Tag: 200-300

Yang, Liu; Lu, Huan-Huan; Lai, Chu-Hui; Li, Gang; Zhang, Wei; Cao, Rui; Liu, Fengyi; Wang, Chao; Xiao, Jianliang; Xue, Dong published an article in Angewandte Chemie, International Edition. The title of the article was 《Light-Promoted Nickel Catalysis: Etherification of Aryl Electrophiles with Alcohols Catalyzed by a NiII-Aryl Complex》.Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol The author mentioned the following in the article:

A highly effective C-O coupling reaction of (hetero)aryl electrophiles with primary and secondary alcs. is reported. Catalyzed by a NiII-aryl complex under long-wave UV (390-395 nm) irradiation in the presence of a soluble amine base without any addnl. photosensitizer, the reaction enables the etherification of aryl bromides and aryl chlorides as well as sulfonates with a wide range of primary and secondary aliphatic alcs., affording synthetically important ethers. Intramol. C-O coupling is also possible. The reaction appears to proceed via a NiI-NiIII catalytic cycle.((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol) was used in this study.

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xie, Mengying; Wang, Zhiyi; Wan, Xinlong; Weng, Jie; Tu, Mengyun; Mei, Jin; Wang, Zhibin; Du, Xiaohong; Wang, Liangxing; Chen, Chan published their research in Journal of Biomaterials Applications on February 29 ,2020. The article was titled 《Crosslinking effects of branched PEG on decellularized lungs of rats for tissue engineering》.Recommanded Product: 76931-93-6 The article contains the following contents:

Poly (ethylene glycol) (PEG) has been paid much attention to its applications in tissue engineering. However, the studies on poly (ethylene glycol) in tissue applications were currently far from enough. To investigate the crosslinking effects of poly (ethylene glycol) in mech. properties, anti-enzymic ability and cytocompatibility, in this study, the poly (ethylene glycol) was crosslinked to decellularized lung scaffolds from rats. In order to obtain the PEGylated decellularized lung scaffold, the N-succinimidyl S-acetylthioacetate was first used to modify the decellularized lung scaffold, and a four-arm- poly (ethylene glycol) containing four acrylate groups was then crosslinked to the decellularized lung scaffold by the Michael addition reaction between acrylate group and sulfhydryl group. The results showed that the optimal concentration of poly (ethylene glycol) and reaction time of PEGylation of decellularized lung scaffold was 40 mg/mL and 4 h, resp. Histol. examinations, SEM and quantification of tissue morphol. by septal thickness consistently indicated no differences between PEGylated and normal decellularized lung scaffold in morphol. Compared with native lung and normal decellularized lung scaffold, the Young’s modulus and stiffness of PEGylated decellularized lung scaffold increased significantly, whereas enzymic degradation rate of PEGylated decellularized lung scaffold decreased significantly, suggesting that poly (ethylene glycol) significantly enhanced the biomech. property and anti-enzymic stability of decellularized lung scaffold. Further, no significant differences in cell viability were found between PEGylated and normal decellularized lung scaffold, suggesting no toxicity introduction of poly (ethylene glycol) into decellularized lung scaffold by the crosslinking. These findings may provide useful information for further applications of poly (ethylene glycol) in tissue engineering.2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Recommanded Product: 76931-93-6) was used in this study.

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine being a good nucleophile easily undergoes electrophilic substitution reactions with different electrophiles such alkyl halides and acyl halides, and forms N-substituted pyrrolidines. N-Alkylpyrrolidine on further reaction with alkyl halide provided quaternary salts.Recommanded Product: 76931-93-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pu, Yanchi; Zhang, Hao; Peng, Yao; Fu, Qiuyi; Yue, Qiming; Zhao, Yi; Guo, Li; Wu, Yong published their research in European Journal of Medicinal Chemistry on December 1 ,2019. The article was titled 《Dual-targeting liposomes with active recognition of GLUT5 and αvβ3 for triple-negative breast cancer》.Product Details of 20880-92-6 The article contains the following contents:

At present, chemo- and radiotherapies remain to be the mainstream methods for treating triple-neg. breast cancer (TNBC), which is known for poor prognosis and high rate of mortality. Two types of novel dual-targeting TNBC liposomes (Fru-RGD-Lip and Fru+RGD-Lip) that actively recognize both fructose transporter GLUT5 and integrin αvβ3 were designed and prepared in this work. Firstly, a Y-shaped Fru-RGD-chol ligand, where a fructose and peptide Arg-Gly-Asp (RGD) were covalently attached to cholesterol, was designed and synthesized. Then, the Fru-RGD-Lip was constructed by inserting Fru-RGD-chol into liposomes, while Fru+RGD-Lip was obtained by inserting both Fru-chol and RGD-chol (with the molar ratio of 1:1) into liposomes. The particle size, zeta potential, encapsulation efficiency and serum stability of the paclitaxel-loaded liposomes were characterized. The results indicated that the paclitaxel-loaded Fru-RGD-Lip had the strongest growth inhibition against GLUT5 and αvβ3 overexpressed MDA-MB-231 and 4T1 cells. The cellular uptake of Fru-RGD-Lip on MDA-MB-231 cells and 4T1 cells was 3.19- and 3.23-fold more than that of the uncoated liposomes (Lip). The uptake of Fru+RGD-Lip was slightly lower, giving a 2.81- and 2.90-fold increase than that of Lip in two cell lines, resp. The mechanism study demonstrated that the cellular uptake of both dual-targeting liposomes was likely to be recognized and mediated by GLUT5 and αvβ3 firstly, then endocytosed through comprehensive pathways in an energy-dependent manner. Moreover, Fru-RGD-Lip displayed the maximum accumulation, which was 2.62-fold higher than that of Lip for instance, at the tumor sites compared to other liposomes using in vivo imaging. Collectively, the liposomes co-modified by fructose and RGD have enormous potential in the development of targeted TNBC treatment, especially the covalently modified Fru-RGD-Lip, making it a promising multifunctional liposome. The experimental part of the paper was very detailed, including the reaction process of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Product Details of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Product Details of 20880-92-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Modukuri, Ram K.; Choudhary, Dharmendra; Gupta, Sampa; Rao, K. Bhaskara; Adhikary, Sulekha; Sharma, Tanuj; Siddiqi, Mohammad Imran; Trivedi, Ritu; Sashidhara, Koneni V. published their research in Bioorganic & Medicinal Chemistry on December 15 ,2017. The article was titled 《Benzofuran-dihydropyridine hybrids: A new class of potential bone anabolic agents》.Recommanded Product: 153759-59-2 The article contains the following contents:

A series of novel benzofuran-dihydropyridine hybrids were designed by mol. hybridization approach and evaluated for bone anabolic activities. Among the screened library, compound I significantly enhanced the ALP production and mineralized nodule formation, which are primary requisites in the process of in vitro osteogenesis. Oral administration of compound I at 10 mg·kg-1·day-1 for two weeks led to restoration of trabecular bone microarchitecture in drill hole fracture model by significantly increasing BV/TV and Tb. N. Furthermore, histol. and mol. studies showed compound I triggering the new bone regeneration in a drill hole defect site by increasing BMP expression. Furthermore, mol. modeling studies were performed to gain insight into the binding approach, which revealed that both benzofuran and dihydropyridine moieties are essential to show similar binding interactions to fit into the active site of BMP2 receptor, an important target of the osteogenic agents. The results suggest that compound I stimulates BMP2 synthesis in osteoblast cells that promotes new bone formation (∼40%) at the fracture site which helps in shorten the healing period. The experimental process involved the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Recommanded Product: 153759-59-2)

5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Recommanded Product: 153759-59-2Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《β-Selective Aroylation of Activated Alkenes by Photoredox Catalysis》 was published in Angewandte Chemie, International Edition in 2019. These research results belong to Lei, Zhen; Banerjee, Arghya; Kusevska, Elena; Rizzo, Eric; Liu, Peng; Ngai, Ming-Yu. Related Products of 20880-92-6 The article mentions the following:

Late-stage synthesis of α,β-unsaturated aryl ketones remains an unmet challenge in organic synthesis. Reported herein is a photocatalytic non-chain-radical aroyl chlorination of alkenes by a 1,3-chlorine atom shift to form β-chloroketones as masked enones that liberate the desired enones upon workup. This strategy suppresses side reactions of the enone products. The reaction tolerates a wide array of functional groups and complex mols. including derivatives of peptides, sugars, natural products, nucleosides, and marketed drugs. Notably, addition of 2,6-di-tert-butyl-4-methylpyridine enhances the quantum yield and efficiency of the cross-coupling reaction. Exptl. and computational studies suggest a mechanism involving PCET (proton-coupled electron transfer), formation and reaction of an α-chloro-α-hydroxy benzyl radical, and 1,3-chlorine atom shift. Thus, e.g., irradiation of a reaction mixture containing 4-fluorobenzoyl chloride, 1,1-diphenylethylene, fac-Ir(ppy)3 and 2,6-di-tert-butyl-4-methylpyridine in CHCl3 in CHCl3 with blue LEDs afforded I (85%) upon isolation. In the part of experimental materials, we found many familiar compounds, such as ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Related Products of 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.Related Products of 20880-92-6 And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Rational combination of covalent-organic framework and nano TiO2 by covalent bonds to realize dramatically enhanced photocatalytic activity》 was published in Applied Catalysis, B: Environmental in 2020. These research results belong to Li, Chang-Cheng; Gao, Meng-Yao; Sun, Xiao-Jun; Tang, Hong-Liang; Dong, Hong; Zhang, Feng-Ming. Recommanded Product: 34374-88-4 The article mentions the following:

Rationally combining the advantage of inorganic and organic semiconductors to construct a heterojunction is an effective way to boost the photocatalytic activity of materials, while it is still a great challenge to tightly integrate these two different components together. In this work, for the first time, the TpPa-1-COF, an excellent visible-light harvesting covalent-organic frameworks (COFs), and TiO2 were combined together by covalent bonds to construct a heterojunction. The resulting TiO2-TpPa-1-COF hybrid materials show efficient photocatalytic activity under visible light irradiation Especially, TiO2-TpPa-1-COF (1:3) exhibits the optimized photocatalytic H2 evolution rate of 11.19 mmol g-1 h-1 and apparent quantum efficiency of 7.6% at λ = 420 nm, which is 5.3 and 3.0 times higher than the TpPa-1-COF and TiO2/TpPa-1-COF, resp. Further investigations confirm that the covalent connection between TiO2 and TpPa-1-COF components can largely improve the transfer of photogenerated charges of COF, leading to the efficient H2 evolution activity. In the experimental materials used by the author, we found 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Recommanded Product: 34374-88-4)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.Recommanded Product: 34374-88-4For acyl phloroglucinols, it is considered the largest category of compounds among phloroglucinols of natural characteristics.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Direct growth of covalent organic framework nanofiltration membranes on modified porous substrates for dyes separation》 were Pan, Fusheng; Guo, Weixiong; Su, Yanlei; Khan, Niaz Ali; Yang, Hao; Jiang, Zhongyi. And the article was published in Separation and Purification Technology in 2019. Formula: C9H6O6 The author mentioned the following in the article:

Covalent organic frameworks (COFs) are emerging as crystalline porous materials for advanced membranes, due to their regular pore structures and high porosity. The fabrication of defect-free ultrathin COFs membranes is still very challenging, since the poor COF-substrate affinity hampers the nucleation of COF crystallites. In this work, a facile direct growth method was developed to deposit continuous imine-based COF layer (TpPa-1, synthesized by the Schiff-base reactions of 1,3,5-triformylphloroglucinol (Tp) with p-phenylenediamine (Pa-1)). Aldehydes groups were firstly immobilized on polyacrylonitrile (PAN) porous substrate as the nucleation sites to promote the growth of continuous TpPa-1 layer via a good COF-to-substrate adhesion. Fourier transform IR spectroscopy (FTIR), scanning electron microscope (SEM) and X-ray diffractometer (XRD) confirmed the formation of COF layer. The TpPa-1/HPAN membrane exhibited high water flux of 418.5 L/(m2 h MPa) under the operation pressure of 0.1 MPa and excellent dyes rejection (93.91% for Orange GII and over 99% for Methyl blue, Congo red and Alcian blue). The high separation performance, coupled with its facile fabrication and remarkable stability, may render imine-based COFs membrane promising for wastewater treatment. In the experimental materials used by the author, we found 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Formula: C9H6O6)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Regarding monomeric phloroglucinols, this group encompasses acryl phloroglucinols, phloroglucinol-terpene adducts, phloroglucinol glycosides, halogenated phloroglucinols, prenylated phloroglucinols, and cyclicroup polyketides.Formula: C9H6O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommanded Product: 24388-23-6In 2021 ,《Rational Optimization of the Petasis Three-Component Reaction as a Feasible Elementary Reaction in Polymer Chemistry》 appeared in Macromolecular Chemistry and Physics. The author of the article were Takahashi, Ryo; Kakuchi, Ryohei. The article conveys some information:

In this research, the Petasis three-component reaction (Petasis-3CR) among aromatic boronic acids, amines, and glyoxylic acids is feasibly optimized to seek integration with polymer synthesis. The Petasis-3CR is expanded using protected boronic acids, bypassing the disadvantages of the polymers featuring boronic acids. Based on the modification, the Petasis-3CR is now highly compatible with synthetic polymer chem., yielding poly(α-amino acids), which are otherwise difficult to synthesize. In the experimental materials used by the author, we found 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Recommanded Product: 24388-23-6)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) also known as boronate ester, is generally used in metal-catalyzed C-C bond formation reactions like Suzuki–Miyaura reaction.Recommanded Product: 24388-23-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Li, Yuting; Kanbur, Uddhav; Cui, Jinlei; Wang, Guocang; Kobayashi, Takeshi; Sadow, Aaron D.; Qi, Long published an article in Angewandte Chemie, International Edition. The title of the article was 《Supported Lanthanum Borohydride Catalyzes CH Borylation Inside Zeolite Micropores》.Product Details of 24388-23-6 The author mentioned the following in the article:

The zeolite-supported lanthanide La(BH4)x-HY30 catalyzes C-H borylation of benzene with pinacolborane (HBpin), providing a complementary approach to precious, late transition metal-catalyzed borylations. The reactive catalytic species are generated from La grafted at the Broensted acid sites (BAS) in micropores of the zeolite, whereas silanoate- and aluminoate-grafted sites are inactive under the reaction conditions. During typical catalytic borylations, conversion to Ph pinacolborane (PhBpin) is zero-order in HBpin concentration A turnover number (TON) of 167 is accessed by capping external silanols, selectively grafting at BAS sites, and adding HBpin slowly to the reaction. The experimental process involved the reaction of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Product Details of 24388-23-6)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used to prepare sulfinamide derivatives by reacting with diethylaminosulfur trifluoride (DAST) and potassium phenyltrifluoroborate.Product Details of 24388-23-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ren, Xinyi; Wang, Zhen; Shen, Chaoren; Tian, Xinxin; Tang, Lin; Ji, Xiaolei; Dong, Kaiwu published their research in Angewandte Chemie, International Edition on August 2 ,2021. The article was titled 《Asymmetric Alkoxy- and Hydroxy-Carbonylations of Functionalized Alkenes Assisted by β-Carbonyl Groups》.Category: alcohols-buliding-blocks The article contains the following contents:

As a fundamental type of carbonylation reaction, the alkoxy- and hydroxy-carbonylation of unsaturated hydrocarbons constitutes one of the most important industrial applications of homogeneous catalysis. However, owing to the difficulties in controlling multi-selectivities for asym. hydrocarbonylation of alkenes, this reaction is typically limited to vinylarenes and analogs. In this work, a highly efficient asym. alkoxy- and hydroxy-carbonylation of β-carbonyl functionalized alkenes was developed, providing practical and easy access to various densely functionalized chiral mols. with high optical purity from broadly available alkenes, CO, and nucleophiles (>90 examples, 84-99% ee). This protocol features mild reaction conditions and a broad substrate scope, and the products can be readily transformed into a diverse array of chiral heterocycles. Control experiments revealed the key role of the β-carbonyl group in determining the enantioselectivity and promoting the activity, which facilitates chiral induction by coordination to the transition metal as rationalized by DFT calculations The strategy of utilizing an innate functional group as the directing group on the alkene substrate might find further applications in catalytic asym. hydrocarbonylation reactions. In the experiment, the researchers used ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Category: alcohols-buliding-blocks)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts