Tag: 200-300

《Solubility of Phenylboronic Acid and its Cyclic Esters in Organic Solvents》 was written by Leszczynski, Pawel; Hofman, Tadeusz; Sporzynski, Andrzej. Recommanded Product: 24388-23-6 And the article was included in Journal of Solution Chemistry in 2020. The article conveys some information:

The solubilities of phenylboronic acid, its pinacol ester and azaester in organic solvents (chloroform, 3-pentanone, acetone, di-Pr ether and methylcyclohexane) have been determined exptl. by a dynamic method, in which the disappearance of turbidity was determined by measuring of light intensity using a luminance probe. Phenylboronic acid has high solubility in ether and ketones, moderate in chloroform and very low in hydrocarbon. Pinacol ester and azaester show better solubility than the parent acid in all tested solvents. For pinacol ester differences between particular solvents are small, while for azaester the differences are significant. For both esters the highest solubility is observed in chloroform and the lowest in the hydrocarbon. The results have been correlated by the Wilson, NRTL and Redlich-Kister equations. For the phenylboronic acid better correlation of the data is obtained by polynomials in comparison with the above equations. It is connected with addnl. acid-anhydride equilibrium in the system. The influence of polarity of the solvents on the solubility is discussed. In the experiment, the researchers used 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Recommanded Product: 24388-23-6)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) also known as boronate ester, is generally used in metal-catalyzed C-C bond formation reactions like Suzuki–Miyaura reaction.Recommanded Product: 24388-23-6

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《MOF@COFs with Strong Multiemission for Differentiation and Ratiometric Fluorescence Detection》 was written by Wang, Xin-Yao; Yin, Hua-Qing; Yin, Xue-Bo. Product Details of 34374-88-4 And the article was included in ACS Applied Materials & Interfaces in 2020. The article conveys some information:

Aggregation-caused quenching (ACQ) is often observed in covalent organic frameworks (COFs) for their low emission. Here, we propose that limited COF layers form on UiO-66 to eliminate the ACQ by the formation of UiO@COF composites. UiO-66 is selected because this metal-organic framework (MOF) is easily prepared in nanosize with Zr4+ ion and 2-aminoterephthalic acid (BDC-NH2). The high affinity of the Zr4+ ion to phosphate species improves sensing selectivity. The surface -NH2 reacts with 2,4,6-triformylphloroglucinol (Tp) to integrate COF1 and COF2, which are prepared with Tp and phenylenediamine or tetraamino-tetraphenylethylene, resp. The hydrogen bond formed between the hydroxyl group in Tp and imine nitrogen realizes excited-state intramol. proton transfer; therefore, multiemission is observed from the enol and keto states of the COFs and UiO-66 at 360, 470, and 613 nm for UiO@COF1 and at 370, 470, and 572 nm for UiO@COF2. When phosphate ion is added in the composites, the emissions from the COFs keep stable, while that from UiO-66 is enhanced. However, adenosine-5′-triphosphate (ATP) improves the emissions from UiO-66 and COF’s enol state, but that from the keto state keeps stable. The differentiation and ratiometric fluorescence detection of ATP and phosphate ion are therefore realized with the multiemission, the affinity of Zr4+ ions, and the structural selectivity of the COFs. Thus, UiO@COF is a novel strategy to integrate multiemission, affinity, and structural selectivity to improve the sensing performance for differentiation and ratiometric detection. After reading the article, we found that the author used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Product Details of 34374-88-4)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Regarding monomeric phloroglucinols, this group encompasses acryl phloroglucinols, phloroglucinol-terpene adducts, phloroglucinol glycosides, halogenated phloroglucinols, prenylated phloroglucinols, and cyclicroup polyketides.Product Details of 34374-88-4

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The author of 《Efficient labeling of organic molecules using 13C elemental carbon: Universal access to 13C2-labeled synthetic building blocks, polymers and pharmaceuticals》 were Ledovskaya, Maria S.; Voronin, Vladimir V.; Rodygin, Konstantin S.; Ananikov, Valentine P.. And the article was published in Organic Chemistry Frontiers in 2020. COA of Formula: C12H20O6 The author mentioned the following in the article:

Among different types of labeling, 13C-labeled compounds are the most demanding in organic chem., life sciences and materials design. However, 13C-labeled organic mols. are very difficult to employ in practice due to extreme cost. The rather narrow range of labeled organic starting materials and the absence of universal synthetic building units further complicate the problem and make utilization of 13C-labeled mols. hardly possible in many cases. Here, we report a versatile approach for 13C2-labeling of organic mols. starting with 13C elemental carbon: 13C carbon is applied for the synthesis of calcium carbide (Ca13C2), which is subsequently used to generate acetylene – a universal 13C2 unit for atom-economic organic transformations. Syntheses of labeled alkynes, O,S,N-functionalized vinyl derivatives, polymers and pharmaceutical substances were demonstrated. Elemental 13C carbon, as the chem. most simple source for 13C2-labeling, was successfully combined with universal synthetic applicability of alkynes. In the experimental materials used by the author, we found ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6COA of Formula: C12H20O6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.COA of Formula: C12H20O6

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Agarwal, Sameer; Sasane, Santosh; Deshmukh, Prashant; Rami, Bhadresh; Bandyopadhyay, Debdutta; Giri, Poonam; Giri, Suresh; Jain, Mukul; Desai, Ranjit C. published their research in ACS Medicinal Chemistry Letters on December 8 ,2016. The article was titled 《Identification of an Orally Efficacious GPR40/FFAR1 Receptor Agonist》.SDS of cas: 865233-35-8 The article contains the following contents:

GPR40/FFAR1 is a G protein-coupled receptor predominantly expressed in pancreatic β-cells and activated by long-chain free fatty acids, mediating enhancement of glucose-stimulated insulin secretion. A novel series of substituted 3-(4-aryloxyaryl)propanoic acid derivatives were prepared and evaluated for their activities as GPR40 agonists, leading to the identification of compound 5, which is highly potent in in vitro assays and exhibits robust glucose lowering effects during an oral glucose tolerance test in nSTZ Wistar rat model of diabetes (ED50 = 0.8 mg/kg; ED90 = 3.1 mg/kg) with excellent pharmacokinetic profile, and devoid of cytochromes P 450 isoform inhibitory activity. In the experiment, the researchers used (S)-3-(4-Hydroxyphenyl)hex-4-ynoic acid(cas: 865233-35-8SDS of cas: 865233-35-8)

(S)-3-(4-Hydroxyphenyl)hex-4-ynoic acid(cas: 865233-35-8) belongs to alkynes. The addition of nonpolar E−H bonds across C≡C is general for silanes, boranes, and related hydrides.SDS of cas: 865233-35-8 The hydroboration of alkynes gives vinylic boranes which oxidize to the corresponding aldehyde or ketone. In the thiol-yne reaction the substrate is a thiol.

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COA of Formula: C13H11ClOOn March 14, 1997, Kline, Richard H.; Izenwasser, Sari; Katz, Jonathan L.; Joseph, David B.; Bowen, Wayne D.; Newman, Amy Hauck published an article in Journal of Medicinal Chemistry. The article was 《3′-Chloro-3α-(diphenylmethoxy)tropane But Not 4′-Chloro-3α-(diphenylmethoxy)tropane Produces a Cocaine-like Behavioral Profile》. The article mentions the following:

A series of 2′- and 3′-substituted and 3′,3”-disubstituted 3α-(diphenylmethoxy)tropane analogs were designed and synthesized as novel probes for the dopamine transporter. All the analogs were evaluated for displacement of [3H]WIN 35,428 binding at the dopamine transporter and for inhibition of [3H]dopamine uptake in rat caudate putamen. Compounds were observed to monophasically displace [3H]WIN 35,428 binding to the dopamine transporter with affinities of 21.6-1836 nM (Ki). Generally, meta-substituted compounds were more potent than benztropine and equipotent to or slightly less potent than their previously reported para-substituted homologs in inhibiting [3H]WIN 35,428 binding. However, these same meta-substituted analogs were typically less potent than the 4′-substituted analogs in inhibiting [3H]dopamine uptake. Ortho-substituted analogs were generally less potent in both binding and inhibition of uptake at the dopamine transporter than either benztropine or other aryl-substituted homologs. The analogs were also tested for binding at norepinephrine and serotonin transporters as well as muscarinic M1 receptors. None of the compounds in the present study bound with high affinity to either the norepinephrine or serotonin transporters, but all bound to muscarinic M1 receptors with high affinity (Ki = 0.41-2.52 nM). Interestingly, 3′-chloro-3α-(diphenylmethoxy)tropane produced effects like cocaine in animals trained to discriminate 10 mg/kg cocaine from saline, unlike its 4′-Cl homolog and all of the previously evaluated benztropine analogs. Further evaluation of 3′-chloro-3-(diphenylmethoxy)tropane and the other benztropine analogs will undoubtedly prove useful in the elucidation of the role of the dopamine transporter in the reinforcing effects of cocaine and the ultimate identification of a cocaine-abuse treatment. In the experimental materials used by the author, we found (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3COA of Formula: C13H11ClO)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.COA of Formula: C13H11ClO

