Tag: 200-300

Wang, Le-Cheng; Chen, Bo; Zhang, Youcan; Wu, Xiao-Feng published their research in Angewandte Chemie, International Edition on August 15 ,2022. The article was titled 《Nickel-Catalyzed Four-Component Carbonylation of Ethers and Olefins: Direct Access to γ-Oxy Esters and Amides》.Synthetic Route of C12H20O6 The article contains the following contents:

Multi-component carbonylation of olefins, a reaction that installs both a carbon-carbon(heteroatom) bond and a carbonyl group across the double bond, is an attractive strategy for alkene functionalization. Herein, a novel nickel-catalyzed four-component carbonylation of olefins with ethers under low CO gas pressure is developed. Using alcs. and amines as the reaction partner, diverse γ-oxy-substituted esters and amides were produced in good yields with excellent functional group tolerance. Notably, Naftidrofuryl, a medicine for the treatment of cerebrovascular disease (CVD), can be synthesized by this process straightforwardly. After reading the article, we found that the author used ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Synthetic Route of C12H20O6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Synthetic Route of C12H20O6

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Manna, Kuntal; Zhang, Teng; Greene, Francis X.; Lin, Wenbin published an article on February 25 ,2015. The article was titled 《Bipyridine- and Phenanthroline-Based Metal-Organic Frameworks for Highly Efficient and Tandem Catalytic Organic Transformations via Directed C-H Activation》, and you may find the article in Journal of the American Chemical Society.Category: alcohols-buliding-blocks The information in the text is summarized as follows:

The authors report the synthesis of robust and porous bipyridyl- and phenanthryl-based metal-organic frameworks (MOFs) of UiO topol. (BPV-MOF, mBPV-MOF, and mPT-MOF) and their postsynthetic metalation to afford highly active single-site solid catalysts. While BPV-MOF was constructed from only bipyridyl-functionalized dicarboxylate linker, both mBPV- and mPT-MOF were built with a mixture of bipyridyl- or phenanthryl-functionalized and unfunctionalized dicarboxylate linkers. The postsynthetic metalation of these MOFs with [Ir(COD)(OMe)]2 provided Ir-functionalized MOFs (BPV-MOF-Ir, mBPV-MOF-Ir, and mPT-MOF-Ir), which are highly active catalysts for tandem hydrosilylation of aryl ketones and aldehydes followed by dehydrogenative ortho-silylation of benzylicsilyl ethers as well as C-H borylation of arenes using B2pin2. Both mBPV-MOF-Ir and mPT-MOF-Ir catalysts displayed superior activities compared to BPV-MOF-Ir due to the presence of larger open channels in the mixed-linker MOFs. Impressively, mBPV-MOF-Ir exhibited high TONs of up to 17000 for C-H borylation reactions and was recycled >15 times. The mPT-MOF-Ir system is also active in catalyzing tandem dehydrosilylation/dehydrogenative cyclization of N-methylbenzyl amines to azasilolanes in the absence of a H acceptor. Importantly, MOF-Ir catalysts are significantly more active (up to 95 times) and stable than their homogeneous counterparts for all three reactions, strongly supporting the beneficial effects of active site isolation within MOFs. This work illustrates the ability to increase MOF open channel sizes by using the mixed linker approach and shows the enormous potential of developing highly active and robust single-site solid catalysts based on MOFs containing N-donor ligands for important organic transformations. In the experiment, the researchers used 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Category: alcohols-buliding-blocks)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Category: alcohols-buliding-blocks

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Hirano, Masao; Morimoto, Takashi published their research in Bulletin of the Chemical Society of Japan on December 31 ,1989. The article was titled 《Oxidation of aromatic secondary alcohols with cobalt(III) acetate in the presence of sodium bromide》.Product Details of 63012-03-3 The article contains the following contents:

Oxidation of aromatic secondary alcs., RC6H4CH(OH)R1 (e.g., R = H, 2-, 3-, 4-Me, 2-, 3-, 4-Br, 2-, 3-, 4-Cl; R1 = Me, Ph) with Co(OAc)3 in presence of NaBr in AcOH gave ketones RC6H4COR1 in 83-97% yields. After reading the article, we found that the author used (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Product Details of 63012-03-3)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Product Details of 63012-03-3

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Hirano, Masao; Kuroda, Hisanori; Morimoto, Takashi published their research in Bulletin of the Chemical Society of Japan on August 15 ,1990. The article was titled 《Oxidation of aromatic alcohols with chromium(VI) trioxide in the presence of wet-aluminum oxide in aprotic solvent》.Computed Properties of C13H11ClO The article contains the following contents:

The title oxidation resulted in a selective formation of the corresponding carbonyl compounds in excellent yields under mild conditions. The experimental process involved the reaction of (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Computed Properties of C13H11ClO)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Computed Properties of C13H11ClO

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《Alcohols as Alkylating Agents: Photoredox-Catalyzed Conjugate Alkylation via In Situ Deoxygenation》 was written by Wang, Johnny Z.; Sakai, Holt A.; MacMillan, David W. C.. Category: alcohols-buliding-blocks And the article was included in Angewandte Chemie, International Edition on August 26 ,2022. The article conveys some information:

Herein, an operationally convenient, N-heterocyclic carbene (NHC)-mediated deoxygenative Giese-type addition of alc.-derived alkyl radicals to electron-deficient alkenes under mild photocatalytic conditions was described. The fragment coupling accommodated a broad range of primary, secondary, and tertiary alc. partners, as well as structurally varied Michael acceptors containing traditionally reactive sites, such as electrophilic or oxidizable moieties. The late-stage diversification of densely functionalized mol. architectures, including drugs and biomols. was demonstrated, and this protocol with metallaphotoredox cross-coupling for step-economic access to sp3-rich complexity was telescoped. In the experiment, the researchers used ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Category: alcohols-buliding-blocks)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.Category: alcohols-buliding-blocks And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

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Safety of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrateIn 2019 ,《The Effect of Temperature on Different Aqueous Two-Phase Diagrams of Polyethylene Glycol (PEG 6000, PEG 8000, and PEG 10000) + Potassium Sodium Tartrate + Water》 was published in Journal of Chemical & Engineering Data. The article was written by Herbst, Jacqueline; Pott, Robert W. M.. The article contains the following contents:

Phase diagrams and models of PEG 6000, PEG 8000, and PEG 10000 in water and potassium sodium tartrate systems were constructed at temperatures 10, 25, and 45 °C. These phase diagrams consist of binodal curves and tie-lines, modeled using the Merchuck equation, and validated using a linearized form of the Othmer-Tobias equation. It was observed that higher system temperatures produced larger binodal envelopes and better phase separation It was also observed that smaller PEG mol. weights produced smaller binodal envelopes. In the experimental materials used by the author, we found Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Safety of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Safety of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate As a Biuret reagent, it is used to measure the protein concentration. Furthermore, it is used as laxative and is also used in food industry.

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Quality Control of Bis[(pinacolato)boryl]methaneIn 2020 ,《Biosynthesis of Pseudomonas-Derived Butenolides》 appeared in Angewandte Chemie, International Edition. The author of the article were Klapper, Martin; Schlabach, Kevin; Paschold, Andre; Zhang, Shuaibing; Chowdhury, Somak; Menzel, Klaus-Dieter; Rosenbaum, Miriam A.; Stallforth, Pierre. The article conveys some information:

Butenolides are well-known signaling mols. in Gram-pos. bacteria. Here, we describe a novel class of butenolides isolated from a Gram-neg. Pseudomonas strain, the styrolides. Structure elucidation was aided by the total synthesis of styrolide A. Transposon mutagenesis enabled us to identify the styrolide biosynthetic gene cluster, and by using a homol. search, we discovered the related and previously unknown acaterin biosynthetic gene cluster in another Pseudomonas species. Mutagenesis, heterologous expression, and identification of key shunt and intermediate products were crucial to propose a biosynthetic pathway for both Pseudomonas-derived butenolides. The Whole Genome Shotgun project for P. fluorescens HKI0874 has been deposited at DDBJ/ENA/GenBank under the accession VCNJ00000000. The experimental process involved the reaction of Bis[(pinacolato)boryl]methane(cas: 78782-17-9Quality Control of Bis[(pinacolato)boryl]methane)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.Quality Control of Bis[(pinacolato)boryl]methane

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Mykura, Rory C.; Songara, Pradip; Luc, Eugenia; Rogers, Jack; Stammers, Ellie; Aggarwal, Varinder K. published an article in 2021. The article was titled 《Studies on the Lithiation, Borylation, and 1,2-Metalate Rearrangement of O-Cycloalkyl 2,4,6-Triisopropylbenzoates》, and you may find the article in Angewandte Chemie, International Edition.Electric Literature of C12H17BO2 The information in the text is summarized as follows:

A broad range of acyclic primary and secondary 2,4,6-triisopropylbenzoate (TIB) esters have been used in lithiation-borylation reactions, but cyclic TIB esters have not. Authors have studied the use of cyclic TIB esters in lithiation-borylation reactions and looked at the effect of ring size (3- → 6-membered rings) on the three key steps of the lithiation-borylation protocol: deprotonation, borylation and 1,2-metalate rearrangement. Although all rings sizes could be deprotonated, the cyclohexyl case was impractically slow, and the cyclopentyl example underwent α-elimination faster than deprotonation at -78° and so could not be used. Both cyclobutyl and cyclopropyl cases underwent rapid borylation, but only the cyclobutyl substrate underwent 1,2-metalate rearrangement. Thus, the cyclobutyl TIB ester occupies a “”Goldilocks zone,”” being small enough for deprotonation and large enough to enable 1,2-migration. The generality of the reaction was explored with a broad range of boronic esters.4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Electric Literature of C12H17BO2) was used in this study.

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used to prepare sulfinamide derivatives by reacting with diethylaminosulfur trifluoride (DAST) and potassium phenyltrifluoroborate.Electric Literature of C12H17BO2

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《Generating Skeletal Diversity and Complexity from Boron-Substituted 1,3-Dienes and Enophiles》 was written by Francois, Benjamin; Eberlin, Ludovic; Berree, Fabienne; Whiting, Andrew; Carboni, Bertrand. Recommanded Product: 78782-17-9 And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:

Boron-substituted 1,3-dienes participate in ene reactions to afford new functionalized synthetic intermediates. After evaluating several enophiles as partners, the resulting products have been engaged in multistep sequences involving first a Diels Alder/allylboration process. A variety of skeletally diverse and complex polycyclic heterocycles were thus synthesized, such as tetrahydro-1H-isoindole-1,3(2H)-diones, eight-membered lactones or tricyclic spiro compounds In addition to this study using Bis[(pinacolato)boryl]methane, there are many other studies that have used Bis[(pinacolato)boryl]methane(cas: 78782-17-9Recommanded Product: 78782-17-9) was used in this study.

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.Recommanded Product: 78782-17-9

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《Diastereo- and Enantioselective Synthesis of Homoallylic Amines Bearing Quaternary Carbon Centers》 was published in Journal of the American Chemical Society in 2020. These research results belong to Green, Jacob C.; Zanghi, Joseph M.; Meek, Simon J.. Synthetic Route of C13H26B2O4 The article mentions the following:

A Cu-catalyzed method for the efficient enantio- and diastereoselective synthesis of chiral homoallylic amines bearing a quaternary C and an alkenylboron is disclosed. Transformations are promoted by a readily prepared (phosphoramidite)-Cu complex and involve bench-stable γ,γ-disubstituted allyldiborons and benzyl imines; products were obtained in up to 82% yield, >20:1 dr, and >99:1 er. Reactions proceed via stereodefined B-stabilized allylic Cu species formed by an enantioselective transmetalation. Utility of the 1-amino-3-alkenylboronate products is highlighted by a variety of synthetic transformations. In addition to this study using Bis[(pinacolato)boryl]methane, there are many other studies that have used Bis[(pinacolato)boryl]methane(cas: 78782-17-9Synthetic Route of C13H26B2O4) was used in this study.

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Synthetic Route of C13H26B2O4 Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.

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Alcohol – Wikipedia,
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