Tag: M.W=0-100

Related Products of 33420-52-9, Adding some certain compound to certain chemical reactions, such as: 33420-52-9, name is 2,2-Difluoropropan-1-ol,molecular formula is C3H6F2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33420-52-9.

To a solution of 2,2-difluoropropan-1-ol (5.00 g, 52.0 mmol) and triethylamine (9.40mL, 67.6 mmol) in DCM (75 mL) was added trifluoromethanesulfonic anhydride (10.5 mL, 62.4mmol) dropwise at -20 C, and then allowed to move to 0 C, stirred overnight. The mixture wasdiluted with DCM (75 mL), then poured into ice water (100 mL). The separated organic layerwas washed with 20% Na2C03 aqueous solution (50 mL) and brine (50 mL) successively, anddried over Na2S04, filtered and concentrated in vacuo to afford the target compound as black oil(11.41 g, yield 96.1%).1HNMR (400 MHz, DMSO-d6) 8 (ppm): 5.08 (t, J= 13.5 Hz, 2H), 1.72 (t, J= 19.3 Hz, 3H);19F NMR (376 MHz, DMSO-d6) 8 (ppm): -74.6, -99.7.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 33420-52-9, 2,2-Difluoropropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; DAI, Weilong; XI, Ning; LI, Minxiong; ZHANG, Tao; LI, Xiaobo; HU, Haiyang; CHEN, Wuhong; WANG, Tingjin; LIU, Jun; (188 pag.)WO2017/48675; (2017); A1;,
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Adding a certain compound to certain chemical reactions, such as: 33420-52-9, 2,2-Difluoropropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 33420-52-9, blongs to alcohols-buliding-blocks compound. SDS of cas: 33420-52-9

To a solution of 2,2-difluoropropan-1-ol (I-10A-7b; 1.76 g, 18.3 mmol), dimethylaminopropylamine (DMAP: 157 mg, 1.3 mmol), and triethylamine (2.20 g, 3.1 ml, 22 mmol) in CH2Cl2 (15 ml) at 0 C. was added triflic anhydride (Tf2O; 6.2 g, 3.7 ml, 22 mmol). The reaction mixture initially turned a pink color, then a yellow color following the complete addition of Tf2O. The reaction mixture was stirred at 0 C. for 2 hours and diluted with CH2Cl2. The organic solution was washed with water, 1 M aqueous citric acid, and saturated aqueous NaHCO3, dried, and concentrated under reduced pressure (225 mm/Hg; bath temperature -30 C.) to give the desired product, trifluoromethanesulfonic acid 2,2-difluoropropyl ester (I-10A-7c), as a pink oil (3 g, 72%): 1H NMR (400 MHz, CDCl3) delta 4.49 (t, J=10.8 Hz, 2H), 1.74 (t, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,33420-52-9, its application will become more common.

Reference:
Patent; Pfizer Inc.; US2004/214837; (2004); A1;,
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Synthetic Route of 96-35-5 ,Some common heterocyclic compound, 96-35-5, molecular formula is C3H6O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

3.85 g of silver perchlorate (18.6 mmol) are added to a solution of 8,8-dibromobicyclo[5.1.0]octane 16 (2.5 g, 9.3 mmol) and methyl glycolate (6.35 ml, 83.9 mmol) dissolved in 5 ml of anhydrous toluene in a dry round-bottomed flask under Ar protected from light by an aluminum film. The reaction mixture is stirred at ambient temperature for 1 h 30 and then the silver salts are filtered off through a sintered glass funnel and washed with AcOEt. The solution is concentrated under vacuum to give a viscous brown oil which is purified by chromatography on silica gel (cyclohexane/2-15% AcOEt) to produce 17 in the form of a yellow oil (w=1.7 g, i.e. 66% yield).1H NMR (CDCl3, 200 MHz): delta (ppm) 0.7-2.2 (m, 8H, H4-4′-5-5′-6-6′-7-7′); 2.28 (m, 1H, H8); 2.70 (ddd, J=5.0-11.5-23.5 Hz, 1H, H8′); 3.72 (s, 3H, OMe); 3.94 (d, J=16.5 Hz, 1H, H9); 4.10 (dd, J=5.0-10.0 Hz, 1H, H3); 4.23 (d, J=16.5 Hz, 1H, H9′); 6.20 (dd, J=4.0-11.5 Hz, 1H, H1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,96-35-5, its application will become more common.

Reference:
Patent; COMMISSARIAT A L’ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES; US2011/118484; (2011); A1;,
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Electric Literature of 534-03-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, molecular weight is 91.1091, as common compound, the synthetic route is as follows.

To a solution of 2-amino-1,3-propanediol (S2, 299 mg, 3.28 mmol, 1.0 equiv) in MeCN (10 mL), K2CO3 (2.27 g, 16.4 mmol, 5.0 equiv) and benzyl bromide (0.98 mL, 1.4 g, 8.3 mmol, 2.5 equiv) were added at room temperature. The reaction mixture was stirred at this temperature for 18 h and then diluted with water (10 mL). The aqueous layer was extracted with EtOAc (3 × 10 mL) and the combined organics were dried over Na2SO4. The solvent was removed under reduced pressure and the resultant residue was purified by column chromatography (SiO2, petroleum ether/EtOAc 1:1) to yield 716 mg (2.64 mmol, 80%) of S3 as a white solid. TLC Rf 0.20 (petroleum ether/EtOAc 1:1); mp 113 C; 1H NMR (300 MHz, C6D6): 2.30 (bs, 2H, OH), 2.93 (tt, 1H, J = 7.5, 5.9 Hz, 2-H), 3.37 (dd, 2H, J = 10.8, 5.9 Hz, 1-Ha, 3-Ha), 3.48 (dd, 2H, J = 10.8, 7.5 Hz, 1-Hb, 3-Hb), 3.53-3.66 (m, 4H, CH2Ph), 7.01-7.32 (m, 10H, Ph-H); 13C NMR (76 MHz, C6D6): 54.4, 60.2, 60.3, 127.4, 128.7, 129.2, 140.1; IR (ATR) nu 3245, 1493, 1451, 1049, 1025, 999, 741, 730, 695; UV (MeCN) lambdamax (log epsilon) 206 (4.28), 259 (2.77); MS (ESI+) m/z 272.2 (M+H+), 294.2 (M+Na+); HRMS (ESI+) m/z calcd for C17H21NNaO2 294.1465 (M+Na+), found 294.1466.

The chemical industry reduces the impact on the environment during synthesis 534-03-2, I believe this compound will play a more active role in future production and life.

Reference:
Article; Ries, Oliver; Bueschleb, Martin; Granitzka, Markus; Stalke, Dietmar; Ducho, Christian; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 1135 – 1142;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2-Aminopropane-1,3-diol

To a solution of TBDMSCI (7.2 g, 48 mmol), A/,A/-diisopropylethylamine (5.0 mL, 29 mmol) and DMAP (50 mg) in dichloromethane (50.0 mL) was added 2-amino-1 ,3-propan-diol (2.0 g, 22 mmol), and the mixture was stirred overnight. Volatiles were removed under high vacuum to give a residue, which was subjected to flash silica gel column purification on ISCO companion (ethyl acetate/hexane, 50 -100% containing 2% triethylamine) to give 1.2 g (17%) of compound S76 as colorless oil. H NMR (500MHz, CDCI3): 53.70 (2H, dd, J 10.0, 5.5 Hz), 3.63 (2H, dd, J 10.0, 5.5 Hz), 3.04 (1 H, m), 0.90 (18H, s), 0.07 (12H, s)

With the rapid development of chemical substances, we look forward to future research findings about 534-03-2.

Reference:
Patent; SOLSTICE BIOLOGICS, LTD.; BRADSHAW, Curt, W.; ELTEPU, Laxman; KABAKIBI, Ayman; LAM, Son; LIU, Bin; LIU, Dingguo; MEADE, Bryan, R.; SAKAMURI, Sukumar; WO2015/69932; (2015); A1;,
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Synthetic Route of 927-74-2, Adding some certain compound to certain chemical reactions, such as: 927-74-2, name is 3-Butyn-1-ol,molecular formula is C4H6O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 927-74-2.

A mixture of but-3-yn-1-ol (2.0 g, 28.6 mmol), imidazole (2.9 g, 42.9mmol), and DMAP (catalytic amount) was dissolved in anhydrousTHF (8 mL) under N2. A solution of tert-butyldimethylsilyl chloride (5.17 g, 34.3 mmol) in anhydrous THF (2 mL) was added dropwise and the mixture was stirred at r.t. for 2 h under N2. The mixture was quenched with sat. aq NH4Cl (20 mL) and extracted with hexane (3 ×20 mL). The combined organic layers were washed with brine (25mL), dried (Na2SO4), and concentrated under reduced pressure. Theresidue was purified by flash chromatography on silica gel (hexane) to afford compound 16 as a colorless oil; yield: 4.46 g (85%); Rf = 0.23 (hexane).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 927-74-2, 3-Butyn-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Puigmarti, Marc; Bosch, Ma Pilar; Guerrero, Angel; Synthesis; vol. 47; 7; (2015); p. 961 – 968;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2516-33-8, name is Cyclopropylmethanol, molecular formula is C4H8O, molecular weight is 72.1057, as common compound, the synthetic route is as follows.Safety of Cyclopropylmethanol

10062] Into a clean, dry reactor equipped with a stirrer and under nitrogen are successively loaded 4.63 kg of DMF (5.1 eqV) and then 4.53 kg of triphenylphosphite. 2.34 kg of bromine is then introduced while maintaining the temperature at less than 12 C. The stirring speed is regulated according to the fluidity of the reaction medium. When casting ends, a very thick medium with a yellow solid suspension is obtained.10063] The set point of the jacket is then adjusted to -12 C. and then 0.96 kg of cyclopropylmethanol is introduced in such a way as not to exceed a temperature of -5 C. On completion of the addition the whole is allowed to return slowly to room temperature. The set point of the jacket is then adjusted to 64 C. for distillation, which is carried out at a pressure of 13 mbar by collecting the first 24 to 30 C. fraction at the top of the colunm, then the second 30 to 40 C. fraction (partial reflux). Two fractions, Fl (1.38 kg) and F2 (293 g), are collected. The two fractions, after washing with carbonated water and then drying by means of CaC12, lead to a final product 2a (mass 1.316 kg) having a GC relative purity of 98.7% with a yield of 73%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2516-33-8, Cyclopropylmethanol, and friends who are interested can also refer to it.

Reference:
Patent; MELCHIOR MATERIAL AND LIFE SCIENCE FRANCE; GUERRET, Olivier; (6 pag.)US2016/355452; (2016); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 616-29-5, name is 1,3-Diaminopropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. Safety of 1,3-Diaminopropan-2-ol

A solution of 1,3-diamino-2-propanol (3.15 g,0.035 mol) and Et3N (4.85 mE, 0.035 mol) in methanol (120mE) was heated to 45 C. To the solution, (l3oc)20 (17.05 g,0.078 mol) in methanol (80 mE) was dropwise added slowly.The reaction solution was stirred at 45 C. for 30 mm. Afteradditional stirring at room temperature for 1.5 h, the solventwas removed under reduced pressure. The crude productwas extracted with diethyl ether (200 mEx3) and dried oversodium sulfate to yield the compound 2 (9.94 g, 97.8%) asa white powdet EC-MS mlz (ES), 291.19 (M+H).

With the rapid development of chemical substances, we look forward to future research findings about 616-29-5.

Reference:
Patent; RC Biotechnologies, Inc.; HUANG, Chang Jiang; FANG, Jianmin; YE, Hui; ZHANG, Lezhi; (63 pag.)US2018/55948; (2018); A1;,
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Related Products of 110-73-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 110-73-6, name is 2-(Ethylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Synthesis of(Intermediate 3) 60ml of N, N-dimethylacetamide Intermediate 2 was added 21.1 g(50 mmol), and stirred in an ice bath, was added dropwise so as to keep the following 10 C N- ethyl ethanolamine 8.9 g (100 mmol) . After completion ofthe dropwise addition, stirring under an ice bath for 2 hours, ethyl acetate100ml reaction solution, ion-exchanged water 100ml, and extracted concentratedhydrochloric acid was added to 3 ml. The organic layer was washed with asaturated sodium chloride aqueous solution, dried over anhydrous magnesiumsulfate, and the solvent was evaporated. Then purified by silica gel columnchromatography (hexane / ethyl acetate = 1/1), Intermediate 3 19.0 g: yield(yield: 80%).

According to the analysis of related databases, 110-73-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FUJIFILM Corporation; Takasaki, Yuta; Ishiwata, Yasuhiro; Morozumi, Kazuma; (58 pag.)JP2015/124376; (2015); A;,
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Application of 14320-38-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14320-38-8, name is Cyclopent-3-enol. This compound has unique chemical properties. The synthetic route is as follows.

C. ((Cyclopent-3-enyloxy)methyl)benzene To a cooled solution of cyclopent-3-enol (30.40 g, 0.36 mol) in THF (300 mL) at 0 C. was added NaH (18.82 g, 0.47 mol, 60% in mineral oil). After effervescence had ceased, benzyl bromide (80.45 g, 0.47 mol) was added dropwise at 0 C. over a 45 min period. The reaction mixture was allowed to warm to RT over a 6 h period. Excess NaH was quenched with MeOH (120 mL) at a temperature below 5 C. The mixture was warmed to RT, diluted with H2O, and the two layers were separated. The aqueous layer was extracted with EtOAc. The organic layers were combined, concentrated, and purified by column chromatography eluting with petroleum ether and EtOAc (PE/EA=40/1 to 30/1) to give the title compound as an oil (45.28 g, 72%). 1H NMR (400 MHz, CDCl3) delta ppm 2.38-2.41 (m, 2H), 2.49-2.54 (m, 2H), 4.20-4.24 (m, 1H), 4.42 (s, 2H), 5.62 (s, 2H), 7.17-7.28 (m, 5H).

According to the analysis of related databases, 14320-38-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Takeda Pharmaceutical Company Limited; US2011/152273; (2011); A1;,
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