Tag: 200-300

Chen, Erbao; Song, Huanlu; Li, Yi; Chen, Haijun; Wang, Bao; Che, Xianing; Zhang, Yu; Zhao, Shuna published an article in 2020, the title of the article was Analysis of aroma components from sugarcane to non-centrifugal cane sugar using GC-O-MS.COA of Formula: C14H22O And the article contains the following content:

A total of 84 volatile aroma components were determined in the 9 samples of sugarcane to non-centrifugal sugar (NCS), including 15 alcs., 12 aldehydes, 10 ketones, 17 carboxylic acids, 11 pyrazines, 7 phenols, 3 esters, 3 hydrocarbons, and 2 sulfur compounds Of these compounds, 10 were with high flavor dilution (FD) factors based on the aroma extract dilution anal. (AEDA). 4-Hydroxy-2,5-dimethyl-3(2H)furanone exhibited the highest FD factor of 2187, followed by (E)-2-nonenal, 2-hydroxy-3-methyl-2-cyclopentene-1-one, and 4-allyl-2,6-dimethoxyphenol with a FD factor of 729. The odor compounds showed no significant change and were similar to that of sugarcane during the first four steps in the production of non-centrifugal cane sugar. In the middle three stages, the heating slightly affected the aroma composition Addnl., a prolonged period of high-temperature heating, lead to the production of the Maillard reaction products, such as pyrazines, pyrroles, and furans, differentiating the step to be unique from the previous seven stages. However, the content of the NCS odorants was significantly reduced due to the loss of odor compounds during the drying process. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).COA of Formula: C14H22O

The Article related to aroma component sugarcane non centrifugal cane sugar, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.COA of Formula: C14H22O

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On September 25, 2007, Jasinski, Marcin; Mloston, Grzegorz; Mucha, Paulina; Linden, Anthony; Heimgartner, Heinz published an article.Electric Literature of 4719-04-4 The title of the article was Synthesis of new bis-imidazole derivatives. And the article contained the following:

The reaction of aldimines with α-(hydroxyimino) ketones (1,2-diketone monooximes) was used to prepare 2-unsubstituted imidazole 3-oxides bearing an alkanol chain at N(1). These products were transformed into 2H-imidazol-2-ones and 2H-imidazole-2-thiones by treatment with Ac2O and 2,2,4,4-tetramethylcyclobutane-1,3-dithione, resp. The three-component reaction of the α-(hydroxyimino) ketones, formaldehyde, and an alkane-1,ω-diamine gave bis[1H-imidazole 3-oxides]. The latter reacted with Ac2O, 2,2,4,4-tetramethylcyclobutane-1,3-dithione or Raney-Ni to give bis[2H-imidazol-2-ones], bis[2H-imidazol-2-thione], and bis[imidazole] derivatives Two structures were established by X-ray crystallog. The experimental process involved the reaction of 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol(cas: 4719-04-4).Electric Literature of 4719-04-4

The Article related to bisimidazole preparation aldimine dione monoxime, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Electric Literature of 4719-04-4

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On December 31, 2020, Fagbohun, Oladapo F.; Oriyomi, Olumayowa V.; Adekola, Mukaila B.; Msagati, Titus A. M. published an article.Computed Properties of 96-76-4 The title of the article was Biochemical applications of Kigelia africana (Lam.) Benth. fruit extracts in diabetes mellitus. And the article contained the following:

Abstract: The use of Kigelia africana plant is beneficial in many medicinal applications. This study investigated the chem. compounds as well as antioxidant and antidiabetic activities of KA fruits in vitro and in vivo. From the result of GC-qTOF-MS, phenol-2,4-bis(1,1-dimethylethyl)-, benzene propanoic acid-3,5-bis(1,1-dimethylethyl)-4-hydroxymethylester, naphthalene-2-methyl-, and oxalic acid-4-chlorophenyl nonyl-ester were newly identified and revealed a strong binding affinity of – 6.1, – 6.3, – 6.8, and – 6.2 kcal/mol resp. The hexane and Et acetate fractions had the highest antioxidant activities with 0.14 and 0.025 mg/mL for DPPH; 91.31 and 99.20 mg AAE/g for FRAP; and 80.61 and 98.88 mg AAE/g for TPC, resp. Hexane fraction (HF) had the lowest IC50 value (1.97 mg/mL) against α-amylase. At low and middle doses, HF showed significant ameliorative activities by restoring islet cells, increasing the number of β cells, and reducing fasting blood glucose levels. Significant differences were observed in the activities of GGT and G-6-PDH. KA fruit exhibited high antidiabetic and antihyperglycemic activities in STZ-induced diabetic rats. According to mol. docking study, the use of the base structure of 2,4-ditert-butylphenol identified from K. africana fruit may serve as the novel approach to the treatment of diabetes mellitus. Graphical abstract: [graphic not available: see fulltext]. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Computed Properties of 96-76-4

The Article related to kigelia fruit extract diabetes mellitus, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Computed Properties of 96-76-4

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On June 30, 2022, Naeem, Hamna; Ahmad, Khuram Shahzad published an article.Recommanded Product: 2,4-Di-tert-butylphenol The title of the article was Fungal and bacterial assisted bioremediation of environmental toxicant (N-[2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl] ethyl]-2-(trifluoromethyl) benzamide) holding benzamidic genesis elucidating the eco-friendly strategy. And the article contained the following:

Fluopyram (FLP) containing benzamidic genesis utilized for seed detoxification and as a foliar application is associated with low profound toxicity in mammals but long-term toxicol. investigations have revealed that FLP can stimulate tumor growth. FLP attenuation has been the first time scrutinized employing microorganisms originally identified from soils. Biodegrative assays of four fungal strains; Aspergillus fumigatus (AFu), Aspergillus terreus (AT), Aspergillus flavus (AF), Aspergillus niger (AN), and three bacterial strains: Streptococcus pneumoniae (SP) Streptococcus pyogenes (SPy), and Escherichia coli (EC), were employed. Ten milligrams per L FLP concentration was made employing sep. microbe and analyzed for 35 days. The anal. technique was inclusive of UV-visible spectrophotometric and high-performance liquid chromatog. procedure endeavored to test FLP biodegradation SP and AT exhibited maximal potentiality to metabolize FLP. HPLC is indicative of several metabolites formations. FLP degradation by AFu, EC, SPy, AN, AF, AT, SP was observed to be 24.2%, 82.7%, 89.8%, 90.7%, 91.3%, 95.4%, and 99.3%, explicating the efficacy of all strains employed in FLP degradation Current investigations are indicative of significant bioremediation strategies for xenobiotic mitigation. Furthermore, the current examinations are inclusive of the augmentation of biodegradative assays to be utilized on a large scale for efficient environmental management cost-effectively and sustainably. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Recommanded Product: 2,4-Di-tert-butylphenol

The Article related to aspergillus streptococcus bioremediation fluopyram environmental toxicant benzamidic genesis, bacteria, benzamide, biodegradation, fungi, microbe, Fermentation and Bioindustrial Chemistry: Industrial Chemicals and other aspects.Recommanded Product: 2,4-Di-tert-butylphenol

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Ni, Hui; Jiang, Qing-Xiang; Zhang, Ting; Huang, Gao-Ling; Li, Li-Jun; Chen, Feng published an article in 2020, the title of the article was Characterization of the aroma of an instant white tea dried by freeze drying.Recommanded Product: 96-76-4 And the article contains the following content:

The aroma of an instant white tea (IWT) was extracted through simultaneous distillation-extraction (SDE) and analyzed by sensory evaluation, gas chromatog.-mass spectrometry-olfactometry (GC-MS-O), aroma reconstruction, omission test and synergistic interaction anal. Sensory evaluation showed the IWT was dominated with floral and sweet notes. The SDE extract had the aroma similar to the IWT. The main volatile components in the SDE extract were benzyl alc., linalool, hotrienol, geraniol, α-terpineol, coumarin, camphene, benzeneacetaldehyde, 2-hexanone, cis-jasmin lactone and phenylethyl alc. GC-MS-O and aroma reconstruction experiments showed 16 aroma-active compounds Linalool, trans-β-damascenone and camphene were the major contributors to floral, sweet and green notes based on flavor dilution anal. and omission test. Linalool and trans-β-damascenone had synergistic effect to promote floral and sweet notes. Camphene and trans-β-damascenone had synergistic effect to reduce green and sweet notes. The study helps to understand the aroma of IWT and antagonism interactions among aroma-active volatiles. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Recommanded Product: 96-76-4

The Article related to aroma instant white tea dried freeze drying, gc-ms, gc-ms-o, aroma reconstruction and omission test, instant white tea, synergistic interactions, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Recommanded Product: 96-76-4

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On May 31, 2020, Sezgin, Sema; Dalar, Abdullah; Uzun, Yusuf published an article.Product Details of 96-76-4 The title of the article was Determination of antioxidant activities and chemical composition of sequential fractions of five edible mushrooms from Turkey. And the article contained the following:

Tricholoma scalpturatum, Tricholoma populinum, Neolentinus cyathiformis, Chlorophyllum agaricoides, and Lycoperdon utriforme have been traditionally utilized as food in Turkey for a long time. The present study focused on determining antioxidant activities, total phenolic groups contents (flavonols, hydroxycinnamic acids, proanthocyanidins, and anthocyanins), phenolic compounds and fatty acids of sequential extracts (n-hexane, Et acetate, chloroform, acetone, ethanol, and pure water) obtained from five wild edible macrofungi species. Ethanol and acetone (or Et acetate) were found as the most efficient solvents in terms of antioxidant activities and extraction efficiency. Antioxidant studies showed that L. utriforme, C. agaricoides, and T. populinum exhibited the highest radical scavenging and reducing activities and contained the highest phenolic contents. Chromatog. studies revealed that phenolic acids (protocatechuic, gallic, and chlorogenic acids) and fatty acids (oleic, linoleic, and palmitic acids) were the major contributors of the antioxidant activities of the extracts The results obtained suggest the utilization of these macrofungi species as significant sources of natural antioxidants. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Product Details of 96-76-4

The Article related to antioxidant activity chem composition sequential fraction edible mushroom, antioxidant, extraction, fatty acid, mushroom, phenolic compound, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Product Details of 96-76-4

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On February 28, 2021, Fan, Xiaojing; Jiao, Xin; Liu, Jinguang; Jia, Meng; Blanchard, Chris; Zhou, Zhongkai published an article.Category: alcohols-buliding-blocks The title of the article was Characterizing the volatile compounds of different sorghum cultivars by both GC-MS and HS-GC-IMS. And the article contained the following:

The current study applied both GC-MS and GC-IMS for characterizing volatile compounds of six Australian sorghum cultivars. For raw sorghum, the result of GC-MS showed that ester compounds were abundant in six raw samples. Among these esters, the content of hexadecanoic acid Et ester was highest in all of the raw samples. Compound 3-octanone only existed in Apollo, Bazley and Liberty, and 2-undecanone was found to be in MR43. Result of GC-IMS showed that signals of benzaldehyde, 2,3-butanedione were generally noted in six raw samples. In general, The Apollo and Buster had more volatile compounds, followed by Bazley and Liberty. In contrast, MR43 and G44 had least volatile compounds For cooked sorghums, more fatty aldehydes are formed compared to its corresponding raw sample, in which current data indicated that 40 volatile compounds were identified by GC-MS, and 11 of them were identified as the key aroma compounds More important, variation in the compounds of hexanal, heptanal, octanal, 2-heptenal, nonanal, trans- 2-octenal, benzeneaceldehyde, (E)-2-nonenal, 1-octen-3-ol, 1-pentanol, 2-methoxy-4-vinylphenol and 2-pentylfuran might be applied for explaining the aroma characteristics among six sorghum cultivars. Result of GC-IMS showed that 26 volatile compounds but not in results from GC-MS detection, indicating advantage of methodol. combination for a better understanding impact of cultivars and cooking on volatile characteristics of sorghums. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Category: alcohols-buliding-blocks

The Article related to sorghum volatile compound gc ms ims, gc-ims, gc-ms, odor-active value, sorghum, volatile compound, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Category: alcohols-buliding-blocks

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On December 14, 2020, Zhang, Jiandong; Yang, Xiaoxiao; Dong, Rui; Gao, Lili; Li, Jing; Li, Xing; Huang, Shuangping; Zhang, Chaofeng; Chang, Honghong published an article.COA of Formula: C9H10F3NO The title of the article was Cascade biocatalysis for regio- and stereoselective aminohydroxylation of styrenyl olefins to enantiopure arylglycinols. And the article contained the following:

Chiral β-amino alcs. are privileged scaffolds frequently found in pharmaceutically active mols. and natural products. Aminohydroxylation of olefins is one of the most powerful strategies to access chiral vicinal amino alcs. However, the direct regio- and stereoselective aminohydroxylation of olefins to unprotected enantioenriched β-amino alcs. remains a long-standing challenge. Herein, we report that a novel one-pot four-enzyme [styrene monooxygenase (SMO)/epoxide hydrolase (EH)/alc. dehydrogenase (ADH)/ω-transaminase (TA)] biocatalytic cascade efficiently catalyzes the direct transformation of readily available styrenyl olefins into unprotected 2-amino-2-Ph ethanols in good yields and excellent enantioselectivity. In vitro cascade biocatalysis aminohydroxylation of styrenyl olefins was first investigated by the combined four enzymes (SMO/EH/ADH/TA) with a trace amount of NADH (0.02 mM) and pyridoxal-5′-phosphate (0.1 mM), affording both enantiomers of β-amino alcs. 5a-j in 13.9-98.7% conversions and 86-99% ee. Whole-cell-based cascade biocatalysis was achieved by using the constructed recombinant Escherichia coli pairwise combinations and single tailor-made whole-cell biocatalyst without an addnl. NADH cofactor; (R)- and (S)-β-amino alcs. 5a-j could be obtained in 14.6-99.7% conversions and 86-99% ee. Moreover, the preparative experiments of this new cascade biocatalysis were demonstrated by the single tailor-made whole-cell biocatalyst [E. coli (CGS-DEM) and E. coli (CGS-DEB)] with the substrates 1a-b and 1h in an aqueous-organic two-phase system, affording chiral β-amino alcs. [(R)- or (S)-5a-b, h] in good yields (50.9-64.3%) and excellent ee (>99%). A new type of cascade biocatalysis was developed for regio- and enantioselective aminohydroxylation of styrenyl olefins to useful and valuable chiral arylglycinols in good yields and excellent ee. The experimental process involved the reaction of (R)-2-Amino-2-(4-(trifluoromethyl)phenyl)ethanol(cas: 306281-86-7).COA of Formula: C9H10F3NO

The Article related to cascade reaction stereoselective aminohydroxylation styrenyl olefin arylglycinol, Fermentation and Bioindustrial Chemistry: Industrial Chemicals and other aspects.COA of Formula: C9H10F3NO

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On May 22, 2003, Walker, Daniel P.; Jacobsen, Jon E.; Acker, Brad A.; Groppi, Vincent E.; Piotrowski, David W. published a patent.Application of 280752-78-5 The title of the patent was Preparation of N-(azabicyclyl)arylamides for therapeutic use as nicotinic acetylcholine receptor agonists. And the patent contained the following:

N-(azabicyclyl)arylamides, such as RNR1C(:X)W [R = azabicyclyl; R1 = H, alkyl, cycloalkyl, haloalkyl, aryl; W = heteroaryl; X = O, S], were prepared for therapeutic use as nicotinic acetylcholine receptor agonists. These amides are useful for the treatment of central nervous system disorders, such as cognitive and attention deficit symptoms of Alzheimer’s, neurodegeneration associated with diseases such as Alzheimer’s disease, pre-senile dementia (mild cognitive impairment), senile dementia, schizophrenia, psychosis, attention deficit disorder, attention deficit hyperactivity disorder, mood and affective disorders, amyotrophic lateral sclerosis, borderline personality disorder, traumatic brain injury, behavioral and cognitive problems associated with brain tumors, AIDS dementia complex, dementia associated with Down’s syndrome, dementia associated with Lewy Bodies, Huntington’s disease, depression, general anxiety disorder, age-related macular degeneration, Parkinson’s disease, tardive dyskinesia, Pick’s disease, post traumatic stress disorder, dysregulation of food intake including bulimia and anorexia nervosa, withdrawal symptoms associated with smoking cessation and dependent drug cessation, Gilles de la Tourette’s Syndrome, glaucoma, neurodegeneration associated with glaucoma, or symptoms associated with pain. Thus, amide I was prepared in 71% yield by an amidation reaction of 1,4-benzodioxane-6-carboxylic acid with 3-(R)-aminoquinuclidine dihydrochloride using DIEA and HATU in MeCN at -10°. The prepared amides were assayed for human α7-5HT3 receptor binding activity. The experimental process involved the reaction of (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol(cas: 280752-78-5).Application of 280752-78-5

The Article related to azabicyclic heteroaryl amide preparation nicotinic acetylcholine receptor agonist, Alkaloids: Alkaloids Containing One Nitrogen Atom At A Bridgehead and other aspects.Application of 280752-78-5

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On February 12, 2015, Aida, Jumpei; Yoshitomi, Yayoi; Hitomi, Yuko; Noguchi, Naoyoshi; Hirata, Yasuhiro; Furukawa, Hideki; Shibuya, Akito; Watanabe, Koji; Miyamoto, Yasufumi; Okawa, Tomohiro; Takakura, Nobuyuki; Miwatashi, Seiji published a patent.Name: 1-[(Dibenzylamino)methyl]cyclopropanol The title of the patent was Preparation of heterocyclic compounds as GPR40 agonists, regulating method for GPR40 receptors, and preventive and therapeutic methods for diabetes. And the patent contained the following:

The heterocyclic compounds or their salts are represented by formula I [A = (un)substituted aromatic ring; B = (un)substituted 4 to 6-membered N-containing alicyclic ring; X = N, CH; R1, R2 = H, substituent; R1 and R2 may form 3 to 10-membered ring with neighbored N atom; R3, R4 = H, halo, C1-6 alkyl; R5, R7-R9 = H, halo, C1-6 alkyl, C1-6 alkoxy; R6 = halo, (un)substituted C1-6 alkyl, C1-6 alkoxy, or C3-10 cycloalkyl; R6 and R7 may form 3 to 10-membered ring with neighbored C atom]. Thus, reacting 2-fluoro-4-methoxy-N-methyl-N-(2-methylpropyl)benzamide (preparation given) with piperidine-4-methanol, etherifying with Me 3-cyclopropyl-3-(3-hydroxyphenyl)propanoate, and hydrolyzing with 1 N NaOH, gave 3-cyclopropyl-3-[3-[[1-[5-methoxy-2-[methyl(2-methylpropyl)carbamoyl]-phenyl]piperidin-4-yl]methoxy]phenyl]propanoic acid with G protein-coupled receptor 40 (GPR40) agonist activity 97%. Formulations containing I are given. The experimental process involved the reaction of 1-[(Dibenzylamino)methyl]cyclopropanol(cas: 428855-17-8).Name: 1-[(Dibenzylamino)methyl]cyclopropanol

The Article related to gpr40 regulation agonist preparation glp1 diabetes therapeutic agent, Heterocyclic Compounds (One Hetero Atom): Other 6-Membered Rings and other aspects.Name: 1-[(Dibenzylamino)methyl]cyclopropanol

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