Tag: 200-300

On October 12, 2000, Link, James; Liu, Gang; Pei, Zhonghua; Von Geldern, Thomas W.; Winn, Martin; Xin, Zhili; Wang, Sheldon; Boyd, Steven A.; Zhu, Gui-Dong; Freeman, Jennifer C.; Gunawardana, Indrani W.; Staeger, Michael A.; Jae, Hwan-soo; Lynch, John K. published a patent.Category: alcohols-buliding-blocks The title of the patent was Preparation of 2- or 4-(phenylthio)cinnamides as cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds. And the patent contained the following:

The title compounds (I) [wherein R1-R5 = independently H, halo, (halo)alkyl, alkoxy, cyano, NO2, CHO, and least one of R1 or R3 is an (un)substituted cis- or trans-cinnamide; Ar = (un)substituted (hetero)aryl] were prepared as cell adhesion inhibitors for the treatment of inflammatory and immune diseases. Examples include syntheses for 443 invention compounds and data for 3 bioassays. For instance, a mixture of 2-[(2,4-dichlorophenyl)thio]benzaldehyde (preparation given), malonic acid, piperidine in anhydrous pyridine was heated at 110° for 2 h and then treated with aqueous HCl to give trans-2-[(2,4-dichlorophenyl)thio]cinnamic acid (91%). Conversion to the acid chloride followed by amidation with 6-amino-1-hexanol gave (E)-II (90%). In an integrin LFA-1/ICAM-1 biochem. interaction assay, I demonstrated inhibition at 4 μM. In cell-based adhesion assays which measure the ability of test compounds to block adherence of JY-8 cells (a human EBV-transformed B cell line expressing LFA-1 on its surface) to immobilized ICAM-1 or ICAM-3, I exhibited blocking activity at 4 μM and 0.6 μM, resp. The experimental process involved the reaction of (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol(cas: 280752-78-5).Category: alcohols-buliding-blocks

The Article related to phenylthio cinnamide preparation cell adhesion inhibitor, aminocarbonylethenylphenyl phenyl sulfide preparation antiinflammatory, sulfide aminocarbonylethenylphenyl phenyl preparation immunosuppressant and other aspects.Category: alcohols-buliding-blocks

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On January 8, 2020, Wang, Zhuolin; Xiao, Qing; Zhuang, Jinda; Feng, Tao; Ho, Chi-Tang; Song, Shiqing published an article.Related Products of 96-76-4 The title of the article was Characterization of aroma-active compounds in four yeast extracts using instrumental and sensory techniques. And the article contained the following:

Gas chromatog.-olfactometry coupled with sensory anal. and partial least-squares regression (PLSR) anal. led to the identification of the odorants responsible for the different flavors of four yeast extracts Sensory anal. showed that LA00L had an intense sulfurous attribute, and LA00 was characterized by fatty and green notes, FA31 exhibited the floral odor, while KA02 had strong phenolic, animal, fermented, roasted, and caramellic notes. A total of 37 key aroma compounds with odor activity values greater than 1 were determined 2,4-Di-tert-butylphenol and methional were the most potent aroma compounds In addition, the key aroma compounds in LA00L were nonanal, di-Me disulfide, and γ-decalactone. Octanal, di-Me disulfide, and benzeneacetaldehyde were the key aroma compounds in LA00. In FA31, styrene, benzeneacetaldehyde, and acetophenone were the key aroma compounds, while indole, 2-methoxyphenol, benzeneacetaldehyde, and p-cresol contributed significantly to the aroma of KA02. PLSR showed that p-cresol and indole were significantly responsible for the phenolic and animal notes inducing the off-flavor (yeasty odor) of yeasty extracts More significantly, indole was first reported to have an important effect on yeasty odor. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Related Products of 96-76-4

The Article related to aroma yeast extract olfactometry gc, aroma-active compounds, gas chromatography−olfactometry, odor activity value, partial least-squares regression, solvent-assisted flavor evaporation, yeast extracts and other aspects.Related Products of 96-76-4

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On May 31, 2021, Thekkangil, Aswani; George, Benu; Prakash, S. M. Udaya; Suchithra, T. V. published an article.Safety of 2,4-Di-tert-butylphenol The title of the article was Mechanism of streptomyces albidoflavus STV1572a derived 1-heneicosanol as an inhibitor against squalene epoxidase of Trichophyton mentagrophytes. And the article contained the following:

An increase in incidences of tinea infections paves the way to discover the novel antifungal drugs from unexplored natural resources. The quality of life in patients with tinea infection may be affected by different factors, including morbidity, length of illness, social and demog. factors. The present investigation explores the functional principle of a bioactive compound isolated from actinomycetes, S. albidoflavus STV1572a by in-silico and in-vitro studies. In continuation of our previous reports on the antidermatophytic potential of S. albidoflavus STV1572a, this study progresses with the in-silico mol. docking study of the seven GC-MS discovered ligands, and six dermatophytic modelled targets. Through virtual screening, it was revealed that a docking score -8.8 between 1-heneicosanol and squalene epoxidase favored partially in understanding the mode of action. Further validation of in-silico study was performed by a sterol quantification assay which confirmed the antidermatophytic mechanism of 1-heneicosanol. Taken together, the evidence from this study suggests that 1-heneicosanol has a potential antidermatophytic compound and can be considered for dermatophytic treatment. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Safety of 2,4-Di-tert-butylphenol

The Article related to trichophyton mentagrophytes streptomyces albidoflavus heneicosanol squalene epoxidase, 1-heneicosanol, squalene epoxidase, sterol quantification assay, streptomyces, t. mentagrophytes, tinea infection and other aspects.Safety of 2,4-Di-tert-butylphenol

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On July 6, 2000, Link, James; Liu, Gang; Pei, Zhonghua; Von Geldern, Tom; Winn, Martin; Xin, Zhili; Boyd, Steven A.; Jae, Hwan-Soo; Lynch, John K.; Zhu, Gui-Dong; Freeman, Jennifer C.; Gunawardana, Indrani W.; Staeger, Michael A. published a patent.Quality Control of (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol The title of the patent was Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds. And the patent contained the following:

The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal. Among the approx. 400 trans-arylthiocinnamamide title compounds, prepared by standard methods, were 6-benzodioxanyl 2-trifluoromethyl-4-[(E)-2-[3-(R)-(ethoxycarbonyl)piperidinocarbonyl]ethenyl]phenyl sulfide (I), 2-ethoxyphenyl 2-trifluoromethyl-4-[(E)-2-[2-carboxy-4-(methoxycarbonyl)-1-piperazinylcarbonyl]ethenyl]phenyl sulfide (II) and 2-isopropylphenyl 2-nitro-4-[(E)-2-[3-(2-oxo-1-pyrrolidinyl)-1-propylaminocarbonyl]ethenyl]phenyl sulfide (III). The abilities of the title compounds to antagonize the interaction between ICAM-1 and LFA-1 were quantified using both biochem. and cell-based adhesion assays. E.g., compounds I-III exhibited 98% inhibition @ 4μM. The experimental process involved the reaction of (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol(cas: 280752-78-5).Quality Control of (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol

The Article related to antiinflammatory arylthiocinnamamide preparation, immune suppressive arylthiocinnamamide preparation, cell adhesion inhibitor arylthiocinnamamide preparation, cinnamamide arylthio hetaryl preparation and other aspects.Quality Control of (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol

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On November 30, 2022, Dieguez-Santana, Karel; Nachimba-Mayanchi, Manuel Mesias; Puris, Amilkar; Gutierrez, Roldan Torres; Gonzalez-Diaz, Humberto published an article.Computed Properties of 4719-04-4 The title of the article was Prediction of acute toxicity of pesticides for Americamysis bahia using linear and nonlinear QSTR modelling approaches. And the article contained the following:

Globally, pesticides are toxic substances with wide applications. However, the widespread use of pesticides has received increasing attention from regulatory agencies due to their various acute and chronic effects on multiple organisms. In this study, Quant. Structure-Toxicity Relationship (QSTR) models were established using Multiple Linear Regression (MLR) and five Machine Learning (ML) algorithms to predict pesticide toxicity in Americamysis bahia. The most influential descriptors included in the MLR model are RBF, JGI2, nCbH, nRCOOR, nRSR, nPO4 and ‘Cl-090′, with pos. contributions to the dependent variable (neg. decimal logarithm of median lethal concentration at 96-h). The Random Forest (RF) regression model was superior amongst the five ML models. We observed higher values of R2 (0.812) and lower values of RMSE (0.595) and MAE (0.462) in the cross-validation training set and external validation set. Similarly, this study had a high level of fitness and was internally robust and externally predictive compared to models presented in similar studies. The results suggest that the developed QSTR models are suitable for reliably predicting the aquatic toxicity of structurally diverse pesticides and can be used for screening, prioritising new pesticides, filling data gaps and overcoming the limitations of in vivo and in vitro tests. The experimental process involved the reaction of 2,2’,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Computed Properties of 4719-04-4

The Article related to pesticide acute toxicity americamysis bahia linear nonlinear qstr modeling, aquatic toxicity, machine learning, multiple linear regression, quantitative structure–toxicity relationship, random forest and other aspects.Computed Properties of 4719-04-4

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On January 31, 2021, Jiang, Qian; Liu, He; Zhang, Yan; Cui, Min-hua; Fu, Bo; Liu, Hong-bo published an article.Name: 2,4-Di-tert-butylphenol The title of the article was Insight into sludge anaerobic digestion with granular activated carbon addition: Methanogenic acceleration and methane reduction relief. And the article contained the following:

In this study, the multiple effects of granular activated carbon (GAC) on sludge anaerobic digestion at ambient (16-24°C), mesophilic (35°C) and thermophilic (55°C) temperature were investigated. After GAC addition, although the methane yields of raw sludge were reduced by 6.5%-36.9%, the lag phases of methanogenesis were shortened by 19.3%-30.6% and the reductions of methane yields were declined to only 5.9%-8.1% simultaneously for pretreated sludge. The inhibitory substances like phenols that generated by thermal pretreatment were reduced after GAC addition, which were demonstrated to be responsible for the methanogenic acceleration. Meanwhile, the methane reduction due to the non-selective adsorption by GAC could be mitigated by pretreatment and elevated temperature Thus, a strategy coupling thermal pretreatment with detoxification by GAC was proposed to improve the methane production rate and avoid the neg. effects during sludge anaerobic digestion with GAC addition The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Name: 2,4-Di-tert-butylphenol

The Article related to methanogenic acceleration methane reduction sludge anaerobic digestion, anaerobic digestion, granular activated carbon, methane reduction relief, methanogenic acceleration, waste activated sludge and other aspects.Name: 2,4-Di-tert-butylphenol

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On April 12, 2005, Link, James; Liu, Gang; Pei, Zhonghua; Von Geldern, Tom; Winn, Martin; Xin, Zhili; Boyd, Steven A.; Zhu, Gui-Dong; Freeman, Jennifer C.; Gunawardana, Indrani W.; Staeger, Michael A.; Jae, Hwan-Soo; Lynch, John K.; Wang, Sheldon published a patent.Application of 280752-78-5 The title of the patent was Preparation of 2- or 4-(phenylthio)cinnamides as cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds. And the patent contained the following:

The title compounds (I) [wherein R1, R2, R4, R5 = independently H, halo, (halo)alkyl, alkoxy, cyano, NO2, CHO, heterocyclylsulfanyl, (un)substituted cis- or trans-cinnamide; R3 = (un)substituted cis- or trans-cinnamide; Ar = (un)substituted (hetero)aryl] were prepared as cell adhesion inhibitors for the treatment of inflammatory and immune diseases. Examples include syntheses for 443 invention compounds and data for 3 bioassays. For instance, a mixture of 2-[(2,4-dichlorophenyl)thio]benzaldehyde (preparation given), malonic acid, piperidine in anhydrous pyridine was heated at 110°C for 2 h and then treated with aqueous HCl to give trans-2-[(2,4-dichlorophenyl)thio]cinnamic acid (91%). Conversion to the acid chloride followed by amidation with 6-amino-1-hexanol gave (E)-II (90%). In an integrin LFA-1/ICAM-1 biochem. interaction assay, I demonstrated inhibition at 4 μM. In cell-based adhesion assays which measure the ability of test compounds to block adherence of JY-8 cells (a human EBV-transformed B cell line expressing LFA-1 on its surface) to immobilized ICAM-1 or ICAM-3, I exhibited blocking activity at 4 μM and 0.6 μM, resp. The experimental process involved the reaction of (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol(cas: 280752-78-5).Application of 280752-78-5

The Article related to phenylthio cinnamide preparation cell adhesion inhibitor icam1 lfa1, aminocarbonylethenylphenyl phenyl sulfide preparation antiinflammatory, sulfide aminocarbonylethenylphenyl phenyl preparation immunosuppressant and other aspects.Application of 280752-78-5

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Alcohol – Wikipedia,
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Tsochatzis, Emmanouil; Lopes, Joao Alberto; Gika, Helen; Theodoridis, Georgios published an article in 2021, the title of the article was Polystyrene biodegradation by Tenebrio molitor larvae: identification of generated substances using a GC-MS untargeted screening method.SDS of cas: 96-76-4 And the article contains the following content:

A GC-MS method has been applied to screen and evaluate the generation of chem. compounds during the biodegradation of polystyrene (PS) with Tenebrio molitor larvae. Several resulting compounds have been identified, including trimers 2,4,6-triphenyl-1-hexene and 1,3,5-triphenylcyclohexane, the volatiles acetophenone and cumyl alc., and 2,4-di-tert butylphenol, a non-intentionally added substance (NIAS) present in the plastic material. The PS monomers styrene and a-Me styrene were also identified in the extracts Bioactive mols. present in the biomass of the studied insects were identified, such as the free fatty acids myristic, palmitic, and oleic acid. Undecanoic acid was also found, but in lower mass fractions. Finally, biochem. formatted amides resulting from their resp. fatty acids were identified, namely tetradecanamide, hexadecanamide and oleamide. The formation of all these substances seems to suggest enzymic and biochem. activity occurring during the biodegradation of PS, and their amounts varied throughout the experience. The overall degradation rate of PS resulted in a 13% rate, which highlights the potential of biorecycling using these insects. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).SDS of cas: 96-76-4

The Article related to tenebrio molitor larvae polystyrene biodegradation gcms screening method, gc-ms analysis, chemical compounds formed during bio-degradation, insects assisted biodegradation of polystyrene, plastics biodegradation and biorecycling and other aspects.SDS of cas: 96-76-4

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Chung, Sheng-Hsuan; Lin, Ting-Ju; Hu, Qian-Yu; Tsai, Chia-Hua; Pan, Po-Shen published an article in 2013, the title of the article was Synthesis of boron-containing primary amines.Product Details of 1333264-06-4 And the article contains the following content:

B-containing primary amines were synthesized for use as building blocks in the study of peptoids. In the 1st step, Gabriel synthesis conditions were modified to enable the construction of seven different aminomethylphenyl boronate esters, e.g., p-(pinB)C6H4CH2NH2 (Bpin = 4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl), in good to excellent yields. These compounds were further used to build peptoid analogs via an Ugi four-component reaction (Ugi-4CR) under microwave irradiation The prepared Ugi-4CR boronate esters were then successfully converted to the corresponding boronic acids. Finally, the peptoid structures were successfully modified by cross-coupling to aryl/heteroaryl chlorides via a Pd-mediated Suzuki coupling reaction to yield the corresponding derivatives in moderate to good yields. The experimental process involved the reaction of [4-Fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol(cas: 1333264-06-4).Product Details of 1333264-06-4

The Article related to aminomethylphenyl boronate ester preparation ugi four component reaction, peptoid boronate ester preparation suzuki coupling aryl heteroaryl chloride, hydroxymethylphenyl boronate ester preparation condensation phthalimide salt and other aspects.Product Details of 1333264-06-4

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On September 30, 2001, Lysenko, I. L.; Kulinkovich, O. G. published an article.Recommanded Product: 1-[(Dibenzylamino)methyl]cyclopropanol The title of the article was A convenient procedure for preparation of 1-(1-aminoalkyl)-1-cyclopropanols from N-benzyl α-amino acid esters. And the article contained the following:

The reaction of N-benzyl α-amino acid Et esters, e.g. I, with ethylmagnesium bromide in the presence of a catalytic amount of titanium tetraisopropoxide leads to formation of the corresponding 1-aminoalkyl-1-cyclopropanols, e.g. II, in high yields. Hydrogenation of the latter over palladium catalyst ensures selective removal of one or two protecting benzyl groups from the nitrogen atom. The experimental process involved the reaction of 1-[(Dibenzylamino)methyl]cyclopropanol(cas: 428855-17-8).Recommanded Product: 1-[(Dibenzylamino)methyl]cyclopropanol

The Article related to aminoalkyl cyclopropanol asym synthesis benzyl amino acid ester cyclopropanation, aminoalkylcyclopropanol asym synthesis benzyl amino acid ester cyclopropanation, deprotection dibenzyl aminoalkyl cyclopropanol hydrogenation and other aspects.Recommanded Product: 1-[(Dibenzylamino)methyl]cyclopropanol

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