Tag: M.W=100-150

Mattocks, A. R. published the artcile< Liver cell enlargement in rats given hydroxymethylpyrroles analogous to pyrrolizidine alkaloid metabolites, followed later by the hepatotoxin dimethylnitrosamine>, Electric Literature of 52160-51-7, the main research area is hydroxymethylpyrrole DMN liver.

Male rats aged 4-5 wk were given single doses of pyrrolic alcs. having alkylating properties similar to those of pyrrolizidine alkaloid metabolites, followed several days later by 1 of the hepatotoxins, DMN [62-75-9], thioacetamide (TA) [62-55-5] or CCl4 [56-23-5]. After 24-32 days the livers of animals given the pyrroles 1-methyl-2,3-bis(hydroxymethyl)pyrrole (I) [53365-77-8] or 1-phenyl-5-methyl-2,3-bis(hydroxymethyl)pyrrole (II) [68384-87-2] and then DMN, contained enlarged parenchymal cells (megalocytes) similar to those seen in chronic pyrrolizidine alkaloid poisoning. At this time such abnormal cells were not found in rats given any of the other pyrroles followed by DMN, or compound I and then TA or CCl4.

Toxicology Letters published new progress about Liver. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Electric Literature of 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Utsukihara, Takamitsu; Horiuchi, C. Akira published the artcile< Production of chiral aromatic alcohol by acetophenone and 1-arylethanol derivatives using vegetables>, Computed Properties of 403-41-8, the main research area is Ducus Solanum chiral aromatic alc acetophenone arylethanol.

We have studied the biotransformation of acetophenone derivatives (1a-1f) and 1-arylethanol derivatives (2a-2e, 2g, 2h) using various vegetables. It is found that the reduction of acetophenone derivatives (1a-1f) using carrot (Ducus carota) gives (S)-1-arylethanols with high enantioselectivity. On the other hand, biooxidation of 1-arylethanols (2a-2e, 2g, 2h) using potato (Solanum tuberosum) is oxidized to give (R)-1-arylethanols as major product with high stereoselectivity. Carrot (D. carota) is the best catalyst for this reduction and shows a good reaction yield and enantioselectivity. On the other hand, it is found that the racemic alcs. are converted into the corresponding (R)-alcs. with high ee using Japanese potato (S. tuberosum) as catalyst. The availability of the enzymic system using various vegetables is convenient and an eco-friendly system.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Allium cepa. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Computed Properties of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Al-Masri, Harbi Tomah; Almejled, Akram Ali published the artcile< Hg(II) and Ru(II) complexes of mono- and dichalcogenides of bis(diphenylphosphino)amine chelating ligands: Synthesis, characterization and catalytic activity in transfer hydrogenation of acetophenone derivatives>, Application In Synthesis of 403-41-8, the main research area is ruthenium aminobisphosphino iodo carbonyl complex catalyst preparation crystal structure; transfer hydrogenatio catalyst ruthenium aminobisphosphino iodo carbonyl complex.

Reactions of C10H7-1-N(PPh2)2 (1) and C10H7-1-N(P(Se)Ph2)2 (2) ligands with mercury(II)iodide in equimolar ratio gave cis-[HgI2{-κ2P,P}] (3) and cis-[HgI2{-κ2Se,Se}] (4). Also, refluxing of monooxidized thioyl and selenoyl bis(phosphino)amine ligands C10H7-1-N(P(E)Ph2)(PPh2) (E = S (5), Se (6)) with [Ru(CO)3Cl2]2 dimer afforded cis-[Ru(CO)2Cl2{-κ2P,S}] (7) and cis-[Ru(CO)2Cl2{-κ2P,Se}] (8). Complexes , , and were identified and characterized by multinuclear NMR (1H, 13C, 31P and 77Se NMR) and IR spectroscopy. The mol. structure of was determined by single x-ray crystallog. is the first structurally characterized example of this kind of κ2P,S -bidentate ligand. The novel ruthenium(II) complexes and show high catalytic activity in the transfer hydrogenation of acetophenone derivatives to 1-phenylethanol derivatives in the presence of 2-propanol as the hydrogen source.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Chalcogenides Role: RCT (Reactant), RACT (Reactant or Reagent) (di-). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Application In Synthesis of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Maji, Milan; Chakrabarti, Kaushik; Panja, Dibyajyoti; Kundu, Sabuj published the artcile< Sustainable synthesis of N-heterocycles in water using alcohols following the double dehydrogenation strategy>, HPLC of Formula: 403-41-8, the main research area is quinoline preparation green chem; acridine preparation green chem; naphthyridine preparation green chem; secondary alc amino aralkylalc dehydrogenation oxidative cyclization iridium complex; nitro aralkylalc secondary alc dehydrogenation oxidative cyclization iridium complex.

The present study describes the first example of synthesis of pharmaceutically relevant N-heterocycles like substituted quinolines I (R1 = Ph, 2-pyridinyl, benzo[d][1,3]dioxol-5-yl, 3-phenylpropyl, etc.; R2 = H, Me; R1R2 = -(CH2)3-; R3 = H, Cl, Br, Me; R4 = H; R3R4 = -CH=CH-CH=CH-), acridines e.g., II and 1,8-naphthyridines III in water under air using 2-aminoaryl alcs. or 2-nitroaryl alcs. 2-R5-4-R4-5-R3C6H2CH2OH (R5 = NH2, NO2) and 2-amino-3-pyridinemethanol with secondary alcs. R1CH(OH)CH2R2 and R6(OH) (R6 = cyclopentyl, 1,2,3,4-tetrahydronaphthalen-2-yl, cyclohexyl, cycloheptyl) in presence of a new water soluble Ir-complex e.g., IV·Cl. The viability and efficiency of this approach were demonstrated by the efficient synthesis of biol. active natural product (±)-galipinine and gram scale synthesis of various N-heteroaromatics Several kinetic experiments and DFT calculations were carried out to support the plausible reaction mechanism which disclosed that this system followed a concerted outer sphere mechanism for the dehydrogenation of alcs.

Journal of Catalysis published new progress about Acridines Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, HPLC of Formula: 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Putta, V. P. Rama Kishore; Gujjarappa, Raghuram; Tyagi, Ujjawal; Pujar, Prasad P.; Malakar, Chandi C. published the artcile< A metal- and base-free domino protocol for the synthesis of 1,3-benzoselenazines, 1,3-benzothiazines and related scaffolds>, Category: alcohols-buliding-blocks, the main research area is arylthiazinone preparation; benzoselenazine preparation; diaryldiazocine dione preparation; benzothiazine preparation.

Efficient protocols have been described for the synthesis of 1,3-benzoselenazines, 1,3-benzothiazines, 2-arylthiazin-4-ones and diaryl[b,f][1,5]diazocine-6,12(5H,11H)-diones. These transformations were successfully driven towards product formation under mild acid catalyzed reaction conditions at room temperature using 2-aminoaryl/hetero-aryl alkyl alcs. and amides as substrates. The merits of the present methods also rely on the easy access of rarely explored bioactive scaffolds like 1,3-benzoselenazine derivatives, for which well-documented methods are rarely known in the literature. A broad range of substrates with both electron-rich and electron-deficient groups were well-tolerated under the developed conditions to furnish the desired products in yields up to 98%. The scope of the devised method was not only restricted to the synthesis of 1,3-benzoselenazines, but it was further extended towards the synthesis of 1,3-benzothiazines, 1,3-benzothiazinones and the corresponding eight-membered N-heterocycles such as diaryl[b,f][1,5]diazocine-6,12(5H,11H)-diones.

Organic & Biomolecular Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent) (amino). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Muthuvinothini, A.; Stella, S. published the artcile< Surface modified nanoparticles: a green catalyst for the reduction of ketones>, Related Products of 403-41-8, the main research area is metal oxide glycerol nanoparticle green catalyst ketone reduction.

In the present study, a creative and eco-friendly synthetic method was demonstrated for the reduction of ketones using surface modified metal oxide nanoparticles (MO NPs). Nickel oxide, iron oxide and copper oxide nanoparticles were biosynthesized from the aqueous immature fruit extract of Cocos nucifera and the nanoparticle’s surface was modified using glycerol to improve the catalytic efficiency. Surface modification of the nanoparticles enhanced the catalytic activity of nanoparticles as compared to the unmodified metal oxide nanoparticles (MO NPs) for the reduction of ketones. Among the MO NPs used as catalysts for the reduction of acetophenone derivatives, glycerol modified iron oxide nanoparticles showed greater results with 74%-91% of yield due to its uniform morphol. The catalyst retained its stability even after seven repeated cycles of reaction.

Inorganic and Nano-Metal Chemistry published new progress about Coconut. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Related Products of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Shi-Qi; Cui, Yao; Guo, Bin; Young, David J.; Xu, Ze; Li, Hong-Xi published the artcile< Efficient synthesis of quinazolines by the iron-catalyzed acceptor-less dehydrogenative coupling of (2-aminophenyl)methanols and benzamides>, Name: (2-Aminophenyl)methanol, the main research area is preparation quinazolines iron catalyzed acceptorless dehydrogenative coupling; aminophenylmethanols benzamides heterocyclization.

The acceptor-less dehydrogenation coupling (ADC) of (2-aminophenyl)methanols with benzamides was achieved with catalytic FeCl2·4H2O in an efficient synthesis of quinazolines. This simple catalytic system is atom-economical, environmentally benign and suited to a variety of substrates.

Tetrahedron published new progress about Benzamides Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Name: (2-Aminophenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thiyagarajan, Subramanian; Gunanathan, Chidambaram published the artcile< Ruthenium-Catalyzed Selective Hydrogenation of Epoxides to Secondary Alcohols>, Reference of 403-41-8, the main research area is secondary alc preparation green chem; epoxide regioselective hydrogenation ruthenium catalyst.

A ruthenium(II)-catalyzed highly selective Markovnikov hydrogenation of terminal epoxides to secondary alcs. is reported. Diverse substitutions on the aryl ring of styrene oxides are tolerated. Benzylic, glycidyl, and aliphatic epoxides as well as diepoxides also underwent facile hydrogenation to provide secondary alcs. with exclusive selectivity. Metal-ligand cooperation-mediated ruthenium trans-dihydride formation and its reaction involving oxygen and the less substituted terminal carbon of the epoxide is envisaged for the origin of the observed selectivity.

Organic Letters published new progress about Epoxides Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Reference of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Maier, Thomas M.; Gawron, Martin; Coburger, Peter; Bodensteiner, Michael; Wolf, Robert; van Leest, Nicolaas P.; de Bruin, Bas; Demeshko, Serhiy; Meyer, Franc published the artcile< Low-Valence Anionic α-Diimine Iron Complexes: Synthesis, Characterization, and Catalytic Hydroboration Studies>, Synthetic Route of 403-41-8, the main research area is iron diimine low valent complex preparation ketone hydroboration catalyst; crystal mol structure iron diimine low valent ferrate complex.

The synthesis of rare anionic heteroleptic and homoleptic α-diimine iron complexes is described. Heteroleptic BIAN complexes [(cod)Fe(BIAN)][K([18]c-6)(thf)0.5] (1) and [(dnbe)Fe(BIAN)][K([18]c-6)(thf)2] (2; H2BIAN = N,N’-Dipp2-1,2-acenaphtylenediamine, cod = 1,5-cyclooctadiene, dnbe = 5,5′-dinorbornene-6,6′-diyl)were synthesized by reduction of the [(BIAN)FeBr2] precursor complex using stoichiometric amounts of potassium graphite in the presence of the corresponding olefin. The electronic structure of these paramagnetic species was investigated by numerous spectroscopic analyses (NMR, EPR, 57Fe Mossbauer, UV-vis), magnetic measurements (Evans NMR method, SQUID), and theor. techniques (DFT, CASSCF). Whereas anion 1 is a low-spin complex, anion 2 consists of an intermediate-spin Fe(III) center. Both complexes are efficient precatalysts for the hydroboration of carbonyl compounds under mild reaction conditions. The reaction of bis(anthracene) ferrate(1-) gave the homoleptic BIAN complex 3-[K([18]c-6)(thf)], which is less catalytically active. The electronic structure was elucidated with the same techniques as described for complexes 1-[K([18]c-6)(thf)0.5] and 2-[K([18]c-6)(thf)2] and revealed an Fe(II) species in a quartet ground state. Highly reduced ferrate anions were synthesized and structurally characterized. The mol. structures were elucidated by X-ray crystallog. Because of the presence of redox-active α-diimine ligands, the electronic situation was thoroughly analyzed using high-level quantum chem. calculations 57Fe-Mossbauer, EPR, NMR, and UV-vis spectroscopies and SQUID magnetization measurements were employed to characterize the spectroscopic and magnetic properties. Two of the new complexes prepared are precatalysts for the hydroboration of carbonyl compounds requiring low catalyst loadings.

Inorganic Chemistry published new progress about Crystal structure. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Synthetic Route of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Plestina, R.; Stoner, H. B.; Jones, Glenys; Butler, W. H.; Mattocks, A. R. published the artcile< Vascular changes in the lungs of rats after the intravenous injection of pyrrole carbamates>, Application of C6H9NO, the main research area is lung pathol pyrrole carbamate; monocrotaline derivative lung toxicity; alkaloid pyrrolizidine derivative lung.

Acute pulmonary edema was produced in mice and rats, after injection into a systemic vein, of 1-methyl-2-(N-ethylcarbamoyloxymethyl)pyrrole (I) [62435-67-0] and 1-methyl-2,3-bis(N-ethylcarbamoyloxymethyl)pyrrole (II) [36504-91-3], 2 synthetic compounds related to monocrotaline pyrrole. 1-Methyl-2-hydroxymethylpyrrole (III) [52160-51-7] and Et N-ethylcarbamate [623-78-9] had no such effect and although 3-(N-ethylcarbamoyloxymethyl)furan (IV) [50884-33-8] did not cause pleural effusion in rats it did in mice. Like monocrotaline pyrrole, the pyrrole carbamates, when injected into other vessels, produced edema in the region of the 1st capillary bed encountered. S labeling occurred in both the postcapillary venules and the capillaries of the lungs when colloidal C was injected i.v. after the pyrrole carbamates. Venular labeling occurred before capillary labeling, which occurred optimally when C was injected >4 h after the pyrrole. No C labeling was observed after IV injection. The effects of the synthetic pyrrole esters were similar to those of monocrotaline pyrrole. The pyrrole carbamates were less active on a mol. basis, but they had a broader action on the pulmonary vasculature, causing both venular and capillary labeling. The compounds required the pyrrole ring structure and ≥1 ester side-chain to affect the lungs acutely.

Journal of Pathology published new progress about Lung. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Application of C6H9NO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts