Tag: 200-300

The author of 《Convenient and flexible syntheses of gem-dimethyl carboxylic triggers via mono-selective β-C(sp3)-H arylation of pivalic acid with ortho-substituted aryl iodides》 were Huang, Yongliang; Du, Yu; Su, Weiping. And the article was published in Organic Chemistry Frontiers in 2022. HPLC of Formula: 20880-92-6 The author mentioned the following in the article:

This work presents a palladium(II)-catalyzed mono-selective C(sp3)-H arylation of pivalic acid for rapid construction of an important library of 3-aryl-2,2-dimethylpropanoic acids, especially ortho-substituted-aryl compounds The strategy greatly streamlines access to a series of trimethyl-lock-type triggers – arylated gem-di-Me carboxylic acids bearing ortho-activatable substituents, which was used as a self-immolative spacer for selective chem. release initiated under specific conditions. Flexible transformation and derivatization of these activatable carboxylic triggers were also showcased. The results came from multiple reactions, including the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6HPLC of Formula: 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.HPLC of Formula: 20880-92-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Stavber, Stojan; Kosir, Iztok; Zupan, Marko published an article in Journal of Organic Chemistry. The title of the article was 《Reactions of Alcohols with Cesium Fluoroxysulfate》.SDS of cas: 63012-03-3 The author mentioned the following in the article:

The reactions of alcs. with cesium fluoroxysulfate (CsSO4F) in MeCN suspension were studied, and the role of the structure of the alc. and the reaction conditions on the course of reaction was determined Secondary benzyl alcs. bearing a nonactivating aromatic ring were selectively oxidized to the corresponding ketones, while the CsSO4F-mediated reaction of phenyl-1-naphthylmethanol resulted in the formation of 1-fluoronaphthalene and benzaldehyde. Cyclic and noncyclic secondary alcs. were readily converted to ketones, as well as 1-hydroxybenzocyclanes to benzocyclanones-1, without any further fluorination or oxidation under the reaction conditions. On the other hand, reactions of primary alcs. with CsSO4F resulted in the formation of acid fluorides derived from further fluorination of aldehydes. Another type of transformation was observed in the case of alcs. bearing a benzyl functional group attached geminal to a hydroxy group, where decarbonylation of reactive intermediates resulting in the formation of benzyl fluoride derivatives became the main process. 2-Phenylethanol was so converted to benzyl fluoride and phenylacetyl fluoride in a 3:1 relative ratio, while 2-phenyl-1-propanol was selectively transformed to 1-phenyl-1-fluoroethane. The presence of the radical inhibitor nitrobenzene in the reaction mixture considerably inhibited conversion of the starting material. The same effect was observed by lowering the solvent polarity. Hammett correlation anal. of the effect of substituents on the reaction rates of oxidation of a set of substituted 1-phenyl-1-ethanols to acetophenones gave the reaction constant ρ+ = -0.32, while anal. of analogous data for the transformations of benzyl alcs. to benzoyl fluorides gave the value of -0.54. A mechanism including radical intermediates was proposed for the transformation of alcs. by CsSO4F. In the part of experimental materials, we found many familiar compounds, such as (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3SDS of cas: 63012-03-3)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.SDS of cas: 63012-03-3 The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Desymmetrization of C2-Symmetric Bis(Boronic Esters) by Zweifel Olefinations》 was published in Chemistry – A European Journal in 2020. These research results belong to Linne, Yannick; Schoenwald, Axel; Weissbach, Sebastian; Kalesse, Markus. Electric Literature of C13H26B2O4 The article mentions the following:

Anti-Configured 1,3-di-Me deoxypropionate motifs are important sub structures in natural products. Herein, we describe a bidirectional approach for the rapid construction of natural products featuring such motifs by using C2-sym. 1,3-bis(boronic esters). As for its application in convergent syntheses it was important to establish a selective mono-Zweifel olefination we describe the scope and limitations by using different 1,3-bis(boronic esters) and nucleophiles. This protocol takes advantage of the combination of the Hoppe-Matteson-Zweifel chem., which was elegantly put into practice by Aggarwal et al. In order to show its applicability the total syntheses of two natural products, serricornin and (+)-invictolide, were performed. The experimental part of the paper was very detailed, including the reaction process of Bis[(pinacolato)boryl]methane(cas: 78782-17-9Electric Literature of C13H26B2O4)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Electric Literature of C13H26B2O4 Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Oxidation-Sensitive Dextran-Based Polymer with Improved Processability through Stable Boronic Ester Groups》 were Manaster, Amanda J.; Batty, Cole; Tiet, Pamela; Ooi, Annabelle; Bachelder, Eric M.; Ainslie, Kristy M.; Broaders, Kyle E.. And the article was published in ACS Applied Bio Materials in 2019. Formula: C12H17BO2 The author mentioned the following in the article:

Particulate immunotherapy holds promise to vaccinate or treat a broad array of illnesses, including cancer, infectious diseases, and autoimmune disorders. The rate of antigen release from nano/microparticles (MPs) can impact both the type and quality of the immune response they elicit. The lysosomes of antigen presenting cells are highly oxidizing. Thus, an oxidation-sensitive vehicle could enable a significant advancement in effective MP immunotherapy. One promising class of materials being developed toward this end are aryl boronate-modified dextran polymers. The boronic esters used for oxidation-sensitive materials and sensors are typically made using pinacol (Pin) as a diol. However, Pin-based aryl boronate-modified polymers are capable of transesterifying with biogenic diols, which can lead to undesirable interactions and poor material properties. To solve this, pinanediol (PD) was used in place of Pin in the synthesis of an aryl-boronate modified dextran polymer (PDB-Dex), yielding a highly stable boronic ester. This modified dextran reverses its water solubility as desired, and improves on Pin-based materials by maintaining its solubility in organic solvents. MPs could be prepared by emulsion, nanopptn., and electrospray techniques. Hydrogen peroxide-triggered degradation of microparticles was quantified colorimetrically, and the mechanism was probed using 1H-NMR. Preliminary in vitro studies show low cytotoxicity and the ability to deliver an immunostimulatory agent. In the experiment, the researchers used 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Formula: C12H17BO2)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) also known as boronate ester, is generally used in metal-catalyzed C-C bond formation reactions like Suzuki–Miyaura reaction.Formula: C12H17BO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanolOn June 3, 2022, Yoshida, Tatsuki; Honda, Yuki; Morofuji, Tatsuya; Kano, Naokazu published an article in Journal of Organic Chemistry. The article was 《Transition-Metal-Free O-Arylation of Alcohols and Phenols with S-Arylphenothiaziniums》. The article mentions the following:

Herein, authors report the transition-metal-free O-arylation of alcs. and phenols with S-arylphenothiaziniums, which can be easily synthesized from boronic acids. Aryl substituents derived from arylboronic acids were selectively introduced into the hydroxy groups in alcs. and phenols, and a variety of aryl ethers were synthesized. This selectivity is supported by theor. calculations In addition to this study using ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, there are many other studies that have used ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol) was used in this study.

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanolOn September 30, 2019 ,《Novel sugar based acrylate: synthesis, characterization and polymerization》 was published in Journal of Polymer Materials. The article was written by Koruyucu, Meryem; Saltan, Fehmi; Kok, Gokhan; Akat, Hakan; Salman, Yesim. The article contains the following contents:

The present study has demonstrated that novel acrylic glycopolymers are successfully prepared by using monosaccharides containing an acrylate group (9-12). For this purpose, sugar based acrylate monomers were synthesized via ring opening method (Method B) and homopolymerization of this sugar oxypropylacrylates was performed using free radical polymerization The characterization of all the monomers and polymers were verified by 1HNMR, 13CNMR, FTIR and GPC techniques. The Glass transition temperatures and thermal characteristics of the polymers were also analyzed by using DSC and TG techniques. The thermal stability of prepared polymers have changed with the stereochem. of the carbohydrate moiety. Also, the mol. weight of the polymers has affected the thermal stability. The experimental process involved the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Reference of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.Reference of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《U(VI) adsorption onto covalent organic frameworks-TpPa-1》 was written by Li, Zhuo Dai; Zhang, Huai Qiang; Xiong, Xiao Hong; Luo, Feng. Related Products of 34374-88-4This research focused onuranium adsorption wastewater triformylphloroglucinol phenylenediamine covalent organic framework adsorbent. The article conveys some information:

Covalent organic frameworks (COFs) represent an exciting new type of porous organic materials, which are constructed with organic building units via strong covalent bonds. Here in, the COF-2,4,6-Triformylphloroglucinol p-Phenylenediamine (COF-TpPa-1) was synthesized by solvothermal method for the removal of U(VI) from aqueous solution Effects of pH, adsorption dose, contact time, uranium solution concentration, temperature and adsorption and desorption cycle on the efficiency of COF-TpPa-1 removal of U(VI) are investigated. SEM, XRD, TGA and FT-IR were employed to characterize the samples and analyze adsorption mechanism. The results manifested COF-TpPa-1 has the high adsorption capacity (qm = 152 mg/g), quick adsorption kinetic, high selectivity, outstanding recycle performance and good resistance to acids, bases and high temperature The experimental process involved the reaction of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Related Products of 34374-88-4)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Phloroglucinol derivatives are a major class of secondary metabolites. Phloroglucinol compounds can be classified into monomeric, dimeric, trimeric and higher phloroglucinols, and phlorotannins.Related Products of 34374-88-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Solvolytic Reactivity of Heptafluorobutyrates and Trifluoroacetates》 was written by Denegri, Bernard; Kronja, Olga. Name: (3-Chlorophenyl)(phenyl)methanol And the article was included in Journal of Organic Chemistry on August 21 ,2009. The article conveys some information:

X,Y-substituted benzhydryl heptafluorobutyrates and trifluoroacetates were subjected to solvolysis in various methanol/water, ethanol/water, and acetone/water mixtures at 25 °C. The LFER equation log k = sf(Ef + Nf) was used to derive the nucleofuge-specific parameters (Nf and sf) for SN1-type reaction. In comparison with TFA, the HFB leaving group is a better nucleofuge for <0.5 unit of Nf. X,Y-Substituted benzhydryl trifluoroacetates solvolyze by way of SN1 reactions unless electron-withdrawing groups are attached to aromatic rings. In such cases the substrates solvolyze faster than predicted for the SN1 route because of the change in mechanism. X,Y-Substituted benzhydryl heptafluorobutyrates examined here (Ef ≥ -7.7) solvolyze according to the SN1 pathway. The almost parallel log k vs. Ef lines in various solvents for HFBs and TFAs, and the corresponding slope parameters (sf are in the range of 0.91 and 0.83), indicate early TS with moderately advanced charge separation NBO charges of HFB and TFA anions and the affinities obtained, all calculated at the PCM-B3LYP/6-311+G(2d,p)//PCM-B3LYP/6-311+G(2d,p) level, revealed that the HFB anion slightly better delocalizes the developing neg. charge than TFA, and that the affinity of the benzhydrylium ion is slightly larger toward TFA than toward the HFB anion, which is in accordance with the greater solvolytic reactivity of HFB.(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Name: (3-Chlorophenyl)(phenyl)methanol) was used in this study.

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Name: (3-Chlorophenyl)(phenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Highly active, separable and recyclable bipyridine iridium catalysts for C-H borylation reactions》 was published in Catalysis Science & Technology in 2018. These research results belong to Mamlouk, Hind; Suriboot, Jakkrit; Manyam, Praveen Kumar; AlYazidi, Ahmed; Bergbreiter, David E.; Madrahimov, Sherzod T.. Reference of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane The article mentions the following:

Iridium complexes generated from Ir(I) precursors and PIB oligomer functionalized bpy ligands efficiently catalyzed the reactions of arenes with bis(pinacolato)diboron under mild conditions to produce a variety of arylboronate compounds The activity of this PIB bound homogeneous catalyst is similar to that of an original non-recyclable catalyst which allows it to be used under milder conditions than other reported recyclable catalysts. This oligomer-supported Ir catalyst was successfully recovered through biphasic extraction and reused for eight cycles without a loss of activity. Biphasic separation after the initial use of the catalyst led to an insignificant amount of iridium leaching from the catalyst to the product, and no iridium leaching from the catalyst was observed in the subsequent recycling runs. Arylboronate products obtained after extraction are sufficiently pure as observed by 1H and 13C-NMR spectroscopy that they do not require further purification In addition to this study using 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, there are many other studies that have used 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Reference of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane) was used in this study.

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains.Reference of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cao, Li; Wu, Hong; Cao, Yu; Fan, Chunyang; Zhao, Rui; He, Xueyi; Yang, Pengfei; Shi, Benbing; You, Xinda; Jiang, Zhongyi published their research in Advanced Materials (Weinheim, Germany) in 2021. The article was titled 《Weakly Humidity-Dependent Proton-Conducting COF Membranes》.Application In Synthesis of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde The article contains the following contents:

State-of-the-art proton exchange membranes (PEMs) often suffer from significantly reduced conductivity under low relative humidity, hampering their efficient application in fuel cells. Covalent organic frameworks (COFs) with pre-designable and well-defined structures hold promise to cope with the above challenge. However, fabricating defect-free, robust COF membranes proves an extremely difficult task due to the poor processability of COF materials. Herein, a bottom-up approach is developed to synthesize intrinsic proton-conducting COF (IPC-COF) nanosheets (NUS-9) in aqueous solutions via diffusion and solvent co-mediated modulation, enabling a controlled nucleation and in-plane-dominated IPC-COF growth. These nanosheets allow the facile fabrication of IPC-COF membranes. IPC-COF membranes with crystalline, rigid ion nanochannels exhibit a weakly humidity-dependent conductivity over a wide range of humidity (30-98%), 1-2 orders of magnitude higher than that of benchmark PEMs, and a prominent fuel cell performance of 0.93 W cm-2 at 35% RH and 80 °C arising from superior water retention and Grotthuss mechanism-dominated proton conduction. After reading the article, we found that the author used 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Application In Synthesis of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.Application In Synthesis of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehydeFor acyl phloroglucinols, it is considered the largest category of compounds among phloroglucinols of natural characteristics.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts