Tag: M.W=0-100

Related Products of 110-73-6 ,Some common heterocyclic compound, 110-73-6, molecular formula is C4H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 14; test-butyl [2-(4-{1-(2,4-dichlorophenyl)-4-methyl-3-[(piperidin-1-ylamino)carbonyl]-1H- pyrazol-5-vl} phenoxy . ethyllethvlcarbamate; Step A: tert-butyl ethyl(2-hydroxyethyl)carbamate; Di-tert-butyl dicarbonate (3.19 g, 14.6 mmol) in THF (10 ml) was added to 2- (ethylamino) ethanol (1.00 g, 11.2 mmol) and reacted at room temperature for 3 hours. The solvent was evaporated at reduced pressure to give the crude product (2.28 g). 1H NMR (499.961 MHz) 8 3.71-3. 65 (br, 2H), 3.55-3. 35 (br, 1H), 3.35-3. 30 (br, 2H), 3. 30- 3.20 (br, 2H), 1.43 (s, 9H), 1.07 (t, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 110-73-6, 2-(Ethylamino)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/80343; (2005); A2;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 616-29-5, name is 1,3-Diaminopropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 1,3-Diaminopropan-2-ol

Example 7 Preparation of 1,3-di(oleylamino)propan-2-ol Oleic acid (5.698 g, 0.020 mol) and 1,3-diaminopropan-2-ol (1 g, 0.011 mol) were placed in a flask and heated at 190 C. for 2 hours. The reaction mixture was cooled to room temperature, then taken up in chloroform and washed with water. The aqueous phase was extracted with chloroform and the organic phases were combined, dried on magnesium sulfate, filtered and evaporated to dryness to yield an oily black residue (6.64 g) which was purified by chromatography on silica gel (eluent:dichloromethane/methanol 99:1). The resulting product was then washed with ether and filtered. Yield: 23% Rf (dichloromethane/methanol 95:5): 0.43 IR: nuNH 3306 cm-1; nuCO amide 1646 and 1630 cm-1

With the rapid development of chemical substances, we look forward to future research findings about 616-29-5.

Reference:
Patent; Gentif; US2006/35977; (2006); A1;,
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Application of 764-48-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 764-48-7, name is Ethylene Glycol Vinyl Ether. A new synthetic method of this compound is introduced below.

General procedure: A dry and argon-flushed 10 mL Schlenk tube, equipped with a stirring bar and septum, wascharged with 2-(vinyloxy)ethanol (5, 132 mg, 1.50 mmol, 1.50 equiv) in Et2O (1.5 mL). Then,iPrMgBr (1.55 mmol, 1.55 equiv) was added dropwise at 25 C. After 5 min of stirring,Sc(OTf)3 (49.2 mg, 0.10 mmol, 0.10 equiv) and aldehyde 6 (1.00 mmol, 1.00 equiv) weresuccessively added and the reaction mixture was stirred at 40 C for the given time. After afull conversion was detected by GC-analysis, sat. aq. NH4Cl (15 mL) was added and theaqueous layer was extracted with EtOAc (3 x 15 mL). The combined organic layers weredried over Na2SO4, filtered and solvent was removed under reduced pressure. Purification viacolumn chromatography (SiO2) afforded expected products 4.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,764-48-7, its application will become more common.

Reference:
Article; Quinio, Pauline; Kohout, Laura; Roman, Daniela Sustac; Gaar, Jakob; Karaghiosoff, Konstantin; Knochel, Paul; Synlett; vol. 27; 11; (2016); p. 1715 – 1719;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.109-83-1, name is 2-(Methylamino)ethanol, molecular formula is C3H9NO, molecular weight is 75.1097, as common compound, the synthetic route is as follows.Application In Synthesis of 2-(Methylamino)ethanol

2-(methylamino)ethanol (3.8 ml), 46.9 mmole) was dissolved in DCM (200 ml) and triethylamine (15 ml, 107 mmole) was added. The solution was cooled to 0 C., a solution of 4-methoxy-2,6-dimethylbenzene-1-sulfonyl chloride (10 g, 42.6 mmole) dissolved in DCM (100 ml) was added, and the whole was stirred for 1.5 hours at RT. After completion of the reaction HCl (0.5 M, 100 ml) was added, the phases were separated, washed with water, dried over Na2SO4 and concentrated by evaporation. The crude product was used without further purification in the next stage. Yield 12.2 g, >100%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,109-83-1, 2-(Methylamino)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; GRUENENTHAL GmbH; US2009/186899; (2009); A1;,
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Reference of 96-35-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 96-35-5, name is Methyl 2-hydroxyacetate, molecular formula is C3H6O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation 69: 2-Hydroxyacetohydrazide Hydrazine monohydrate (1.08 g, 22.2 mmol) was added to a solution of methyl glycolate (0.84 mL, 11.1 mmol) in methanol (10 mL) and the mixture was heated under reflux for 2 hours and stirred at room temperature for 72 hours. The reaction mixture was then concentrated in vacuo to afford the title compound as a white solid in quantitative yield. 1H NMR(400 MHz, CDCl3) delta: 4.04(s, 2H)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 96-35-5, Methyl 2-hydroxyacetate.

Reference:
Patent; Pfizer Inc; US2006/160786; (2006); A1;,
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Reference of 124-68-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 124-68-5 as follows.

1) N-Benzyl-2-amino-2-methyl-1-propanol A solution of 2-amino-2-methyl-1-propanol (10.0 g), benzaldehyde (11.98 mL) and p-toluenesulfonic acid (10 mg) in benzene (300mL) was heated to reflux for 4 hours using a Dean-Stark dehydrating apparatus. After air cooling, the reaction solvent was evaporated under reduced pressure, and a residue thus obtained was dissolved in methanol (200 mL). Under ice cooling, sodium cyanoborohydride (8. 89 g) was added to the solution, and the mixture was stirred for 1. 5 hours. The reaction solvent was evaporated under reduced pressure, then a saturated aqueous solution of sodium hydrogen carbonate and ethyl acetate were added to the residue thus obtained, and the resultant mixture was partitioned. The organic layer was washed with saturated brine, and then was dried over anhydrous magnesium sulfate. After separating the organic layer by filtration, the solvent was evaporated under reduced pressure, and a residue thus obtained was purified by silica gel column chromatography (dichloromethane-methanol-aqueous ammonia), to obtain N-benzyl-2-amino-2-methyl-1-propanol (10. 36 g, 52%) as a solid. 1H-NMR (400MHz, CDCl3) delta: 1.15 (6H, s), 1.86 (2H, br s), 3.35 (2H, s), 3.68 (2H, s), 7.30 (5H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,124-68-5, its application will become more common.

Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1803719; (2007); A1;,
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Reference of 96-35-5 ,Some common heterocyclic compound, 96-35-5, molecular formula is C3H6O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediate P1082-phenyl-4,6-dihydro-2H-furo [3 ,4-c]pyrazol-31006951 Step A: Preparation of 4-oxotetrahydrofuran-3-carbonitrile: To a suspension of KOtBu (996.6 mg, 8.88 1 mmol) in THF (640.4 mg, 8.88 1 mmol) cooled to 0 C was added dropwise methyl 2-hydroxyacetate (675.7 jiL, 8.881 mmol) and stirred for 10 minutes. The acrylonitrile (589.1 jiL, 8.881 mmol) was then added and the reaction stirred at ambient temperature. After 3 hours, the reaction was diluted with 1120 (50 mL), then extracted with Et20 (25 mL) to remove any starting ester. The basic aqueous phase was acidified with 2M HC1 (5 mL), then extracted with Et20 (2 x 50 mL). The combined organic phases were dried with MgSO4, filtered, and concentrated to afford a light brown oil (446 mg, 45.2% yield). ?H NMR (CDC13) 4.63 (t, 111), 4.24 (t, 111), 4.14 (d, 1H), 4.02 (d, 1H), 3.57 (t, 111).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 96-35-5, Methyl 2-hydroxyacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARRAY BIOPHARMA INC.; BLAKE, James F.; BRANDHUBER, Barbara J.; HAAS, Julia; NEWHOUSE, Brad; THOMAS, Allen A.; WINSKI, Shannon L.; WO2014/78331; (2014); A1;,
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Synthetic Route of 627-27-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.627-27-0, name is But-3-en-1-ol, molecular formula is C4H8O, molecular weight is 72.1057, as common compound, the synthetic route is as follows.

To a suspension of 8.0 g NaH (333.32 mmol, 60 % w/vdispersion in mineral oil, 4.0 eq) in 100 cm3, anhydrousTHF was added drop wise to a solution of 6.0 g 3-buten-1-ol 8 (83.33 mmol, 1.0 eq) at 0 C. To this mixture, 0.150 gTBAI and 11.9 cm3 benzyl bromide (99.99 mmol, 1.2 eq)were added, and stirring was continued for 2 h at the sametemperature and overnight at 25 C. The reaction mixturewas quenched by small crushed ice flakes until a clearsolution (biphasic) had formed. The reaction mixture wasextracted with ether and the extract was washed with water(1 9 100 cm3), brine (1 9 100 cm3) and dried over anhydrousNa2SO4. Evaporation of the solvents followed bycolumn chromatography (silica gel, 60-120 mesh, 5 %EtOAc in pet. ether) afforded the pure product 9 (12.2 g,91 % yield) as a colorless liquid.

Statistics shows that 627-27-0 is playing an increasingly important role. we look forward to future research findings about But-3-en-1-ol.

Reference:
Article; Pratapareddy, Bommareddy; Sreenivasulu, Reddymasu; Hatti, Islavathu; Venkata Basaveswara Rao, Mandava; Raju, Rudraraju Ramesh; Monatshefte fur Chemie; vol. 146; 11; (2015); p. 1921 – 1926;,
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Adding a certain compound to certain chemical reactions, such as: 3279-95-6, 2-(Aminooxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-(Aminooxy)ethanol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 2-(Aminooxy)ethanol

To a solution of 1-(3-(3-(morpholinomethyl)quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethanone hydrochloride (79.3) (23 mg, 0.047 mmol) and 2-(aminooxy)ethanol (10.80 mg, 0.140 mmol) in MeOH (5 ml) was added 2 drops of HCl (2 N) by a 1-ml syringe to reach pH about 3 and the mixture was stirred in a sealed tube at 85 C. for 3 h. The mixture was evaporated to dryness and the residue was dissolved in water. The solution was neutralized by adding solid NaHCO3 until pH reached 9, then extracted by DCM (3×). The combined organic layers were washed by water again, dried over Na2SO4, filtered and evaporated. The residue was purified by preparative base HPLC (gradient eluent NB from 20/80 to 95/5. mobile phase A: NH4OH/CH3CN 0.04%; mobile phase B: NH4OH/H2O 0.04%). The desired fractions were collected, evaporated by BUCHI under 30 mbar at 35 C. to remove CH3CN. The remained solution was lyophilized to afford the title compound (12.2 mg, yield 54.2%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3279-95-6, 2-(Aminooxy)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; NOVARTIS AG; CHEN, Chao; DENG, Haibing; GUO, Haibing; HE, Feng; JIANG, Lei; LIANG, Fang; MI, Yuan; WAN, Huixin; XU, Yao-Chang; YU, Hongping; ZHANG, Ji Yue; US2013/245002; (2013); A1;,
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Reference of 4415-82-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4415-82-1, name is Cyclobutylmethanol, molecular formula is C5H10O, molecular weight is 86.13, as common compound, the synthetic route is as follows.

Intermediate D: tert-butyl [(5i?,7S)-8-(cyclobutylmethyl)-l-(3-fluorophenyl)-7-methyl-2-oxo- l,3,8-triazaspiro[4.5]dec-3-en-4-yl]carbamate; To a solution of intermediate C (1.45 g, 3.85 mmol) and cyclobutane carboxaldehyde (0.97 g, 11.6 mmol prepared from alcohol using TPAP/NMO) in DCM (60 mL) at 0 0C was added NaHB(OAc)3 (1.23 g, 5.8 mmol). The mixture was allowed to slowly warm to rt and stir for 18h. The mixture was diluted with aq. NaHCO3 and DCM. The organic layer was isolated, washed sequentially with water and brine, dried with Na2SO4 and concentrated to dryness to give 2.6 g of crude material. Purification using automated SiO2 chromatography (MeOH/DCM) provided 1.5 g of desired tert-butyl [(5i?,7iS)-8-(cyclobutylmethyl)-l-(3-fluorophenyl)-7-methyl- 2-oxo-l,3,8-triazaspiro[4.5]dec-3-en-4-yl]carbamate as a white foam. LCMS (M+H) = 445.

Statistics shows that 4415-82-1 is playing an increasingly important role. we look forward to future research findings about Cyclobutylmethanol.

Reference:
Patent; MERCK & CO., INC.; WO2008/54698; (2008); A2;,
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