Tag: 200-300

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Kong, Weifu; Jia, Wei; Wang, Rong; Gong, Yifan; Wang, Changchun; Wu, Peiyi; Guo, Jia. Recommanded Product: 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde. The article was titled 《Amorphous-to-crystalline transformation toward controllable synthesis of fibrous covalent organic frameworks enabling promotion of proton transport》. The information in the text is summarized as follows:

Reversible imine exchange is adopted to molecularly re-arrange polyazomethine-based amorphous fibers into covalent organic frameworks (COFs) retaining pristine fibrous characters with periodic and oriented micropore channels. Such fibrous COFs can immobilize the assembled Nafion to form long-range proton conduction pathways, thus largely promoting proton transport. In addition to this study using 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde, there are many other studies that have used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Recommanded Product: 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde) was used in this study.

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.Recommanded Product: 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehydePhloroglucinols are known for their broad-spectrum antiviral, antibacterial, antifungal, antihelminthic, and phytotoxic activities.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Late-stage construction of stapled peptides through Fujiwara-Moritani reaction between tryptophan and olefins》 were Liu, Jiang; Wang, Peng; Zeng, Wei; Lu, Qi; Zhu, Qing. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2021. Application of 20880-92-6 The author mentioned the following in the article:

Herein, the first example of a palladium-catalyzed Fujiwara-Moritani reaction for olefination of tryptophan (Trp) residues, free from directing groups, was presented. The developed reaction proceeds efficiently for peptide modification, ligation and peptide stapling. In the part of experimental materials, we found many familiar compounds, such as ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Application of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Application of 20880-92-6

Referemce:
Alcohol – Wikipedia,
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Sashidhara, Koneni V.; Rao, K. Bhaskara; Kushwaha, Vikas; Modukuri, Ram K.; Verma, Richa; Murthy, P. K. published an article in European Journal of Medicinal Chemistry. The title of the article was 《Synthesis and antifilarial activity of chalcone-thiazole derivatives against a human lymphatic filarial parasite, Brugia malayi》.COA of Formula: C12H14O3 The author mentioned the following in the article:

Here we report the synthesis of novel chalcone-thiazole compounds and their antifilarial activity. The antifilarial properties of these hybrids were assessed against microfilariae as well as adult worms of Brugia malayi. Among all the synthesized compounds, only two compounds, namely (E,E)-I (R = iPr, R1 = 2-furyl; R = tBu, R1 = 2-thienyl) were identified to be promising in vitro. These active compounds were tested in B. malayi-jird (Meriones unguiculatus) and B. malayi-Mastomys coucha models. Compound (E,E)-I (R = tBu, R1 = 2-thienyl) showed 100% embryostatic effect and 49% macrofilaricidal in jird and M. coucha models, resp. This study provides a new structural clue for the development of novel antifilarial lead mols. In the part of experimental materials, we found many familiar compounds, such as 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2COA of Formula: C12H14O3)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.COA of Formula: C12H14O3Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

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Alcohol – Wikipedia,
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In 2022,Li, Yu-Hang; Wang, Chong-Chen; Zeng, Xu; Sun, Xue-Zi; Zhao, Chen; Fu, Huifen; Wang, Peng published an article in Chemical Engineering Journal (Amsterdam, Netherlands). The title of the article was 《Seignette salt induced defects in Zr-MOFs for boosted Pb(II) adsorption: universal strategy and mechanism insight》.Application In Synthesis of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate The author mentioned the following in the article:

Within this work, a green and facile approach was proposed to modulate NH2-UiO-66 for purpose of obtaining SS-NH2-UiO-66-X (“”X”” implied the dosage of used SS) using seignette salt (SS). The generation of abundant vacancies with the formation of hierarchical pores boosted their sorption performance for lead (Pb(II)), which strengthened the mass transfer of Pb(II) in SS-NH2-UiO-66-X interior. Particularly, the optimal SS-NH2-UiO-66-5 exhibited good adsorption capacity toward Pb(II) (186.14 mg g-1) and fast diffusion rate (32.1 mg g-1·min0.5) at 25°C and initial pH = 5.46, which were about 34.2 and 66.9 times higher than those of the pristine NH2-UiO-66, resp. SS-NH2-UiO-66-5 could selectively capture the Pb(II) from simulated wastewater containing different co-existing ions. The mechanism was proposed that the defect sites played a significant role in boosting the Pb(II) capture performance, which was further affirmed by X-ray absorption spectroscopy (XAS) and X-ray photoelectron spectra (XPS). The d. functional theory calculations (DFT calculations) illustrated that the hierarchical pores and rich vacancies enhanced the Pb(II) mobility toward the adsorption active sites and reduced the adsorption energy between SS-NH2-UiO-66-X and Pb(II). This defect engineering approach could be introduced to modulate other Zr-MOFs like MOF-801, UiO-66 and MOF-808, which presented a general strategy to fabricate defective Zr-MOFs for the boosted adsorption performance toward pollutants removal from wastewater. In the experimental materials used by the author, we found Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Application In Synthesis of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Application In Synthesis of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate It may be used as a constituent to prepare DNS (3,5- dinitrosalicylic acid) reagent and Fehling′s solution B, which are used in the determination of reducing sugar.

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《Boosting visible-light hydrogen evolution of covalent-organic frameworks by introducing Ni-based noble metal-free co-catalyst》 was written by Dong, Hong; Meng, Xiang-Bin; Zhang, Xin; Tang, Hong-Liang; Liu, Jun-Wang; Wang, Jian-Hui; Wei, Jin-Zhi; Zhang, Feng-Ming; Bai, Lin-Lu; Sun, Xiao-Jun. Synthetic Route of C9H6O6 And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2020. The article conveys some information:

Covalent-organic frameworks (COFs) have been recognized as an emerging type of photocatalysts for H2 evolution and some of them have shown really outstanding photocatalytic activity with the help of Pt co-catalyst. To avoid the utilization of noble metal in COF-based photocatalysts, for the first time, we designed and constructed a series of nickel hydroxide-modified COF (TpPa-2) composite materials Ni(OH)2-X%/TpPa-2 (X: molar fraction of Ni(OH)2), which show apparently improved photocatalytic H2 evolution activity than that of the parent COF and the activity is comparable to that with Pt (0.3 wt%) co-catalyst. A series of Ni(OH)2-X%/TpPa-2 were prepared by in-situ adding TpPa-2 into the reaction system of Ni(OH)2, and the resulting Ni(OH)2-X%/TpPa-2 exhibit a novel sandwich-like morphol. The results of photocatalytic hydrogen evolution under visible light irradiation show that the optimized photocatalytic H2-evolution rate for Ni(OH)2-2.5%/TpPa-2 is up to 1895.99μmol·h-1·g-1, which is about 26.3 times higher than that of the parent TpPa-2 and is one of the best performing 2D COF-based photocatalyst for H2 evolution. Further investigation confirm the improved activity should be attributed to the enhanced visible-light absorption of the composite materials contributed from Ni(OH)2 and the synergetic effect of Ni(OH)2 and metallic Ni derived from the in-situ reduction of Ni(OH)2, which promoted the separation of photogenerated electron-holes of the resulting materials. This work not only presents a series of new photocatalysts for efficient H2 evolution but also open an avenue for future design and synthesis of COF-based composite materials acting as a substitute of noble-metal-containing photocatalytic systems. In the experiment, the researchers used many compounds, for example, 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Synthetic Route of C9H6O6)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Regarding monomeric phloroglucinols, this group encompasses acryl phloroglucinols, phloroglucinol-terpene adducts, phloroglucinol glycosides, halogenated phloroglucinols, prenylated phloroglucinols, and cyclicroup polyketides.Synthetic Route of C9H6O6

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Sashidhara, Koneni V.; Modukuri, Ram K.; Singh, Seema; Bhaskara Rao, K.; Aruna Teja, G.; Gupta, Sampa; Shukla, Shubha published an article on January 15 ,2015. The article was titled 《Design and synthesis of new series of coumarin-aminopyran derivatives possessing potential anti-depressant-like activity》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Related Products of 153759-59-2 The information in the text is summarized as follows:

A new series of coumarin based aminopyran derivatives I [ R1 = Me, iso-Pr, sec-Bu, tert-Bu; R2 = H, OMe; R3 = OMe; R4 = H, OMe; R5 = H, Me] were designed, synthesized and evaluated for their preclin. antidepressant effect on Swiss albino mice. Among the series, compounds I [ R1 = iso-Pr, R2 = R4 = H, R3 = OMe, R5 = Me; R1 = iso-Pr, R2 = R4 = = R5 = H, R3 = OMe; R1 = iso-Pr, R2 = R5 = H, R3 = R4= OMe; R1 = iso-Pr, R2 = H, R3 = R4= OMe, R5 = Me; R1 = sec-Bu, R2 = R4 = H, R3 = OMe, R5 = Me; R1 = sec-Bu, R2 = H, R3 = R4= OMe, R5 = Me] exhibited significant activity profile in forced swimming test (FST). Compound I [R1 = iso-Pr, R2 = H, R3 = R4= OMe, R5 = Me] was most efficacious, which at a very low dose of 0.5 mg/kg reduced the time of immobility by 86.5% as compared to the standard drug fluoxetine (FXT) which reduced the immobility time by 69.8% at the dose of 20 mg/kg, i.p. In addition, all active compounds were screened in dose dependent manner (at doses of 0.25, 0.5, 1 mg/kg i.p.) in FST and tail suspension test (TST). Interestingly, all active compounds did not caused any significant alteration of locomotor activity in mice as compared to control, indicating that the hybrids did not produce any motor impairment effects. The results indicate that coumarin-aminopyran derivatives may have potential therapeutic value for the management of mental depression. After reading the article, we found that the author used 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Related Products of 153759-59-2)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Related Products of 153759-59-2

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Alcohol – Wikipedia,
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In 2022,Chemical Communications (Cambridge, United Kingdom) included an article by Du, Linlin; Sun, Li; Zhang, Hua. Computed Properties of C14H21BO2. The article was titled 《Photochemical and electrochemical C-N borylation of arylhydrazines》. The information in the text is summarized as follows:

The C-N borylation of arylhydrazine hydrochlorides ArNHNH2·HCl with bis(pinacolato)diboron B2pin2 was achieved under photochem. and electrochem. conditions, resp., affording arylboronates ArBpin with high yields. This novel and scalable transformation provides two efficient and mild transition-metal-free synthetic routes towards aryl boronate esters from easily available arylhydrazines. After reading the article, we found that the author used 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Computed Properties of C14H21BO2)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Computed Properties of C14H21BO2

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Recommanded Product: 153759-59-2On October 15, 2014 ,《Synthesis and evaluation of new 3-phenylcoumarin derivatives as potential antidepressant agents》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Sashidhara, Koneni V.; Rao, K. Bhaskara; Singh, Seema; Modukuri, Ram K.; Aruna Teja, G.; Chandasana, Hardik; Shukla, Shubha; Bhatta, Rabi S.. The article contains the following contents:

A series of amine substituted 3-phenylcoumarin derivatives was designed and synthesized as potential antidepressant agents. In preliminary screening, all compounds were evaluated in forced swimming test (FST), a model to screen antidepressant activity in rodents. Among the series, compounds I and II potentially decreased the immobility time by 73.4% and 79.7% at a low dose of 0.5 mg/kg as compared to standard drug fluoxetine (FXT) which reduced the immobility time by 74% at a dose of 20 mg/kg, i.p. Addnl., these active compounds also exhibited significant efficacy in tail suspension test (TST) (another model to screen antidepressant compounds). Interestingly, rotarod and locomotor activity tests confirmed that these two compounds do not have any motor impairment effect and neurotoxicity in mice. Our studies demonstrate that the new 3-phenylcoumarin derivatives may serve as a promising antidepressant lead and hence pave the way for further investigation. The experimental process involved the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Recommanded Product: 153759-59-2)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Recommanded Product: 153759-59-2Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 401797-00-0On May 14, 2010 ,《Nano-Fe2O3-catalyzed direct borylation of arenes》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Yan, Guobing; Jiang, Yubo; Kuang, Chunxiang; Wang, Shuai; Liu, Haichao; Zhang, Yan; Wang, Jianbo. The article conveys some information:

Nano-Fe2O3-catalyzed borylation of arenes with diboron pinacol ester B2pin2 has been found to give borylation products with selectivity controlled by electronic effects of substituents. The experimental part of the paper was very detailed, including the reaction process of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Related Products of 401797-00-0)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group.Related Products of 401797-00-0 Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.

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Alcohol – Wikipedia,
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《Improving Covalent Organic Frameworks Fluorescence by Triethylamine Pinpoint Surgery as Selective Biomarker Sensor for Diabetes Mellitus Diagnosis》 was written by Wang, Jinmin; Yan, Bing. SDS of cas: 34374-88-4This research focused ontriethylamine covalent organic framework fluorescent sensor diabetes biomarker. The article conveys some information:

The nitrogen-containing imine or hydrazone linked covalent organic frameworks (COFs) are poorly luminescent due to the fluorescence quenching by nitrogen atoms in the linkages, even if highly luminescent units and linkers are employed. The fluorescence quenching pathway to prevent linkage-originated to mitigate the inherent limitations of the linkage is a promising method for luminescent COFs. The generation of N- by deprotonation of the N-H unit eliminates the electron transfer from N lone pair to COF (TpPa-1) and enhances the luminescence. In this work, TpPa-1 achieved turn-on luminescence response with good sensitivity and reproducibility toward triethylamine (TEA) vapor in the process of deprotonation. The fabricated detector offers a viable approach for sensing ppm-level TEA, which can remind people to take timely measures to reduce the environmental hazards caused by TEA. The fluorescent sensor TpPa-1@LE constructed by the products of TpPa-1 and TEA can quant. trace biomarker methylglyoxal (MGO) for diabetes mellitus diagnosis in serum system. Furthermore, using TEA and MGO as input signals and the two fluorescence emissions G476 and Y525 as output signals, an advanced anal. device based on two Boolean logic gates with INH and AND function is constructed. This work provides a new strategy for improving the weak luminescence of COF in aqueous solution and realizes selective response to biomarker (MGO) for diabetes mellitus diagnosis. The results came from multiple reactions, including the reaction of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4SDS of cas: 34374-88-4)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Phloroglucinol derivatives are a major class of secondary metabolites. Phloroglucinol compounds can be classified into monomeric, dimeric, trimeric and higher phloroglucinols, and phlorotannins.SDS of cas: 34374-88-4

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Alcohol – Wikipedia,
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