Tag: 200-300

Pang, Yue-Hong; Huang, Yu-Ying; Shen, Xiao-Fang; Wang, Yi-Ying published their research in Analytica Chimica Acta in 2021. The article was titled 《Electro-enhanced solid-phase microextraction with covalent organic framework modified stainless steel fiber for efficient adsorption of bisphenol A》.COA of Formula: C9H6O6 The article contains the following contents:

In this work, electro-enhanced solid-phase microextraction (EE-SPME) and covalent organic framework (COF) were adopted to improve the extraction efficiency. A conductive COF synthesized of 2,6-diaminoanthraquinone (DQ) and 1,3,5-triformylphloroglucinol (TP) was in situ bonded to the stainless steel wire via facile solution-phase approach and used as the EE-SPME fiber coating to preconc. a typical endocrine disruptor bisphenol A (BPA). Compared with conventional SPME, the DQTP bonded fiber coupled with EE-SPME device exhibited higher extraction efficiency and achieved extraction equilibrium within 10 min. The proposed approach based on EE-SPME and gas chromatog. coupled with flame ionization detector gave a linear range of 0.05-10μg mL-1 and detection limit of 3μg L-1 (S/N = 3) with good precision (<6.7%) and reproducibility (<7.1%) spiked with 0.1, 0.5, 1.0μg mL-1 BPA. Quant. determination of BPA in extracts of food packagings (mineral water bottles, milk boxes and milk tea cups) was achieved with recoveries from 88.6 to 118.0%.2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4COA of Formula: C9H6O6) was used in this study.

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.COA of Formula: C9H6O6For acyl phloroglucinols, it is considered the largest category of compounds among phloroglucinols of natural characteristics.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《A functionalized magnetic covalent organic framework for sensitive determination of trace neonicotinoid residues in vegetable samples》 was written by Lu, Junyu; Wang, Rui; Luan, Jingyi; Li, Yijun; He, Xiwen; Chen, Langxing; Zhang, Yukui. Electric Literature of C9H6O6 And the article was included in Journal of Chromatography A in 2020. The article conveys some information:

A functionalized magnetic covalent organic framework containing the nitro groups (Fe3O4@COF-(NO2)2) with core-shell structure was synthesized for magnetic solid phase extraction (MSPE) of six neonicotinoid insecticides residue in vegetable samples. The structure of Fe3O4@COF-(NO2)2 was investigated by various characterization techniques. The Fe3O4@COF-(NO2)2 exhibits the excellent thermal and chem. stability, high surface area (254.72 m2 g-1), total pore volume (0.19 cm3 g-1), high magnetic responsivity (27.7 emu g-1), which can be used as an ideal adsorbent for rapid isolation and enrichment of target analytes. A sensitive method was developed by using Fe3O4@COF-(NO2)2-based MSPE coupled with HPLC with UV detection. It offered good linearity within the range of 0.1-30 ng mL-1, low limits of detection (S/N = 3) of 0.02-0.05 ng mL-1. Furthermore, high enrichment factors of 170-250 for six neonicotinoid insecticides were obtained. The applicability of Fe3O4@COF-(NO2)2 is demonstrated for measuring trace neonicotinoid residues in vegetable samples with satisfactory recoveries, which ranged from 77.5 to 110.2%. The results indicated that the Fe3O4@COF-(NO2)2 microspheres offer great potential for efficient extraction of neonicotinoid insecticides from complex samples. In the experimental materials used by the author, we found 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Electric Literature of C9H6O6)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Regarding monomeric phloroglucinols, this group encompasses acryl phloroglucinols, phloroglucinol-terpene adducts, phloroglucinol glycosides, halogenated phloroglucinols, prenylated phloroglucinols, and cyclicroup polyketides.Electric Literature of C9H6O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Zhang, Qi; Wang, Bing; Liu, Jia-Qin; Fu, Yao; Wu, Yu-Cheng published 《Mechanistic Insights into Solvent and Ligand Dependency in Cu(I)-Catalyzed Allylic Alkylation with gem-Diborylalkanes》.Journal of Organic Chemistry published the findings.Related Products of 78782-17-9 The information in the text is summarized as follows:

The recent Cu-catalyzed allylic substitution reaction between gem-diborylalkane and allyl electrophiles shows intriguing solvent and ligand-controlled regioselectivity. The α-alkylation product was obtained in DMF solvent, while γ-alkylation product was obtained in dioxane solvent and the dioxane and NHC ligand situation. In the present study, d. functional theory calculations have been used to investigate the reaction mechanism and origin of the regioselectivity. For both dioxane and DMF, γ-alkylation undergoes successive oxidative addition (CH2Bpin trans to leaving group) and direct Cγ-C reductive elimination. The α-alkylation is found to undergo oxidative addition (CH2Bpin trans to leaving group), isomerization, and Cα-C reductive elimination rather than the previously proposed oxidative addition (-CH2Bpin cis to the leaving group) and Cα-C reductive elimination. The γ-alkylation and α-alkylation is, resp., favorable for dioxane and DMF solvent, which is consistent with the γ- and α-selectivity in experiment The solvent interferes the isomerization step, thereby affects the relative facility of the α- and γ-alkylation. Further investigation shows that η1-intermediate formation promoted by solvent is the rate-determining step of the isomerization. The stronger electron-donating ability of DMF than dioxane facilitates the η1-intermediate formation and finally results in the easier isomerization in DMF. For dioxane and NHC situation, in the presence of neutral NHC ligand, the -PO4Et2 group tightly coordinates with the Cu center after the oxidative addition, preventing the isomerization process. The regioselectivity is determined by the relative facility of the oxidative addition step. Therefore, the favorable oxidative addition (in which -CH2Bpin trans to the leaving group) results in the facility of γ-alkylation.Bis[(pinacolato)boryl]methane(cas: 78782-17-9Related Products of 78782-17-9) was used in this study.

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.Related Products of 78782-17-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Construction of diverse C-S/C-Se bonds via nickel catalyzed reductive coupling employing thiosulfonates and a selenosulfonate under mild conditions》 were Liu, Yong; Xing, Shuya; Zhang, Jing; Liu, Wen; Xu, Yuenian; Zhang, Yan; Yang, Kefang; Yang, Lei; Jiang, Kezhi; Shao, Xinxin. And the article was published in Organic Chemistry Frontiers in 2022. COA of Formula: C12H20O6 The author mentioned the following in the article:

A nickel-catalyzed reductive cross coupling between organic iodides and thiosulfonates and a selenosulfonate under mild conditions was disclosed. This practical method provides a facile access to a series of unsym. thioethers with low catalyst loading, good functional group tolerance, and excellent chemo-selectivity. Notably, the synthetic applications of the approach feature scaling-up of reactions, late-stage modification of pharmaceuticals, and preparation of various useful targeted compounds, including sulfoximine, bipyridine, and vortioxetine. Primary mechanistic studies showed that a radical pathway was involved. Moreover, diverse C-S/C-Se bond formations were achieved under mild reaction conditions. The experimental process involved the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6COA of Formula: C12H20O6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.COA of Formula: C12H20O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Newar, Rajashree; Begum, Wahida; Antil, Neha; Shukla, Sakshi; Kumar, Ajay; Akhtar, Naved; Balendra; Manna, Kuntal published their research in Inorganic Chemistry on August 3 ,2020. The article was titled 《Single-Site Cobalt-Catalyst Ligated with Pyridylimine-Functionalized Metal-Organic Frameworks for Arene and Benzylic Borylation》.COA of Formula: C14H21BO2 The article contains the following contents:

A highly active single-site heterogeneous cobalt-catalyst is reported based on a porous and robust pyridylimine-functionalized metal-organic frameworks (pyrim-MOF) for chemoselective borylation of arene and benzylic C-H bonds. The pyrim-MOF having UiO-68 topol., constructed from zirconium-cluster secondary building units and pyridylimine-functionalized dicarboxylate bridging linkers, was metalated with CoCl2 followed by treatment of NaEt3BH to give the cobalt-functionalized MOF-catalyst (pyrim-MOF-Co). Pyrim-MOF-Co has a broad substrate scope, allowing the C-H borylation of halogen-, alkoxy-, alkyl-substituted arenes as well as heterocyclic ring systems using B2pin2 or HBpin (pin = pinacolate) as the borylating agent to afford the corresponding arene- or alkyl-boronate esters in good yields. Pyrim-MOF-Co gave a turnover number (TON) of up to 2500 and could be recycled and reused at least 9 times. Pyrim-MOF-Co was also significantly more robust and active than its homogeneous control, highlighting the beneficial effect of active-site isolation within the MOF framework that prevents intermol. decomposition The exptl. and computational studies suggested (pyrim•-)CoI(THF) as the active catalytic species within the MOF, which undergoes a mechanistic pathway of oxidative addition, turnover limiting σ-bond metathesis, followed by reductive elimination to afford the boronate ester. The pyridylimine-functionalized metal-organic framework (pyrim-MOF)-based single-site cobalt-catalyst is efficient for chemoselective borylation of arene and benzylic C-H bonds. The heterogeneous MOF-catalyst is significantly more robust and active than its homogeneous control, highlighting the beneficial effect of active-site isolation within the MOF framework that prevents intermol. decomposition In the part of experimental materials, we found many familiar compounds, such as 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0COA of Formula: C14H21BO2)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.COA of Formula: C14H21BO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safety of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetateOn March 1, 2020, Townsend, Jakob M.; Sali, Goksel; Homburg, Hannah B.; Cassidy, Nina T.; Sanders, Megan E.; Fung, Kar-Ming; Andrews, Brian T.; Nudo, Randolph J.; Bohnstedt, Bradley N.; Detamore, Michael S. published an article in Acta Biomaterialia. The article was 《Thiolated bone and tendon tissue particles covalently bound in hydrogels for in vivo calvarial bone regeneration》. The article mentions the following:

Bone regeneration of large cranial defects, potentially including traumatic brain injury (TBI) treatment, presents a major problem with non-crosslinking, clin. available products due to material migration outside the defect. Com. products such as bone cements are permanent and thus not conducive to bone regeneration, and typical com. bioactive materials for bone regeneration do not crosslink. Our previous work demonstrated that non-crosslinking materials may be prone to material migration following surgical placement, and the current study attempted to address these problems by introducing a new hydrogel system where tissue particles are themselves the crosslinker. Specifically, a pentenoate-modified hyaluronic acid (PHA) polymer was covalently linked to thiolated tissue particles of demineralized bone matrix (TDBM) or devitalized tendon (TDVT), thereby forming an interconnected hydrogel matrix for calvarial bone regeneration. All hydrogel precursor solutions exhibited sufficient yield stress for surgical placement and an adequate compressive modulus post-crosslinking. Critical-size calvarial defects were filled with a 4% PHA hydrogel containing 10 or 20% TDBM or TDVT, with the clin. product DBX being employed as the standard of care control for the in vivo study. At 12 wk, micro-computed tomog. anal. demonstrated similar bone regeneration among the exptl. groups, TDBM and TDVT, and the standard of care control DBX. The group with 10% TDBM was therefore identified as an attractive material for potential calvarial defect repair, as it addnl. exhibited a sufficient initial recovery after shearing (i.e., > 80% recovery). Future studies will focus on applying a hydrogel in a rat model for treatment of TBI. Non-crosslinking materials may be prone to material migration from a calvarial bone defect following surgical placement, which is problematic for materials intended for bone regeneration. Unfortunately, typical crosslinking materials such as bone cements are permanent and thus not conducive to bone regeneration, and typical bioactive materials for bone regeneration such as tissue matrix are not crosslinked in com. products. The current study addressed these problems by introducing a new biomaterial where tissue particles are themselves the crosslinker in a hydrogel system. The current study successfully demonstrated a new material based on pentenoate-modified hyaluronic acid with thiolated demineralized bone matrix that is capable of rapid crosslinking, with desirable paste-like rheol. of the precursor material for surgical placement, and with bone regeneration comparable to a com. available standard-of-care product. Such a material may hold promise for a single-surgery treatment of severe traumatic brain injury (TBI) following hemicraniectomy. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Safety of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate)

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine being a good nucleophile easily undergoes electrophilic substitution reactions with different electrophiles such alkyl halides and acyl halides, and forms N-substituted pyrrolidines. N-Alkylpyrrolidine on further reaction with alkyl halide provided quaternary salts.Safety of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Iron-catalyzed Versatile and Efficient C(sp2)-H Borylation》 was published in Chemistry Letters in 2019. These research results belong to Kamitani, Masahiro; Kusaka, Haruki; Yuge, Hidetaka. Recommanded Product: 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane The article mentions the following:

The efficient C-H borylation of a variety of aromatic hydrocarbons and heteroarenes has been achieved using an iron complex bearing a quinoline-based PNN pincer ligand. Mechanistic studies revealed the formation of a bis-boryl complex, which plays a crucial role in the catalytic cycle. The methodol. allows the borylation of unactivated arenes using iron catalysts. The experimental process involved the reaction of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Recommanded Product: 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group.Recommanded Product: 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《In-situ layer-by-layer synthesized TpPa-1 COF solid-phase microextraction fiber for detecting sex hormones in serum》 was written by Zheng, Jiating; Huang, Shuyao; Tong, Yuanjun; Wei, Songbo; Chen, Guosheng; Huang, Siming; Ouyang, Gangfeng. Reference of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehydeThis research focused onTpPa1 COF solid phase microextraction fiber serum sex hormone; testosterone progesterone dehydroepiandrosterone TpPa1 COF; In-situ layer-by-layer synthesis; Sex hormone detection; Solid-phase microextraction; TpPa-1 COFs. The article conveys some information:

The secretion disorder of sex hormones is the source that leads to the occurrence of many diseases such as polycystic ovarian syndrome (PCOS), hyperandrogenism and so on. There exist physiol. changes in human body when slight fluctuations in concentrations of sex hormones happen. Therefore, it′s of great significance for accurate detection of sex hormones in human body. In this work, TpPa-1 COF solid-phase microextraction (SPME) fiber was prepared using high-efficient in-situ synthesis strategy and coupled with HPLC-MS/MS to detect three sex hormones, including Progesterone (P), testosterone (T) and dehydroepiandrosterone (DHEA) in human serum. The thickness of the coating reached 7 μm within 2 h. Under the optimal conditions, the established method presented low limit of detections (LODs, ≤ 0.75 ng/mL), wide linear ranges (0.100-100 ng mL-1) and good reproducibility, and three sex hormones (T, P, DHEA) were successfully detected and quantified in human serum. In conclusion, the established SPME method presented high-efficient fiber preparation and good anal. performances of sex hormone detection, therefore was in great potential for application in clin.2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Reference of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde) was used in this study.

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Phloroglucinol derivatives are a major class of secondary metabolites. Phloroglucinol compounds can be classified into monomeric, dimeric, trimeric and higher phloroglucinols, and phlorotannins.Reference of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zagranyarski, Yulian; Mutovska, Monika; Petrova, Petia; Tomova, Reni; Ivanov, Petar; Stoyanov, Stanimir published their research in Dyes and Pigments in 2021. The article was titled 《Dioxin-annulated 1,8-naphthalimides – Synthesis, spectral and electrochemical properties, and application in OLED》.HPLC of Formula: 24388-23-6 The article contains the following contents:

A synthetic approach for preparation of a new class of 1,8-naphthalimide derivatives with fused benzo and naphtho-dioxin systems is reported. The proposed reaction conditions for the first step allow selective bromination of 1,8-naphthalic anhydride to the corresponding 3,4,6-tribromo derivative, which has the potential to be versatile building block in the chem. of naphthalimides. The dioxin-annulated products were isolated in very good yields and their applicability for further modifications by metal-catalyzed coupling reactions was proven. The synthesized fluorescent dyes showed media dependant emission and their photophys. and electroluminescent properties were evaluated with respect to their application in OLED. TGA measurements showed that all compounds are stable up to above 400°C. The best OLED test device has turn-on voltage of 8 V; maximum luminescent intensity of 3031 cd/m2, and current efficiency of 6.9 cd/A. In the part of experimental materials, we found many familiar compounds, such as 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6HPLC of Formula: 24388-23-6)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used to prepare sulfinamide derivatives by reacting with diethylaminosulfur trifluoride (DAST) and potassium phenyltrifluoroborate.HPLC of Formula: 24388-23-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Zhe; Yin, Congcong; Yang, Guanghui; Xiao, Ankang; Shi, Xiansong; Xing, Weihong; Wang, Yong published their research in Journal of Membrane Science in 2021. The article was titled 《Stitching nanosheets of covalent organic frameworks to build aligned nanopores in nanofiltration membranes for precise ion separations》.Application of 34374-88-4 The article contains the following contents:

Embedding nanofillers into polyamide (PA) matrixes is considered as a simple yet effective strategy for boosting the performances of thin-film nanocomposite (TFN) nanofiltration (NF) membranes. However, the NF performances are usually compromised by the inadequate interface compatibility between nanofillers and PA matrixes as well as the anisotropic orientation of nanofillers. Herein, we propose a distinctive fabrication strategy for TFN membranes featuring excellent compatibility and highly-aligned microstructures. The reactive covalent organic framework (COF) nanosheets are chem. stitched at oil-water interfaces to form continuous nanofilms, and the PA matrixes are then in-situ formed to encapsulate them, giving the TFN membranes. The stitched nanofilms contain two types of perpendicularly oriented pores: intrinsic apertures in COF nanosheets, and gaps among adjacent nanosheets. Together with the abundant reactive sites, the stitched nanofilms not only mediate the controllable synthesis of PA matrixes, but also are covalently fused into the matrixes. The aligned pores of the stitched nanosheets are capable of sieving salt ions, endowing TFN membranes with high separation precision and fast water permeation. This work demonstrates a strategy to control the orientation of COF nanosheets, which is highly desired in diverse fields not limited to membrane separation In the experimental materials used by the author, we found 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Application of 34374-88-4)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives.Application of 34374-88-4For acyl phloroglucinols, it is considered the largest category of compounds among phloroglucinols of natural characteristics.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts