Tag: 200-300

The author of 《Radiolabeling and in vitro evaluation of a new 5-fluorouracil derivative with cell culture studies》 were Ilem-Ozdemir, Derya; Atlihan-Gundogdu, Evren; Ekinci, Meliha; Halay, Erkan; Ay, Kadir; Karayildirim, Tamer; Asikoglu, Makbule. And the article was published in Journal of Labelled Compounds and Radiopharmaceuticals in 2019. Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol The author mentioned the following in the article:

The clin. impact and accessibility of 99mTc tracers for cancer diagnosis would be greatly enhanced by the availability of a new, simple, and easy labeling process and radiopharmaceuticals. 5-Fluorouracil is an antitumor drug, which has played an important role for the treatment of breast carcinoma. In the present study, a new derivative of 5-Fluorouracil was synthesized as (1-[{1′-(1”-deoxy-2”,3”:4”,5”-di-O-isopropylidene-β-D-fructopyranose-1”-yl)-1’H-1′,2′, 3′-triazol-4′-yl}methyl]-5-fluorouracil) (E) and radiolabeled with 99mTc. It was analyzed by radio thin layer chromatog. for quality control and stability. The radiolabeled complex was subjected to in vitro cell-binding studies to determine healthy and cancer cell affinity using HaCaT and MCF-7 cells, resp. In addition, in vitro cytotoxicity studies of compound E were performed with HaCaT and MCF-5 cells. The radiochem. purity of the [99mTc]TcE was found to be higher than 90% at room temperature up to 6 h. The radiolabeled complex showed higher specific binding to MCF-7 cells than HaCaT cells. IC50 values of E were found 31.5 ± 3.4μM and 20.7 ± 2.77μM for MCF-7 and HaCaT cells, resp. The results demonstrated the potential of a new radiolabeled E with 99mTc has selective for breast cancer cells. The experimental process involved the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol

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The author of 《Intramolecular hydrogen bonding as a synthetic tool to induce chemical selectivity in acid catalyzed porphyrin synthesis》 were Megiatto, Jackson D.; Patterson, Dustin; Sherman, Benjamin D.; Moore, Thomas A.; Gust, Devens; Moore, Ana L.. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2012. COA of Formula: C12H14O3 The author mentioned the following in the article:

A straightforward procedure based on the formation of intramol. hydrogen bonds to impart selectivity in the preparation of multi-functionalized porphyrins has been developed. To illustrate the concept, the synthesis of a biomimetic artificial photosynthetic model able to undergo electron and proton transfer reactions upon irradiation is reported. The results came from multiple reactions, including the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2COA of Formula: C12H14O3)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).COA of Formula: C12H14O3

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The author of 《Improved synthesis of β-ketoenamine-linked covalent organic frameworks via monomer exchange reactions》 were Daugherty, Michael C.; Vitaku, Edon; Li, Rebecca L.; Evans, Austin M.; Chavez, Anton D.; Dichtel, William R.. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Recommanded Product: 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde The author mentioned the following in the article:

β-Ketoenamine-linked covalent organic frameworks (COFs) offer excellent structural versatility and outstanding aqueous stability, but their stability complicates obtaining samples with high crystallinity and surface areas. In contrast, imine-linked COFs are often isolated with superior materials quality. Here we synthesize several β-ketoenamine-linked COFs, including two unreported structures, with unmatched crystallinity and high surface areas by preparing the corresponding imine-linked COF and exchanging its triformylbenzene monomers with triformylphloroglucinol. After reading the article, we found that the author used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Recommanded Product: 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Regarding monomeric phloroglucinols, this group encompasses acryl phloroglucinols, phloroglucinol-terpene adducts, phloroglucinol glycosides, halogenated phloroglucinols, prenylated phloroglucinols, and cyclicroup polyketides.Recommanded Product: 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde

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Product Details of 591-70-8On October 31, 1999 ,《Removal of pollutants from municipal wastewater by electron-beam treatment in an aerosol flow》 appeared in High Energy Chemistry (Translation of Khimiya Vysokikh Energii). The author of the article were Podzorova, E. A.; Pikaev, A. K.; Belyshev, V. A.; Lysenko, S. L.. The article conveys some information:

The removal of inorganic and organic pollutants from municipal wastewater by electron-beam treatment in an aerosol flow was examined The concentrations of pollutants (heavy metals, phosphates, sulfates, chlorides, carbonates, phenol, naphthalene, biphenyl, cholesterol, and their derivatives, alkylbenzenes, S-containing compounds, etc.) became lower than the maximum permissible values for service water as a result of this treatment (a dose of several KGrays). The majority of the above compounds was trapped by the precipitate formed upon irradiation In the experiment, the researchers used many compounds, for example, Octadecan-9-ol(cas: 591-70-8Product Details of 591-70-8)

Octadecan-9-ol(cas: 591-70-8) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group.Product Details of 591-70-8 Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.

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The author of 《Photocatalyzed borylation using water-soluble quantum dots》 were Chandrashekar, Hediyala B.; Maji, Arun; Halder, Ganga; Banerjee, Sucheta; Bhattacharyya, Sayan; Maiti, Debabrata. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Application In Synthesis of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane The author mentioned the following in the article:

The synthesis of arylboronates by Sandmeyer-type reactions in the presence of water still remains a significant challenge. Herein, we report the use of water-soluble MPA-capped quantum dot (QD) photocatalysts for the borylation of diazonium salts in the presence of water. A biphasic system under mild acidic conditions remains critical to prevent decomposition and competitive disulfide bond formation. The present protocol offers a broader scope of substrates and borylating agents. Addnl., this catalytic system offers a significantly high turnover number (TON). The present methodol. can effectively distinguish subtle reactivity differences between boronic acids and boronates. Mechanistic investigation suggests an excited-state electron transfer pathway.4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Application In Synthesis of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane) was used in this study.

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) also known as boronate ester, is generally used in metal-catalyzed C-C bond formation reactions like Suzuki–Miyaura reaction.Application In Synthesis of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane

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《Isolation of Anti-Hapten Antibodies by Fluorescence-Activated Cell Sorting of Yeast-Displayed B-Cell Receptor Gene Repertoires》 was published in Methods in Molecular Biology (New York, NY, United States) in 2020. These research results belong to Jaeger, Sebastian; Krah, Simon; Koenning, Doreen; Rosskopf, Janis; Dickgiesser, Stephan; Rasche, Nicolas; Kolmar, Harald; Hecht, Stefan; Schroeter, Christian. COA of Formula: C8H9NO5S The article mentions the following:

Anti-hapten antibodies are widely used as specific immunochem. detection tools in a variety of clin. and environmental analyses. The sensitivity, however, is limited due to the resulting antibody affinities to the haptens which, in turn, leads to a high demand for specific affinity reagents. A well-established path for the generation of high-affinity antibodies is the immunization of animals with the target antigen. However, the generation of anti-hapten antibodies via immunization remains challenging as small mol. haptens usually possess low immunogenicity and, therefore, must be coupled to an immunogenic and high mol. weight carrier to provoke an immune response.Consequently, antibodies are primarily raised against the carrier mol. or structural features of the hapten-linker fused to the carrier protein. This turns the generation of antibodies which bind exclusively to the hapten structure into a search for the needle in a haystack. In the following chapter, we describe how yeast surface display and high-throughput fluorescence-activated cell sorting can be used to isolate anti-hapten antibodies from a large, yeast-displayed B-cell receptor gene library derived from immunized animals. For this, we describe in detail the preparation of protein-hapten conjugates, the immunization procedure, and the subsequent screening process. Moreover, we provide a simple flow cytometry protocol that allows for a rapid anal. of the enriched clones toward free hapten binding. In the experiment, the researchers used 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6COA of Formula: C8H9NO5S)

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine on reaction with ketenedithioacetals gave mono- and dipyrrolidino derivatives. Reaction of parent pyrrolidine with alkyl/aryl isocyanates or isothiocyanates provided 1,3-disubstituted ureas/thioureas.COA of Formula: C8H9NO5S

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In 2019,Journal of Materials Chemistry A: Materials for Energy and Sustainability included an article by Wang, Hongjian; Chen, Long; Yang, Hao; Wang, Meidi; Yang, Leixin; Du, Haiyan; Cao, Chenliang; Ren, Yanxiong; Wu, Yingzhen; Pan, Fusheng; Jiang, Zhongyi. Reference of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde. The article was titled 《Bronsted acid mediated covalent organic framework membranes for efficient molecular separation》. The information in the text is summarized as follows:

Covalent organic frameworks (COFs) hold great promise in mol. separation However, since the aperture size of most COFs is in the range of 0.8-4.9 nm, constructing COF membranes with a smaller aperture size is thus in urgent demand yet remains a grand challenge. In this study, a Bronsted acid mediated one-step self-assembly method for the fabrication of COF membranes is proposed by segregating the organic phase (containing Bronsted acids and aldehydes) from the aqueous phase (containing amines) with a polymeric support and implementing an interfacial polymerization reaction thereby. Bronsted acids, serving as a versatile mediator, can facilitate the amorphous-to-crystalline transformation, ensure the confined membrane growth at the interface and regulate the assembly behavior of COF subunits, and thus play a critical role in manipulating the microstructure evolution of COF-JLU2 membranes. More intriguingly, a correlation among membrane structures, separation performance and the partition coefficient (log P) of Bronsted acids was established. When log P lies in between 1.0 and 3.0, the COF membranes with continuous active layers, tunable thickness (50-400 nm) and small aperture size (0.49-0.51 nm) can be fabricated, achieving superior alc. dehydration performances to all the reported membrane counterparts. Our findings may stimulate further research on bottom-up construction of COF membranes and other kinds of organic framework membranes (XOF membranes). In the experiment, the researchers used many compounds, for example, 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Reference of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.Reference of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehydePhloroglucinols are known for their broad-spectrum antiviral, antibacterial, antifungal, antihelminthic, and phytotoxic activities.

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In 2019,Journal of Materials Chemistry A: Materials for Energy and Sustainability included an article by Liu, Chuanyao; Jiang, Yunzhe; Nalaparaju, Anjaiah; Jiang, Jianwen; Huang, Aisheng. Product Details of 34374-88-4. The article was titled 《Post-synthesis of a covalent organic framework nanofiltration membrane for highly efficient water treatment》. The information in the text is summarized as follows:

Nanofiltration (NF) membranes with ultrahigh water flux and high ion rejection are substantially beneficial for desalination and wastewater treatment. However, synthesis of NF membranes with high water permeance while maintaining high ion rejection remains a great challenge. Herein, we report a highly stable covalent organic framework (COF) IISERP-COOH-COF1 membrane with high ion rejection and relatively high water flux. Through post-modification, the pore aperture of the IISERP-COOH-COF1 membrane can be constricted, thus preventing ions from accessing the pores. Further, covalent post-functionalization is helpful to reduce non-selective transport through invisible intercrystalline defects, thus enhancing salt rejection. Demonstrated by both exptl. and simulation studies, the IISERP-COOH-COF1 membrane shows superior ion rejection (e.g., 96.3% for Na2SO4, 97.2% for MgSO4, 99.6% for FeCl3, 90.6% for MgCl2, and 82.9% for NaCl) based on size exclusion, with a water flux above 0.5 L m-2 h-1 bar-1. In addition to this study using 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde, there are many other studies that have used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Product Details of 34374-88-4) was used in this study.

