Tag: 200-300

In 2022,Wilhelmsen, Christopher A.; Zhang, Xuntong; Myhill, Jesse A.; Morken, James P. published an article in Angewandte Chemie, International Edition. The title of the article was 《Enantioselective Synthesis of Tertiary β-Boryl Amides by Conjunctive Cross-Coupling of Alkenyl Boronates and Carbamoyl Chlorides》.COA of Formula: C13H26B2O4 The author mentioned the following in the article:

Synthesis of versatile β tert-boryl amides is accomplished by conjunctive cross-coupling of α-substituted alkenyl boron “”ate”” complexes and carbamoyl chloride electrophiles. This reaction can be accomplished in an enantioselective fashion using a palladium catalyst in combination with MandyPhos. The addition of water results in enhanced chemoselectivity for the conjunctive coupling product relative to the Suzuki-Miyaura cross-coupling product. Transformations of the reaction products were examined as well as application to the synthesis of (+)-adalinine. The experimental process involved the reaction of Bis[(pinacolato)boryl]methane(cas: 78782-17-9COA of Formula: C13H26B2O4)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.COA of Formula: C13H26B2O4 Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.

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The author of 《Novel molecular triad exhibiting aggregation-induced emission and thermally activated fluorescence for efficient non-doped organic light-emitting diodes》 were Kim, Hyung Jong; Kim, Seong Keun; Godumala, Mallesham; Yoon, Jiwon; Kim, Chae Yeong; Jeong, Ji-Eun; Woo, Han Young; Kwon, Jang Hyuk; Cho, Min Ju; Choi, Dong Hoon. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Name: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane The author mentioned the following in the article:

A light-emitting mol. triad (BPCP-2CPC) with dual functionality was successfully synthesized and applied to solution-processed non-doped organic light-emitting diodes. The BPCP-2CPC triad contains 9-phenyl-9H-carbazole units as a host moiety tethered to a green-emitting core (BPCP) through a cyclohexane unit and exhibits thermally activated delayed fluorescence (TADF) and aggregation-induced emission (AIE) characteristics simultaneously. The BPCP-2CPC-based non-doped TADF-OLED devices showed a high external quantum efficiency (EQE) of 13.4%. The experimental part of the paper was very detailed, including the reaction process of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Name: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used to prepare sulfinamide derivatives by reacting with diethylaminosulfur trifluoride (DAST) and potassium phenyltrifluoroborate.Name: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane

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Jaiswal, Anil Kumar; Rao, K. Bhaskara; Kushwaha, Pragati; Rawat, Keerti; Modukuri, Ram K.; Khare, Prashant; Joshi, Sumit; Mishra, Shikha; Rai, Ambak; Sashidhara, Koneni V.; Dube, Anuradha published their research in International Journal of Antimicrobial Agents on December 31 ,2016. The article was titled 《Development of Leishmania donovani stably expressing DsRed for flow cytometry-based drug screening using chalcone thiazolyl-hydrazone as a new antileishmanial target》.COA of Formula: C12H14O3 The article contains the following contents:

Green fluorescent protein produces significant fluorescence and is extremely stable, however its excitation maximum is close to the UV range and thus can damage living cells. Hence, Leishmania donovani stably expressing DsRed were developed and their suitability for flow cytometry-based antileishmanial screening was assessed by evaluating the efficacies of standard drugs as well as newly synthesized chalcone thiazolyl-hydrazone compounds The DsRed gene was successfully integrated at the 18S rRNA locus of L. donovani and transfectants (LdDsRed) were selected using hygromycin B. Enhanced expression of DsRed and a high level of infectivity to J774A.1 macrophages were achieved, which was confirmed by fluorescence microscopy and flow cytometry. Furthermore, these LdDsRed transfectants were utilized for development of an in vitro screening assay using the standard antileishmanial drugs miltefosine, amphotericin B, pentamidine and paromomycin. The response of transfectants to standard drugs correlated well with previous reports. Subsequently, the suitability of this system was further assessed by screening a series of 18 newly synthesized chalcone thiazolyl-hydrazone compounds in vitro for their antileishmanial activity, wherein 8 compounds showed moderate antileishmanial activity. The most active compound I, with ∼73% splenic parasite reduction, exerted its activity via generating nitric oxide and reactive oxygen species and inducing apoptosis in LdDsRed-infected macrophages. Thus, these observations established the applicability of LdDsRed transfectants for flow cytometry-based antileishmanial screening. Further efforts aimed at establishing a high-throughput screening assay and determining the in vivo screening of potential antileishmanial leads are required. The experimental process involved the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2COA of Formula: C12H14O3)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).COA of Formula: C12H14O3

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In 2015,Chemical Communications (Cambridge, United Kingdom) included an article by Furukawa, Takayuki; Tobisu, Mamoru; Chatani, Naoto. Safety of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane. The article was titled 《Nickel-catalyzed borylation of arenes and indoles via C-H bond cleavage》. The information in the text is summarized as follows:

The 1st Ni-catalyzed method for the borylation of C-H bonds in arenes and indoles is described. The use of an N-heterocyclic carbene ligand is essential for an efficient reaction, with an N-cyclohexyl-substituted derivative being optimal. This method is readily applied to the gram scale synthesis of 2-borylindole. In the experiment, the researchers used many compounds, for example, 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Safety of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Safety of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

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In 2013,Kjartansdottir, Cecilia Kristin; Nielsen, Lars Pleth; Moeller, Per published 《Development of durable and efficient electrodes for large-scale alkaline water electrolysis》.International Journal of Hydrogen Energy published the findings.Name: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate The information in the text is summarized as follows:

A new type of electrodes for alk. water electrolysis is produced by phys. vapor depositing (PVD) of aluminum onto a nickel substrate. The PVD Al/Ni is heat-treated to facilitate alloy formation followed by a selective aluminum alk. leaching. The obtained porous Ni surface is uniform and characterized by a unique interlayer adhesion, which is critical for industrial application. IR-compensated polarization curves prepared in a half-cell setup with 1 M KOH electrolyte at room temperature reveals that at least 400 mV less potential is needed to decompose water into hydrogen and oxygen with the developed porous PVD Al/Ni electrodes as compared to solid nickel electrodes. High-resolution scanning electron microscope (HR-SEM) micrographs reveal Ni-electrode surfaces characterized by a large surface area with pores down to a few nanometer sizes. Durability tests were carried out in a com. produced bipolar electrolyzer stack. The developed electrodes showed stable behavior under intermittent operation for over 9000 h indicating no serious deactivation in the d. of active sites. The experimental process involved the reaction of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Name: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Name: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate As a Biuret reagent, it is used to measure the protein concentration. Furthermore, it is used as laxative and is also used in food industry.

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《Upper-rim functionalization and supramolecular polymerization of a feet-to-feet-connected biscavitand》 was written by Shimoyama, Daisuke; Sekiya, Ryo; Haino, Takeharu. Reference of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

An octaiodobiscavitand was synthesized via an aromatic Finkelstein iodination reaction in good yield. Sonogashira and Suzuki coupling reactions of the octaiodobiscavitand gave rise to upper-rim-functionalized biscavitands that self-assembled to form a supramol. polymer in the solid state. The results came from multiple reactions, including the reaction of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Reference of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used to prepare sulfinamide derivatives by reacting with diethylaminosulfur trifluoride (DAST) and potassium phenyltrifluoroborate.Reference of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane

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The author of 《Iron-catalysed enantioselective Suzuki-Miyaura coupling of racemic alkyl bromides》 were Iwamoto, Takahiro; Okuzono, Chiemi; Adak, Laksmikanta; Jin, Masayoshi; Nakamura, Masaharu. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Formula: C12H17BO2 The author mentioned the following in the article:

The first iron-catalyzed enantioselective Suzuki-Miyaura coupling reaction has been developed. In the presence of catalytic amounts of FeCl2 and (R,R)-QuinoxP*, lithium arylborates are cross-coupled with tert-Bu α-bromopropionate in an enantioconvergent manner, enabling facile access to various optically active α-arylpropionic acids including several nonsteroidal anti-inflammatory drugs (NSAIDs) of com. importance. (R,R)-QuinoxP* is specifically able to induce chirality when compared to analogous P-chiral ligands that give racemic products, highlighting the critical importance of transmetalation in the present asym. cross-coupling system. In the part of experimental materials, we found many familiar compounds, such as 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Formula: C12H17BO2)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used to prepare sulfinamide derivatives by reacting with diethylaminosulfur trifluoride (DAST) and potassium phenyltrifluoroborate.Formula: C12H17BO2

