy and their Mechanistic Studies>, Recommanded Product: (2-Aminophenyl)methanol, the main research area is preparation quinoline organoruthenium catalyst; ketone alc alkylation; amino benzyl alc ketone cyclization; tertiary amide alc alkylation.

A new family of phosphine free organometallic ruthenium(II) catalysts supported by bidentate NN Schiff base ligands I (R = NMe2, NEt2) and II was prepared These half-sandwich complexes acted as catalysts for C-C bond formation and exhibited excellent performance in the dehydrogenative coupling of ketones and amides. In the synthesis of C-C bonds, alcs. were utilized as the alkylating agent. A broad range of substrates, including sterically hindered ketones and alcs., were well tolerated under the optimized conditions (TON up to 47000 and TOF up to 11750 h-1). This ruthenium (II) catalysts were also active towards the dehydrogenative cyclization of o-amino benzyl alc. for the formation of quinolines derivatives Various polysubstituted quinolines were synthesized in moderate to excellent yields (TON up to 71000 and TOF up to 11830 h-1). Control experiments were carried out and the ruthenium hydride intermediate was characterized to support the reaction mechanism and a probable reaction pathway of dehydrogenative coupling for the C-C bond formation has been proposed.

ChemCatChem published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Recommanded Product: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts