Tag: 200-300

Recommanded Product: 76931-93-6On November 1, 2021 ,《Generation and characterisation of a semi-synthetic siderophore-immunogen conjugate and a derivative recombinant triacetylfusarinine C-specific monoclonal antibody with fungal diagnostic application》 appeared in Analytical Biochemistry. The author of the article were Moloney, Nicola M.; Larkin, Annemarie; Xu, Linan; Fitzpatrick, David A.; Crean, Holly L.; Walshe, Kieran; Haas, Hubertus; Decristoforo, Clemens; Doyle, Sean. The article conveys some information:

Invasive pulmonary aspergillosis (IPA) is a severe life-threatening condition. Diagnosis of fungal disease in general, and especially that caused by Aspergillus fumigatus is problematic. A. fumigatus secretes siderophores to acquire iron during infection, which are also essential for virulence. We describe the chemoacetylation of ferrated fusarinine C to diacetylated fusarinine C (DAFC), followed by protein conjugation, which facilitated triacetylfusarinine C (TAFC)-specific monoclonal antibody production with specific recognition of the ferrated form of TAFC. A single monoclonal antibody sequence was ultimately elucidated by a combinatorial strategy involving protein LC-MS/MS, cDNA sequencing, and RNAseq. The resultant murine IgG2a monoclonal antibody was secreted in, and purified from, mammalian cell culture (5 mg) and demonstrated to be highly specific for TAFC detection by competitive ELISA (detection limit: 15 nM) and in a lateral flow test system (detection limit: 3 ng), using gold nanoparticle conjugated-DAFC-bovine serum albumin for competition. Overall, this work reveals for the 1st time a recombinant TAFC-specific monoclonal antibody with diagnostic potential for IPA diagnosis in traditional and emerging patient groups (e.g., COVID-19) and presents a useful strategy for murine Ig sequence determination, and expression in HEK293 cells, to overcome unexpected limitations associated with aberrant or deficient murine monoclonal antibody production In addition to this study using 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate, there are many other studies that have used 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Recommanded Product: 76931-93-6) was used in this study.

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine being a good nucleophile easily undergoes electrophilic substitution reactions with different electrophiles such alkyl halides and acyl halides, and forms N-substituted pyrrolidines. N-Alkylpyrrolidine on further reaction with alkyl halide provided quaternary salts.Recommanded Product: 76931-93-6

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Product Details of 63012-03-3On November 30, 2021 ,《Regio- and Stereoselective Synthesis of (Z)- 3-Ylidenephthalides via H3PMo12O40-Catalyzed Cyclization of 2-Acylbenzoic Acids with Benzylic Alcohols》 appeared in Chinese Journal of Chemistry. The author of the article were Yang, Guoping; Li, Ke; Lin, Xiaoling; Li, Yijin; Cui, Chengxing; Li, Shixiong; Cheng, Yuanyuan; Liu, Yufeng. The article conveys some information:

Author report an exclusively tandem C-O and C-C bond forming beyond the esterification and cyclization reaction of 2-acylbenzoic acids with alcs. to regio- and stereoselective synthesis of the (Z)-3-ylidenephthalides. The reaction uses the nontoxic, inexpensive H3PMo12O40 as catalyst and produces water as the sole byproduct, making the reaction environmentally benign and sustainable. Moreover, this reaction features an eco-friendly reaction condition, facile scalability, and easy derivatization of the products to drugs and bioactive compounds The mechanism studies and d. functional theory calculations reveal that the appropriate acid catalyst is the key to the selectivity of this transformation. The experimental part of the paper was very detailed, including the reaction process of (3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3Product Details of 63012-03-3)

(3-Chlorophenyl)(phenyl)methanol(cas: 63012-03-3) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Product Details of 63012-03-3

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《Regioselective C(sp3)-H alkylation of a fructopyranose derivative by 1,6-HAT》 was published in Organic & Biomolecular Chemistry in 2021. These research results belong to Li, Yanru; Miyamoto, Shoto; Torigoe, Takeru; Kuninobu, Yoichiro. Recommanded Product: 20880-92-6 The article mentions the following:

Regioselective C(sp3)-H alkylation of a fructopyranose derivative using electron-deficient alkenes as alkylation reagents was achieved. The reaction proceeded via 1,6-hydrogen atom transfer under photoredox iridium catalysis. Several functional groups were introduced into the fructopyranose derivative The experimental process involved the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Recommanded Product: 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.Recommanded Product: 20880-92-6 And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

Referemce:
Alcohol – Wikipedia,
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《Photocatalytic C-X borylation of aryl halides by hierarchical SiC nanowire-supported Pd nanoparticles》 was written by Jiao, Zhi-Feng; Zhao, Ji-Xiao; Guo, Xiao-Ning; Guo, Xiang-Yun. COA of Formula: C12H17BO2 And the article was included in Chinese Journal of Catalysis in 2020. The article conveys some information:

Hierarchical SiC nanowire-supported Pd nanoparticles showed high photocatalytic activity for the C-X (X = Br, I) borylation of aryl halides at 30°C. The SiC/Pd Mott-Schottky contact enhances the rapid transfer of the photogenerated electrons from SiC to the Pd nanoparticles. As a result, the concentrated energetic electrons in the Pd nanoparticles can facilitate the cleavage of C-I or C-Br bonds, which normally requires high-temperature thermal processes. We show that the present Pd/SiC photocatalyst is capable of catalyzing the transformation of a large variety of aryl halides to their corresponding boronate esters under visible light irradiation, with excellent yields. In the experiment, the researchers used 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6COA of Formula: C12H17BO2)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) also known as boronate ester, is generally used in metal-catalyzed C-C bond formation reactions like Suzuki–Miyaura reaction.COA of Formula: C12H17BO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Ion Rejection in Covalent Organic Frameworks: Revealing the Overlooked Effect of In-Pore Transport》 were Xu, Fang; Wei, Mingjie; Zhang, Xin; Wang, Yong. And the article was published in ACS Applied Materials & Interfaces in 2019. Product Details of 34374-88-4 The author mentioned the following in the article:

Covalent organic frameworks (COFs), possessing highly ordered and intrinsic nanopores with high d. and tunable sizes, are expected to find important applications in ion separation and desalination. The design of COF membranes with outstanding permselectivity requires understanding the ion rejection behaviors of COF multilayers. However, the ion rejection mechanism of COF multilayers remains to be elucidated because it may significantly differ from that of conventional polyamide membranes. Herein, we use nonequilibrium mol. dynamics simulations to investigate the ion transport through multilayers of TpHZ, which is a stable, imine-linked COF. Surprisingly, we find that the rejection to NaCl is determined by its rejection to Na+ rather than to Cl-, although hydrated Cl- is bigger than hydrated Na+. Inside the channels of the TpHZ multilayers, Na+ ions transport evidently slower than water mols., implying that the in-pore transport effect instead of the commonly thought pore-entrance sieving effect governs ion rejection. The in-pore transport effect of Na+ is mainly due to the hydration of Na+ with pore wall and stronger capability of the hydrated Na+ ions to form hydrogen bonds with pore wall, both of which are primarily originated from the polarity of the COF. This work reveals the significant role of in-pore transport in ion rejection, which is overlooked in commonly used polyamide desalination membranes, and develops a universal equation capable of describing ion rejections of all membranes, especially those that contain structures of nanopores or nanochannels by considering both the effects of pore-entrance sieving and in-pore transport. The results came from multiple reactions, including the reaction of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Product Details of 34374-88-4)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Regarding monomeric phloroglucinols, this group encompasses acryl phloroglucinols, phloroglucinol-terpene adducts, phloroglucinol glycosides, halogenated phloroglucinols, prenylated phloroglucinols, and cyclicroup polyketides.Product Details of 34374-88-4

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《A Sequential Process of Graphene Exfoliation and Site-Selective Copper/Graphene Metallization Enabled by Multifunctional 1-Pyrenebutyric Acid Tetrabutylammonium Salt》 were Zhao, Jie; Wen, Chenyu; Sun, Rui; Zhang, Shi-Li; Wu, Biao; Zhang, Zhi-Bin. And the article was published in ACS Applied Materials & Interfaces in 2019. HPLC of Formula: 6381-59-5 The author mentioned the following in the article:

This paper reports a procedure leading to shear exfoliation of pristine few-layer graphene flakes in water and subsequent site-selective formation of Cu/graphene films on polymer substrates, both of which are enabled by employing the water soluble 1-pyrenebutyric acid tetrabutylammonium salt (PyB-TBA). The exfoliation with PyB-TBA as an enhancer leads to as-deposited graphene films dried at 90°C that are characterized by elec. conductivity of ∼110 S/m. Owing to the good affinity of the tetrabutylammonium cations to the catalyst PdCl42-, electroless copper deposition selectively in the graphene films is initiated, resulting in a self-aligned formation of highly conductive Cu/graphene films at room temperature The excellent solution-phase and low-temperature processability, self-aligned copper growth, and high elec. conductivity of the Cu/graphene films have permitted fabrication of several electronic circuits on plastic foils, thereby indicating their great potential in compliant, flexible, and printed electronics. In the experiment, the researchers used many compounds, for example, Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5HPLC of Formula: 6381-59-5)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. HPLC of Formula: 6381-59-5 Potassium sodium tartrate tetrahydrate has been used in the preparation of Lowry reagent for the determination of microsomal protein concentration in rat hepatic microsomes by Lowry method.

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,ACS Applied Materials & Interfaces included an article by Wu, Yang; Yan, Dongwan; Zhang, Zhongyue; Matsushita, Michio M.; Awaga, Kunio. Electric Literature of C9H6O6. The article was titled 《Electron Highways into Nanochannels of Covalent Organic Frameworks for High Electrical Conductivity and Energy Storage》. The information in the text is summarized as follows:

To enhance the electron transfer within the covalent organic frameworks (COFs), we obtained a nanocomposite of conductive poly(3,4-ethylenedioxythiophene) (PEDOT) and redox-active AQ-COF by performing a facile in situ solid-state polymerization inside the nanochannels of COFs. The PEDOT chains functioned like electron highways within the nanochannels, resulting in a PEDOT@AQ-COF nanocomposite with an excellent elec. conductivity of 1.1 S cm-1 and a remarkably improved performance in faradaic energy storage. The all-organic PEDOT@AQ-COF electrode showed specific capacitance as high as 1663 F g-1 (at 1 A g-1), ultrafast charge/discharge rate performance (998 F g-1 at 500 A g-1), and excellent stability for 10 000 cycles. This research demonstrates a promising strategy for increasing the conductivity of COF-based materials and broadening their applications. The experimental process involved the reaction of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Electric Literature of C9H6O6)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.Electric Literature of C9H6O6For acyl phloroglucinols, it is considered the largest category of compounds among phloroglucinols of natural characteristics.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2014,Yin, Qun-jian; Chen, Xiao-xiao; Yang, Hong-sheng; Lin, Ming-shi; Mao, Xin-qi; Fang, Zai-guang published 《Fermentation conditions optimization for agarase-producing strain and the enzymatic properties》.Shipin Gongye (Shanghai, China) published the findings.Application of 6381-59-5 The information in the text is summarized as follows:

To improve enzyme activity, optimize the fermentation conditions and study its enzymic properties, the optimum fermentation conditions were determined by single factor experiments and orthogonal experiments: 0.3% yeast extract, 1.2% agar, pH 8, 28 °C, 0.02% K2HPO4 and 0.02% CaCl2. The optimized enzyme activity was up to 576.25 U/mL, which was 2.05 times compared with that before. Among yeast extract concentration, agar concentration and pH the three factors, pH played the most important role in the enzymic activity while yeast extract concentration the least. Studies on enzymic properties showed that its optimal temperature and pH were 36 °C and 7.5, resp. It was stable at pH 6.5-8 and 20-45 °C. The strain had the potential to produce agar oligosaccharide efficiently because of its high efficient degradation and good stability. After reading the article, we found that the author used Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Application of 6381-59-5)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Application of 6381-59-5 It is utilized to break up emulsion in organic synthesis as well as a common precipitant in protein crystallography.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xing, Wei-Long; Wang, Jia-Xin; Fu, Ming-Chen; Fu, Yao published an article on February 1 ,2022. The article was titled 《Efficient Decarboxylative/Defluorinative Alkylation for the Synthesis of gem-Difluoroalkenes through an SN2′ Type Route》, and you may find the article in Chinese Journal of Chemistry.Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol The information in the text is summarized as follows:

An efficient decarboxylative/defluorinative alkylation for synthesizing gem-difluoroalkenes F2C:CRCH2CR1R2R3 [R = 4-PhC6H4, naphthalen-2-yl, 1-methyl-1H-indol-5-yl, etc.; R1 = H, Me, Et; R2 = H, Me, Et, Ph, etc.; R1R2 = (CH2)3; R3 = Ph, CN, COOEt, etc.] is described, providing a general method for installation of the challenging alkyl fragments containing γ-electron-withdrawing groups into γ-trifluoromethyl alkenes RC(CF3):CH2. Mechanistic studies suggest that this process involves an SN2′-type synthetic route in the absence of transition-metal catalysts or photocatalysis. Moreover, this protocol can easily be scaled up, and successfully applied to the modification of biol. active mols., thus complementing methodologies that give access to structurally versatile gem-difluoroalkenes. The experimental process involved the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Base-Mediated O-Arylation of Alcohols and Phenols by Triarylsulfonium Triflates》 were Ming, Xiao-Xia; Tian, Ze-Yu; Zhang, Cheng-Pan. And the article was published in Chemistry – An Asian Journal in 2019. Recommanded Product: 20880-92-6 The author mentioned the following in the article:

A mild and efficient protocol for O-arylation of alcs. and phenols by triarylsulfonium triflates was developed under transition-metal-free conditions. Various alcs., including primary, secondary and tertiary and phenols bearing either electron-donating or electron-withdrawing groups on the aryl rings were smoothly converted to form the corresponding aromatic ethers e.g., I in moderate to excellent yields. The reactions were conducted at 50 or 80 °C for 24 h in the presence of a certain base and showed good functional group tolerance. The base-mediated arylation with asym. triarylsulfonium salts could selectively transfer the aryl groups of sulfoniums to alcs., depending on their inherent electronic nature. The mechanistic studies revealed that the reaction might proceed through the nucleophilic attack of the in situ formed alkoxy or phenoxy anions at the aromatic carbon atoms of the C-S bonds of triarylsulfonium cations to furnish the target products. In the experiment, the researchers used ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Recommanded Product: 20880-92-6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Recommanded Product: 20880-92-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts