Tag: M.W=0-100

Synthetic Route of 109-83-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 109-83-1, name is 2-(Methylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Example 1(f) Preparation of 2-(1,1-dicyanopropen-2-yl)-6-(2-[18F]-fluoroethyl)-methylamino)-naphthalene ([F-18]FDDNP) A mixture of 4.15 g (55.5 mmol) NaHSO3, 8 mL of water, 0.78 g (4.19 mmol) of 1-(6-hydroxy-2-naphthyl)-1-ethanone (prepared as described in Example 1(b)), and 8 mL of 2-methylaminoethanol was heated and stirred in a steel bomb at 140 C. for 28 hours. After cooling, the mixture was distributed between ethyl acetate and water (500 mL and 200 mL, respectively). The organic layer was dried and evaporated to leave raw 1-(6-(2-hydroxyethyl-methylamino)-2-naphthyl)-1-ethanone (0.749 g, 73%) of which was further purified by radial chromatography (4 mm SiO2, CH2Cl2).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 109-83-1, 2-(Methylamino)ethanol.

Reference:
Patent; Barrio, Jorge R.; Petric, Andre J.; Satyamurthy, Nagichettiar; Kepe, Vladimir; Small, Gary W.; US2007/53831; (2007); A1;,
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Electric Literature of 16545-68-9 ,Some common heterocyclic compound, 16545-68-9, molecular formula is C3H6O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

At 0C and under nitrogen flux, NaH (60% dispersion in mineral oil) (0.510 g; 12.8 mmol) was added portionwise to a solution of cyclopropanol (0.64 mL, 12.74 mmol) in Me-THF (24mL). The reaction was stirred at room temperature for 10 minutes. (1844) At -78C, the above described suspension was added dropwise to a solution of 1,4- dinitro-lH-pyrazole (3.00 g; 18.98 mmol) in Me-THF (6.50 mL, 64.9 mmol). The reaction mixture was stirred at -78C for 1 h then allowed to stir at rt for 5 hours. The reaction mixture was poured out onto water, made acidic with 3N HCl(aq), extracted with DCM, dried over MgS04, filtered and evaporated. The crude was purified via preparative LC (Stationary phase irregular SiOH 15-40muiotaeta 24g GraceResolv, Mobile phase: gradient from 80% Heptane, 20% EtOAc to 40% heptane, 60% EtOAc). The pure fractions were collected and the solvent was evaporated to give 466 mg of intermediate 746 (22%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16545-68-9, its application will become more common.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; STANSFIELD, Ian; QUEROLLE, Olivier, Alexis, Georges; LIGNY, Yannick, Aime, Eddy; GROSS, Gerhard, Max; JACOBY, Edgar; MEERPOEL, Lieven; GREEN, Simon, Richard; HYND, George; KULAGOWSKI, Janusz, Jozef; MACLEOD, Calum; MANN, Samuel, Edward; (472 pag.)WO2018/2217; (2018); A1;,
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Synthetic Route of 110-73-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 110-73-6, name is 2-(Ethylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

in a four-necked flask of 300ml, formula dye intermediate 34.3 parts obtained in step 5-1, put the NMP146 parts of 2- (ethylamino) ethanol 16.3 parts, 90 in it stirred 1.5 hours.The reaction mixture was poured into 2N aqueous hydrochloric acid, the precipitated crystals were collected by filtration, washed, and dried to give Intermediate 34.9 parts of the dye represented by the following formula (104).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 110-73-6, 2-(Ethylamino)ethanol.

Reference:
Patent; NIPPON KAYAKU COMPANY LIMITED; MIFUJI, AKIHIRO; (16 pag.)JP2016/65220; (2016); A;,
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Synthetic Route of 1072-52-2, Adding some certain compound to certain chemical reactions, such as: 1072-52-2, name is 2-(Aziridin-1-yl)ethanol,molecular formula is C4H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1072-52-2.

Example 16 (Table 1, entry 8 and Scheme 11): Preparation of methyl 3-[N-(2- iodoethyl)-N- [2- [(methylsulfonyl)oxy] ethyl] amino] -2,6-dinitrobenzoate (27c); A stirred5 solution of methyl 3-chloro-2,6-dinitrobenzoate (25) (140 mg, 0.54 mmol) in DMF (1.5 mL) at» , room temperature was treated with NaI (405 mg, 2.7 mmol) for 5 min, then cooled to 0 0C and treated with aziridineethanol (0.15 mL, 1.87 mmol). The mixture was stirred at 30 0C for 16 h, then diluted with IN aqueous AcOH (15 mL) and extracted with EtOAc (2×15 mL). The combined organic phases were washed with water (2x), dried, and concentrated under10 reduced pressure. The residue was chromatographed on silica gel, eluting with EtOAc/petroleum ether (1:1). The middle fractions were combined and concentrated to small volume, then hexane was added to precipitate methyl 3-[N-(2-hydroxyethyl)-N-2- (iodoethyl)amino]-2,6-dinitrobenzoate (26c) (138 mg, 58%) as a yellow gum: 1H NMR [(CDj)2SO] delta 8.24 (d, J = 9.7 Hz, 1 H), 7.59 (d, J = 9.7 Hz, 1 H), 4.79 (tj = 5.2 Hz, 1 H), 3.8715 (s, 3 H), 3.71 (t, / = 7.2 Hz, 2 H), 3.53 (q, / = 5.1 Hz, 2 H), 3.40-3.33 (m, 4 H). HRMS(FAB) calcd. for C12H15IN3O7 [MH+] m/* 439.9955; found 439.9960.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1072-52-2, 2-(Aziridin-1-yl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2008/30112; (2008); A1;,
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Application of 2919-23-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2919-23-5 as follows.

A mixture of 2-chloro-5-nitropyridine (7.12 g, 45.0 mmol) and cyclobutanol (3.40 g, 47.2 mmol) in THF (30 mL) was vigorously stirred at 0 C. while NaH (1.18 g, 46.7 mmol) was added in three portions over 10-20 s under air (Caution: Extensive gas evolution). Reaction residue was rinsed down with additional THF (5 mL), followed by stirring under positive argon pressure in the ice bath for 1-2 more minutes. The ice bath was then removed and the brown homogeneous solution was stirred for 1 h. The reaction mixture was concentrated under reduced pressure at 80 C., taken up in 0.75 M EDTA (tetrasodium salt) (150 mL), and extracted with CH2Cl2 (1*100 mL, 1*50 mL). The combined organic layers were dried (Na2SO4), concentrated, taken up in MeOH (2*100 mL) and concentrated under reduced pressure at 60 C. to provide the title compound as a thick dark amber oil that crystallized upon standing (7.01 g, 80%). 1H NMR (CDCl3) delta 9.04 (dd, J=2.84 and 0.40 Hz, 1H), 8.33 (dd, J=9.11 and 2.85 Hz, 1H), 6.77 (dd, J=9.11 and 0.50 Hz, 1H), 5.28 (m, 1H), 2.48 (m, 2H), 2.17 (m, 2H), 1.87 (m, 1H), 1.72 (m, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2919-23-5, its application will become more common.

Reference:
Patent; Baumann, Christian Andrew; Gaul, Michael David; US2006/281755; (2006); A1;,
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Electric Literature of 2566-44-1, Adding some certain compound to certain chemical reactions, such as: 2566-44-1, name is 2-Cyclopropylethanol,molecular formula is C5H10O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2566-44-1.

To a solution of oxalyl chloride (7.4 mL, 87 mmol) in DCM (100 mL) was added DMSO (12.4 mL, 174 mmol) dropwise at -78C and the solution was stirred at -78C for 15 minutes, then to the reaction solution was added cyclopropyl ethylalcohol (5 g, 58 mmol, dissolved in DCM lOmL). After being stirred at -78C for 1 hour, to the reaction solution was added TEA (40.4 ml, 290 mmol). The reaction solution was allowed to warm to room temperature and stirred for another 30 minutes. The reaction was quenched with water (50 ml) and extracted with DCM (50 mL) three times. The organic phase was combined, washed with saturated NH4CI solution, water and brine, and dried over anhydrous Na2SO4. The organic layer was concentrated and the residue was fractionally distilled to give 2-cyclopropylacetaldehyde (compound 23a) 1.3 g as a colorless oil. Compound 23a: 1H NMR (400 MHz, DMSO-d6) delta ppm: 9.64 – 9.76 (m, 1 H), 2.28 – 2.37 (m, 2 H), 0.89 – 0.98 (m, 1 H), 0.51 (dd, J = 8.16, 1.63 Hz, 2 H), 0.14 (dd, J = 4.83, 1.44 Hz, 2 H).

According to the analysis of related databases, 2566-44-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FENG, Song; LIU, Haixia; WU, Guolong; YUN, Hongying; CHEN, Dongdong; LI, Chao; (102 pag.)WO2016/55553; (2016); A1;,
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Related Products of 2919-23-5 ,Some common heterocyclic compound, 2919-23-5, molecular formula is C4H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a suspension of sodium hydride (2 equiv, 60% in mineral oil) in dry THF (0.44 M) under nitrogen atmosphere was added a solution of cyclobutanol (1.05 equiv) in dry THF (1.4 M) at 0 C. The reaction mixture was stirred at room temperature for 30 minutes before 2,4-dichloro-5-iodo-7-((2-(trimethylsilyl)ethoxy)-methyl)-7H-pyrrolo[2,3-d]pyrimidine (1 equiv) in dry THF (0.33 M) was added and the resulting reaction mixture was stirred at 30 C. for 1 h. The reaction mixture was quenched with saturated aqueous ammonium chloride solution. The organic solvent was removed under reduced pressure and the resulting aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with brine, dried over anhydrous sodium sulfate and filtered. The filtrate was evaporated under reduced pressure. The crude obtained was purified by flash column chromatography on silica gel (5% ethyl acetate in petroleum ether) to afford the title compound (95% yield) as a white solid. MS (ESI) m/z 479.2 [M+1]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2919-23-5, Cyclobutanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Signal Pharmaceutical LLC; Calabrese, Andrew Antony; Jeffy, Brandon; Robinson, Dale; Zhu, Dan; Huang, Dehua; Elsner, Jan; Boylan, John; Tehrani, Lida; Nagy, Mark A.; Moghaddam, Mehran Fallah; Raheja, Raj Kumar; Erdman, Paul; Narla, Rama K.; Harris, Roy L.; Tran, Tam Minh; Riggs, Jennifer; Ning, Yuhong; US2014/200206; (2014); A1;,
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Adding a certain compound to certain chemical reactions, such as: 3279-95-6, 2-(Aminooxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-(Aminooxy)ethanol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 2-(Aminooxy)ethanol

[0106] Step 3: To a solution of l-(4-(5-chloro-4-(5-methyl-lH-pyrazol-3- ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)ethanone (60 mg, 0.16 mmol) in MeOH (1 niL) was added AcOH (15 mg, 0.25 mmol), followed by the addition of 2- (aminooxy)ethanol (20 mg, 0.26 mmol). The mixture was heated to 60 0C for 14 h and cooled down to room temperature. The mixture was then purified directly by preparative RP-EtaPLC to provide l-(4-(5-chloro-4-(5-methyl-lH-pyrazol-3- ylamino)pyrimidin-2-ylamino)-2,5-dimethylphenyl)ethanone O-2-hydroxyethyl oxime; ESMS m/z 430.2 (M + H+).

The synthetic route of 3279-95-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IRM LLC; WO2009/158431; (2009); A2;,
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Adding a certain compound to certain chemical reactions, such as: 764-48-7, Ethylene Glycol Vinyl Ether, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

10098] Compound 2, 1 -(6-(7-azabicyclo[2.2. 1]heptan-7- yl)naphthalen-2-yl)ethanone, was synthesized by the inventors.10099] Specifically, Compound 2c obtained in Example1-3 (184 mg, 0.61 mmol), palladium(II) acetate (Pd(OAc)2,6.8 mg, 0.03 mmol), diphenylphosphinopropane (DPPP,25.2 mg, 0.06 mmol), and ethyleneglycol (1.5 mE) were added to an oven-dried flask with two necks and charged with argon gas. Afier oxygen present in the mixture was removed by adding the argon gas to the mixture, ethyleneglycol vinyl ether (279 pL, 1.53 mmol) and Et3N (255 pL, 1.83 mmol) obtained by distillation were sequentially added thereto. The resulting mixture was stirred at 145 C. for 5 hours using a silicone oil container. The mixture was cooled to room temperature, and stirred with a 6N hydrochloric acid (HC1) aqueous solution (4 mE) at 60 C. for 4 hours. The mixture was cooled to room temperature, and diluted with ethyl acetate (100 mE). An organic layer was washed with water (50 mE), a 5% sodium bicarbonate aqueous solution (50 mE), and a saturated saline solution (50 mE) and dehydrated with anhydrous sodium sulfate (10 g). The solvent was removed under a reduced pressure condition of 40 mbar, and the resulting product was purified by colunm chromatography through a silica gel (Merck-silicagel 60, 230-400 mesh; using EtOAc/hexane as a developer), thereby obtaining a yellow solid, Compound 2 (100 mg, 62%). By further purification using recrystallization (using 3% CH2C12/hexane as a solvent), a yellow solid, Compound 2 (32 mg, 20%), was obtained.10100] ?H NMR (CDC13, 300 MHz, 298 K, oe): 8.32 (d, J=1.5 Hz, 1H), 7.93 (dd, J=8.7, 1.8 Hz, 1H), 7.78 (d, J=9.0 Hz, 1H), 7.64 (d, J=8.7 Hz, 1H), 7.24 (dd, J=8.7, 2.1 Hz, 1H), 7.11 (d, J=2.4 Hz, 1H), 4.37-4.34 (m, 2H), 2.67 (s, 3H),1.87-1.84 (m, 4H), 1.54-1.5 (m, 4H); ?3C NMR (CDC13, 75 MHz, 298 K, oe): 198.0, 148.6, 137.7, 131.9, 131.0, 130.4, 127.0, 126.7, 124.7, 119.8, 110.3, 58.3, 29.0, 26.7; IR (KBr, cm?): 1670; HRMS: mlz calcd for C,8H,9N0 [M] 265. 1467, C,8H2QNO [MH] 266.1545; found 265.1467 [M],266.1547 [MW]; mp: 118-120 C.

The synthetic route of 764-48-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; POSTECH ACADEMY-INDUSTRY FOUNDATION; AHN, Kyo Han; MOON, Hyunsoo; KIM, Dokyoung; SINGHA, Subhankar; ROY, Basab; SAMBASIVAN, Sunderraman; (45 pag.)US2017/327509; (2017); A1;,
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Related Products of 110-73-6 ,Some common heterocyclic compound, 110-73-6, molecular formula is C4H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In 100mL 1-neck round bottom flask[A-1] (Benzenesulfonate Dichlorosulfofluorescein) (3 g, 7.40 mmol, 1 eq), [A-2] (2-(Ethylamino)ethanol) (5.28g, 59.22mmol, 8eq) and 50 g of DI-water were added thereto, followed by stirring at 100 C. Then stirred for 20 hours. The reaction was terminated by quenching in 1M HCl Solution, and the reaction was precipitated by the addition of sodium chloride (NaCl).The resulting precipitate was filtered under reduced pressure and dried at 80 C Oven. After drying, the resultant was dissolved in DMF (Dimethylformamide) to remove NaCl between the products, filtered, and the filtrate was quenched with diethyl ether, filtered under reduced pressure, and dried to obtain Compound [A] (2.98 g, 5.84 mmol, 78.9%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,110-73-6, its application will become more common.

Reference:
Patent; LG Chem, Ltd.; Lee Da-mi; Choi Sang-a; Yang Seung-jin; Lee Jae-yong; Kim Hye-jin; Kim Ji-seon; Kim Yeong-ung; Park Jong-ho; (27 pag.)KR2020/7157; (2020); A;,
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