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《Synthesis, Biological Evaluation, and Binding Mode of Novel 1-[2-(Diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles Targeted at the HIV-1 Reverse Transcriptase》 was written by Silvestri, Romano; Artico, Marino; De Martino, Gabriella; Ragno, Rino; Massa, Silvio; Loddo, Roberta; Murgioni, Chiara; Loi, Anna Giulia; La Colla, Paolo; Pani, Alessandra. Quality Control of (3-Chlorophenyl)(phenyl)methanol And the article was included in Journal of Medicinal Chemistry on April 11 ,2002. The article conveys some information:

A novel series of 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazole (DAMNI) analogs were synthesized and tested in cell-based assays and in enzyme assays against HIV-1 recombinant reverse transcriptase (RT). Preparation of the new derivatives was performed by reacting the appropriate benzhydrols or the corresponding bromides with 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole or the 3-hydroxypropyl homolog. Several compounds showed anti-HIV-1 activity in the submicromolar range. Structure-activity relationship studies suggested that meta substitution at one Ph ring of the diarylmethane moiety strongly influences the antiviral activity. 3,5-Disubstitution at the same Ph ring led to less potent derivatives Mol. modeling and docking studies within the RT non-nucleoside binding site confirmed that DAMNIs, similar to other NNRTIs such as TNK-651 and delavirdine (BHAP U90152), assume a butterfly-like conformation that appears to be halfway between that of classical NNRTIs, such as nevirapine, HEPT, TBZ, TIBO, and DABOs, and the conformation of BHAPs. In particular, the diphenylmethane moiety mimics the wings whereas the 1-(2-methyl-5-nitroimidazolyl)ethane portion resembles the BHAP 5-methanesulfonamidoindole-2-carbonylpiperazine portion. In the experiment, the researchers used many compounds, for example, (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Quality Control of (3-Chlorophenyl)(phenyl)methanol)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The creation of a peptide bond to link two amino acids to make a protein removes the −OH from the carboxy group of one amino acid.Quality Control of (3-Chlorophenyl)(phenyl)methanol

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《Phytochemical and chemotaxonomic investigation from the roots of Anemone vitifolia Buch.-Ham. (Ranunculaceae)》 was written by Mou, Lin-Yun; Guo, Jie-Yun; Jiang, Wei; Zhang, Feng-Mei; Li, Jian-Long. HPLC of Formula: 20880-92-6 And the article was included in Biochemical Systematics and Ecology on August 31 ,2021. The article conveys some information:

Phytochem. investigation from the roots of Anemone vitifolia Buch.-Ham. led to the isolation of eight compounds, including one triterpenoid saponin, two sugars, one coumarin, one amide, one saturated alkane, one olefin and one fatty acid. The structures of these metabolites were elucidated by spectroscopic data and comparisons with the data available in the literature. Among them, compound 7 ((6Z,9Z,12Z)-6,9,12-Eicosatriene) was isolated for the first time as a natural product. Furthermore, compounds 2 (D-(+)-raffinose), 3 (mixture of β-D-fructopyranose and β-D-fructofuranose) and 5 (bonaroside) were obtained from the Ranunculaceae family for the first time. Compounds 4 (siderin) and 6 (n-hexadecane) were isolated from A. vitifolia for the first time. The chemotaxonomic significance of the isolated compounds was discussed. In the part of experimental materials, we found many familiar compounds, such as ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6HPLC of Formula: 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.HPLC of Formula: 20880-92-6 And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

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Alcohol – Wikipedia,
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《EDTA-Functionalized Covalent Organic Framework for the Removal of Heavy-Metal Ions》 was written by Jiang, Yunzhe; Liu, Chuanyao; Huang, Aisheng. Recommanded Product: 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehydeThis research focused onwastewater treatment heavy metal ion adsorptive removal; EDTA functionalized covalent organic framework adsorbent wastewater treatment; Adsorption; Covalent organic framework (COF); Ethylenediaminetetraacetic acid (EDTA); Post-synthesis; Removal of heavy-metal ions. The article conveys some information:

Heavy metal ion removal from wastewater has gained intense attention due to metal toxicity, bioaccumulation tendency, and persistence. Adsorption is a most promise method because of its simplicity and efficiency. This work reports preparation of an EDTA-functionalized covalent organic framework (COF) for heavy metal ion removal. A COF, TpPa-NO2, was reduced to TpPa-NH2 using a Na2S2O4 reductant, then EDTA dianhydride was grafted on the TpPa-NH2 to form TpPa-NH2@EDTA via post-modification. COF morphol. and structure remained unchanged after post-modification. TpPa-NH2@EDTA displayed excellent heavy metal ion adsorption performance (e.g., soft Lewis acids [Ag+, Pd2+], hard Lewis acids [Fe3+, Cr3+], borderline Lewis acids [Cu2+, Ni2+]) with removal efficiencies all >85% within 5 min due to the EDTA strong chelation effect. TpPa-NH2@EDTA also showed high adsorption ability in a pH ≥3 environment with an adsorption capacity >50 mg/g for six representative heavy metal ions. This work provided an idea to use COF materials to remove heavy metal ions from wastewater. In addition to this study using 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde, there are many other studies that have used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Recommanded Product: 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde) was used in this study.

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Phloroglucinol derivatives are a major class of secondary metabolites. Phloroglucinol compounds can be classified into monomeric, dimeric, trimeric and higher phloroglucinols, and phlorotannins.Recommanded Product: 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde

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Recommanded Product: 6381-59-5In 2020 ,《Synthesis and Biological Evaluation of Pyrroloindolines as Positive Allosteric Modulators of the α1β2γ2 GABAA Receptor》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Blom, Annet E. M.; Su, Justin Y.; Repka, Lindsay M.; Reisman, Sarah E.; Dougherty, Dennis A.. The article conveys some information:

Here, the synthesis and functional evaluation of a novel series of pyrroloin-dolines, e.g., I that displayed significant modulation of the γ-aminobutyric acid type A (GABAA) receptor, acting as pos. allosteric modulators (PAMs) was described. It was found that halogen incorporation at the C5 position greatly increased the PAM potency relative to the parent ligand, while substitutions at other positions generally decreased potency. Mutagenesis studies suggested that the binding site lies at the top of the transmembrane domain. In the experimental materials used by the author, we found Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Recommanded Product: 6381-59-5)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Recommanded Product: 6381-59-5 As a Biuret reagent, it is used to measure the protein concentration. Furthermore, it is used as laxative and is also used in food industry.

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Category: alcohols-buliding-blocksIn 2013 ,《Characterization of salt interferences in second-harmonic generation detection of protein crystals》 appeared in Journal of Applied Crystallography. The author of the article were Closser, R. G.; Gualtieri, E. J.; Newman, J. A.; Simpson, G. J.. The article conveys some information:

Studies were undertaken to assess the merits and limitations of second-harmonic generation (SHG) for the selective detection of protein and polypeptide crystal formation, focusing on the potential for false positives from SHG-active salts present in crystallization media. The SHG activities of salts commonly used in protein crystallization were measured and quant. compared with reference samples. Out of 19 salts investigated, six produced significant background SHG and 15 of the 96 wells of a sparse-matrix screen produced SHG upon solvent evaporation SHG-active salts include phosphates, hydrated sulfates, formates and tartrates, while chlorides, acetates and anhydrous sulfates resulted in no detectable SHG activity. The identified SHG-active salts produced a range of signal intensities spanning nearly three orders of magnitude. However, even the weakest SHG-active salt produced signals that were several orders of magnitude greater than those produced by typical protein crystals. In general, SHG-active salts were identifiable through characteristically strong SHG and negligible two-photon-excited UV fluorescence (TPE-UVF). Exceptions included trials containing either potassium dihydrogen phosphate or ammonium formate, which produced particularly strong SHG, but with residual weak TPE-UVF signals that could potentially complicate discrimination in crystallization experiments using these precipitants. In the experiment, the researchers used many compounds, for example, Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Category: alcohols-buliding-blocks)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Category: alcohols-buliding-blocks It is utilized to break up emulsion in organic synthesis as well as a common precipitant in protein crystallography.

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