Tag: 200-300

In 2019,Rapid Communications in Mass Spectrometry included an article by Pinto, Eduardo Costa; Xu, Chengdong; Cabral, Lucio Mendes; Armstrong, Daniel W.; de Sousa, Valeria Pereira. Synthetic Route of C12H20O6. The article was titled 《Sensitive detection of topiramate degradation products by high-performance liquid chromatography/electrospray ionization mass spectrometry using ion-pairing reagents and polarity switching》. The information in the text is summarized as follows:

Rationale : The chromatog. anal. of topiramate and its degradation products is challenging due to the absence of chromophoric moieties in their structures, the wide polarity range of the compounds and their ionization differences. This work proposes two new mass spectrometry approaches for evaluating these analytes. Methods : Based on the calculated exptl. limit of detection (LOD), a highly sensitive high-performance liquid chromatog. (HPLC) paired-ion electrospray ionization mass spectrometry (PIESI-MS) method was developed for the determination of topiramate inorganic degradation products. The influence of different solvent systems on the LODs for topiramate and its main degradation products was determined in both pos./neg. ionization modes. In addition, a HPLC method to analyze both organic and inorganic degradation products was proposed by mass spectrometry with pos./neg. ion switching electrospray ionization. Results : A sensitive HPLC/PIESI-MS method was achieved for the efficient separation of topiramate inorganic degradation products. Both sulfate and sulfamate were detected in the pos. selected ion monitoring (SIM) mode with an increased sensitivity compared with the neg. SIM mode. The HPLC/ESI-MS anal. with pos./neg. ion switching allowed the simultaneous separation and detection of the major degradation products of topiramate in a 10-min run using a single column and a single detector. Conclusions : Two new alternative MS approaches for analyzing the main degradation products of topiramate were developed. The proposed methods are considered advantageous over the existing methods and can be applied to quality control studies of topiramate. The experimental process involved the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Synthetic Route of C12H20O6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Synthetic Route of C12H20O6

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Electric Literature of C14H21BO2On October 16, 2019 ,《Origin of the Difference in Reactivity between Ir Catalysts for the Borylation of C-H Bonds》 was published in Journal of the American Chemical Society. The article was written by Oeschger, Raphael J.; Larsen, Matthew A.; Bismuto, Alessandro; Hartwig, John F.. The article contains the following contents:

A mechanistic study on the origin of the difference in reactivity between Ir catalysts for C-H borylation reactions is reported. Catalytic reactions of B2pin2 with a series of substrates that require high temperatures and long reaction times were conducted. These reactions catalyzed by the combination of [Ir(COD)(OMe)]2 and 3,4,7,8-tetramethylphenanthroline (tmphen) occur in yields that are substantially higher than those of reactions catalyzed by [Ir(COD)(OMe)]2 and 4,4′-di-tert-butylbipyridine (dtbpy). The electronic properties of Ir catalysts ligated by dtbpy or tmphen and their stoichiometric reactivity were investigated. It was found that a longer lifetime rather than higher reactivity of the catalyst leads to higher yields of reactions catalyzed by Ir-tmphen. The catalyst ligated by dtbpy decomposes principally by dissociation of the ligand and rapid borylation at the positions alpha to nitrogen. Thus, the greater stability of the catalyst containing tmphen results from its greater binding constant In the experiment, the researchers used 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Electric Literature of C14H21BO2)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Electric Literature of C14H21BO2 The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

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Related Products of 153759-59-2On October 31, 2013 ,《Hybrid benzofuran-bisindole derivatives: New prototypes with promising anti-hyperlipidemic activities》 appeared in European Journal of Medicinal Chemistry. The author of the article were Sashidhara, Koneni V.; Modukuri, Ram K.; Sonkar, Ravi; Rao, K. Bhaskara; Bhatia, Gitika. The article conveys some information:

A series of different benzofuran-bisindole hybrids I [R = Me, Cl, t-Bu, etc.; R1 = Cl, MeO, NC; R3 = H, HO, MeO, O2N] were synthesized and evaluated in vitro for their antioxidant and in vivo for antidyslipidemic activity in triton WR-1339 induced hyperlipidemic rats. four compounds showed significant decrease in plasma levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG) followed by increase in postheparin lipolytic activity (PHLA). In addition, the active hybrids possessed moderate antioxidant properties and increased the plasma lecithin cholesterol acyltransferase (LCAT) activity, which plays a key role in lipoprotein metabolism contributing to an increased level of HDL-C in serum. These results indicate that these hybrids constitute novel prototypes for the management of dyslipidemia. The results came from multiple reactions, including the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Related Products of 153759-59-2)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Related Products of 153759-59-2

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HPLC of Formula: 153759-59-2On October 20, 2015 ,《Designing, synthesis of selective and high-affinity chalcone-benzothiazole hybrids as Brugia malayi thymidylate kinase inhibitors: In vitro validation and docking studies》 was published in European Journal of Medicinal Chemistry. The article was written by Sashidhara, Koneni V.; Avula, Srinivasa Rao; Doharey, Pawan Kumar; Singh, L. Ravithej; Balaramnavar, Vishal M.; Gupta, Jyoti; Misra-Bhattacharya, Shailja; Rathaur, Sushma; Saxena, Anil K.; Saxena, Jitendra Kumar. The article contains the following contents:

In our continuing search for safe and efficacious antifilarials, a series of novel chalcone-benzothiazole hybrids have been synthesized and evaluated for their Brugia malayi thymidylate kinase (BmTMK) enzyme inhibition activity. Their selectivity towards BmTMK was studied and compared to the human TMK (HsTMK) by an in silico method. Out of seventeen derivatives, compounds I and II showed higher interactions with the BmTMK active site. MolDock docking model revealed the interactions of these two derivatives and the results corroborated well with their in vitro antifilarial activities. Our studies suggest that these hybrids are selective towards the BmTMK enzyme and may serve as potential therapeutic agents against filariasis. The experimental process involved the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2HPLC of Formula: 153759-59-2)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.HPLC of Formula: 153759-59-2Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

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Category: alcohols-buliding-blocksIn 2020 ,《Ring-Opening Lithiation-Borylation of 2-Trifluoromethyl Oxirane: A Route to Versatile Tertiary Trifluoromethyl Boronic Esters》 was published in Angewandte Chemie, International Edition. The article was written by Nandakumar, Meganathan; Rubial, Belen; Noble, Adam; Myers, Eddie L.; Aggarwal, Varinder K.. The article contains the following contents:

Stereogenic trifluoromethyl-substituted carbon centers are highly sought-after moieties in pharmaceutical and agrochem. discovery. Here, we show that lithiation-borylation reactions of 2-trifluoromethyl oxirane give densely functionalized and highly versatile trifluoromethyl-substituted α-tertiary boronic esters. The intermediate boronate complexes undergo the desired 1,2-rearrangement of the carbon-based group with complete retentive stereospecificity, a process that was only observed in non-polar solvents in the presence of TESOTf. Although the trifluoromethyl group adversely affects subsequent transformations of the α-boryl group, Zweifel olefinations provide trifluoromethyl-bearing quaternary stereocenters substituted with alkenes, alkynes and ketones. In the experiment, the researchers used many compounds, for example, 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Category: alcohols-buliding-blocks)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) also known as boronate ester, is generally used in metal-catalyzed C-C bond formation reactions like Suzuki–Miyaura reaction.Category: alcohols-buliding-blocks

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Wang, Lucia; Lin, Shengjia; Zhu, Yawei; Ferrante, Daniel; Ishak, Timaf; Baba, Yuki; Sharma, Abhishek published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《α-Hydroxy boron-enabled regioselective access to bifunctional halo-boryl alicyclic ethers and α-halo borons》.Electric Literature of C13H26B2O4 The article contains the following contents:

α-Hydroxy borons are an underused class of compounds and their only previous application involved oxidation into acylborons. Herein, the authors describe the synthesis of functionalized olefinic α-hydroxy borons and their utility to enable a novel and regioselective route to hitherto unknown bifunctional halo-boryl tetrahydrofurans/tetrahydropyrans and α-halo MIDA boronates. The orthogonally functionalized alicyclic ethers provided a building block-based approach for diversification of the THF core. In the experimental materials used by the author, we found Bis[(pinacolato)boryl]methane(cas: 78782-17-9Electric Literature of C13H26B2O4)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.Electric Literature of C13H26B2O4

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《Study of Liquid-Liquid Equilibrium of Aqueous Two-Phase Systems Based on Ethyl Lactate and Partitioning of Rutin and Quercetin》 was written by Requejo, Patricia F.; Velho, Pedro; Gomez, Elena; Macedo, Eugenia A.. Application of 6381-59-5 And the article was included in Industrial & Engineering Chemistry Research in 2020. The article conveys some information:

Two Et lactate (EL)-based aqueous two-phase systems (ATPSs) were studied at T = 298.15 K and atm. pressure. Sodium tartrate and potassium sodium tartrate organic salts have been used to form biphasic systems. To assess the phase splitting, binodal curves and tie-lines were obtained exptl. by the cloud point method and a technique, which consist of the d. and refractive index, resp. Binodal curves were fitted with the Merchuk equation obtaining a good fit. Moreover, modeling with the universal quasichem. thermodn. equation was carried out to accurately represent the two-biphasic systems. Furthermore, exptl. binodal curves obtained in this work and literature results for the same systems and for systems with EL and other salts were analyzed regarding their similarity. Finally, the application of the adopted ATPS in the partitioning of two flavonoids, rutin and quercetin, was studied in terms of the partition coefficients and the percentage of extraction Rutin and quercetin showed better affinity to the EL-rich phase, evidencing that the use of the proposed ATPS may be a successful technique in the biotechnol. industry for the separation of each flavonoid. In the experiment, the researchers used many compounds, for example, Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Application of 6381-59-5)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Application of 6381-59-5 Potassium sodium tartrate tetrahydrate has been used in the preparation of Lowry reagent for the determination of microsomal protein concentration in rat hepatic microsomes by Lowry method.

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《Storage and release of two electrons from an electron-rich carbon-carbon bond: boron mediated reversible coupling of DMAP and 9-azajulolidine》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Cui, Yunshu; Xiang, Libo; Wang, Junyi; Li, Chunlei; Hao, Wei; Ye, Qing. Application In Synthesis of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane The article mentions the following:

This manuscript describes the preparation of [{(dpp-bian)BBr}Li(DME)3] (2, dpp-bian = 1,2-bis[(2,6-diisopropylphenyl) imino]acenaphthene) and [{(dpp-bian)BL}+Br-] (5, L = DMAP; 6, L = 9-azajulolidine). The 4,4-coupling of DMAP and 2,2-coupling of 9-azajulolidine can be achieved either by the reaction of 2 with L, or by one-electron reduction of borenium cations 5 and 6. Oxidation of 3 and 4 leads to C-C cleavage and regeneration of 5 and 6. All new compounds were structurally characterized. In the experiment, the researchers used many compounds, for example, 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Application In Synthesis of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used as a substrate in the study of Suzuki–Miyaura coupling of various aryl iodides over SiliaCat Pd(0).Application In Synthesis of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane

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The author of 《Boosting photocatalytic H2 evolution on g-C3N4 by modifying covalent organic frameworks (COFs)》 were Luo, Maolan; Yang, Qing; Liu, Kewei; Cao, Hongmei; Yan, Hongjian. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Electric Literature of C9H6O6 The author mentioned the following in the article:

Modifying g-C3N4 with covalent organic frameworks (COFs) through imine linkage results in a dramatically enhanced visible-light-driven photocatalytic hydrogen evolution, which reached 10.1 mmol g-1 h-1 when 2 wt% Pt and triethanolamine were used as co-catalyst and sacrificial agent, resp., corresponding to an apparent quantum efficiency (AQE) of 20.7% at 425 nm. The experimental process involved the reaction of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Electric Literature of C9H6O6)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Regarding monomeric phloroglucinols, this group encompasses acryl phloroglucinols, phloroglucinol-terpene adducts, phloroglucinol glycosides, halogenated phloroglucinols, prenylated phloroglucinols, and cyclicroup polyketides.Electric Literature of C9H6O6

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In 2019,Journal of the American Chemical Society included an article by Sasmal, Himadri Sekhar; Halder, Arjun; Kunjattu H, Shebeeb; Dey, Kaushik; Nadol, Athulya; Ajithkumar, Thalasseril G.; Ravindra Bedadur, Prachiti; Banerjee, Rahul. Name: 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde. The article was titled 《Covalent Self-Assembly in Two Dimensions: Connecting Covalent Organic Framework Nanospheres into Crystalline and Porous Thin Films》. The information in the text is summarized as follows:

Insolubility of covalent organic frameworks (COFs) in organic solvents is one of the major obstacles for the potential application of these extended networks such as drug delivery, sensing, optoelectronics, and semiconductor device fabrication. The present work proposes a unique way to make uniform, solution-processable, crystalline, and porous COF nanospheres directly from the homogeneous solution of amine and aldehyde via spatial and temporal control of the nucleation and growth. This strategy of direct nucleation simultaneously showcases the caliber to tune the size of the COF nanospheres from 25 to 570 nm. We have also demonstrated the concept of mesoscale covalent self-assembly of those solution-processable COF nanospheres in the liquid-liquid interface (DCM-water bilayer) for the very first time, transmuting them into self-standing COF thin films with long-range ordered arrangements in two dimensions. The crystalline and porous (with TpAzo showing highest SBET of 1932 m2 g-1) free-standing COF thin films could be fabricated in a wide range of thicknesses from as low as 21 nm to as high as 630 nm. Both β-ketoenamine (TpAzo, TpDPP) and imine (TpOMeAzo, TpOMeDPP) linked COF thin films have been synthesized via mesoscale covalent self-assembly of the solution-processable COF nanospheres illustrating the generality of this eloquent methodol. Further, the solution processability has been tested and utilized to cast COF thin films uniformly in the inner and outer surface of an alumina hollow fiber membrane. The COF thin film-alumina hollow fiber membrane composites have showcased promising selective mol. separation of He and O2, He and CO2, and He and N2. The experimental process involved the reaction of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Name: 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.Name: 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehydeFor acyl phloroglucinols, it is considered the largest category of compounds among phloroglucinols of natural characteristics.

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