Tag: M.W=0-100

Synthetic Route of 4415-82-1 ,Some common heterocyclic compound, 4415-82-1, molecular formula is C5H10O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of Pyridinium chiorochromate (41.3 g, 191.6 mmol) in dichioromethane (120 mL) was added Cyclobutanemethanol (7.5 g, 87.1 mmol). The mixture was stirred fbr 1.5 hours then filtered through a pad of silica and rinsed with further dichioromethane (300 rnL). The solvent was removed under reduced pressure to give 2-cyciobutylcarbaldehyde (10,0 g, contains residual dichioromethane) that wasused without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4415-82-1, Cyclobutylmethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ALKERMES PHARMA IRELAND LIMTED; DEAVER, Dan; BLUMBERG, Laura, Cook; EYERMAN, David; WYNN, Thomas; WO2014/190271; (2014); A2;,
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Related Products of 2919-23-5 , The common heterocyclic compound, 2919-23-5, name is Cyclobutanol, molecular formula is C4H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-Bromo-6-chloronicotinic acid (CAN 29241-62-1, 2.0 g, 8.46 mmol) was dissolved in DMSO (20.0 mL). Cyclobutanol (793 mg, 857 muL, 11.0 mmol) and potassium hydroxide powder (1.42 g, 25.4 mmol) were added and the mixture was stirred at room temperature overnight. Water (20 mL) was added and the mixture was acidified (under ice-water bath cooling) with 37% HCL in water (pH=2). The suspension was filtered, washed with water and the solid was dried to yield 1.88 g (82%) of the title compound as a white solid; MS (ESI): 270.2 (M-H)-.

The synthetic route of 2919-23-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hebeisen, Paul; Matile, Hugues; Roever, Stephan; Wright, Matthew; Jensen, Sannah Zoffmann; US2012/65212; (2012); A1;,
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Reference of 1072-52-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1072-52-2, name is 2-(Aziridin-1-yl)ethanol. A new synthetic method of this compound is introduced below.

Example 10 (Table 1, entry 4 and Scheme 7): Preparation of 2- [(2-iodoethyl)-2,4- dinitro-6-({[2-(tetrahydro-2/£pyran-2-yloxy)ethyl]amino}carbonyl)anih’no]ethyl methanesulfonate (17c); A slurry of 15 (520 mg, 1.4 mmol) in dry 3-methyl-2-butanone (20 mL) and NaI (3.1 g) was cooled to below 5 0C, and aziridineethanol (240 mg, 2.76 mmol) was added. The reaction was kept at 20 0C overnight, then water (100 mL) was added, and the mixture was extracted with EtOAc (3×50 mL). The combined organic layer was washed with water, dried and concentrated under pressure, then passed through a short column of silica gel, eluting with heptane/EtOAc (1:1), to give 2-[(2-hydroxyethyl)(2-iodoethyl)amino]-3,5- dinitro-N-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]benzamide (16c) (630 mg, 82%) as a yellow foam; 1H NMR (CDCl3) delta 8.63 (d, / = 2.8 Hz, 1 H), 8.56 (dj = 2.8 Hz, 1 H), 8.24 (br, 1 H), 4.54 (m, 1 H), 4.48 (m, 1 H), 3.93 (m, 2 H), 3.84 (m, 1 H), 3.70 (m, 6 H), 3.54 (m, 1 H), 3.30 (m, 2 H), 3.18 (m, 2 H), 1.90-1.40 (m, 6 H); 13C NMR delta 165.7, 146.7, 144.4, 140,9, 134.5, 129.2, 123.5, 101.6, 67.0, 65.4, 58.0, 55.0, 53.7, 40.7, 31.3, 25.1, 21.2, 0.3; HRMS (FAB) calcd for C18H26IN4O8 [MH]+ m/z 553.0795; found 533.0797.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1072-52-2, 2-(Aziridin-1-yl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2008/30112; (2008); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6153-05-5, name is (Z)-3-Methylpent-2-en-4-yn-1-ol. A new synthetic method of this compound is introduced below., Recommanded Product: (Z)-3-Methylpent-2-en-4-yn-1-ol

General procedure: To a stirred solution of (Z)-3-methylpent-2-en-4-yn-1-ol (0.88 g, 9.2 mmol) in dry THF (20 mL)wascooled to 78 °C under an atmosphere of argon. n-Butyl lithium (7.7 mL, 18.4 mmol, 2.4 Min hexane) was then added slowly, via syringe. The mixture was allowed to stir at 78 °C for 1 h,after which, 6-methoxy-2,2-dimethyl-2,3-dihydronaphthalene-1,4-dione 9b (2 g, 9.2 mmol), dissolvedin dry THF (10 mL) was added. The mixture was stirred for a further 1 h at 78 °C, and then thecold bath was removed. The reaction mixture was stirred at r.t. for a further 16 h. The reactionwas quenched by addition of a saturated aqueous solution of NH4Cl. The mixture was stirred for10 min and extracted with ethyl acetate (3 50 mL), washed with water (2 30 mL) and driedover anhydrous Na2SO4. Evaporation of the solvent yielded the desired alcohol as a yellowishoil. The residue was subjected to silica gel chromatography using PE and EtOAc (4:1) as eluentto afford (Z)-(10-hydroxy-30,30-dimethyl-40-oxo-70-methoxy-tetrahydronaphthalene-one-yl)-3-methylpentyl-2-em-4-yn-1-ol 18b (2.37 g, 82percent) as a yellow oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 6153-05-5, (Z)-3-Methylpent-2-en-4-yn-1-ol.

Reference:
Article; Wan, Chuan; Wang, Mingan; Yang, Dongyan; Han, Xiaoqiang; Che, Chuanliang; Ding, Shanshan; Xiao, Yumei; Qin, Zhaohai; Molecules; vol. 22; 12; (2017);,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 764-48-7, name is Ethylene Glycol Vinyl Ether. A new synthetic method of this compound is introduced below., SDS of cas: 764-48-7

General procedure: A dry and argon-flushed 10 mL Schlenk tube, equipped with a stirring bar and septum, wascharged with 2-(vinyloxy)ethanol (5, 132 mg, 1.50 mmol, 1.50 equiv) in Et2O (1.5 mL). Then,iPrMgBr (1.55 mmol, 1.55 equiv) was added dropwise at 25 C. After 5 min of stirring,Sc(OTf)3 (49.2 mg, 0.10 mmol, 0.10 equiv) and aldehyde 6 (1.00 mmol, 1.00 equiv) weresuccessively added and the reaction mixture was stirred at 40 C for the given time. After afull conversion was detected by GC-analysis, sat. aq. NH4Cl (15 mL) was added and theaqueous layer was extracted with EtOAc (3 x 15 mL). The combined organic layers weredried over Na2SO4, filtered and solvent was removed under reduced pressure. Purification viacolumn chromatography (SiO2) afforded expected products 4.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 764-48-7, Ethylene Glycol Vinyl Ether.

Reference:
Article; Quinio, Pauline; Kohout, Laura; Roman, Daniela Sustac; Gaar, Jakob; Karaghiosoff, Konstantin; Knochel, Paul; Synlett; vol. 27; 11; (2016); p. 1715 – 1719;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 534-03-2, name is 2-Aminopropane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C3H9NO2

General procedure: To a stirred mixture of serinol 8 (1 equivalent) and K2CO3 (3 equivalents) in DMSO at 70-80 oC wasadded the appropriate fluoroaromatic 7d-f in portions over 5 minutes. The resulting colouredmixture was stirred (typically 3 hours), allowed to cool to room temperature, and then poured intoice-water with stirring. The resulting diol 9c-f was collected, washed with water and allowed to dry inair.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 534-03-2, 2-Aminopropane-1,3-diol.

Reference:
Article; Chappel, Lucy; Leong, Chee-Onn; Mai, Chun-Wai; Meikle, Ian T.; Stanforth, Stephen P.; Truong, Thang V.; Wong, Lai Chun; Bioorganic and medicinal chemistry letters; (2019);,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 627-30-5, name is 3-Chloropropan-1-ol, molecular formula is C3H7ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 627-30-5

Example 1 Preparation of 5-methyl-5-(3-chloropropyl)oxycarboxyl-1,3-dioxan-2-one, (MTCOPrCl), molecular weight 236.65 A catalytic amount (3 drops) of DMF was added to a THF solution (200 mL) of MTCOH (11.1 g, 69 mmol), followed by a solution of oxalyl chloride (7.3 mL, 87 mmol) in THF (100 mL), gently added over 20 min under N2 atmosphere. The solution was stirred for 1 hour, bubbled with N2 flow to remove volatiles, and evaporated under vacuum to give the intermediate MTCCl. A mixture of 3-chloro-1-propanol (5.4 mL, 76 mmol) and pyridine (6.2 mL, 65 mmol) in dry THF (50 mL) was added dropwise to a dry THF solution (100 mL) of the intermediate MTCCl over 30 min, while maintaining a solution temperature below 0 C. with an ice/salt bath. The reaction mixture was kept stirring for another 3 hours at room temperature before it was filtered and the filtrate evaporated. The residue was dissolved in methylene chloride and washed with 1N HCl aqueous solution, saturated NaHCO3 aqueous solution, brine and water, stirred with MgSO4 overnight, and the solvent evaporated. The crude product was passed through a silica gel column by gradient eluting of ethyl acetate and hexane (50/50 to 80/20) to provide the product as a colorless oil that slowly solidified to a white solid (9.8 g, 60%).

With the rapid development of chemical substances, we look forward to future research findings about 627-30-5.

Reference:
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; INTERNATIONAL BUSINESS MACHINES CORPORATION; US2012/231060; (2012); A1;,
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Reference of 124-68-5 ,Some common heterocyclic compound, 124-68-5, molecular formula is C4H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

STR93 a) Synthesis of N-(tert-butoxycarbonyl)-2-amino-2-methyl-1-propanol To solution of 2-amino-2-methyl-1-propanol (87 mmol, 8.3 ml) in 200 ml of CH2 Cl2 is added di-tert-butyl dicarbonate (96 mmol, 21.52 g) in 50 ml of CH2 Cl2. After 14 hours under argon, the solvent is evaporated under vacuum and 16.08 g (98% yield of pure compound is obtained. 1 H NMR (200 MHz, CDCl3): delta 4.70 (1 H, bs), 4.09 (1 H, bs), 3.57 (1H, d, J=6.0), 1.42 (9 H, s), 1.24 (6 H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,124-68-5, its application will become more common.

Reference:
Patent; Ciba Specialty Chemicals Corporation; US6140326; (2000); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 110-73-6, name is 2-(Ethylamino)ethanol. A new synthetic method of this compound is introduced below., HPLC of Formula: C4H11NO

Stage 1: Ethyl-(2-hydroxyethyl)carbamic acid tert-butyl ester: A solution is prepared from 15.2 g of Boc2O and 30 ml of dichloromethane. This solution is added dropwise to a mixture containing 7.36 g of 2-ethylaminoethanol and 30 ml of dichloromethane in the cold state. The reaction medium is allowed to stand for 24 hours at room temperature. After concentrating to dryness, the reaction medium is taken up in an NaCl solution. The medium is extracted three times with ethyl acetate and then washed with a saturated NaCl solution. The organic phase is dried over sodium sulfate and then concentrated to dryness using a vane pump in order to give 12 g of expected product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 110-73-6, 2-(Ethylamino)ethanol.

Reference:
Patent; sanofi-aventis; US2008/269170; (2008); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3279-95-6, name is 2-(Aminooxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C2H7NO2

33 mg (0.10 mmol) of 8-[(2,6-difluorobenzyl)oxy]-2,6-dimethylimidazo[1,2-a]pyrazine-3-carboxylic acid from Example 3A were initially charged in a 96-well deep well multititre plate. A solution of 8 mg (0.10 mmol) of 2-(aminooxy)ethanol in 0.4 ml of DMF and a solution of 45.6 mg (0.12 mol) of HATU in 0.4 ml of DMF were added successively. After adding 20.2 mg (0.20 mmol) of 4-methylmorpholine, the mixture was shaken at RT overnight. Then the mixture was filtered and the target compound was isolated from the filtrate by preparative LC-MS (Method 9). The product-containing fractions were concentrated under reduced pressure using a centrifugal dryer. The residue of each product fraction was dissolved in 0.6 ml of DMSO. These were combined and finally freed of the solvent in a centrifugal dryer. 0.4 mg (1% of theory) were obtained. (1378) LC-MS (Method 10): Rt=0.94 min (1379) MS (ESpos): m/z=393 (M+H)+

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3279-95-6, 2-(Aminooxy)ethanol.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; VAKALOPOULOS, Alexandros; FOLLMANN, Markus; HARTUNG, Ingo; BUCHGRABER, Philipp; JAUTELAT, Rolf; LINDNER, Niels; WUNDER, Frank; STASCH, Johannes-Peter; REDLICH, Gorden; Dietz, Lisa; LI, Volkhart Min-Jian; (85 pag.)US2016/176880; (2016); A1;,
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