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.Product Details of 34374-88-4For acyl phloroglucinols, it is considered the largest category of compounds among phloroglucinols of natural characteristics.

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《Tuning proton dissociation energy in proton carrier doped 2D covalent organic frameworks for anhydrous proton conduction at elevated temperature》 was written by Chen, Shuhui; Wu, Yue; Zhang, Ying; Zhang, Wenxiang; Fu, Yu; Huang, Wenbo; Yan, Tong; Ma, Heping. Category: alcohols-buliding-blocksThis research focused ontwo dimentional covalent organic framework proton conduction. The article conveys some information:

A theor. and exptl. study gives insights into the change of proton dissociation energy of anhydrous proton carriers (phosphoric acid and 1,2,4-triazole) doped in 2D covalent organic frameworks (COFs) with neutral, polar, Lewis base and pos. charged sites in their 1D channels. The dielec. properties of proton carrier incorporated COFs were investigated to determine the formation of nanoscale ionic phases in COFs′ channels. The proton carrier doped cationic COF exhibits a much higher dielec. constant in the frequency range of 103 Hz to 107 Hz than other doped COFs, which may arise from the formation of ethidium-biphosphate or ethidium-triazole ion-pairs in charged COF channels. The ion-pairs lined along cationic COFs′ channels produce an enhanced proton dissociation degree coupled with a high dielec. response, leading to a new proton conductivity record (2.77 x 10-2 S cm-1) set by the cationic COF among all reported porous materials under anhydrous conditions and elevated temperatures After reading the article, we found that the author used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Category: alcohols-buliding-blocks)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Phloroglucinol derivatives are a major class of secondary metabolites. Phloroglucinol compounds can be classified into monomeric, dimeric, trimeric and higher phloroglucinols, and phlorotannins.Category: alcohols-buliding-blocks

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《Salen-porphyrin-based conjugated microporous polymer supported Pd nanoparticles: highly efficient heterogeneous catalysts for aqueous C-C coupling reactions》 was published in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2019. These research results belong to Ju, Pengyao; Wu, Shujie; Su, Qing; Li, Xiaodong; Liu, Ziqian; Li, Guanghua; Wu, Qiaolin. Computed Properties of C12H14O3 The article mentions the following:

The salen-porphyrin based conjugated microporous polymer (SP-CMP) was first constructed by polycondensation reaction of a salen-dialdehyde derivative and pyrrole. Due to the outstanding chem. and thermal stability, abundant micropores with a reasonable pore size, and ordered salen-porphyrin arrays in the A4B4-type polymer framework, the functional CMP was further applied as a Pd nanoparticle support by the coordinate interactions between the polydentate chelating sites with Pd(OAc)2 and subsequent reduction with NaBH4. The as-synthesized composite material (Pd@SP-CMP) was fully characterized by powder X-ray diffraction (PXRD), thermogravimetric anal. (TGA), Fourier transform IR (FT-IR) spectroscopy, XPS, and solid-state 13C NMR (NMR). The porous property of Pd@SP-CMP was also characterized by N2 adsorption/desorption isotherms and the obtained material exhibited a Brunauer-Emmett-Teller (BET) surface area of 266 m2 g-1, together with a pore volume of 0.192 cm3 g-1. The microscopic morphol. of Pd@SP-CMP was further evaluated by SEM (SEM) and transmission electron microscopy (TEM). The Pd@SP-CMP material with highly dispersed Pd nanoparticles exhibited excellent catalytic activity towards Suzuki-Miyaura and Heck-Mizoroki coupling reactions in water or in the dioxane/water mixture In addition, Pd@SP-CMP also displayed outstanding stability and recyclability, and it can be reused without loss of activity in ten successive reactions. More importantly, the salen-porphyrin based CMPs could be the promising candidates for developing high-performance heterogeneous catalysts. In the experimental materials used by the author, we found 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Computed Properties of C12H14O3)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Computed Properties of C12H14O3Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

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Alcohol – Wikipedia,
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