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In 2022,Chen, Dexin; Zhu, Shimeng; Li, Wei; Kang, Zhixin published an article in Colloids and Surfaces, A: Physicochemical and Engineering Aspects. The title of the article was 《Stable superhydrophobic and conductive surface: Fabrication of interstitial coral-like copper nanostructure by self-assembly and spray deposition》.Quality Control of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate The author mentioned the following in the article:

Water permeation is an important issue in both fundamental research and industrial applications. In this work, stable superhydrophobic copper surfaces were obtained by self-assembly and spray deposition on cotton fabrics. SEM revealed that micro/nano dual-scale coral-like structures were established by the stacking of copper nanoparticles, thus forming a stable Cassie model for superhydrophobic feathers. The water contact angle of the surface was 161°, while the slide angle was as low as 3°. Chem. bonds were formed between substructures and copper nanoparticles by mol. grafting, which improved its mech. stability, since the surface was verified to maintain a large contact angle after long-distance abrasion and folding. Compared with the superhydrophilic copper surface, the superhydrophobic coating showed better corrosion resistance in 3.5 wt% NaCl solution and artificial sweat. Combined with the inherent conductivity of copper, fabrics have potential applications in the new generation of advanced textiles. In the experiment, the researchers used many compounds, for example, Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Quality Control of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Quality Control of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate As a Biuret reagent, it is used to measure the protein concentration. Furthermore, it is used as laxative and is also used in food industry.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Chemical characterization of water and ethanolic extracts of Turkish propolis by HPLC-DAD and GC-MS》 were Bozkus, Tugba Nigar; Deger, Orhan; Yasar, Ahmet. And the article was published in Journal of Liquid Chromatography & Related Technologies in 2021. Application of 20880-92-6 The author mentioned the following in the article:

This study aims to determine the qual. and quant. contents of Turkish propolis collected from various regions of Turkey using high-performance liquid chromatog. with the diode-array detector (HPLC-DAD) and gas chromatog.-mass spectrometry (GC-MS) in water and ethanolic extracts In HPLC-DAD analyses, it was determined that water extract of Turkish propolis contains phenolic acids such as caffeic acid (204.00 μg/mL), trans-cinnamic, chlorogenic, and caffeoylquinic acids, responsible for its antioxidant activity; whereas, the ethanolic extract of Turkish propolis contains chrysin (641.33 μg/mL), caffeic acid phenethyl ester (630.67 μg/mL), pinocembrin (572.67 μg/mL), galangin (534.11 μg/mL), naringenin (372.39 μg/mL), and also kaempferol, trans-cinnamic acid, caffeic acid, myricetin, and quercetin. GC-MS analyses showed that ethanolic extract of propolis contains caffeic acid by Rtx-1 column and the water extract of propolis contains quinic acid and ferulic acid by Rtx-5ms column. Various sugar derivatives were detected by both columns in water and ethanolic extracts of Turkish propolis. HPLC-DAD can be considered as a more effective method than GC-MS for the chem. characterization of propolis. Water extract of Turkish propolis can be a good source of raw materials for various sectors, as it is both cheap and has less health risk than ethanolic extract, and is suitable for human use. In the experimental materials used by the author, we found ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Application of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Application of 20880-92-6

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《Transborylation of alkenylboranes with diboranes》 was written by Dominguez-Molano, Paula; Bru, Gerard; Salvado, Oriol; Maza, Ricardo J.; Carbo, Jorge J.; Fernandez, Elena. Recommanded Product: 78782-17-9This research focused ontransborylation alkenylborane diborane stereospecific cross metathesis DFT. The article conveys some information:

Exchange of boryl moieties between alkenylboranes and diboron reagents has been postulated as a stereospecific cross-metathesis pathway with concomitant formation of mixed diboron reagents. DFT calculations propose a mechanism for the stereocontrolled C(sp2)-B/B’-B’ cross-metathesis with both sym. and non-sym. diboron reagents. The experimental process involved the reaction of Bis[(pinacolato)boryl]methane(cas: 78782-17-9Recommanded Product: 78782-17-9)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Recommanded Product: 78782-17-9 Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts