Tag: 200-300

In 2017,Lee, Yeosan; Baek, Seung-yeol; Park, Jinyoung; Kim, Seoung-Tae; Tussupbayev, Samat; Kim, Jeongho; Baik, Mu-Hyun; Cho, Seung Hwan published 《Chemoselective Coupling of 1,1-Bis[(pinacolato)boryl]alkanes for the Transition-Metal-Free Borylation of Aryl and Vinyl Halides: A Combined Experimental and Theoretical Investigation》.Journal of the American Chemical Society published the findings.Recommanded Product: Bis[(pinacolato)boryl]methane The information in the text is summarized as follows:

A new transition-metal-free borylation of aryl and vinyl halides using 1,1-bis[(pinacolato)boryl]alkanes as boron sources is described. In this transformation one of the boron groups from 1,1-bis[(pinacolato)boryl]alkanes is selectively transferred to aryl and vinyl halides in the presence of sodium tert-butoxide as the only activator to form organoboronate esters. Under the developed borylation conditions, a broad range of organohalides are borylated with excellent chemoselectivity and functional group compatibility, thus offering a rare example of a transition-metal-free borylation protocol. Exptl. and theor. studies have been performed to elucidate the reaction mechanism, revealing the unusual formation of Lewis acid/base adduct between organohalides and α-borylcarbanion, generated in situ from the reaction of 1,1-bis[(pinacolato)boryl]alkanes with an alkoxide base, to facilitate the borylation reactions. In the experiment, the researchers used many compounds, for example, Bis[(pinacolato)boryl]methane(cas: 78782-17-9Recommanded Product: Bis[(pinacolato)boryl]methane)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Recommanded Product: Bis[(pinacolato)boryl]methane Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.

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The author of 《Grignard Reactions in Cyclopentyl Methyl Ether》 were Kobayashi, Shoji; Shibukawa, Keisuke; Miyaguchi, Yuta; Masuyama, Araki. And the article was published in Asian Journal of Organic Chemistry in 2016. Computed Properties of C13H11ClO The author mentioned the following in the article:

A systematic study of Grignard reactions using cyclopentyl Me ether (CPME) as a reaction solvent was studied. Diisobutylaluminum hydride was found to be the most appropriate activator of magnesium and a number of Grignard reagents could be prepared as homogeneous or heterogeneous solutions in CPME. The CPME used in the Grignard reaction was efficiently recycled without affecting the reaction yield of the second experiment GC-MS anal. of the recovered solvent revealed that CPME was stable under the Grignard conditions. Some of the Grignard reagents in CPME were stable for at least several months and therefore these solutions could replace existing com. reagents. Tramadol hydrochloride, an analgesic that is used worldwide, and tamoxifen, an anti-estrogenic drug for estrogen-receptor-pos. breast cancer were synthesized using Grignard reactions in CPME. In the experiment, the researchers used many compounds, for example, (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Computed Properties of C13H11ClO)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Computed Properties of C13H11ClO

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Zhou, Xukai; Xu, Yan; Dong, Guangbin published their research in Journal of the American Chemical Society on December 8 ,2021. The article was titled 《Olefination via Cu-Mediated Dehydroacylation of Unstrained Ketones》.Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol The article contains the following contents:

The dehydroacylation of ketones to olefins was realized under mild conditions, which exhibited a unique reaction pathway involving aromatization-driven C-C cleavage to remove the acyl moiety, followed by Cu-mediated oxidative elimination to form an alkene between the α and β carbons. The newly adopted N’-methylpicolinohydrazonamide (MPHA) reagent was key to enable efficient cleavage of ketone C-C bonds at room temperature Diverse alkyl- and aryl-substituted olefins, dienes and special alkenes were generated with broad functional group tolerance. Strategic applications of this method were also demonstrated. In the part of experimental materials, we found many familiar compounds, such as ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol

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Wang, Jiao; Fan, Xiuju; Feng, Xiao; Li, Yueming published an article on February 28 ,1993. The article was titled 《Studies on enantioselective effect of chiral titanate reagents on the synthesis of substituted benzhydrols》, and you may find the article in Chemical Research in Chinese Universities.Recommanded Product: 63012-03-3 The information in the text is summarized as follows:

Chiral titanate reagents were prepared for use in the asym. synthesis of substituted benzhydrols from Grignard reagents and aldehydes. The solvents, reaction temperature, and exchange of reactants by crossing experiments were investigated. Favored attack of the nucleophile upon the prochiral face of the aromatic aldehyde is proposed, the absolute configurations of the resulting benzhydrols are suggested, and a preliminary reaction mechanism is described. Thus, PhMgBr reacted with 3-ClC6H4CHO in Et2O in the presence of the (+)-tartarate-titanate I to give (-)-(R)-PhCH(OH)C6H4Cl-3 in 34% enantiomeric excess, in contrast, similar reaction of 3-ClC6H4MgBr with PhCHO in the presence of (+)-I gave (+)-(S)-PhCH(OH)C6H4Cl-3 in 73% enantiomeric excess. In addition to this study using (3-Chlorophenyl)(phenyl)methanol, there are many other studies that have used (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Recommanded Product: 63012-03-3) was used in this study.

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group.Recommanded Product: 63012-03-3 Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lee, Minhan; Jung, Hoimin; Kim, Dongwook; Park, Jung-Woo; Chang, Sukbok published an article in Journal of the American Chemical Society. The title of the article was 《Modular Tuning of Electrophilic Reactivity of Iridium Nitrenoids for the Intermolecular Selective α-Amidation of β-Keto Esters》.Formula: C12H20O6 The author mentioned the following in the article:

Ir-catalyzed intermol. amino group transfer to β-keto esters (amides) to α-aminocarbonyl products with excellent chemoselectivity was reported. The key strategy was engineered electrophilicity of the putative Ir-nitrenoids by tuning electronic property of the κ2-N,O chelating ligands, thus facilitated nucleophilic addition of enol π-bonds of 1,3-dicarbonyl substrates. The results came from multiple reactions, including the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Formula: C12H20O6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Formula: C12H20O6

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In 2019,Angewandte Chemie, International Edition included an article by Yu, Wan-Lei; Luo, Yong-Chun; Yan, Lei; Liu, Dan; Wang, Zhu-Yin; Xu, Peng-Fei. Product Details of 20880-92-6. The article was titled 《Dehydrogenative Silylation of Alkenes for the Synthesis of Substituted Allylsilanes by Photoredox, Hydrogen-Atom Transfer, and Cobalt Catalysis》. The information in the text is summarized as follows:

A synergistic catalytic method combining photoredox catalysis, hydrogen-atom transfer, and proton-reduction catalysis for the dehydrogenative silylation of alkenes was developed. With this approach, a highly concise route to substituted allylsilanes has been achieved under very mild reaction conditions without using oxidants. This transformation features good to excellent yields, operational simplicity, and high atom economy. Based on control experiments, a possible reaction mechanism is proposed. The experimental process involved the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Product Details of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Product Details of 20880-92-6

Referemce:
Alcohol – Wikipedia,
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Product Details of 20880-92-6On June 8, 2022, Zhou, Xukai; Yu, Tingting; Dong, Guangbin published an article in Journal of the American Chemical Society. The article was 《Site-Specific and Degree-Controlled Alkyl Deuteration via Cu-Catalyzed Redox-Neutral Deacylation》. The article mentions the following:

A Cu-catalyzed degree-controlled deacylative deuteration of diverse alkyl groups with the methylketone (acetyl) moiety as a traceless activating group was reported. The use of N-methylpicolino-hydrazonamide (MPHA) promotes efficient aromatization-driven C-C cleavage. Mono-, di-, and trideuteration at specific sites was selectively achieved. The reaction is redox-neutral with broad functional group tolerance. The utility of this method was demonstrated in forming a complete set of deuterated Et groups, merging with the Diels-Alder reaction, a net devinylative deuteration, and the synthesis of the d2-analog of Austedo. In the part of experimental materials, we found many familiar compounds, such as ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Product Details of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.Product Details of 20880-92-6 And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

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《ZnMe2-Mediated, Direct Alkylation of Electron-Deficient N-Heteroarenes with 1,1-Diborylalkanes: Scope and Mechanism》 was written by Jo, Woohyun; Baek, Seung-yeol; Hwang, Chiwon; Heo, Joon; Baik, Mu-Hyun; Cho, Seung Hwan. Formula: C13H26B2O4This research focused onzinc promoted regioselective alkylation pyridine quinoline diborylalkane. The article conveys some information:

The regioselective, direct alkylation of electron-deficient N-heteroarenes is, in principle, a powerful and efficient way of accessing alkylated N-heteroarenes that are important core structures of many biol. active compounds and pharmaceutical agents. Herein, we report a ZnMe2-promoted, direct C2- or C4-selective primary and secondary alkylation of pyridines and quinolines using 1,1-diborylalkanes as alkylation sources. While substituted pyridines and quinolines exclusively afford C2-alkylated products, simple pyridine delivers C4-alkylated pyridine with excellent regioselectivity. The reaction scope is remarkably broad, and a range of C2- or C4-alkylated electron-deficient N-heteroarenes are obtained in good yields. Exptl. and computational mechanistic studies imply that ZnMe2 serves not only as an activator of 1,1-diborylalkanes to generate (α-borylalkyl)methylalkoxy zincate, which acts as a Lewis acid to bind to the nitrogen atom of the heterocycles and controls the regioselectivity, but also as an oxidant for rearomatizing the dihydro-N-heteroarene intermediates to release the product.Bis[(pinacolato)boryl]methane(cas: 78782-17-9Formula: C13H26B2O4) was used in this study.

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Formula: C13H26B2O4 Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Zinc triflate catalyzed synthesis of thioethers》 was written by Baddam, Sudhakar Reddy; Neelam, Uday Kumar; Manne, Naga Raju; Adulla, Panasa Reddy; Bandichhor, Rakeshwar. Related Products of 63012-03-3 And the article was included in Chemistry & Biology Interface on April 30 ,2014. The article conveys some information:

Zinc triflate-catalyzed aralkylation of thiols using various substituted benzylic alcs. was developed for the synthesis of thioether (sulfide) derivatives This procedure presents a greener approach for the synthesis of sulfides. The experimental process involved the reaction of (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Related Products of 63012-03-3)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Related Products of 63012-03-3

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《Free-Standing Covalent Organic Framework Membrane for High-Efficiency Salinity Gradient Energy Conversion》 was written by Hou, Shuhua; Ji, Wentao; Chen, Jianjun; Teng, Yunfei; Wen, Liping; Jiang, Lei. Related Products of 34374-88-4This research focused ontriformylphloroglucinol covalent organic framework salinity energy conversion; aligning ionic transport; energy conversion; membranes; salinity gradient energy. The article conveys some information:

Both high ionic conductivity and selectivity of a membrane are required for efficient salinity gradient energy conversion. An efficient method to improve energy conversion is to align ionic transport along the membrane thickness to address low ionic conductivity in traditional membranes used for energy harvesting. We fabricated a free-standing covalent organic framework membrane (TpPa-SO3H) with excellent stability and mech. properties. This membrane with one-dimensional nanochannels and high charge d. demonstrated high ionic conductivity and selectivity. Its power d. reached up to 5.9 W m-2 by mixing artificial seawater and river water. Based on our results, we attribute the high energy conversion to the high ion conductivity through aligned one-dimensional nanochannels and high ion selectivity via the size of the nanochannel at ≈1 nm in the membrane. This study paves the way for designing covalent organic framework membranes for high salinity gradient energy conversion. After reading the article, we found that the author used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Related Products of 34374-88-4)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Phloroglucinol derivatives are a major class of secondary metabolites. Phloroglucinol compounds can be classified into monomeric, dimeric, trimeric and higher phloroglucinols, and phlorotannins.Related Products of 34374-88-4

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